Combination of Cold Plasma and Pulsed Electric Fields – A Rationale for Cancer Patients in Palliative Care
Publication date: Available online 3 February 2020Source: Clinical Plasma MedicineAuthor(s): Christina M. Wolff, Anna Steuer, Ingo Stoffels, Thomas von Woedtke, Klaus-Dieter Weltmann, Sander Bekeschus, Juergen F. KolbAbstractCancer continues to be a significant threat to human health. Oncotherapy, therefore, relies on the combination of different approaches to increase a patient's chances. If therapeutic options are exhausted, effective palliation can at least still improve the quality of life. Over two decades ago, electrochemotherapy (ECT), which is based on pulsed electric field (PEF) exposures, was introduced in pallia...
Source: Clinical Plasma Medicine - February 3, 2020 Category: Research Source Type: research
Healing of wounds in lower extremities employing a non-thermal plasma
Conclusion: The non-thermal plasma generated in a needle reactor with helium gas is a promising candidate for clinical and therapeutic use in the treatment of neuropathic leg ulcers, with time reduction healing, and it can be applied everyday. In the study conducted, it was found that the non-thermal plasma applied to patients with autoimmune diseases clinically was not beneficial. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - January 30, 2020 Category: Research Source Type: research
Innovative Cold Atmospheric Plasma (iCAP) Decreases Mucopurulent Corneal Ulcer Formation and Edema and Reduces Bacterial Load in Pseudomonas Keratitis
ConclusionOur results strongly suggest that iCAP treatment was effective in improving corneal epithelial defect closure in vitro, reducing ulcer formation and decreasing inflammation in P. aeruginosa infected corneas in vivo and decreasing bacterial loads in P. aeruginosa infected corneas in vivo which led to improved overall cornea health outcomes in vivo. Further studies to investigate iCAP's safety and efficacy against other infectious microbes responsible for causing ulcerative keratitis, with and without co-treatment with antimicrobial therapies are warranted. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - December 28, 2019 Category: Research Source Type: research
Magnetic Field Enhanced Cold Plasma Sterilization
Publication date: Available online 19 October 2019Source: Clinical Plasma MedicineAuthor(s): Madeline A. Mackinder, Keliang Wang, Bocong Zheng, Maheshwar Shrestha, Qi Hua FanAbstractCold plasma sterilization offers an efficient way to sterilize medical components and instruments. This paper reports using a magnetized plasma to realize low-temperature sterilization. A radio frequency dielectric barrier discharge is created in a quartz tube using a mixture of argon and oxygen gas. A uniform amount of Escherichia coli is applied onto glass slides and exposed to the plasma afterglow at different pressures with and without a ma...
Source: Clinical Plasma Medicine - October 19, 2019 Category: Research Source Type: research
Biofilm Inactivation by Synergistic Treatment of Atmospheric Pressure Plasma and Chelating Agents
In this study, we investigated the bacterial biofilm reduction by combined treatment of atmospheric pressure plasma (APP) and chelating agents. Many of hospital acquired infections (HAI) are related to biofilm infections. APP and chelating agents were reported to be effective in bacterial biofilm inactivation and eradication. It is believed that chelating agents disrupt the biofilm formation through bonding metal ions, while APP inactivates bacteria mainly through reactive species [1], [2], [3]. In our study, we used a surface micro-discharge (SMD) driven by sinusoidal power input of 2 kHz and peak to peak voltage of 9 kV ...
Source: Clinical Plasma Medicine - June 22, 2019 Category: Research Source Type: research
Ethanolic extract of the natural product of Daun sirih (Piper betle) leaves may impede the effectiveness of the plasma jet contact style for acute wounds
ConclusionPlasma jet treatment alone is able to promote inflammation, neo-epithelialisation and new collagen formation to accelerate acute wound healing; however, its admixture with EPB may impede such effectiveness. Based on the characterization of the ROS and RNS results, the ethanol solvent may play a primary role in impeding its effectiveness. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - June 13, 2019 Category: Research Source Type: research
Publishers Note
Publication date: June 2019Source: Clinical Plasma Medicine, Volume 14Author(s): (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - May 29, 2019 Category: Research Source Type: research
Can the effect of cold physical plasma-derived oxidants be transported via thiol group oxidation?
