Plasma Cancer Therapy In Dermatology
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Georg Daeschlein, Claudia Sicher, Sebastian von Podewils, Rico Rutkowski, Michael Jünger Main topics in cancer treatment in dermatology are melanoma (MM), basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and metastatic skin tumors. Thereof stage IV MM because of fatal outcome is uf utmost importance. Despite some substantial therapeutic progress now in this entity by immunologic treatments alternatives are warranted when disease is progressing under therapy or the tumor basically appears refractory. National gu...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Interaction Between Cap- Derived Singlet Oxygen And Tumor Cell Protective Catalase: Update And Chances
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Georg Bauer Transformation of cells from various tissues requires NADPH oxidase-dependent generation of extracellular superoxide anions. These drive the proliferation, but also cause the elimination of malignant cells through the HOCl and the NO/peroxynitrite signaling pathways. These intercellular signaling pathways induce apoptosis selectively in malignant cells, due to site-specific concerted interaction of defined reactive oxygen and nitrogen species (ROS/RNS). Tumor progression requires the expression of membrane-associ...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Non-Thermal Plasma Induced Immunogenic Cell Death In Pancreatic Cancer
We report (Figure 1) decreased cell viability in a dose-dependent fashion in vitro. Additionally, ICD, as evidenced by increased expression of Calreticulin (CRT), a damage associated molecular pattern (DAMP) protein, is shown in Table 1. Mitoxantrone (MTX) is a candidate positive control for ICD in the Panc-02 cell line with a 45-fold increase in CRT expression associated with an approximate 20-25% decrease in cell viability. Cisplatin resulted in a 2-fold increase in CRT expression and an approximate 20-25% decrease in cell viability. The cell viability results were dose-independent for both MTX and Cisplatin. Vaccination...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Adaptation Of Operational Parameters Of Cold Atmospheric Plasma And Their Role In Cancer Therapy
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Eda Gjika, Sonali Pal-Ghosh, Li Lin, Gauri Tadvalkar, Zhitong Chen, Colin Young, Jerome Canady, Jonathan Sherman, Mary Ann Stepp, Michael Keidar The evaluation of CAP in cancer treatment has been significantly fueled by the growing demand for more effective therapies. CAP has been reported as a selective treatment method with a higher affinity of inducing cell death in cancer cells while leaving normal cells unharmed. However, the extent of its effectiveness varies significantly per cancer type. Studies have reveale...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Non-Thermal Plasma As An Innovative Anticancer Strategy On Leukemia Models
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Eleonora Turrini, Augusto Stancampiano, Emanuele Simoncelli, Romolo Laurita, Elena Catanzaro, Cinzia Calcabrini, Matteo Gherardi, Vittorio Colombo, Carmela Fimognari Antitumor chemotherapy is often hampered by the low therapeutic index of most anticancer drugs and the development of chemoresistance. Furthermore, in leukemia incidence and death rates in patients are really close to each other, when compared to other kind of tumors; pointing out that efficacy of anticancer therapy is suboptimal. Thus, there is a contin...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Immuno-modulatory effect of bio-plasma against cancer and other dreadful disease
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Nagendra Kumar Kaushik, Neha Kaushik, Manish Adhikari, Su-Jae Lee, Eun Ha Choi The application of plasma medicine technology has been actively explored over last several years. Recently, non-thermal plasma has demonstrated potential as a safe anticancer therapeutic approach that can kill various types of cancer targets [1-4]. There is the urgent need of new human health care’s technology against cancers based on immuno-modulations. Main target of our study is to enhance efficacy and selectivity of plasma on cancer cell...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Contribution Of Intracellular Mobile Zinc To Anti-Cancer Effects Of Plasma-Activated Medium
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Hirokazu Hara, Tetsuo Adachi Non-thermal plasma (NTP) irradiation has been reported to have a broad array of biological effects, and has been found to preferentially kill cancer cells. Therefore, NTP is a promising approach for cancer therapy. The indirect NTP irradiation method using plasma-activated medium (PAM) induces cancer cell death to the same extent as the direct NTP irradiation method. The anti-cancer effects of PAM are thought to be attributed to reactive oxygen species (ROS), mainly H2O2. On the other hand, oxid...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
The Role Of Cytoglobin In The Plasma-Treatment Of Melanoma
