Enhanced antibacterial activity of carbon dots functionalized with ampicillin combined with visible light triggered photodynamic effects
In this study, we demonstrate that amine-terminated carbon dots (CDs-NH2) functionalized with ampicillin (AMP) offer a new perspective for antibacterial treatment. The amine-functionalized carbon dots were used as a carrier for immobilization and delivery of ampicillin (CDs-AMP) and as a visible light-triggered antibacterial material. Additionally, AMP immobilization on the CDs-NH2 surface improves its stability in solution as compared to free AMP. The AMP conjugated CDs platform combines the antibacterial function of AMP and conserves the intrinsic theranostic properties of CDs-NH2. Therefore, the AMP immobilized onto CDs...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Facile preparation of biocompatible nanostructured lipid carrier with ultra-small size as a tumor-penetration delivery system
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Xin Zhao, Dongyang Tang, Tie Yang, Cheng WangAbstractInsufficient tumor penetration is one of the major obstacles for satisfactory cancer therapy. As a result, the ability to push the lower limits of size for nanoparticle platforms that have traditionally existed in larger forms is highly desirable. In our study, a facile solvent diffusion method was applied to prepare an ultra-small nanostructured lipid carrier (usNLC) which was capable of encapsulating hydrophobic molecules. Our results demonstrate that the as-prepared us...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Polysaccharide-based cationic hydrogels for dye adsorption
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Xiaoliang Qi, Lipen Wu, Ting Su, Jianfa Zhang, Wei DongAbstractWith advances in soft material design and engineering, naturally resourced polysaccharides have frequently been used to construct hydrogels because of their unique properties such as renewability, biodegradability and biocompatibility. In this work, we use a water-soluble microbial polysaccharide, salecan as a trapped natural polymer, poly(acrylamide-co-diallyldimethylammonium chloride) (PAD) as a functional matrix to prepare salecan/PAD hydrogels through a faci...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Reduction/temperature/pH multi-stimuli responsive core cross-linked polypeptide hybrid micelles for triggered and intracellular drug release
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Jing Qu, Qiu-yue Wang, Kang-long Chen, Jian-bin Luo, Qing-han Zhou, Juan LinAbstractThe high toxicity, poor stability, premature drug release, and lack of intracellular stimuli responsibility of current polymeric micelles still hinder them for potential clinical applications. To address these challenges, a novel type of multi-stimuli responsive, core cross-linked polypeptide hybrid micelles (CCMs) was developed for triggered anticancer drug delivery in tumor microenvironment. The CCMs was prepared via free radical copolymer...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

N-halamine-based multilayers on titanium substrates for antibacterial application
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Bailong Tao, Xinkun Shen, Zhang Yuan, Qichun Ran, Tingting Shen, Yuxia Pei, Ju Liu, Ye He, Yan Hu, Kaiyong CaiAbstractBacterial infection is one of the most severe postoperative complications leading to clinical orthopedic implants failure. To improve the antibacterial property of titanium (Ti) substrates, a bioactive coating composed of chitosan-1-(hydroxymethyl)- 5,5-dimethylhydantoin (Chi–HDH-Cl) and gelatin (Gel) was fabricated via layer-by-layer (LBL) assembly technique. The results of Fourier transform infrared ...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

