Cytological features of adenocarcinoma admixed with small cell neuroendocrine carcinoma of the uterine cervix
Naoshi Shimojo, Yoshifumi S Hirokawa, Kazuki Kanayama, Misao Yoneda, Ryotaro Hashizume, Akinobu Hayashi, Katsunori Uchida, Hiroshi Imai, Yuji Kozuka, Taizo ShiraishiCytoJournal 2017 14(1):12-12Adenocarcinoma admixed with neuroendocrine carcinoma of the uterine cervix is a rare malignancy with a poor prognosis, and few reports have described the cytological features of this carcinoma. To characterize the cytological features of this malignancy in cervical smears, we report a case of a 52-year-old Japanese woman with cervical adenocarcinoma admixed with small cell neuroendocrine carcinoma (SCNEC). Cytologically, there were t...
Source: CytoJournal - May 26, 2017 Category: Pathology Authors: Naoshi Shimojo Yoshifumi S Hirokawa Kazuki Kanayama Misao Yoneda Ryotaro Hashizume Akinobu Hayashi Katsunori Uchida Hiroshi Imai Yuji Kozuka Taizo Shiraishi Source Type: research
& #8220;Low-grade squamous intraepithelial lesion, cannot exclude high-grade: & #8221; TBS says & #8220;Don & #39;t Use It! & #8221; should I really stop it ?
Conclusions: “LSIL-H” category detects more HGD+ than LSIL, and fewer than ASC-H and HSIL. If LSIL-H is eliminated, Paps with this finding are best reported as ASC-H to ensure that women with potential HGD+ undergo colposcopy in a timely manner. Reporting LSIL-H as LSIL may delay colposcopy since management of LSIL Paps depends on multiple factors (age, HPV status, etc.). (Source: CytoJournal)
Source: CytoJournal - May 26, 2017 Category: Pathology Authors: Jeanine M Chiaffarano Melissa Alexander Robert Rogers Fang Zhou Joan Cangiarella Melissa Yee-Chang Paul Elgert Aylin Simsir Source Type: research
Ultrasound-guided fine-needle aspiration of hyperenhancing lesion suspicious for pancreatic neuroendocrine tumor in the tail of pancreas-potential pitfalls
Kinda Hayek, Tatyana Kalinicheva, Vinod B ShidhamCytoJournal 2017 14(1):8-8 (Source: CytoJournal)
Source: CytoJournal - April 28, 2017 Category: Pathology Authors: Kinda Hayek Tatyana Kalinicheva Vinod B Shidham Source Type: research
Indian visceral leishmaniasis with extensive lymphadenopathy & #8211; An unusual presentation: A case report with literature review
We report a case of a patient clinically suspected of disseminated tuberculosis, but fine needle aspiration cytology of cervical and axillary lymph nodes yielded a diagnosis of leishmaniasis. Diagnosis of VL was challenging as the disease closely mimicked tuberculosis in the setting of extensive lymphadenopathy including conglomerate of mesenteric lymph nodes, on and off fever, and granulomatous lymphadenitis on aspiration. Bone marrow examination was further performed. A detailed workup revealed patient to be severely immunocompromised and newly diagnosed human immunodeficiency virus (HIV) positive. Worldwide, India has t...
Source: CytoJournal - April 28, 2017 Category: Pathology Authors: Poojan Agarwal Vijay Kumar Manju Kaushal Manju Kumari Arvind Chaudhary Source Type: research
Cytomorphologic features distinguishing Bethesda category IV thyroid lesions from parathyroid
Conclusions: There are cytomorphologic features that distinguish Beth-IV thyroid lesions and (intrathyroidal) parathyroid. These features can aid in rendering correct diagnoses and appropriate management. (Source: CytoJournal)
Source: CytoJournal - April 28, 2017 Category: Pathology Authors: Simon Sung Anjali Saqi Elizabeth M Margolskee John P Crapanzano Source Type: research
Falling under the umbrella cells: A single institutional experience and literature review of urothelial carcinoma presenting as a primary pancreatic mass on endoscopic ultrasound-guided fine-needle aspiration
We report two cases of metastatic UC mimicking a primary pancreatic lesion. Two female patients, aged 48 and 83 years, presented with isolated pancreatic lesions causing obstructive jaundice suspicious for pancreatic adenocarcinoma and underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with rapid on-site evaluation (ROSE). On cytopathology, the lesions were found to be UC, confirmed with immunohistochemical (IHC) staining. UC rarely metastasizes to the pancreas, and diagnosis through EUS-FNA can be challenging. However, the utilization of ROSE, dedicated cell block passes, and IHC have proved to be eff...
