Immunotherapy delays type 1 diabetes mellitus in high-risk individuals
Certain individuals at high risk of developing type 1 diabetes mellitis can delay progression to clinical disease by two years or more with a two-week course of teplizumab, according to a phase II study Source: Shutterstock.com (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 3, 2019 Category: Drugs & Pharmacology Source Type: research

Vitamin D not protective against cardiovascular events
Vitamin D supplementation is not associated with a reduced risk of major cardiovascular events, a meta-analysis suggests. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 1, 2019 Category: Drugs & Pharmacology Source Type: research

Alzheimer ’s drug reduces illicit opioid use in methadone recipients
People who take methadone use fewer illicit opioids when galantamine is added to their therapy, research shows. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 1, 2019 Category: Drugs & Pharmacology Source Type: research

Prednisolone reduces hand osteoarthritis pain
Patients with hand osteoarthritis experienced improvements in pain and function with low-dose prednisolone treatment, according to a study presented at the European Congress of Rheumatology. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 27, 2019 Category: Drugs & Pharmacology Source Type: research

Creating a coaching culture to support staff wellbeing in an NHS trust
More is being expected of trainee healthcare professionals; clinical educators must enable trainees to feel empowered and encourage them to seek their own solutions, as opposed to professionals telling them what they should do[1]. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 26, 2019 Category: Drugs & Pharmacology Source Type: research

Esketamine nasal spray effective for rapid improvement of depressive symptoms
The ketamine-related nasal spray esketamine is effective at relieving the symptoms of treatment-resistant depression, a phase III study has shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 24, 2019 Category: Drugs & Pharmacology Source Type: research

Weekly contact with pharmacist improves medicine adherence in people with heart failure
Regular consultations with pharmacists lead to improved medicine adherence in people with chronic heart failure (HF), research results show. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 19, 2019 Category: Drugs & Pharmacology Source Type: research

Room for improvement in UK heart failure care, researchers find
National reporting and incentive schemes, such as the Quality and Outcomes Framework, have not prevented suboptimal management of heart failure in the UK, research published in PLoS Medicine has concluded. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Managing osteoporosis in older people
How to understand bone health in the context of the older person, including risk assessment, prevention and the management of osteoporosis in patients likely to have multiple comorbidities. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 12, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of statin on MS progression not related to cholesterol reduction
A previously demonstrated effect of simvastatin in delaying progression of an advanced form of multiple sclerosis is not related to its effect on cholesterol levels, a study published in PNAS has shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 12, 2019 Category: Drugs & Pharmacology Source Type: research

We need a more rational approach to opioid prescribing
The rates of opioid misuse and related deaths may be lower  in the UK than in the United States, but healthcare professionals should remain vigilant when caring for patients with chronic pain. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 11, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetic considerations and challenges in oral anticancer drug therapy
A review of the pros and cons of oral anticancer drug therapy, as well as the pharmacokinetic barriers and potential solutions to oral chemotherapy in the home. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Daily isradipine is ineffective at slowing Parkinson ’s disease
The blood pressure therapy isradipine does not slow disease progression in people with early-stage Parkinson ’s disease, findings presented at the American Academy of Neurology Annual Meeting have shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 31, 2019 Category: Drugs & Pharmacology Source Type: research

Concern over new flushing guidance for small volume intravenous infusions
In November 2018, I raised concerns about incomplete and underdosed intravenous (IV) infusions in Clinical Pharmacist[1]. On this occasion, I am writing to raise concern over the National Infusion and Vascular Access Society ’s (NIVAS’s) new ... (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 30, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacy staff should be aware of drug misusers' methods of extracting opioids from OTC products
Misuse of codeine can cause serious harm. There are restrictions around use of the medicine, but people still find ways to misuse ... (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 28, 2019 Category: Drugs & Pharmacology Source Type: research