The discovery of segmented flaviviruses: implications for viral emergence
Publication date: February 2020Source: Current Opinion in Virology, Volume 40Author(s): Xu Zhang, Nina Wang, Zedong Wang, Quan Liu (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - March 25, 2020 Category: Virology Source Type: research
Influence of herd immunity in the cyclical nature of arboviruses
Publication date: February 2020Source: Current Opinion in Virology, Volume 40Author(s): Guilherme S Ribeiro, Gabriel L Hamer, Mawlouth Diallo, Uriel Kitron, Albert I Ko, Scott C Weaver (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - March 19, 2020 Category: Virology Source Type: research
Combating vaccine hesitancy and other 21st century social determinants in the global fight against measles
Publication date: April 2020Source: Current Opinion in Virology, Volume 41Author(s): Peter J Hotez, Tasmiah Nuzhath, Brian Colwell (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - February 27, 2020 Category: Virology Source Type: research
Editorial Board
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - December 7, 2019 Category: Virology Source Type: research
Reprogramming of cellular metabolic pathways by human oncogenic viruses
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): John G Purdy, Micah A LuftigOncogenic viruses, like all viruses, relies on host metabolism to provide the metabolites and energy needed for virus replication. Many DNA tumor viruses and retroviruses will reprogram metabolism during infection. Additionally, some viral oncogenes may alter metabolism independent of virus replication. Virus infection and cancer development share many similarities regarding metabolic reprogramming as both processes demand increased metabolic activity to produce biomass: cell proliferation in the case of canc...
Source: Current Opinion in Virology - November 23, 2019 Category: Virology Source Type: research
Editorial overview: Viruses and cancer
Publication date: Available online 13 November 2019Source: Current Opinion in VirologyAuthor(s): Marta M Gaglia, Karl Munger (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - November 13, 2019 Category: Virology Source Type: research
Editorial Board
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - November 10, 2019 Category: Virology Source Type: research
Editorial overview: Engineering cellular resistance towards the HIV cure
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Chen Liang, Ben Berkhout (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - November 10, 2019 Category: Virology Source Type: research
Cytomegalovirus is a tumor-associated virus: armed and dangerous
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Charles CobbsHuman cytomegalovirus (HCMV) gene products are present in multiple human malignancies, often in specific association with tumor cells and tumor vasculature. Emerging evidence from human and mouse models of CMV infection in cancer indicate that CMV can transform epithelial cells, promote epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial (MET) in tumor cells, promote tumor angiogenesis and proliferation and incapacitate the host anti-CMV immune response. This review will discuss the increasing role of H...
Source: Current Opinion in Virology - September 14, 2019 Category: Virology Source Type: research
Applications of CRISPR/Cas9 tools in deciphering the mechanisms of HIV-1 persistence
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Roxane Verdikt, Gilles Darcis, Amina Ait-Ammar, Carine Van LintHIV-1 infection can be controlled but not cured by combination antiretroviral therapy. Indeed, the virus persists in treated individuals in viral reservoirs, the best described of which consisting in latently infected central memory CD4+ T cells. However, other cell types in other body compartments than in the peripheral blood contribute to HIV-1 persistence. Addressing the molecular mechanisms of HIV-1 persistence and their cell-specific and tissue-specific variations is thu...
Source: Current Opinion in Virology - September 8, 2019 Category: Virology Source Type: research
Targeting HIV-1 proviral transcription
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Alex Olson, Binita Basukala, Wilson W Wong, Andrew J HendersonDespite the success of antiretroviral therapies, there is no cure for HIV-1 infection due to the establishment of a long-lived latent reservoir that fuels viral rebound upon treatment interruption. ‘Shock-and-kill’ strategies to diminish the latent reservoir have had modest impact on the reservoir leading to considerations of alternative approaches to target HIV-1 proviruses. This review explores approaches to target HIV-1 transcription as a way to block the provirus expre...
Source: Current Opinion in Virology - August 30, 2019 Category: Virology Source Type: research
Dynamic factors affecting HPV-attributable fraction for head and neck cancers
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Jitesh B Shewale, Maura L GillisonHead and neck squamous cell carcinoma (HNSCC) is attributable to carcinogen and oncogenic virus exposure and rates are driven by the prevalence, intensity, and duration of exposures. Recent dramatic shifts in human behavior have resulted in substantial heterogeneity in HNSCC incidence trends over calendar time. For example, changes in sexual behavior during the 1900s likely increased exposure to oral human papillomavirus (HPV) infection and, consequently, rates of HPV-positive HNSCC. Shifting rate-ratio...
Source: Current Opinion in Virology - August 28, 2019 Category: Virology Source Type: research
Detecting viral sequences in NGS data
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Paul G Cantalupo, James M PipasNext generation sequencing (NGS) technologies provide an increasingly important avenue for detecting known viruses, and for discovering novel viruses present in clinical or environmental samples. Several computational pipelines capable of identifying and classifying viral sequences in NGS data have been developed and used to search for viruses in human or animal samples, microbiomes, and in various environments. In this review we summarize the different approaches used to determine viral presence in sequen...
Source: Current Opinion in Virology - August 28, 2019 Category: Virology Source Type: research
Elimination of infectious HIV DNA by CRISPR–Cas9
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Atze T Das, Caroline S Binda, Ben BerkhoutCurrent antiretroviral drugs can efficiently block HIV replication and prevent transmission, but do not target the HIV provirus residing in cells that constitute the viral reservoir. Because drug therapy interruption will cause viral rebound from this reservoir, HIV-infected individuals face lifelong treatment. Therefore, novel therapeutic strategies are being investigated that aim to permanently inactivate the proviral DNA, which may lead to a cure. Multiple studies showed that CRISPR–Cas9 gen...
Source: Current Opinion in Virology - August 25, 2019 Category: Virology Source Type: research
The potential of engineered antibodies for HIV-1 therapy and cure
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Marloes Grobben, Richard AL Stuart, Marit J van GilsBroadly neutralizing antibodies (bnAbs) are currently under investigation as a therapy for HIV-1 infection and recent clinical trials have shown prolonged viral suppression by bnAbs during antiretroviral treatment interruption. Interestingly, these bnAbs also showed the ability to activate the host immune system to clear HIV-1 infected cells. There are many possibilities to further increase the potential efficacy of bnAbs. Most notably, Fc domain engineering to improve half-life and inc...
Source: Current Opinion in Virology - August 15, 2019 Category: Virology Source Type: research
