Post-transplant Desensitization for Deceased Donor Kidney Transplant Recipients: A Single Center Experience.
Authors: Kumar D, Fattah H, Kimball PM, LeCorchick S, McDougan FA, King AL, Gupta G
Abstract
The highly-sensitized kidney transplant candidate with no available living donors remains at a major disadvantage with decreased access and worse outcomes post-transplant. We have previously reported our initial data on both pre-transplant and post-transplant desensitization. We observed only a modest decline in unacceptable antigens with pretransplant intravenous immunoglobin (IVIG) and rituximab. Due to these observations, we have focused on a peri-operative post-transplant desensitization protocol in our program...
Source: Clinical Transplants - June 2, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
From Accurate Assessment of Anti-HLA Antibody MFI to Complement-Binding Assays.
Authors: Claisse G, Mariat C, Maillard N
Abstract
Single antigen bead (SAB) and complement-binding assays are commonly used to monitor immunization in transplant patients. Like all new diagnostic assays, some considerations have to be appreciated to avoid a biased utilization. By truly decreasing antibody concentration, SAB monitoring in sensitized patients experiencing apheresis offers a good opportunity to explore analytical interference. We explored analytical artifacts by analyzing the role of prozone and saturation effects through a concrete example of a single patient who experienced immunoadsorption...
Source: Clinical Transplants - June 2, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
Influenza Immunization and the Generation of Anti-HLA and Anti-MICA Antibodies in Patients with Renal Failure and in Kidney Transplant Recipients.
In conclusion, the development of de novo anti-HLA and anti-MICA antibodies after an external stimulus other than HLA antigens is possible. However, not all cases can be attributed to the vaccine.
PMID: 28564534 [PubMed - in process] (Source: Clinical Transplants)
Source: Clinical Transplants - June 2, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
Clinical Relevance of Donor-Specific IgM Antibodies in HLA Incompatible Renal Transplantation: A Retrospective Single-Center Study.
This study shows additional testing of post-transplant IgM DSA over and above IgG is important as post-transplant IgM DSA is associated with graft failure.
PMID: 28564535 [PubMed - in process] (Source: Clinical Transplants)
Source: Clinical Transplants - June 2, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
Recent Trends in Kidney Transplant in the United States.
Authors: Sampaio M, Shekhtman G, Ahearn P, Huang E, Bunnapradist S
Abstract
The number of new wait list registrants has increased in the last decade but not to the same magnitude as the increase in the number of end stage renal disease patients in the United States. The number of wait list patients has increased at a much higher pace due to the lack of kidney supply. The overall number of kidney transplants only increased slightly. Paired exchange kidney transplant is a viable source of increasing the availability of kidney transplant and also offers access to transplant to patients with immunologic barrie...
Source: Clinical Transplants - May 20, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
MELD Exceptions for Hepatocellular Carcinoma: Regional Variations in the Impact of the Share 35 Liver Allocation Policy.
This report emphasizes the geographic inequities and regional variations in transplant practices, with a focus on liver transplant candidates with hepatocellular carcinoma exceptions, and highlights the need for strategies to promote equitable organ distribution across geographical regions and patient conditions.
PMID: 28514564 [PubMed] (Source: Clinical Transplants)
Source: Clinical Transplants - May 20, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
An Update on Cardiac Transplantation in the United States Based on an Analysis of the UNOS Registry.
Authors: Khatiwala JR, Everly MJ
Abstract
Cardiac transplantation remains a viable option for those with end-stage heart disease. In the last few years, the number of heart transplants has begun to increase slightly. Over the last 27 years, the major reasons for cardiac transplant remain coronary artery disease and dilated cardiomyopathy. Currently, heart transplants have an average lifespan of 10.5 years. The main United Network for Organ Sharing characteristics correlating with poor allograft survival include repeat transplantation, ischemic time, post-transplant dialysis, and age at the time of transpla...
Source: Clinical Transplants - May 20, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
Long-Term Pancreas Allograft Survival in Simultaneous Pancreas-Kidney Transplantation by Era.
Authors: Waki K, Hayashi A, Yamaguchi S, Nangaku M, Ohe K, Kadowaki T, Kokudo N
Abstract
Data collected by the United Network for Organ Sharing from all approved United States transplant programs were analyzed; the data included 20,290 adult diabetic patients who received primary pancreas transplants between October 1987 and December 2014. Simultaneous pancreas-kidney (SPK) transplantation has become the major therapeutic option for diabetes patients. The number of SPKs per year has not increased since 1999; it leveled off or decreased slightly each year. Recipients in the most recent period, 2010-2014, we...
Source: Clinical Transplants - May 20, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
Impact of Diabetes Mellitus on Survival Outcome of Lung Transplant Recipients: An Analysis of OPTN/UNOS Data.