Source: CytoJournal - March 19, 2017 Category: Pathology Authors: Michael Chambers Konrad Krall Shantel H & #233;bert-Magee Source Type: research
Next-generation sequencing of non-small cell lung cancer using a customized, targeted sequencing panel: Emphasis on small biopsy and cytology
Conclusions: NGS using a comprehensive gene panel was performed successfully in 95% of all NSCLC cases in this series, including 94% small biopsy and cytology specimens and 100% surgical resections. This custom assay was performed on a range of tumor specimens and demonstrates that small specimens are able to provide a similar depth of information as larger ones. As many patients present at an advanced stage and only small specimens are obtained, the information these provide has the potential for guiding treatment in highly selected patients with advanced lung adenocarcinoma. (Source: CytoJournal)
Source: CytoJournal - March 19, 2017 Category: Pathology Authors: David M DiBardino David W Rawson Anjali Saqi Jonas J Heymann Carlos A Pagan William A Bulman Source Type: research
Thyroid fine-needle aspiration of an immunocompromised patient: Cytomorphological clues
Longwen Chen, Nirvikar Dahiya, Matthew A ZarkaCytoJournal 2017 14(1):3-3 (Source: CytoJournal)
Source: CytoJournal - February 23, 2017 Category: Pathology Authors: Longwen Chen Nirvikar Dahiya Matthew A Zarka Source Type: research
Detection of BRAF mutation in the cytocentrifugation supernatant fluid from fine-needle aspiration of thyroid lesions may enhance the diagnostic yield
Conclusions: The vast majority of routinely discarded FNA supernatants contain amplifiable DNA. In addition, profiling the mutations of BRAF and other genes using supernatant DNA may provide valuable diagnostic information to assist the diagnosis of PTC in patients with clinical/morphologic findings suspicious for malignancies and cellular DNA showing no mutations. (Source: CytoJournal)
Source: CytoJournal - February 23, 2017 Category: Pathology Authors: Ashley E Brown Khin Sandar Lim George Corpus Martha T Hustek Tien Anh N Tran Chung-Che Chang Source Type: research
KRAS detection on archival cytological smears by the novel fully automated polymerase chain reaction-based Idylla mutation test
Conclusion: Even in less experienced laboratories, a cytopathologist may easily integrate morphological diagnostic report with accurate KRAS mutation detection, which is relevant for diagnostic and treatment decisions. (Source: CytoJournal)
Source: CytoJournal - February 23, 2017 Category: Pathology Authors: Caterina De Luca Elena Vigliar Melania d & #39;Anna Pasquale Pisapia Claudio Bellevicine Umberto Malapelle Giancarlo Troncone Source Type: research
Evaluation of polymerase chain reaction in space-occupying lesions of liver reported as granulomatous inflammation/tuberculosis on fine-needle aspiration cytology
Conclusion: Cytomorphology alone may not be sufficient for differentiating various granulomatous lesions reported in liver SOLs. DNA can be extracted from the archival cytological MGG-stained smears. PCR should be carried out if Ziehl–Neelsen staining is negative in granulomatous lesions, especially when material has not been submitted for culture. (Source: CytoJournal)
Source: CytoJournal - January 19, 2017 Category: Pathology Authors: Kusum Sharma Nalini Gupta Kapil Goyal Ajay Kumar Duseja Aman Sharma Arvind Rajwanshi Source Type: research
Primary orbital mantle cell lymphoma: Flow cytometric immunophenotyping as an adjunct to fine-needle aspiration cytology for diagnosis
Sangeeta Verma, Nalini Gupta, Satyawati Mohindra, Manupdesh Singh Sachdeva, Arvind RajwanshiCytoJournal 2017 14(1):2-2 (Source: CytoJournal)
Source: CytoJournal - January 19, 2017 Category: Pathology Authors: Sangeeta Verma Nalini Gupta Satyawati Mohindra Manupdesh Singh Sachdeva Arvind Rajwanshi Source Type: research
Detection of in situ and invasive endocervical adenocarcinoma on ThinPrep Pap Test: Morphologic analysis of false negative cases
Conclusion: A significant proportion of AIS/EAC is discovered after Pap showing squamous cell abnormality. FN cases were most commonly related to nuclear overlap in tight three-dimensional clusters. (Source: CytoJournal)
Source: CytoJournal - December 19, 2016 Category: Pathology Authors: Michael Chaump Edyta C Pirog Vinicius J. A. Panico Alexandre Buckley d Meritens Kevin Holcomb Rana Hoda Source Type: research
An unexpected diagnosis of ectopic liver diagnosed by fine needle aspiration
Gonzalo Barazza, Douglas G Adler, Rachel E FactorCytoJournal 2016 13(1):29-29The differential diagnosis of perigastric masses is broad, ranging from benign to malignant entities. Among the benign entities, accessory liver lobes and ectopic liver are unusual and often incidentally discovered. Here, we report a patient with malignant melanoma who was clinically suspected to have a perigastric metastasis or a gastrointestinal stromal tumor but was ultimately diagnosed by fine needle aspiration (FNA) to have benign ectopic liver. A 47-year-old male was diagnosed with malignant melanoma of the scalp in May 2015 at a tertiary ca...
Source: CytoJournal - December 19, 2016 Category: Pathology Authors: Gonzalo Barazza Douglas G Adler Rachel E Factor Source Type: research
Diagnostic utility of double immunostaining of a urine cytology preparation for cytokeratin 20/p53 expression in a young woman with micropapillary urothelial carcinoma of the renal pelvis presenting as an unknown primary malignancy
We report a case presenting as an unknown primary malignancy, which illustrated the diagnostic utility of direct double immunostaining for cytokeratin 20 (CK20)/p53 expression in a urine CYT specimen. A 42-year-old woman visited the emergency room for pain in her right lower abdominal quadrant. Computed tomography revealed postrenal obstructive hydronephrosis, and her urine CYT showed malignancy, type undetermined. Atypical cells that are positive for cytoplasmic expression of CK20 and nuclear expression of p53 could facilitate the decision to perform a nephroureterectomy for urothelial carcinoma. (Source: CytoJournal)
Source: CytoJournal - November 15, 2016 Category: Pathology Authors: Hyun-Jung Kim Lucky Sung Jung-Yeon Kim Kyeongmee Park Source Type: research
