Feasibility and preliminary effects of a peer-led motivationally-embellished workplace walking intervention: A pilot cluster randomized trial (the START trial)
Walking interventions can be effective in increasing physical activity amongst physically inactive employees. However, despite their promising potential regarding sustainability and scalability, peer-led workplace walking interventions have not been tested. We evaluated a peer-led workplace group walking intervention designed to engage physically inactive employees. A 16-week pilot cluster randomized controlled trial consisted of enhanced (5 worksites; n = 50 participants) and minimal treatment (3 worksites; n = 47) conditions. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 26, 2020 Category: Radiology Authors: C. Th øgersen-Ntoumani, E. Quested, B.S. Smith, J. Nicholas, J. McVeigh, S.A.M. Fenton, E. Stamatakis, S. Parker, G. Pereira, D.F. Gucciardi, N. Ntoumanis Source Type: research
Evaluating the effect of individually-targeted food incentives on grocery purchases: The smart cart study protocol for a randomized controlled cross-over trial
Health stakeholders are interested in the promise of healthy food incentives to improve dietary quality. The Smart Cart Study tested whether targeting healthful food incentives based on customer preferences and purchase history was effective for improving grocery purchase quality. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 20, 2020 Category: Radiology Authors: Maya K. Vadiveloo, Xintong Guan, Haley W. Parker, Elie Perraud, Ashley Buchanan, Stephen Atlas, Anne N. Thorndike Source Type: research
The SMARTER Trial: Design of a trial testing tailored mHealth feedback to impact self-monitoring of diet, physical activity, and weight
Self-monitoring food intake and physical activity (PA) is positively related to weight loss and the addition of feedback (FB) messages has been shown to reinforce behavior change. Moreover, the more immediate the delivery of reinforcing FB messages, the more likely they will promote the desired behaviors. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 18, 2020 Category: Radiology Authors: Lora E. Burke, Susan M. Sereika, Bambang Parmanto, Britney Beatrice, Mia Cajita, India Loar, Wayan Pulantara, Yuhan Wang, Jacob Kariuki, Yang Yu, Maribel Cedillo, Jess Cheng, Molly B. Conroy Source Type: research
The impact of financial incentives on utilization and outcomes of diabetes prevention programs among Medicaid managed care adults in New York state
This study aimed to evaluate the impact of different financial incentive strategies on the utilization of the DPP for Medicaid managed care adults in New York State.A four-arm randomized controlled trial was conducted among Medicaid managed care adult enrollees diagnosed with prediabetes and/or obesity. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 18, 2020 Category: Radiology Authors: Jo-Yu Chin, Jacqueline Matson, Susan McCauley, Joseph Anarella, Foster Gesten, Patrick Roohan Source Type: research
N-acetylcysteine for the treatment of comorbid alcohol use disorder and posttraumatic stress disorder: Design and methodology of a randomized clinical trial
Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are two prevalent psychiatric conditions in the U.S. The co-occurrence of AUD and PTSD is also common, and associated with a more severe clinical presentation and worse treatment outcomes across the biopsychosocial spectrum (e.g., social and vocational functioning, physical health) as compared to either disorder alone. Despite the high co-occurrence and negative outcomes, research on effective medications for AUD/PTSD is sparse and there is little empirical evidence to guide treatment decisions. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 18, 2020 Category: Radiology Authors: Sudie E. Back, Kevin Gray, Elizabeth Santa Ana, Jennifer L. Jones, Amber M. Jarnecke, Jane E. Joseph, James Prisciandaro, Therese Killeen, Delisa G. Brown, Linda Taimina, Ebele Compean, Robert Malcolm, Julianne C. Flanagan, Peter W. Kalivas Source Type: research
Considerations for development of an evidence dossier to support the use of mobile sensor technology for clinical outcome assessments in clinical trials
Mobile sensors offer enormous potential for the collection of informative clinical endpoints in clinical trials to support regulatory decision making and product labelling. There are currently no specific guidelines on the information needed to enable regulators to review and accept proposed endpoints derived from mobile sensors for use in drug development trials. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 18, 2020 Category: Radiology Authors: M.K. Walton, J.C. Cappelleri, B. Byrom, J.C. Goldsack, S. Eremenco, D. Harris, E. Potero, N. Patel, E. Flood, M. Daumer Tags: Review Source Type: research
The OaSiS trial: A hybrid type II, national cluster randomized trial to implement smoking cessation during CT screening for lung cancer
When the Centers for Medicare and Medicaid Services announced coverage for low dose CT lung cancer screening, they also mandated that imaging centers offer smoking cessation services. We designed the Optimizing Lung Screening (OaSiS) trial to evaluate strategies to implement the Public Health Service Guidelines for Treating Tobacco Use and Dependence during CT screening for lung cancer. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 18, 2020 Category: Radiology Authors: Kristie Long Foley, David P. Miller, Kathryn Weaver, Erin L. Sutfin, W. Jeffrey Petty, Christina Bellinger, John Spangler, Rebecca J. Stone, Donna Lawler, Whitney Davis, Emily Dressler, Glenn Lesser, Caroline Chiles Source Type: research
Pragmatic trial design of an intervention to reduce cardiovascular risk in people with serious mental illness