ConclusionExtracellular thiol groups scavenge plasma-generated species and form a multitude of covalent modifications. Unexpectedly, human keratinocytes show only small functional consequences for treated physiologic cysteine concentrations. Results for high concentrated cysteine solutions indicate an improved cytostatic/cytotoxic impact by plasma treatment suggesting a potential application as a “preserving agent” of the chemical energy of plasma-derived species. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - March 28, 2019 Category: Research Source Type: research
When plasma jet is effective for chronic wound bacteria inactivation, is it also effective for wound healing?
ConclusionIn the context of wound healing, the non-contact style of plasma jet treatment may be better than the contact style of plasma jet treatment. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - March 24, 2019 Category: Research Source Type: research
Safety Evaluation of the Plasma on Ocular Surface Tissue: an Animal Study and Histopathological Findings
ConclusionAccording to the plasma safety results, it seems that plasma soft surgery has the potential to be used as an alternative method for treatment of some of the ocular surface disorders without needing to conventional surgical procedures. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - March 16, 2019 Category: Research Source Type: research
Cold physical plasma-induced oxidation of cysteine yields reactive sulfur species (RSS)
ConclusionTranslating these data into the in-vivo application, a strong direct oxidation of protein thiol groups with subsequent changes in protein biochemistry must be considered. Plasma derived RSS may in part contribute to the observed biomedical effects of CAP. Care must be taken to control discharge parameter tightly as chemical dynamics at or in the liquid are subject to change easily. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - March 9, 2019 Category: Research Source Type: research
Cold atmospheric plasma (CAP) differently affects migration and differentiation of keratinocytes via hydrogen peroxide and nitric oxide-related products
ConclusionCAP treatment theoretically could kill several birds with one stone—overcome bacterial contamination, improve microcirculation and additionally compensate missing H2O2 and nitric oxide— facilitating wound healing. However, clinical CAP treatment must be well balanced to avoid possible unwanted side effects, such as a delayed healing process and tissue damage. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - November 29, 2018 Category: Research Source Type: research
Wound Healing using Plasma Modified Collagen
ConclusionsCombining a biologic therapy with a plasma treatment showed promising results in the treatment of chronic wounds in an animal model and demonstrated the potential to combine biologic therapies with plasma deposition for targeted local delivery and enhanced healing.Graphical abstract (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - October 27, 2018 Category: Research Source Type: research
Potentiating Anti-Tumor Immunity with Physical Plasma
Publication date: Available online 5 October 2018Source: Clinical Plasma MedicineAuthor(s): Sander Bekeschus, Ramona Clemen, Hans-Robert MetelmannAbstractThe age of checkpoint blockage emphasizes the importance of adaptive antitumor immune responses. This arm of immune defense is key in recognizing molecules via specific receptors to distinguish between self and foreign or mutated structures. Antigen-specific T-cells identify non-self epitopes, tumor-associated antigens, or neo-epitopes on tumors to carry out attacks on malignant cells. Although tumor cells are immunogenic by nature, they have developed strategies to evade...
Source: Clinical Plasma Medicine - October 6, 2018 Category: Research Source Type: research
Surface treatment with non-thermal humid argon plasma as a treatment for allergic contact dermatitis in a mouse model
Publication date: December 2018Source: Clinical Plasma Medicine, Volume 12Author(s): Qing Xiong, Xia Wang, Rui Yin, Lin Xiong, Qiang Chen, Meng-Xue Zheng, Le Xu, Qing-Hua Huang, Michael R HamblinAbstractCold plasma generated at atmospheric pressure has attracted intense interest in biomedical applications, particularly as an antimicrobial treatment. Here we report the therapeutic effect of humidified cold argon plasma on allergic contact dermatitis (ACD) in a mouse model. Treatment was carried out with different gas compositions: argon gas containing small amounts of either N2, O2, or H2O. The best effect was obtained usin...
Source: Clinical Plasma Medicine - October 6, 2018 Category: Research Source Type: research