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Joey De Backer, Jamoliddin Razzokov, Dietmar Hammerschmid, Carl Mensch, Naresh Kumar, Annemie Bogaerts, Sylvia Dewilde Globins are ancient proteins that are present in all kingdoms of life. At the moment, there are 8 different globins known in vertebrates with distinct expression patterns. Human cytoglobin (CYGB), a member of this globin superfamily, is a hexacoordinated heme-protein that is mostly expressed in fibroblasts and fibroblast-related cells, but is also present in neurons, macrophages, muscles and epithelium...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Plasma, Cancer, Immunity
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Sander Bekeschus, Thomas von Woedtke, Klaus-Dieter Weltmann, Hans-Robert Metelmann Incidence and prevalence of most types of cancers are continuously rising. Oncological research progresses as well, with many new drugs and treatment modalities launched in the last years. Cold physical plasma is a promising new technology for oncology, and already applied in many cancer models successfully. First tumor patients benefited from plasma therapy in the palliative setting. While superficial tumors provide an excellent treatment ...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Immune modulatory properties of radiotherapy
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Udo S. Gaipl Radiotherapy (RT) is a common treatment for cancer and about 60% of all cancer patients will receive it during their course of illness. RT primarily aims to achieve local tumor control. The induction of DNA damage by reactive oxygen species (ROS), tumor cell death and the modulation of the tumor microenvironment are the main effects of ionizing irradiation to reduce tumor masses, but also to modulate the immune system. RT might thereby act as an in situ cancer vaccine under certain microenvironmental conditions....
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Controlling of apoptosis and proliferation of HepG2 cancer cells by treatment of plasma jet and N-acetylcysteine combination
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Zilan Xiong, Shasha Zhao It is well known that atmospheric pressure plasma could induce apoptosis of cancer cells. [1][2] However, the interaction and mechanism between plasma and cancer cells has not been fully understood yet. [3] Here, we report the controlment of apoptosis and proliferation of human hepatocellular carcinoma cell (HepG2) by combined treatment of He/O2 plasma jet and N-acetylcysteine (NAC, free radical scavenger). It is found that the fate of HepG2 cells could be controlled by plasma treatment time togethe...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Computational And Experimental Study Of The Impact Of Plasma On The Human Epidermal Growth Factor And Its Implications For Wound Healing And Cancer Treatment
In this study, we perform computer simulations and experiments to investigate the impact of plasma treatment on hEGF. Conformational changes with different degrees of oxidation, corresponding to short or longer CAP treatment times, are studied by combining simulation results with Fourier transform infrared spectroscopy. Additional experiments are performed with circular dichroism spectroscopy to verify the simulated conformational changes. The results, being qualitatively in good agreement, indicate a more flexible structure after oxidization, due to conformational changes and breakage of disulfide bonds. Docking simulatio...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Plasma-Derived Oxidants And The Modulation Of Immunsuppression In Melanoma
This study illustrates the importance and potential of utilizes plasmas to manipulate the redox environment for tumor immune control. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Differential Cell Death In Hepatocellular Cell Lines Induced By Non-Thermal Plasma
In this study we examined the influence of non-thermal air-plasma on human hepatocellular carcinoma cell lines. We show how air non-thermal plasma induces cell death in two hepatocellular carcinoma cell lines (HepG2 and Huh7) via the formation of multiple intracellular reactive oxygen/nitrogen species. Interestingly, NTP demonstrated greater selective anti-proliferative activity against Huh7 cells relative to HepG2. Our results showed a discrepancy in the superoxide accumulation and lysosomal activity in response to plasma in these cell lines, suggesting that plasma-triggered signaling cascades might be grossly different b...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
Radiobiological Response Of Breast Cancer Cells, Exposed To Atmospheric Pressure Plasmas And Ionizing Radiation, An In-Vitro Essay. (Project Overview)
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): A.G. Cordero, S. Quirós, M. Porras, E. Avendaño The purpose of this project is to describe the application of an ionized gas to different lines of breast cancer cells, added to application of a clinical photon beam, by measuring variations in cell death rate. This procedure may lead to implementation of a new in vitro technique for studying new radiobiological approaches for adjuvant methods to radiotherapy techniques. Characterization of the plasma generator An in-house developed Cold Atmospheric Plasma "CAP" will be ...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research