In vitro and in vivo tumor annihilation by near-infrared photothermal effect of a NiFe2O4/C nanocomposite
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): M. Gorgizadeh, N. Azarpira, N. SattarahmadyAbstractNanothechnology-mediated photothermal therapy (PTT) is emerging as one of the inspiring alternative modality of cancer therapy that applies near-infrared radiation. High favorability of this approach is due to its minimum invasiveness, safety of non-targeted area, quick recovery, and capable simultaneous imaging. In this approach, photoabsorbing nanomaterials convert energy of infrared light to vibrational motion and generate heat. In the present study, a nanocomposite comp...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Antimicrobial potency of differently coated 10 and 50 nm silver nanoparticles against clinically relevant bacteria Escherichia coli and Staphylococcus aureus
This study aimed at evaluating potency of different nanoAg against healthcare infections associated bacteria: Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. A library of differently coated nanoAg of two different sizes (10 and 50 nm) were prepared using coating agents poly-L-Lysine (PLL), cetyltrimethyl-ammonium bromide (CTAB), citrate (CIT), polyvinyl-pyrrolidone (PVP), polysorbate 80 (Tween 80), and dioctyl-sodium sulfosuccinate (AOT). Stability evaluation by means of agglomeration and dissolution behaviour was performed for all nanoAg under conditions relevant for this study.Antibacterial prop...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Xanthan gum-functionalised span nanoparticles for gene targeting to endothelial cells
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): I. Fernandez-Piñeiro, J. Alvarez-Trabado, J. Márquez, I. Badiola, A. SanchezAbstractEndothelial cells play a critical role in many physiological processes; therefore, there is increasing evidence that the future of many treatments for pathologies depends on the development of endothelium-targeting systems. Thus, we have incorporated the natural polysaccharide xanthan gum (XG) into sorbitan monooleate nanoparticles to provide them with a hydrophilic and negatively charged surface shell with stabilising properti...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Incorporation of BMP-2 nanoparticles on the surface of a 3D-printed hydroxyapatite scaffold using an ε-polycaprolactone polymer emulsion coating method for bone tissue engineering
This study aimed at improving the osteoinductivity and compressive strength of the HAp-based 3D scaffold for bone regeneration. Bone morphogenetic protein-2–loaded nanoparticles (BMP-2/NPs) were prepared by a double emulsion-solvent evaporation method and incorporated onto the surface of 3D scaffolds using ε-polycaprolactone (PCL) and NPs emulsion solution. The surface morphology of the scaffold was characterized using scanning electron microscopy and its biocompatibility and osteogenic effects evaluated in vitro using human mesenchymal stem cells. The in vivo bone regeneration efficiency was determined using...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Unraveling the molecular mechanism of the effects of sodium dodecyl sulfate, salts, and sugars on amyloid fibril formation in camel IgG
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Mohamad Alhasan Ismael, Javed Masood Khan, Ajamaluddin Malik, Mohammad A. Alsenaidy, Syed Hidayathulla, Rizwan Hasan Khan, Priyankar Sen, Mohammad Irfan, Abdulrahman M. AlsenaidyAbstractSodium dodecyl sulfate (SDS) is an anionic surfactant that can be used to stimulate protein fibrillation in vitro. Here, we investigated the effects of SDS on camel IgG aggregation at pH 3.5 and 7.4. SDS-induced amyloid fibril formation in camel IgG was examined by turbidity measurements, Rayleigh scattering, Thioflavin T (ThT) fluorescence,...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Emulsifying properties of ruptured microalgae cells: Barriers to lipid extraction or promising biosurfactants?
This study provides a new mechanistic understanding of emulsification during wet lipid extraction from microalgae that will be useful for determining strategies to improve solvent recovery. The results also suggest potential for developing effective bioemulsifiers or biosurfactants from fractionated microalgae biomass for commercial application.Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Preliminary analysis of the interactions between CdTe quantum dots and human metallothionein
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Ewelina Guszpit, Pavel Kopel, Soňa Křížková, Halina MilnerowiczAbstractMetallothionein (MT) plays the important role in the detoxification of heavy metals, protection against oxidative compounds and as a prognostic marker in the development of tumors. It is important to find selective, stable and sensitive tools and probes to evaluate the presence of MT in biological fluids or tissues. QDs linked with ligands such as peptides or small molecules are a promising tool for selective, fast, and sensitive tagging...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Cellular interactions of functionalized superparamagnetic iron oxide nanoparticles on oligodendrocytes without detrimental side effects: Cell death induction, oxidative stress and inflammation
