Clinicopathologic Significance of LAIR-1 Expression in Hepatocellular Carcinoma
Worldwide, hepatocellular carcinoma (HCC) currently represents the fifth most commonly occurring solid tumor mass and the third leading cause of cancer-related deaths [1, 2]. In spite of remarkable progress in the treatment and understanding of HCC, the molecular mechanisms underlying HCC carcinogenesis remain to be elucidated [3, 4]. Most HCC patients are considered incurable as a result of extensive heterogeneity in clinical presentations and tumor biology, which complicates the classification and procedures for therapy [5, 6]. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 28, 2018 Category: Cancer & Oncology Authors: Xiaojie Wu, Leyan Zhang, Jiadi Zhou, Luying Liu, Qiang Fu, Aili Fu, Xiaoying Feng, Rui Xin, Hongrui Liu, Yong Gao, Jiangnan Xue Source Type: research
COMPARISON OF 7th TNM AND 8th TNM STAGING SYSTEM IN STAGE III NON-SMALL CELL LUNG CANCER PATIENTS TREATED WITH CONCURRENT CHEMORADIOTHERAPY
Stage classification of a cancer is important as it provides a nomenclature for description and grouping of the patients and helping clinicians for selecting treatment options and predicting the probable outcomes. It enables the comparison and classification of patients with different size and extent of disease. TNM classification is used for staging of lung cancer, according to the definitions regarding primary tumor for T, nodal stations for N and metastatic lesions for M. [1] The eighth edition of TNM lung cancer staging and proposals has been introduced in 2015 and implemented through January 2017 in countries beside U...
Source: Current Problems in Cancer - April 28, 2018 Category: Cancer & Oncology Authors: Ufuk Y ılmaz, Özer Özdemir, Ülkü Yılmaz Source Type: research
Gearing up T-cell immunotherapy in cervical cancer
The World Health Organization estimates more than 270,000 deaths annually by cervical cancer. Present vaccines are prophylactic in nature which cannot treat huge bulk of cervical cancer patients worldwide. Available therapies like radiotherapy, chemotherapy, or surgery are not effective in high-grade lesion, and hence, there is an unmet medical need for an effective form of therapy. T cells play a significant role in cervical cancer pathogenesis as human papilloma virus uses multiple mechanisms that dodge host T-cell immune-surveillance aiding in persistence of infection and establishment of cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 20, 2018 Category: Cancer & Oncology Authors: Shilpa Raghuvanshi Chauhan, Mausumi Bharadwaj Source Type: research
Gearing up t cell immunotherapy in cervical cancer
The World Health Organization (WHO) estimates more 270000 deaths annually by cervical cancer. Present vaccines are prophylactic in nature which cannot treat huge bulk of cervical cancer patients worldwide. Available therapies like radiotherapy, chemotherapy or surgery are not effective in high grade lesion and hence, there is an unmet medical need for an effective form of therapy. T cells play a significant role in cervical cancer pathogenesis as Human Papilloma Virus (HPV) uses multiple mechanisms that dodge host T cell immune-surveillance aiding in persistence of infection and establishment of cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 20, 2018 Category: Cancer & Oncology Authors: Shilpa Raghuvanshi Chauhan, Mausumi Bharadwaj Source Type: research
Influence of wellness education on first-line icotinib hydrochloride patients with stage IV non –small cell lung cancer and their family caregivers
This study aims to examine the effects of wellness education (WE) intervention on the behavioral change, psychological status, performance status on patients with stage IV non –small cell lung cancer (NSCLC) undergoing icotinib hydrochloride treatment and their relationships with family caregivers. Methods: We conducted an intervention study involving 126 individuals with confirmed activating epidermal growth factor receptor mutation-positive stage IV NSCLC who received icotinib hydrochloride as first-line therapy between January 2014 and January 2016; their caregivers were also included in the study. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 10, 2018 Category: Cancer & Oncology Authors: Li Yanwei, Fang Minghui, Quan Manman, Yan Zhuchun, Liu Dongying, Pan Zhanyu Source Type: research
Influence of wellness-education on first-line icotinib hydrochloride patients with stage IV non-small cell lung cancer and their family caregivers
This study aims to examine the effects of wellness-education (WE) intervention on the behavioral change, psychological status, performance status on patients with stage IV non-small cell lung cancer (NSCLC) undergoing icotinib hydrochloride treatment and their relationships with family caregivers. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 10, 2018 Category: Cancer & Oncology Authors: Li Yanwei, Fang minghui, Quan manman, Yan zhuchun, Liu dongying, Pan zhanyu Source Type: research
HPV: Molecular pathways and targets
Infection of high-risk human papillomaviruses (HPVs) is a prerequisite for the development of cervical carcinoma. HPV infections are also implicated in the development of other types of carcinomas. Chronic or persistent infection of HPV is essential but HPV alone is inadequate, additional endogenous or exogenous cues are needed along with HPV to induce cervical carcinogenesis. The strategies that high-risk HPVs have developed in differentiating epithelial cells to reach a DNA-synthesis competent state leading to tumorigenic transformation are basically due to overexpression of the E6 and E7 oncoproteins and the activation ...
