A crossover randomized comparative study of zofenopril and ramipril on cough reflex and airway inflammation in healthy volunteers
Background:
Persistent dry cough is a well known unwanted effect of Angiotensin-Converting Enzyme inhibitors (ACE-i). Animal studies have shown that the ACE-i zofenopril has a less tussigenic effect compared to the widely used ACE-i ramipril. The aim of this study was to compare cough sensitivity to inhaled tussigens, as well as spontaneous cough in response to the administration of zofenopril and ramipril in healthy volunteers; pharmacokinetic (PK) data of both zofenopril and ramipril, as well as their respective active forms, zofenoprilat and ramiprilat, was also collected.
Methods:
Forty healthy volunteers were enrolled...
Source: Cough - December 24, 2014 Category: Respiratory Medicine Authors: Federico LavoriniElisa ChelliniMargherita InnocentiGiacomo CampiColin EganSelene MogaveroGiovanni Fontana Source Type: research
A crossover randomized comparative study of zofenopril and ramipril on cough reflex and airway inflammation in healthy volunteers
Background:
Persistent dry cough is a well known unwanted effect of Angiotensin-Converting Enzyme inhibitors (ACE-i). Animal studies have shown that the ACE-i zofenopril has a less tussigenic effect compared to the widely used ACE-i ramipril. The aim of this study was to compare cough sensitivity to inhaled tussigens, as well as spontaneous cough in response to the administration of zofenopril and ramipril in healthy volunteers; pharmacokinetic (PK) data of both zofenopril and ramipril, as well as their respective active forms, zofenoprilat and ramiprilat, was also collected.
Methods:
Forty healthy volunteers were enrolled...
Source: Cough - December 24, 2014 Category: Respiratory Medicine Authors: Federico LavoriniElisa ChelliniMargherita InnocentiGiacomo CampiColin EganSelene MogaveroGiovanni Fontana Source Type: research
Standardized method for solubility and storage of capsaicin-based solutions for cough induction
Conclusion:
We recommend the use of a 10% ethanol/water solvent system without Tween in the preparation of capsaicin solutions for tussigenic challenges. While this solvent system does not provide complete solubility, we have detailed a method for capsaicin solution preparation that will account for this loss of solubility, while maintaining a solution that is Tween-free and safe for human inhalation. (Source: Cough)
Source: Cough - September 25, 2014 Category: Respiratory Medicine Authors: Michael CostanzoRichard YostPaul Davenport Source Type: research
On the definition of chronic cough and current treatment pathways: an international qualitative study
Conclusion:
There is significant international variation in our understanding and management of chronic cough. Further work is required to bring forth clear guidance and effective medicines for these patients. (Source: Cough)
Source: Cough - May 29, 2014 Category: Respiratory Medicine Authors: Shoaib FaruqiRobert MurdochFabrice AllumAlyn Morice Source Type: research
Effect of acid suppression therapy on gastroesophageal reflux and cough in idiopathic pulmonary fibrosis: an intervention study
Conclusions:
This study confirms that non-acid reflux is prevalent; and that proximal oesophageal reflux occurs in the majority, of subjects with Idiopathic Pulmonary Fibrosis. It is the first study to investigate the effect of acid suppression therapy on gastroesophageal reflux and cough in patients with Idiopathic Pulmonary Fibrosis. The observation that cough frequency does not improve despite verifiable reductions in oesophageal acid exposure challenges the role of acid reflux in Idiopathic Pulmonary Fibrosis associated cough. The finding that non-acid reflux is increased following the use of acid suppression therapies...
Source: Cough - April 30, 2014 Category: Respiratory Medicine Authors: Claire KilduffMelanie CounterGareth ThomasNicholas HarrisonBenjamin Hope-Gill Source Type: research
Severity of cough in idiopathic pulmonary fibrosis is associated with MUC5 B genotype
Conclusions:
Cough severity, a common disabling phenotypic component of IPF, is significantly associated with the presence of the minor allele of a MUC5B promoter polymorphism. This study highlights a possible genetic mechanism for phenotypic heterogeneity in pulmonary fibrosis. (Source: Cough)
Source: Cough - March 25, 2014 Category: Respiratory Medicine Authors: Mary ScholandRoger WolffPeter CrossnoKrishna SundarMolly WinegarSpencer WhipplePatrick CareyNicholas SunchildHilary Coon Source Type: research
A real ¿ life observational pilot study to evaluate the effects of two-week treatment with montelukast in patients with chronic cough
Conclusion:
Patients with CC due to upper airway cough syndrome or gastroesophageal reflux (GER) but not asthma reported significant relief of their symptoms after two weeks of treatment with montelukast. ECP, lactoferrin, MPO altered significantly, highlighting their role in the pathological mechanisms in CC. Clinical trial ID at Clinicaltrials.gov is NCT01754220. (Source: Cough)