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): S. Sruthi, L. Maurizi, T. Nury, F. Sallem, J. Boudon, J.M. Riedinger, N. Millot, F. Bouyer, G. LizardAbstractIron oxide nanoparticles have the capability to cross Blood Brain Barrier (BBB) and hence are widely investigated for biomedical operations in the central nervous system. Before being used for the biomedical purpose, it is necessary to investigate its biocompatibility, dosimetry and biological interaction. In the present study, in-house synthesized superparamagnetic iron oxide nanoparticles (SPIONs) were functionaliz...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Activity enhancement of selective antitumoral selenodiazoles formulated with poloxamine micelles
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Amaia Úriz, Carmen Sanmartín, Daniel Plano, Raquel de Melo Barbosa, Cécile A. Dreiss, Gustavo González-GaitanoAbstractSelenium (Se) incorporated into organic frameworks has demonstrated anticancer activity against several cancer types. One of the drawbacks of most of these constructs is their poor solubility and bioavailability, which can be overcome with the use of suitable nanocarriers. We have synthesized a series of 5-substituted amide selenodiazoles, based on the parent structure of ebselen,...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Selective contrast agents with potential to the earlier detection of tumors: Insights on synthetic pathways, physicochemical properties and performance in MRI assays
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): María Gabriela Montiel Schneider, María Julia Martin, Diego Fernando Coral, Diego Muraca, Claudia Gentili, Marcela Fernández van Raap, Verónica Leticia LassalleAbstractMagnetic iron oxide nanoparticles (MNPs) have been prepared and stabilized with three organic acids (tartaric, malic and ascorbic) in order to obtain biocompatible and water dispersible MNPs with potential to bind specifically to tumoral cancer cells. An in deep characterization was performed aiming to verify the presence and effec...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Biophysical characterization of asolectin-squalene liposomes
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Maria Assunta Costa, Maria Rosalia Mangione, Radha Santonocito, Rosa Passantino, Daniela Giacomazza, Fabio Librizzi, Oscar Moran, Rita CarrottaAbstractLiposomes are shell nanoparticles able to embed hydrophobic molecules into their lipid layers to be released to cells. In pharmaceutical sciences, liposomes remain the delivery system with the highest biocompatibility, stability, loading characteristics, tunable physicochemical properties. Squalene is a natural, water insoluble, lipid, abundant in olive oil and shark liver. S...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Irinotecan delivery by unimolecular micelles composed of reduction-responsive star-like polymeric prodrug with high drug loading for enhanced cancer therapy
This study demonstrated that CPIO carrier could provide a rational design of a stimuli-responsive polymeric prodrug for delivery of irinotecan.Graphical abstractTherapeutic unimolecular micelles extended form β-cyclodextrin conjugated star-like polymer for reductive agent-triggered drug release of irinotecan. (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Three dimensional macroporous hydroxyapatite/chitosan foam-supported polymer micelles for enhanced oral delivery of poorly soluble drugs
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Yanzhuo Zhang, Kai Dong, Fang Wang, Hongtao Wang, Jing Wang, Ziqiu Jiang, Shuai DiaoAbstractIn the current study, a novel three-dimensional macroporous hydroxyapatite/ chitosan foam (HA/CS)-supported polymer micelle (PM/HA/CS) was developed, and its potential as an oral drug delivery system to enhance the solubility and oral bioavailability of poorly soluble compounds was systemically studied. Candesartan cilexetil (CC) was selected as a poorly soluble model drug. Firstly, HA/CS foam was synthesized using a wet chemical co-...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Promising effects of silver tungstate microcrystals on fibroblast human cells and three dimensional collagen matrix models: A novel non-cytotoxic material to fight oral disease
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Natali Lisette Haro Chávez, Erica Dorigatti de Avila, Paula Aboud Barbugli, Regiane Cristina de Oliveira, Camila Cristina de Foggi, Elson Longo, Carlos Eduardo VerganiAbstractSilver tungstate (α-Ag2WO4) microcrystals have shown encouraging results regarding their antimicrobial activity. However, in addition to the promising outcomes in fighting oral disease, cytotoxic tests are mandatory for screening new materials for biological applications. Here, we developed a better understanding of the effects of microcry...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