Source: Current Problems in Cancer - April 5, 2018 Category: Cancer & Oncology Authors: Shilpi Gupta, Prabhat Kumar, Bhudev C. Das Source Type: research
HPV: Molecular Pathways and Targets
Infection of high-risk human papillomaviruses (HR-HPVs) is a prerequisite for the development of cervical carcinoma. HPV infections are also implicated in the development of other types of carcinomas. Chronic or persistent infection of HPV is essential but HPV alone is inadequate, additional endogenous and/or exogenous cues are needed along with HPV to induce cervical carcinogenesis. The strategies that HR-HPVs have developed in differentiating epithelial cells to reach a DNA-synthesis competent state leading to tumorigenic transformation are basically due to overexpression of the E6 and E7 oncoproteins and the activation ...
Source: Current Problems in Cancer - April 5, 2018 Category: Cancer & Oncology Authors: Shilpi Gupta, Prabhat Kumar, Bhudev C. Das Source Type: research
Combined chemoradiation vs radiation therapy alone in stage-II nasopharyngeal carcinoma: A meta-analysis of the published literature
The aim of this meta-analysis was to evaluate the efficacy and toxicity of adding chemotherapy to radiotherapy (RT) in the treatment of stage-II nasopharyngeal carcinoma (NPC). We searched Pubmed, Cochrane Library, Embase, China National Knowledge Internet, China Biology Medicine, VIP, and Wanfang database for studies of the RT with or without chemotherapy in patients with stage-II NPC that were published in any language. Analyses were carried out using RevMan 5.3 software. The relative risk was used to evaluate the data, the I2 test was used to compare heterogeneity, sensitivity analysis was used to evaluate the stability...
Source: Current Problems in Cancer - April 2, 2018 Category: Cancer & Oncology Authors: Sufang Wang, Shan Li, Liangfang Shen Source Type: research
Combined Chemoradiation Versus Radiation Therapy Alone in stage-II Nasopharyngeal Carcinoma: A Meta-analysis of the published literature
The aim of this meta-analysis was to evaluate the efficacy and toxicity of adding chemotherapy to radiotherapy (RT) in the treatment of stage-II nasopharyngeal carcinoma (NPC). (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 2, 2018 Category: Cancer & Oncology Authors: Sufang Wang, Shan Li, Liangfang Shen Source Type: research
Encapsulated papillary carcinoma of the breast: A clinicopathological study of 49 cases
Background: Encapsulated papillary carcinoma (EPC) has been considered as a variant of ductal carcinoma in situ. Recent studies suggest that EPC could be invasive, as it often lacks myoepithelial cells (MECs) at their periphery. The current study was performed to investigate the biological features of EPC. Methods: Forty-nine EPC patients admitted to the Tai'an Central Hospital and Qilu Hospital of Shandong University from January 2004-December 2014 were included in this study. We retrospectively analyzed the clinicopathological findings, the presence and distribution of MECs, as well as the outcomes. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 30, 2018 Category: Cancer & Oncology Authors: Xiaomei Li, Yanmei Xu, Hong Ye, Shuming Qin, Feng Hou, Wenlou Liu Source Type: research
Encapsulated papillary carcinoma of the breast: A clinicopathological study of 49 cases
Encapsulated papillary carcinoma (EPC) has been considered as a variant of ductal carcinoma in situ (DCIS). Recent studies suggest that EPC could be invasive, as it often lacks myoepithelial cells (MECs) at their periphery. The current study was performed to investigate the biological features of EPC. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 30, 2018 Category: Cancer & Oncology Authors: Xiaomei Li, Yanmei Xu, Hong Ye, Shuming Qin, Feng Hou, Wenlou Liu Source Type: research
Bifocal hepatocellular carcinoma: Magnetic resonance imaging features after transarterial embolization
The aim of this article is to show the typical appearance of a bifocal hepatocellular carcinoma on contrast enhanced magnetic resonance imaging before and after locoregional treatment consisting of transarterial embolization (TAE). (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 28, 2018 Category: Cancer & Oncology Authors: Picchia Simona, Bali Maria Antonietta Source Type: research
Bifocal hepatocellular carcinoma (HCC): Magnetic resonance imaging features after trans-arterial embolization (TAE)
Typical imaging findings of HCC are demonstrated in this case. The spontaneous high signal intensity on unenhanced T1-weighted fat saturation (Fig. 1a; arrow) is likely related to the presence of glycogen.1 On post-contrast T1-weighted (Gadoterate meglumine. Dotarem, Guerbet, France) the tumour appears hypervascular at the arterial phase (wash-in) followed by hypovascular appearance at the portal venous phase (wash-out) when compared to the surrounding non-tumoral hepatic parenchyma (Fig. 1b-c). (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 28, 2018 Category: Cancer & Oncology Authors: Picchia Simona, Bali Maria Antonietta Source Type: research