CONCLUSIONS: Diabetes was associated with mortality in lung transplant recipients overall and in lung recipients without cystic fibrosis. However, there was no association between diabetes and mortality in lung recipients with cystic fibrosis.
PMID: 28514567 [PubMed] (Source: Clinical Transplants)
Source: Clinical Transplants - May 20, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
The 25th Anniversary of the National Transplantation Pregnancy Registry.
Authors: Coscia LA, Constantinescu S, Armenti DP, Moritz MJ
Abstract
The National Transplantation Pregnancy Registry (NTPR) is a unique resource for comprehensive information about parenthood after transplantation. To date, 1461 female solid organ transplant recipients with 2609 pregnancies and 879 male recipients who fathered 1358 pregnancies have participated in the NTPR. Over the first 25 years of the NTPR, pregnancy after transplantation has progressed from a situation where termination was once advised, to a topic of pre-transplant counselling with likelihood for success if established criteria are me...
Source: Clinical Transplants - May 20, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
Hepatitis C and Human Immunodeficiency Virus Kidney Transplantation: The Mount Sinai Experience.
Authors: Nair V, Khaim R, El-Salem F, Kent R, Lerner S, Berger A, Miko L, Rollins B, Ebcioglu Z, Delaney V, Sehgal V, Menon M, Ames S, Benvenisty A, Wadhera V, Arvelakas A, Schiano T, Rana M, Huprikar S, Florman S, Shapiro R
Abstract
Mount Sinai Hospital in New York has a long history in the field of organ transplantation. The first kidney transplant at Mount Sinai was performed in 1967 by the late Dr. Lewis Burrows and the first laparoscopic donor nephrectomy in New York was performed at Mount Sinai in 1996. Over 3000 kidney transplantations have been performed at Mount Sinai. In the early 1990s, the firs...
Source: Clinical Transplants - May 20, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
Liver Transplant at the University of Pennsylvania 2015.
CONCLUSION: Our program activity data mirrors trends that are seen in many of the established busy liver transplant centers in the United States. There is greater recognition that liver transplantation can be offered to a larger number of candidates who are diagnosed with progressive liver failure of primary cancer in the setting of liver cirrhosis, and there is an increase in donor organs from either extended criteria cadaveric donors or living donors. Despite more complex candidate populations and increased utilization of extended criteria donors, Penn's outcomes continue to be excellent. We postulate that the future dep...
Source: Clinical Transplants - May 20, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
ISMETT: An International Collaboration on Organ Transplantation.
Authors: Vizzini GB, Gruttadauria S, Spada M, Bertani A, Bertani T, Casu A, Raffa G, Sciacca S, Di Gesaro G, Pilato M, De Monte L, Vitulo P, Luca A, Arcadipane A, Gridelli B
Abstract
The Institute of the Mediterranean for Transplantation and High Specialty Therapies (ISMETT) is a multi-organ transplant and high specialty center located in Palermo, Italy and managed by the University of Pittsburgh Medical Center. Clinical transplant activity started in 1999 and, herein, we illustrate the outcomes achieved over the past 15 years. In total, ISMETT has performed 997 liver transplants (83.9% adults, 16.1% pedia...
Source: Clinical Transplants - May 20, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
Liver Transplantation in Groningen, The Netherlands: A Single Center Status Report.
Authors: de Vries Y, de Jong IEM, Berendsen TA, Lisman T, Verkade HJ, Scheenstra R, Reyntjens KMEM, de Boer MT, Blokzijl J, Peeters PMG, van den Berg AP, Porte RJ
Abstract
The liver transplantation program of the University Medical Center Groningen in the Netherlands was started in 1979, making it one of the first programs worldwide. During the past 36 years, a total of 1478 liver transplantations have been performed, 459 of which were in children. One of the first patients transplanted in 1979 is still alive and is one of the longest surviving patients after liver transplantation worldwide. During the las...
Source: Clinical Transplants - May 20, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
Pancreas Transplant at the University of Maryland.
Authors: Yi SY, Shaw K, Costa N, Leeser DB
Abstract
The characteristic of our diabetic population has been ever changing. No longer are our Type 1 diabetics young and thin; they too suffer from the obesity epidemic and now present later with the complications of diabetes (renal dysfunction, hypoglycemic unawareness, vision loss, neuropathy, etc.). Even with all of our medical and technological advances to combat diabetes, there are many who are not very well controlled. We evaluated the pancreas transplant recipients in the last three years at the University of Maryland to study the outcomes of these older...
Source: Clinical Transplants - May 20, 2017 Category: Transplant Surgery Tags: Clin Transpl Source Type: research