pH sensitive liposomes delivering tariquidar and doxorubicin to overcome multidrug resistance of resistant ovarian cancer cells
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Yuqiong Xia, Mei Fang, Jingyu Dong, Chunzhong Xu, Zhen Liao, Pengbo Ning, Qi ZengAbstractMultidrug resistance of tumour cells is one of the most important hurdles in tumour chemotherapy. To overcome the multidrug resistance, we constructed a pH-sensitive liposome formulation (pHSL) by loading tariquidar (TQR) and DOX simultaneously in this work. The formulation showed high stability at pH 7.4 and excellent sensitivity at acidic pH, which facilitated the delivery of TQR and DOX into cells. Cellular experiments demonstrated t...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Mixed micellar system stabilized with saponins for oral delivery of vitamin K
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Feilong Sun, Chengpei Ye, Kaushik Thanki, Donglei Leng, Peter M. van Hasselt, Wim E. Hennink, Cornelus F. van NostrumAbstractPoorly soluble vitamin K cannot be absorbed by patients suffering from cholestasis due to extremely low level of bile salts in the intestine. A formulation of vitamin K including glycocholic acid (i.e. Konakion® MM), does not increase bioavailability because it is unstable due to protonation of glycocholic acid at gastric pH. To develop a stable formulation, saponins were introduced as neutral sur...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Multi-functional nanocarriers based on iron oxide nanoparticles conjugated with doxorubicin, poly(ethylene glycol) and folic acid as theranostics for cancer therapy
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): S. Rajkumar, M. PrabaharanAbstractMulti-functional nanocarriers based on iron oxide nanoparticles (IONPs) conjugated with doxorubicin (DOX), poly(ethylene glycol) (PEG), and folic acid (FA) (IO-MMA-DOX-PEG-OCH3/FA) were prepared as theranostics for cancer therapy. Using mono-methyl adipate (MMA) as a linker, the anticancer drug, DOX, was conjugated on the surface of IONPs by acid-cleavable hydrazone bond. The average size of the IO-MMA-DOX-PEG-OCH3/FA nanocarriers was determined as 14 and 40 nm by TEM and DLS, respectivel...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Development and characterization of iron-pectin beads as a novel system for iron delivery to intestinal cells
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): F. Ghibaudo, E. Gerbino, A.A. Hugo, M.G. Simões, P. Alves, B.F.O. Costa, V. Campo Dallˊ Orto, A. Gómez-Zavaglia, P.N. SimõesAbstractIron deficiency is the most common nutritional deficit worldwide. The goal of this work was to obtain iron-pectin beads by ionic gelation and evaluate their physiological behavior to support their potential application in the food industry. The beads were firstly analyzed by scanning electronic microscopy, and then physical-chemically characterized by performing swelling, ...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Diamond nanoparticles suppress lateral growth of bacterial colonies
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Petra Lišková, Jana Beranová, Egor Ukraintsev, Radovan Fišer, Olga Kofroňová, Oldřich Benada, Ivo Konopásek, Alexander KromkaAbstractDiamond nanoparticles (DNPs) of various types have been recently reported to possess antibacterial properties. Studies have shown a decrease of the colony forming ability on agar plates of the bacteria that had been previously co-incubated with DNPs in the suspension. Before plating, bacteria with DNPs were adequately diluted in order to obtain a sui...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Immobilization of trypsin onto Fe3O4@SiO2 –NH2 and study of its activity and stability
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Esmaeil Aslani, Abdolreza Abri, Mohammad PazhangAbstractThe preparation of biocatalysts based on immobilized trypsin is of great importance for proteomic research, industrial applications and organic synthesis. Here in, we have developed a facile method to immobilize trypsin on magnetic nanoparticles. Fe3O4 nanoparticles were synthesized by co-precipitating Fe2+and Fe3+in an ammonia solution and then coated by silicon dioxides were developed by sol–gel method. The silica-coated Fe3O4 nanoparticles were further modifie...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Highly dispersed lithium doped mesoporous silica nanospheres regulating adhesion, proliferation, morphology, ALP activity and osteogenesis related gene expressions of BMSCs
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Jue Zhang, Liang Cai, Liangchen Tang, Xiaochen Zhang, Lili Yang, Kai Zheng, Axiang He, Aldo R. Boccaccini, Jie Wei, Jun ZhaoAbstractLithium (Li) doped mesoporous silica nanospheres (LMSNs) were synthesized by incorporation of 5 wt% Li into mesoporous silica nanospheres (MSNs) using sol-gel method. The results showed that LMSNs with a mean size of approximate 300 nm exhibited uniform and highly dispersed spherical morphology, which was similar to the morphology of MSNs. Moreover, the degradability of MSNs was significant...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Fractal properties of biophysical models of pericellular brushes can be used to differentiate between cancerous and normal cervical epithelial cells
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Juan de Dios Hernández Velázquez, Sergio Mejía-Rosales, Armando Gama GoicocheaAbstractFractal behavior is found on the topographies of pericellular brushes on the surfaces of model healthy and cancerous cells, using dissipative particle dynamics models and simulations. The influence of brush composition, chain stiffness and solvent quality on the fractal dimension is studied in detail. Since fractal dimension alone cannot guarantee that the brushes possess fractal properties, their lacunarity was obtain...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Investigation of different core-shell toward Janus morphologies by variation of surfactant and feeding composition: A study on the kinetics of DOX release
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Mehrab Fallahi-Sambaran, Mehdi Salami-Kalajahi, Elham Dehghani, Farhang AbbasiAbstractComposite particles with two individual hydrophilic parts were synthesized via seeded emulsion polymerization. As first part, nearly-monodisperse ethylene glycol dimethacrylate (EGDMA)-crosslinked poly(acrylic acid) (PAA) particles were synthesized by distillation precipitation polymerization (DPP). These particles were used as seeds in emulsion polymerization of 2-(dimethylamino)ethyl methacrylate (DMAEMA). Effects of type of surfactant, ...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Reusable anionic sulfonate functionalized nanofibrous membranes for cellulase enzyme adsorption and separation
