Clinical and Microbiological Characteristics of Clostridium difficile Infection Among Hospitalized Children in the Netherlands
Conclusions. Pediatric CDI in hospitals has remained stable over the last 6 years and resulted in fewer complications than for adult CDI. Further studies are needed to elucidate the source and epidemiology of PCR ribotype 265, primarily found in children. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: van Dorp, S. M., Smajlovic, E., Knetsch, C. W., Notermans, D. W., de Greeff, S. C., Kuijper, E. J. Tags: Major Article Source Type: research

Treating Sick Young Infants With Only Fast Breathing With Oral Amoxicillin in Resource-Limited Settings: Taking the High Road?
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Jehan, F., Qazi, S. Tags: Editorial commentary Source Type: research

Ambulatory Treatment of Fast Breathing in Young Infants Aged
Conclusions. This trial failed to show equivalence of placebo to amoxicillin in the management of isolated fast breathing without hypoxemia or other clinical signs of illness in term young infants. Clinical Trials Registration. NCT01533818. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Tikmani, S. S., Muhammad, A. A., Shafiq, Y., Shah, S., Kumar, N., Ahmed, I., Azam, I., Pasha, O., Zaidi, A. K. M. Tags: Major Article Source Type: research

Long-term Impact of a "3 + 0" Schedule for 7- and 13-Valent Pneumococcal Conjugate Vaccines on Invasive Pneumococcal Disease in Australia, 2002-2014
Conclusions. Reductions in vaccine-type IPD post-PCV13 were inferior to Australian experience with PCV7 and reports from high-income countries giving a PCV booster dose. Applicability of findings to other settings would depend on age of IPD onset, serotype profile, and timeliness of vaccination. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Jayasinghe, S., Menzies, R., Chiu, C., Toms, C., Blyth, C. C., Krause, V., McIntyre, P. Tags: Major Article Source Type: research

Fixed-Dose Artesunate-Amodiaquine Combination vs Chloroquine for Treatment of Uncomplicated Blood Stage P. vivax Infection in the Brazilian Amazon: An Open-Label Randomized, Controlled Trial
Conclusions. ASAQ exhibited high efficacy against CQ resistant P. vivax and is an adequate alternative in the study area. Studies with an efficacious comparator, longer follow-up and genotype-adjustment can improve CQR characterization. Clinical Trials Registration. NCT01378286. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Siqueira, A. M., Alencar, A. C., Melo, G. C., Magalhaes, B. L., Machado, K., Alencar Filho, A. C., Kuehn, A., Marques, M. M., Manso, M. C., Felger, I., Vieira, J. L. F., Lameyre, V., Daniel-Ribeiro, C. T., Lacerda, M. V. G. Tags: Major Article Source Type: research

Prediction of Congenital Cytomegalovirus Infection in High-Risk Pregnant Women
Conclusions. This is the first prospective cohort study to suggest that the presence of CMV-DNA in the maternal uterine cervical secretion and ultrasound fetal abnormalities are predictive of the occurrence of congenital CMV infection in high-risk pregnant women. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Tanimura, K., Tairaku, S., Ebina, Y., Morioka, I., Nagamata, S., Deguchi, K., Morizane, M., Deguchi, M., Minematsu, T., Yamada, H. Tags: Major Article Source Type: research

Thymic Function Impacts the Peripheral CD4/CD8 Ratio of HIV-Infected Subjects
Conclusions.  Our data indicate the relevance of the remaining thymic function before the start of treatment to the CD4/CD8 ratio of HIV- infected subjects and, hence, potentially, in their clinical progression. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Rosado-Sanchez, I., Herrero-Fernandez, I., Genebat, M., Ruiz-Mateos, E., Leal, M., Pacheco, Y. M. Tags: Major Article Source Type: research

Preexposure Prophylaxis in the United States: An Evolving HIV Prevention Opportunity
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Goldschmidt, R. H. Tags: Editorial commentary Source Type: research

Uptake of HIV Preexposure Prophylaxis Among Commercially Insured Persons--United States, 2010-2014
Conclusions. Our analytic method provides the only feasible means to monitor PrEP uptake in the United States. Although a marked increasing trend in uptake was observed for men, the number of women who used PrEP remained very low during the study period. Interventions are needed to increase PrEP use by women at substantial risk of acquiring HIV infection. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Wu, H., Mendoza, M. C. B., Huang, Y.-l. A., Hayes, T., Smith, D. K., Hoover, K. W. Tags: Major Article Source Type: research

Emergence of Candida auris: An International Call to Arms
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Clancy, C. J., Nguyen, M. H. Tags: Editorial commentary Source Type: research

Very Early ART and Persistent Inflammation in Treated HIV
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Hunt, P. W. Tags: Editorial commentary Source Type: research

Risk of Acute Kidney Injury in Patients on Concomitant Vancomycin and Piperacillin-Tazobactam Compared to Those on Vancomycin and Cefepime
Conclusion. The VPT combination was associated with both an increased AKI risk and a more rapid onset of AKI compared to the VC combination. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Navalkele, B., Pogue, J. M., Karino, S., Nishan, B., Salim, M., Solanki, S., Pervaiz, A., Tashtoush, N., Shaikh, H., Koppula, S., Koons, J., Hussain, T., Perry, W., Evans, R., Martin, E. T., Mynatt, R. P., Murray, K. P., Rybak, M. J., Kaye, K. S. Tags: Major Article Source Type: research

In the Literature
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Tags: In the Literature Source Type: research

News
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Authors: Kaye, D. Tags: News Source Type: research

Table of Contents
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 3, 2017 Category: Infectious Diseases Tags: Cover / Standing Material Source Type: research