Source: Cough - March 20, 2014 Category: Respiratory Medicine Authors: Roxana MinchevaTanya KralimarkovaMiroslava RashevaZlatko DimitrovDenislava NedevaMaria StaevskaVera PapochievaPenka PerenovskaKarina BachevaVasil DimitrovTodor Popov Source Type: research
A real - life observational pilot study to evaluate the effects of two-week treatment with montelukast in patients with chronic cough
Conclusion:
Patients with CC due to upper airway cough syndrome or gastroesophageal reflux (GER) but not asthma reported significant relief of their symptoms after two weeks of treatment with montelukast. ECP, lactoferrin, MPO altered significantly, highlighting their role in the pathological mechanisms in CC. Clinical trial ID at Clinicaltrials.gov is NCT01754220. (Source: Cough)
Source: Cough - March 20, 2014 Category: Respiratory Medicine Authors: Roxana MinchevaTanya KralimarkovaMiroslava RashevaZlatko DimitrovDenislava NedevaMaria StaevskaVera PapochievaPenka PerenovskaKarina BachevaVasil DimitrovTodor Popov Source Type: research
Development and validation of the Newcastle laryngeal hypersensitivity questionnaire
Conclusion:
The Newcastle Laryngeal Hypersensitivity Questionnaire is a simple, non-invasive tool to measure laryngeal paraesthesia in patients with laryngeal conditions such as chronic cough, paradoxical vocal fold movement(vocal cord dysfunction), muscle tension dysphonia, and globus pharyngeus. It can successfully differentiate patients from healthy controls and measure change following intervention. It is a promising tool for use in clinical research and practice. (Source: Cough)
Source: Cough - February 19, 2014 Category: Respiratory Medicine Authors: Anne VertiganSarah BonePeter Gibson Source Type: research
Airway oxidative stress in chronic cough
Conclusions:
Chronic cough seems to be associated with airway oxidative stress in subjects with chronic cough but without chronic lung diseases. This finding may help to develop novel antitussive drugs.Trial registration: The study was registered in ClinicalTrials.gov database (KUH5801112), identifier NCT00859274. (Source: Cough)
Source: Cough - December 2, 2013 Category: Respiratory Medicine Authors: Heikki KoskelaMinna Purokivi Source Type: research
Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial
Conclusions:
The effects of Cineole in the treatment of acute bronchitis were clearly measurable and could be proven after a treatment period of merely 4 days. This study corroborates the fact that Cineole actively and significantly reduces cough frequency after four days. Therefore it has been shown to have a great socioeconomic impact.Trial registration: ISRCTN: ISRCTN37784439 (Source: Cough)
Source: Cough - November 21, 2013 Category: Respiratory Medicine Authors: Juergen FischerUwe Dethlefsen Source Type: research
Chronic cough and obstructive sleep apnoea in a sleep laboratory-based pulmonary practice
Conclusion:
The incidence of chronic cough was significantly higher in the OSA patients. In addition, CPAP treatment significantly improved chronic cough. Therefore, OSA may be a contributory factor to chronic cough. (Source: Cough)
Source: Cough - November 5, 2013 Category: Respiratory Medicine Authors: Tsai-Yu WangYu-Lun LoWen-Te LiuShu-Min LinTing-Yu LinChih-Hsi KuoFu-Tsai ChungPai-Chien ChouPo-Jui ChangYung-Lun NiShu-Chuan HoHorng-Chyuan LinChun-Hua WangChih-Teng YuHan-Pin Kuo Source Type: research
Altitude-related cough
Dr Mason reviews the possible aetiology of altitude-related cough, once attributed to exposure to dry, cold air, and considers that infection or water loss causing trauma to the respiratory tract, possibly worsened by exercise, could be contributing factors. (Source: Cough)
Source: Cough - October 31, 2013 Category: Respiratory Medicine Authors: Nicholas Mason Source Type: research
Inhibitory effect of cervical trachea and chest wall vibrations on cough reflex sensitivity and perception of urge-to-cough in healthy male never-smokers
Conclusions:
Both cervical and trachea vibrations significantly inhibited cough reflex sensitivity and perception of urge-to-cough. These vibration techniques might be options for symptomatic cough management. (Source: Cough)
Source: Cough - October 2, 2013 Category: Respiratory Medicine Authors: Naohiro KashiwazakiSatoru EbiharaPeijun GuiNorihiro KatayamaKumiko ItoRyuhei SatoChika OyamaTakae EbiharaMasahiro Kohzuki Source Type: research
Resuscitation and auto resuscitation by airway reflexes in animals
Various diseases often result in decompensation requiring resuscitation. In infants moderate hypoxia evokes a compensatory augmented breath -- sigh and more severe hypoxia results in a solitary gasp. Progressive asphyxia provokes gasping respiration saving the healthy infant -- autoresuscitation by gasping. A neonate with sudden infant death syndrome, however, usually will not survive. Our systematic research in animals indicated that airway reflexes have similar resuscitation potential as gasping respiration. Nasopharyngeal stimulation in cats and most mammals evokes the aspiration reflex, characterized by spasmodic inspi...
Source: Cough - August 22, 2013 Category: Respiratory Medicine Authors: Zoltan TomoriViliam DonicRoman BenackaJan JakusSona Gresova Source Type: research