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Noha Amaly, Yang Si, Yike Chen, Ahmed Y. El-Moghazy, Cunyi Zhao, Ruihong Zhang, Gang SunAbstractPoly (vinyl alcohol-co-ethylene) nanofibrous membranes (PVA-co-PE NFM) were successfully modified by sodium-3-sulfobenzoate to become negatively charged with sulfonate groups, and the sulfonated (PVA-co-PE) nanofiber membrane SS (PVA-co-PE NFM) was used in non-covalent adsorption of cellulases via electrostatic attraction. The modified NFM showed excellent adsorption to the enzyme molecules due to the incorporated static charge i...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Bacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): M.L. Cacicedo, G.A. Islan, I.E. León, V.A. Álvarez, I. Chourpa, E. Allard-Vannier, N. García-Aranda, Z.V. Díaz-Riascos, Y. Fernández, S. Schwartz, I. Abasolo, G.R. CastroAbstractThe use of hybrid materials, where a matrix sustains nanoparticles controlling the release of the chemotherapeutic drug, could be beneficial for the treatment of primary tumors prior or after surgery. This localized chemotherapy would guarantee high drug concentrations at the tumor site while precluding systemic dr...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Soft nanoparticles charge expression within lipid membranes: The case of amino terminated dendrimers in bilayers vesicles
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Domenico Lombardo, Pietro Calandra, Salvatore Magazù, Ulderico Wanderlingh, Davide Barreca, Luigi Pasqua, Mikhail A. KiselevAbstractInteractions of charged nanoparticles with model bio-membranes provide important insights about the soft interaction involved and the physico-chemical parameters that influence lipid bilayers stability, thus providing key features of their cytotoxicity effects onto cellular membranes. With this aim, the self-assembly processes between polyamidoamine dendrimers (generation G = 2.0 and...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Fabrication of tannic acid/poly(N-vinylpyrrolidone) layer-by-layer coating on Mg-based metallic glass for nerve tissue regeneration application
This study investigates the biocorrosion and biocompatibility of Mg-Zn-Ca metallic glass ribbon with Mg70Zn26Ca4 composition. For controlling biocorrosion, layer-by-layer coating of tannic acid/ poly(N-vinylpyrrolidone) was applied on Mg70Zn26Ca4 ribbon and characterized by SEM and FTIR. Immersion and potentiodynamic polarization test results indicated that coating significantly improved the corrosion resistance of Mg70Zn26Ca4. Schwann cells were selected for the cytocompatibility evaluation of samples due to their key role in peripheral nerve regeneration and ability to repair spinal cord injuries. The MTT assay and cell ...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Finding the ideal polyethylenimine-plasmid DNA system for co-delivery of payloads in cancer therapy
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Diana Costa, Artur J.M. Valente, João A. Queiroz, Ângela SousaAbstractResearchers still hold for the development of a safety and advanced delivery system able of efficient therapeutic action. The co-delivery of different payloads is part of this strategy and has already demonstrated to be a valuable tool against the most severe diseases. In the pursuit of an “ideal” drug/gene co-delivery vector for cancer therapy, we present a complete comparison study of different morphology and molecular weight po...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Armamentarium of nanoscaled lipid drug delivery systems customized for oral administration: In silico docking patronage, absorption phenomenon, preclinical status, clinical status and future prospects
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Ashish Baldi, Monika Chaudhary, Sheshank Sethi, Abhiav, Ramesh Chandra, Jitender MadanAbstractPoor drug solubility and bioavailability remain a significant and frequently encountered concern for pharmaceutical scientists. Nanoscaled lipid drug delivery systems (NSLDDS) have exhibited great potentials in oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successful clinical products. In the past few years, we have find out that optimized composition of drug in lipid, surfactant, or mixt...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Encapsulation of green tea polyphenol by pH responsive, antibacterial, alginate microgels used for minimally invasive treatment of bone infection
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Zhenhua Chen, Xinyan Lv, Mengen Zhao, Peng Zhang, Xiuli Ren, Xifan MeiAbstractThe treatment of bone infection requires drug carriers take large number of cargo, be antibacterial, promote proliferation and differentiation of osteoblasts. Herein, we proposed a strategy of preparing pH responsive, antibacterial, multistage structured microspheres encapsulated with green tea polyphenol used for minimally invasive treatment of bone infection. Tea polyphenol (TP) were encapsulated by porous silica nanospheres (SiO2 NSs). Then, so...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Corrigendum to “Multifunctional organically modified silica nanoparticles for chemotherapy, adjuvant hyperthermia and near infrared imaging” [Colloids Surf. B: Biointerfaces 147 (2016) 492–500]
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Abhignyan Nagesetti, Anthony J. McGoron (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Ultrasonic fabrication of flexible antibacterial ZnO nanopillar array film
Publication date: 1 October 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 170Author(s): Kwang Se Lee, Chi Hyun Kim, Soon Woo Jeong, Younseong Song, Nam Ho Bae, Seok Jae Lee, Kyoung G. LeeAbstractAntibacterial activity is essential and highly demanded in worldwide to prevent potential bacterial infection. Here in this work, we report a new approch for the fabrication of flexible zinc oxide nanopillar arrays (ZG-NPA) film with an efficient antibacterial activity. A flexible NPA film served as a substrate for the rapid formation of ZnO by using ultrasound-assisted method. The enhancement of antibacterial activity...
Source: Colloids and Surfaces B: Biointerfaces - July 6, 2018 Category: Biochemistry Source Type: research

