Acknowledgements to Reviewers
(Source: Current Immunology Reviews)
Source: Current Immunology Reviews - December 22, 2020 Category: Allergy & Immunology Source Type: research
Forecasting of COVID-19 Cases in India: A Predictive Study
An outbreak of new coronavirus (COVID-19) originated by SARS-CoV has reached 212 countries throughout the world. India is the second-highest populated country, so it is critical to forecasting the confirmed cases and deaths due to pandemic. To fulfil the purpose, three machine learning models Linear Regression, Multilayer Perceptron, and Sequential Minimal Optimization Regression are used. The predictive data of three geographic regions (India, Maharashtra, and Tamil Nadu) are compared with the data considered to be adequate in practice. The analysis concluded that Sequential Minimal Optimization Regression can be adopted ...
Source: Current Immunology Reviews - December 22, 2020 Category: Allergy & Immunology Source Type: research
Thymosin α1; Potential Therapeutic Implications of an Immunoregulatory Drug in the Treatment of Lymphocytopenia Associated with COVID-19
It is not unbeknownst to us that since the very onset of the COVID-19 outbreak, many patients from different age groups have suffered greatly, and in a remarkable number of cases, succumbed to their untimely demise as a result of infection with the novel coronavirus or SARS-CoV- -2. The elderly are perhaps the most vulnerable community, who stand at the pinnacle of morbidity and mortality rates due to contracting severe forms of COVID-19. Hopefully, based on the recent findings and the present evidence, there might be a number of medications that would possibly be of great prophylactic and therapeutic value to the elderly ...
Source: Current Immunology Reviews - December 22, 2020 Category: Allergy & Immunology Source Type: research
Warm Reactive Anti-A1 Agglutinin in an A2B individual: A Rare Case with Review of Literature
We report herein, a case of a massively bleeding A2B Indian lady after the expulsion of her dead fetus and an underlying uterine fibroid having a warm reactive allo-anti-A1 agglutinin that warranted an urgent blood transfusion management. (Source: Current Immunology Reviews)
Source: Current Immunology Reviews - December 22, 2020 Category: Allergy & Immunology Source Type: research
Seroprevalence of Hepatitis B, Hepatitis C, and Human Immunodeficiency Viruses in End-Stage Renal Disease Patients, Southern Iran
Background: Hemodialysis [HD] patients are more prone to blood-borne viruses, such as hepatitis B virus [HBV], hepatitis C virus [HCV], and, to a lesser extent, Human Immunodeficiency Virus [HIV]. Chronic HBV and HCV infections are associated with liver cirrhosis, hepatocellular carcinoma, and early graft failure after kidney transplantation. As there was no recent information, this study aimed to evaluate the prevalence of HBV, HCV, and HIV infection in HD patients in Fars province, southern Iran. This could help health policymakers to run more effective infection control practices for reducing such blood-borne virus infe...
Source: Current Immunology Reviews - December 22, 2020 Category: Allergy & Immunology Source Type: research
Interleukin-10 in Oral Lichen Planus – Review and Meta-Analysis
Conclusion: IL-10, in concert with its receptors, has a crucial role in the pathogenesis of various diseases, including inflammatory, infectious, and autoimmune diseases. Both over-expression, as well as IL-10 deficiency, have been described in oral lichen planus. With Meta-Analysis on serum IL-10 levels, it is speculated that no significant relationship exists between IL-10 and OLP pathogenesis. With respect to the importance of cytokines in the autoimmunity process, performing additional studies is of necessity to understand the association of other cytokines with OLP predisposition and its underlying pathological proces...
Source: Current Immunology Reviews - December 22, 2020 Category: Allergy & Immunology Source Type: research
Immunomodulation in Multiple Sclerosis by Phytotherapy
Multiple sclerosis is a chronic inflammatory and demyelinating disorder of the central nervous system (CNS) that can cause cognition, mobility, and sensory impairments. Studies have shown that the immune system through inflammation and autoreactive T cells are involved in the progression of MS. The present article aimed to review the potent anti-inflammatory, antioxidant, and immunomodulatory agents that could modulate the immune response in MS. In herbal medicine, various medicinal plants including Olive, Silybum marianum, Grape, Pomegranate peel extract, Nigella sativa, Turmeric, Green tea, Aloysia citrodora, Boswellia p...
Source: Current Immunology Reviews - December 22, 2020 Category: Allergy & Immunology Source Type: research
Is Immune Response Relevant in Interstitial Lung Disease?