Cardiovascular (CV) disease is the leading cause of death for people with serious mental illness (SMI), but clinicians are often slow to address this risk. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 18, 2020 Category: Radiology Authors: Rebecca C. Rossom, Patrick J. O'Connor, A. Lauren Crain, Stephen Waring, Kris Ohnsorg, Allise Taran, Kris Kopski, JoAnn M. Sperl-Hillen Source Type: research
Treatment for anxiety: Mindfulness meditation versus escitalopram (TAME): Design of a randomized, controlled non-inferiority trial
We present the trial protocol for the first study comparing first-line medication treatment with Mindfulness-Based Stress Reduction (MBSR), a popular mindfulness meditation training program, for the treatment of anxiety disorders. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 18, 2020 Category: Radiology Authors: Elizabeth A. Hoge, Eric Bui, Mihriye Mete, Samantha R. Philip, Caroline Gabriel, Meredith J. Ward, Rebecca Suzuki, Mary Ann Dutton, Naomi M. Simon Source Type: research
Supporting Treatment Adherence Regimens in young children with epilepsy and their families: Trial design and baseline characteristics
This article describes the methodology, recruitment, design, and baseline participant characteristics of the Supporting Treatment Adherence Regimens (STAR) trial. STAR is a randomized controlled clinical trial of an education and problem-solving adherence intervention for young children (2 –12 years old) with newly diagnosed epilepsy and their families. Using an enrichment design, only participants who demonstrated non-adherence to antiseizure drugs within the baseline period were randomized to treatment or control arms. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 13, 2020 Category: Radiology Authors: Avani C. Modi, Tracy A. Glauser, Shanna M. Guilfoyle Source Type: research
Athletes for life: Rationale and methodology of a community- and family-based randomized controlled trial to promote cardiovascular fitness among primarily Latino families
We describe the rationale and design of Athletes for Life (AFL), a community- and family-based intervention for Latino families. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 12, 2020 Category: Radiology Authors: Jacob Szeszulski, Sonia Vega-L ópez, Michael Todd, Frank Ray, Alma Behar, Maria Campbell, Adrian Chavez, Ryan Eckert, Anabell Lorenzo-Quintero, Leopoldo Hartmann Manrique, Noe C. Crespo Source Type: research
Research methods and baseline findings of the improving the safety of opioid therapy (ISOT) cluster-randomized trial
There are adverse effects associated with long-term opioid therapy (LTOT) for chronic pain and clinicians infrequently adhere to opioid treatment guideline recommendations for reducing risk and mitigating opioid-related harms. The primary goal of the Improving the Safety of Opioid Therapy (ISOT) intervention is to reduce harms related to prescription opioids. Secondary aims focus on enhancing the clinician-patient relationship and not having a negative impact on pain-related outcomes (to be examined through a non-inferiority analysis). (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 12, 2020 Category: Radiology Authors: Benjamin J. Morasco, Melissa H. Adams, Patricia E. Maloy, Elizabeth R. Hooker, Megan O. Iacocca, Erin E. Krebs, Thomas P. Carr, Travis I. Lovejoy, Somnath Saha, Steven K. Dobscha Source Type: research
Development and evaluation of an 1-day Acceptance and Commitment Therapy workshop for Veterans with comorbid chronic pain, TBI, and psychological distress: Outcomes from a pilot study
To 1) develop and refine a 1-day trans-diagnostic psychotherapeutic “ACT on Life” workshop tailored for Veterans with mild traumatic brain injury, stress-based psychopathology, and pain; 2) examine the feasibility, acceptability, and preliminary effects of this intervention. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 3, 2020 Category: Radiology Authors: Lilian Dindo, Adrienne L. Johnson, Brent Lang, Merlyn Rodrigues, Lindsey Martin, Ricardo Jorge Source Type: research
A parametric multiple test procedure to adaptive group-sequential trials allowing for mid-term modifications
Adaptive group-sequential trials incorporating mid-term design modifications, such as selection of hypotheses or treatment groups, or sample size reestimation during the interim analysis, provide efficient tools to utilize the data from enrolled patients. A graphical multiple test procedure using weighted Bonferroni test has been proposed in adaptive group-sequential designs based on a marginal p-value combination approach.Multiple test procedures using weighted Bonferroni test may result in potential power loss when the test statistics are positively correlated. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - February 2, 2020 Category: Radiology Authors: Man Jin Source Type: research
DIAL now protocol: A randomized trial examining the provision of phone coaching to those with sub-optimal early weight loss during an Internet weight management program
While low-intensity Internet-delivered weight loss (IDWL) programs are efficacious, many patients fail to achieve clinically significant weight loss (WL). Given the positive association between 4-week and post-treatment WL, providing a more intensive intervention for those with sub-optimal 4-week WL may improve outcomes for a greater proportion of individuals. This stepped-care approach would minimize cost by reserving more aggressive treatment for those with sub-optimal early WL. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - January 31, 2020 Category: Radiology Authors: Jessica L. Unick, Christine A. Pellegrini, Shira I. Dunsiger, Kathryn E. Demos, J. Graham Thomas, Dale S. Bond, Jennifer Webster, Rena R. Wing Source Type: research