Solvent-free and one-pot synthesis of silver and zinc oxide nanoparticles: Activity toward cell membrane component and insulin signaling pathway in experimental diabetes
Conclusion AgNPs and ZnONPs represent promising materials in attenuating diabetic complications and insulin resistance in experimental diabetes; no Impressive differences were observed between the effect of ZnONPs and AgNPs in this current research. Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - July 5, 2018 Category: Biochemistry Source Type: research

Unraveling the molecular mechanism of the effects of sodium dodecyl sulfate, salts, and sugars on amyloid fibril formation in camel IgG
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Mohamad Alhasan Ismael, Javed Masood Khan, Ajamaluddin Malik, Mohammad A. Alsenaidy, Syed Hidayathulla, Rizwan Hasan Khan, Priyankar Sen, Mohammad Irfan, Abdulrahman M. Alsenaidy Sodium dodecyl sulfate (SDS) is an anionic surfactant that can be used to stimulate protein fibrillation in vitro. Here, we investigated the effects of SDS on camel IgG aggregation at pH 3.5 and 7.4. SDS-induced amyloid fibril formation in camel IgG was examined by turbidity measurements, Rayleigh scattering, Thioflavin T (ThT) fluorescence, intr...
Source: Colloids and Surfaces B: Biointerfaces - June 27, 2018 Category: Biochemistry Source Type: research

