The Discovery of the Iron-Regulatory Hormone Hepcidin [Citation Classics]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Ganz, T. Tags: Citation Classics, Hematology Source Type: research
Correlation Between Kappa Prozone Effect and IgA Kappa M Proteins in Serum Free Light-Chain Assay [Letter to the Editor]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Turner, K. A., Eckelkamp, L. L., Kalass, S. J., Martinez, M. A., Brewer, H. R., Hoyne, J. B., Snyder, M. R., Murray, D. L., Willrich, M. A. V. Tags: Clinical Immunology Letter to the Editor Source Type: research
Reference Values for 30 Common Biochemistry Analytes Across 5 Different Analyzers in Neonates and Children 30 Days to 18 Years of Age [Pediatric Clinical Chemistry]
CONCLUSIONS:
This study provides quantitative and qualitative measures of the extent to which results for individual children can or cannot be compared across analyzer types, and the feasibility of RI harmonization. The reported equations enable incorporation of age-specific RIs into laboratory information systems for improving evidence-based clinical decisions in children. (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Hoq, M., Matthews, S., Karlaftis, V., Burgess, J., Cowley, J., Donath, S., Carlin, J., Yen, T., Ignjatovic, V., Monagle, P., on behalf of the HAPPI Kids study team Tags: Pediatric Clinical Chemistry Source Type: research
Amplicon Sequencing-Based Noninvasive Fetal Genotyping for RHD-Positive D Antigen-Negative Alleles [Molecular Diagnostics and Genetics]
CONCLUSIONS:
This method is a reliable noninvasive fetal RHD genotyping method for Japanese and other East Asian populations. The genotyping principle of amplifying 2 different regions using the same primer pair and distinguishing them by their sequence difference during the subsequent mapping procedure is also theoretically applicable to RHD-positive D antigen-negative alleles prevalent in Africans. Therefore, this method offers an opportunity to consider targeted administration of anti-D immunoglobulin to RhD-negative pregnant women in East Asian and African countries and to increase the specificity of the fetal RHD geno...
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Takahashi, K., Migita, O., Sasaki, A., Nasu, M., Kawashima, A., Sekizawa, A., Sato, T., Ito, Y., Sago, H., Okamoto, A., Nakabayashi, K., Hata, K. Tags: Molecular Diagnostics and Genetics Source Type: research
Cytidine Diphosphate-Ribitol Analysis for Diagnostics and Treatment Monitoring of Cytidine Diphosphate-L-Ribitol Pyrophosphorylase A Muscular Dystrophy [Molecular Diagnostics and Genetics]
CONCLUSIONS:
Sensitive detection of CDP-ribitol with LC-MS allows fast diagnosis of patients with severe and mild CRPPA myopathy. Ribose offers a readily testable dietary therapy for CRPPA myopathy, with possible applicability for patients with FKRP and FKTN myopathy. Evaluation of CDP-ribitol in blood is a promising tool for the evaluation and monitoring of dietary therapies for CRPPA myopathy in a patient-specific manner. (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: van Tol, W., van Scherpenzeel, M., Alsady, M., Riemersma, M., Hermans, E., Kragt, E., Tasca, G., Kamsteeg, E.-J., Pennings, M., van Beusekom, E., Vermeulen, J. R., van Bokhoven, H., Voermans, N. C., Willemsen, M. A., Ashikov, A., Lefeber, D. J. Tags: Molecular Diagnostics and Genetics Source Type: research
Circular RNAs in Urine of Kidney Transplant Patients with Acute T Cell-Mediated Allograft Rejection [Molecular Diagnostics and Genetics]
CONCLUSIONS:
CircRNA concentrations are significantly dysregulated in patients with acute rejection at subclinical time points. Urinary hsa_circ_0001334 is a novel biomarker of acute kidney rejection, identifying patients with acute rejection and predicting loss of kidney function. (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Kolling, M., Haddad, G., Wegmann, U., Kistler, A., Bosakova, A., Seeger, H., Hubel, K., Haller, H., Mueller, T., Wuthrich, R. P., Lorenzen, J. M. Tags: Molecular Diagnostics and Genetics Source Type: research
Prognostic Relevance of Steroid Sulfation in Adrenocortical Carcinoma Revealed by Molecular Phenotyping Using High-Resolution Mass Spectrometry Imaging [Cancer Diagnostics]
CONCLUSIONS:
MALDI-MSI provides novel insights into the pathophysiology of ACC. Steroid hormone sulfation may be used for prognostication and treatment stratification. Sulfation-related metabolic reprogramming may be of relevance also in conditions beyond the rare ACC and can be directly investigated by the use of MALDI-MSI. (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Sun, N., