Potential protective effects of naringin on oculo-pulmonary injury induced by wood smoke PM10 exposure by modulation of oxidative damage and acetylcholine esterase activity in a rat model
Publication date: Available online 20 April 2020Source: Current Therapeutic ResearchAuthor(s): J.K. Akintunde, J.B. Abioye, O.N. Ebinama (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 21, 2020 Category: Drugs & Pharmacology Source Type: research
Multiple Relapses of Visceral Leishmaniasis in HIV Co-Infected Patients: A Case Series from Ethiopia
Publication date: Available online 8 April 2020Source: Current Therapeutic ResearchAuthor(s): Rezika Mohammed, Helina Fikre, Angela Schuster, Tigist Mekonnen, Johan van Griensven, Ermias Diro (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 9, 2020 Category: Drugs & Pharmacology Source Type: research
Drug-Induced Liver Injury in Critically Ill Children Taking Antiepileptic Drugs: A Retrospective Study
Publication date: 2020Source: Current Therapeutic Research, Volume 92Author(s): Kannan Sridharan, Amal Al Daylami, Reema Ajjawi, Husain A.M. Al Ajooz (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 6, 2020 Category: Drugs & Pharmacology Source Type: research
Effect of Polyarginine Peptide R18D Following a Traumatic Brain Injury in Sprague-Dawley Rats
Publication date: Available online 19 March 2020Source: Current Therapeutic ResearchAuthor(s): Li Shan Chiu, Ryan S. Anderton, Vince W. Clark, Jane L. Cross, Neville W. Knuckey, Bruno P. Meloni (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 19, 2020 Category: Drugs & Pharmacology Source Type: research
Drug-induced liver injury in critically ill children on anti-epileptic drugs: A retrospective study
Publication date: Available online 9 March 2020Source: Current Therapeutic ResearchAuthor(s): Kannan Sridharan, Amal Al Daylami, Reema Ajjawi, Husain AM Al Ajooz (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 10, 2020 Category: Drugs & Pharmacology Source Type: research
The Effects of Clinical Pharmacist Education on Lifestyle Modifications of Postmyocardial Infarction Patients in South India: A Prospective Interventional Study
Publication date: 2020Source: Current Therapeutic Research, Volume 92Author(s): Sarumathy Sundararajan, Shanmugarajan Thukani Sathanantham, Shanmugasundaram Palani (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 26, 2020 Category: Drugs & Pharmacology Source Type: research
Prevalence of Chronic Kidney Disease and Associated Factors among Patients with Diabetes in Northwest Ethiopia: A Hospital-Based Cross-Sectional Study
Publication date: Available online 26 February 2020Source: Current Therapeutic ResearchAuthor(s): Hailemaryam Alemu, Workagegnehu Hailu, Aynshet Adane (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 26, 2020 Category: Drugs & Pharmacology Source Type: research
Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: A Postmarket, Open-Label, Long-Term Historical Control Study with Analysis Detailed per Krellgren-Lawrence Radiologic Osteoarthritis Scale Grade
Publication date: Available online 26 February 2020Source: Current Therapeutic ResearchAuthor(s): Patrice Vincent, Thibaut Lucas de Couville, Thierry Thomas (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 26, 2020 Category: Drugs & Pharmacology Source Type: research
Medical reversals in family practice: a review
ConclusionWhile these practices were implemented because of sound biologic plausibility or encouraging observational data, well-done RCTs have failed to show evidence of effectiveness. These examples raise caution in introducing new clinical interventions into widespread clinical practice without sufficient high quality evidence demonstrating efficacy. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 23, 2020 Category: Drugs & Pharmacology Source Type: research
Synergistic Effect of 1,3,6-Trihydroxy-4,5,7-Trichloroxanthone in Combination with Doxorubicin on B-Cell Lymphoma Cells and Its Mechanism of Action Through Molecular Docking
ConclusionsThe xanthone-doxorubicin combination showed promising in vitro activity against lymphoma cells. The results also indicate that the TTX and doxorubicin combination's effect was due to the interaction between TTX with Raf-1 and c-Jun N-kinase receptors, 2 determinants of doxorubicin resistance progression. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 21, 2020 Category: Drugs & Pharmacology Source Type: research
Clinical Pharmacist Education on Lifestyle modifications of Post Myocardial Infarction Patients of South India- A Prospective Interventional Study
ConclusionClinical Pharmacist counseling improved the medication adherence and lifestyle modifications in post MI patients with the reduction in blood glucose, blood pressure and total cholesterol levels among the study population. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 31, 2020 Category: Drugs & Pharmacology Source Type: research
Potential use of 1,3,6-trihydroxy-4,5,7-trichloroxanthone and doxorubicin combination on B-cell lymphoma and its mechanism of actions through molecular docking study
ConclusionsThe xanthone-doxorubicin combination showed promising in vitro activity against lymphoma cells. The results also indicate that the TTX and doxorubicin combination's effect was due to the interaction between TTX with Raf-1 and JNK receptors, two determinants of doxorubicin resistance progression. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 31, 2020 Category: Drugs & Pharmacology Source Type: research
Intra-Articular Hyaluronic Acid and Chondroitin Sulfate: Pharmacokinetic Investigation in Osteoarthritic Rat Models
ConclusionsDespite differences in their molecular size, HA and CS showed PK behavior similarly characterized by prolonged residence inside the joint and slow release in plasma, favoring long-term beneficial effects. (Curr Ther Res Clin Exp. 2020; 92:XXX–XXX) (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 12, 2020 Category: Drugs & Pharmacology Source Type: research
Gonadotropin versus Follicle-Stimulating Hormone for Ovarian Response in Patients Undergoing in vitro Fertilization: A Retrospective Cohort Comparison
Conclusionshp-HMG and rFSH did not lead to significantly different treatment outcomes in patients with poor ovarian response undergoing in vitro fertilization/intracytoplasmic sperm injection with a gonadotropin-releasing hormone antagonist protocol, although significantly higher serum insulin-like growth factor-1 level and insignificantly lower serum insulin-like growth factor binding protein-1 level on the day of oocyte retrieval associated with hp-HMG might suggest a beneficial endocrine environment. (Curr Ther Res Clin Exp. 2020; 81:XXX–XXX) (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 3, 2020 Category: Drugs & Pharmacology Source Type: research
Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1
ConclusionsIn contrast to PSNCBAM-1, the synthesized compounds are analogs with fewer rings. The compounds LDK1317 (12a) and LDK1321 (6a) contained only 2 or 3 rings, respectively, and showed the binding parameters (KB = 110 nM, α = 2.3, and KB = 85 nM, α = 5.9). Further, the computationally predicted drug-like properties and solubility suggest these compounds are acceptable new lead compounds for further development of CB1 allosteric modulators. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 25, 2019 Category: Drugs & Pharmacology Source Type: research