Incorporation of BMP-2 nanoparticles on the surface of a 3D-printed hydroxyapatite scaffold using an ε-polycaprolactone polymer emulsion coating method for bone tissue engineering
This study aimed at improving the osteoinductivity and compressive strength of the HAp-based 3D scaffold for bone regeneration. Bone morphogenetic protein-2–loaded nanoparticles (BMP-2/NPs) were prepared by a double emulsion-solvent evaporation method and incorporated onto the surface of 3D scaffolds using ε-polycaprolactone (PCL) and NPs emulsion solution. The surface morphology of the scaffold was characterized using scanning electron microscopy and its biocompatibility and osteogenic effects evaluated in vitro using human mesenchymal stem cells. The in vivo bone regeneration efficiency was determined using...
Source: Colloids and Surfaces B: Biointerfaces - June 27, 2018 Category: Biochemistry Source Type: research

Xanthan gum-functionalised span nanoparticles for gene targeting to endothelial cells
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): I. Fernandez-Piñeiro, J. Alvarez-Trabado, J. Márquez, I. Badiola, A. Sanchez Endothelial cells play a critical role in many physiological processes; therefore, there is increasing evidence that the future of many treatments for pathologies depends on the development of endothelium-targeting systems. Thus, we have incorporated the natural polysaccharide xanthan gum (XG) into sorbitan monooleate nanoparticles to provide them with a hydrophilic and negatively charged surface shell with stabilising properties an...
Source: Colloids and Surfaces B: Biointerfaces - June 25, 2018 Category: Biochemistry Source Type: research

Antimicrobial potency of differently coated 10 and 50  nm silver nanoparticles against clinically relevant bacteria Escherichia coli and Staphylococcus aureus
This study aimed at evaluating potency of different nanoAg against healthcare infections associated bacteria: Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. A library of differently coated nanoAg of two different sizes (10 and 50 nm) were prepared using coating agents poly-L-Lysine (PLL), cetyltrimethyl-ammonium bromide (CTAB), citrate (CIT), polyvinyl-pyrrolidone (PVP), polysorbate 80 (Tween 80), and dioctyl-sodium sulfosuccinate (AOT). Stability evaluation by means of agglomeration and dissolution behaviour was performed for all nanoAg under conditions relevant for this study. Antibacterial pro...
Source: Colloids and Surfaces B: Biointerfaces - June 24, 2018 Category: Biochemistry Source Type: research

In vitro and in vivo tumor annihilation by near-infrared photothermal effect of a NiFe2O4/C nanocomposite
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): M. Gorgizadeh, N. Azarpira, N. Sattarahmady Nanothechnology-mediated photothermal therapy (PTT) is emerging as one of the inspiring alternative modality of cancer therapy that applies near-infrared radiation. High favorability of this approach is due to its minimum invasiveness, safety of non-targeted area, quick recovery, and capable simultaneous imaging. In this approach, photoabsorbing nanomaterials convert energy of infrared light to vibrational motion and generate heat. In the present study, a nanocomposite comprised...
Source: Colloids and Surfaces B: Biointerfaces - June 24, 2018 Category: Biochemistry Source Type: research

N-halamine-based multilayers on titanium substrates for antibacterial application
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Bailong Tao, Xinkun Shen, Zhang Yuan, Qichun Ran, Tingting Shen, Yuxia Pei, Ju Liu, Ye He, Yan Hu, Kaiyong Cai Bacterial infection is one of the most severe postoperative complications leading to clinical orthopedic implants failure. To improve the antibacterial property of titanium (Ti) substrates, a bioactive coating composed of chitosan-1-(hydroxymethyl)- 5,5-dimethylhydantoin (Chi–HDH-Cl) and gelatin (Gel) was fabricated via layer-by-layer (LBL) assembly technique. The results of Fourier transform infrared spect...
Source: Colloids and Surfaces B: Biointerfaces - June 24, 2018 Category: Biochemistry Source Type: research