Interstitial lung disease, a term for a group of disorders, causes lung fibrosis, is mostly refractory to treatments and has a high death rate. After diagnosis the survival is up to 3 years but in some cases the patients live much longer. It involves a heterogenous group of lung diseases that exhibit progressive and irreversible destruction of the lung due to the formation of scars. This results in lung malfunction, disruption of gas exchange, and eventual death because of respiratory failure. The etiology of lung fibrosis is mostly unknown with a few exceptions. The major characteristics of the disease are comprised of in...
Source: Current Immunology Reviews - December 22, 2020 Category: Allergy & Immunology Source Type: research
The Potential Prognostic Performance of Neutrophil CD64 and Monocyte HLA-DR in Patients with Complicated Intra-abdominal Infections
Conclusion: Our review showed heterogeneous data about nCD64 survival prediction. Further investigations with surgical patients exclusively are needed to evaluate its prognostic value in cIAIs. However, we observed a good prognostic performance of low mHLA-DR expression. After a validation in larger multicentre studies, mHLA-DR could be used as promising prognostic biomarker in cIAIs. (Source: Current Immunology Reviews)
Source: Current Immunology Reviews - December 22, 2020 Category: Allergy & Immunology Source Type: research
Can Mandated BCG Vaccine Promote herd Immunity against Novel Coronavirus? A Potential Solution at Hand to Tackle Covid-19 Pandemic
The 2019 novel coronavirus (2019-nCoV) infection is an emerging pandemic that poses a severe threat to global public health. This pandemic started from the Wuhan City of Hubei Province in China, and is speculated to have originated from bats and spread among humans with an unknown intermediate transmitter. The virus binds to angiotensin-converting enzyme 2 (ACE2), which is abundantly expressed on various human cells, including lung epithelial and intestinal cells, thereby entering into these cells and causing infection. It is transmitted to other humans through airborne droplets from infected patients. Presently there are ...
Source: Current Immunology Reviews - December 22, 2020 Category: Allergy & Immunology Source Type: research
COVID-19: Update on Pathogenesis and Treatment Strategies
COVID-19 (Coronavirus disease) is the most contagious virus, which has been characterized as a global pandemic by WHO. The pathological cycle of COVID-19 virus can be specified as RNAaemia, severe pneumonia, along with the Ground-glass opacity (GGO), and acute cardiac injury. The S protein of Coronavirus has been reported to be involved in the entry of the virus into the host cell, which can be accomplished by direct membrane fusion between the virus and plasma membrane. In the endoplasmic reticulum or Golgi membrane, the newly formed enveloped glycoproteins are introduced. The spread of disease occurs due to contact and d...
Source: Current Immunology Reviews - December 22, 2020 Category: Allergy & Immunology Source Type: research
Acknowledgements to Reviewers
(Source: Current Immunology Reviews)
Source: Current Immunology Reviews - June 30, 2020 Category: Allergy & Immunology Source Type: research
Interleukin-6 and Malondialdehyde in Women with Preterm Birth
Conclusion: Elevated maternal serum levels of Interleukin-6 and Malondialdehyde in preterm as compared to full-term birth might suggest that inflammation and oxidative stress play a critical role in PTB. (Source: Current Immunology Reviews)
Source: Current Immunology Reviews - June 30, 2020 Category: Allergy & Immunology Source Type: research
Managing Febrile Illness in Malaria-endemic Areas: Developing Novel Diagnostics Using Host Immunological Signatures as Surrogate Markers of Infection
Recent research has highlighted the growing public health concern arising from mismanagement of malarial and non-malarial febrile illnesses that present with similar clinical symptoms. A retrospective examination of patient records suggests that a syndrome-based diagnosis results in over-diagnosis of malaria. Consequently, interventions to mitigate the frequency of presumptive treatment of fever in malaria-endemic settings have been sought, especially for resourcelimited areas. Guidelines that promote the use of microbiological tests and modern diagnostic kits have demonstrated laudable progress in the ongoing challenge of...
Source: Current Immunology Reviews - June 30, 2020 Category: Allergy & Immunology Source Type: research
Recent Advances in Metabolites from Medicinal Plants in Cancer Prevention and Treatment
Cancer is the second leading cause of death and morbidity in the world among noncommunicable diseases after cardiovascular ailments. With the advancement in science and research, a number of therapies have been developed to treat cancer, including chemotherapy, radiotherapy and immunotherapy. Chemo and radiotherapy have been in use since the last two decades, however these are not devoid of their own intrinsic problems, such as myelotoxicity, cardiotoxicity, nephrotoxicity, neurotoxicity and immunosuppression. Hence, there is an urgent need to develop alternative methods for the treatment of cancer. An increase in the case...
Source: Current Immunology Reviews - June 30, 2020 Category: Allergy & Immunology Source Type: research