Reduction/temperature/pH multi-stimuli responsive core cross-linked polypeptide hybrid micelles for triggered and intracellular drug release
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Jing Qu, Qiu-yue Wang, Kang-long Chen, Jian-bin Luo, Qing-han Zhou, Juan Lin The high toxicity, poor stability, premature drug release, and lack of intracellular stimuli responsibility of current polymeric micelles still hinder them for potential clinical applications. To address these challenges, a novel type of multi-stimuli responsive, core cross-linked polypeptide hybrid micelles (CCMs) was developed for triggered anticancer drug delivery in tumor microenvironment. The CCMs was prepared via free radical copolymerizati...
Source: Colloids and Surfaces B: Biointerfaces - June 24, 2018 Category: Biochemistry Source Type: research

Polysaccharide-based cationic hydrogels for dye adsorption
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Xiaoliang Qi, Lipen Wu, Ting Su, Jianfa Zhang, Wei Dong With advances in soft material design and engineering, naturally resourced polysaccharides have frequently been used to construct hydrogels because of their unique properties such as renewability, biodegradability and biocompatibility. In this work, we use a water-soluble microbial polysaccharide, salecan as a trapped natural polymer, poly(acrylamide-co-diallyldimethylammonium chloride) (PAD) as a functional matrix to prepare salecan/PAD hydrogels through a facile on...
Source: Colloids and Surfaces B: Biointerfaces - June 24, 2018 Category: Biochemistry Source Type: research

Facile preparation of biocompatible nanostructured lipid carrier with ultra-small size as a tumor-penetration delivery system
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Xin Zhao, Dongyang Tang, Tie Yang, Cheng Wang Insufficient tumor penetration is one of the major obstacles for satisfactory cancer therapy. As a result, the ability to push the lower limits of size for nanoparticle platforms that have traditionally existed in larger forms is highly desirable. In our study, a facile solvent diffusion method was applied to prepare an ultra-small nanostructured lipid carrier (usNLC) which was capable of encapsulating hydrophobic molecules. Our results demonstrate that the as-prepared usNLC i...
Source: Colloids and Surfaces B: Biointerfaces - June 24, 2018 Category: Biochemistry Source Type: research

Enhanced antibacterial activity of carbon dots functionalized with ampicillin combined with visible light triggered photodynamic effects
In this study, we demonstrate that amine-terminated carbon dots (CDs-NH2) functionalized with ampicillin (AMP) offer a new perspective for antibacterial treatment. The amine-functionalized carbon dots were used as a carrier for immobilization and delivery of ampicillin (CDs-AMP) and as a visible light-triggered antibacterial material. Additionally, AMP immobilization on the CDs-NH2 surface improves its stability in solution as compared to free AMP. The AMP conjugated CDs platform combines the antibacterial function of AMP and conserves the intrinsic theranostic properties of CDs-NH2. Therefore, the AMP immobilized onto CDs...
Source: Colloids and Surfaces B: Biointerfaces - June 24, 2018 Category: Biochemistry Source Type: research

The role of formulation and follicular pathway in voriconazole cutaneous delivery from liposomes and nanostructured lipid carriers
In conclusion, both LP and NLC seem to be valuable systems for cutaneous VOR delivery. Fluidic formulations could provide better efficiency for cutaneous drug delivery from LP. Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - June 24, 2018 Category: Biochemistry Source Type: research

Paclitaxel delivered by CD44 receptor-targeting and endosomal pH sensitive dual functionalized hyaluronic acid micelles for multidrug resistance reversion
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Yanhua Liu, Chengming Zhou, Shijie Wei, Tong Yang, Yang Lan, Aichen Cao, Jianhong Yang, Yanhui Hou The drug efflux mediated by P-glycoprotein (P-gp) transporter is a major factor responsible for multidrug resistance (MDR) of paclitaxel (PTX). The efficient intracellular PTX delivery is a promising strategy for overcoming the MDR of tumor cells. A CD44 receptor targeting and endosome-pH sensitive dual functionalized hyaluronic acid-deoxycholic acid-histidine (HA-DOCA-His) micellar formulation was developed to overcome MDR,...
Source: Colloids and Surfaces B: Biointerfaces - June 22, 2018 Category: Biochemistry Source Type: research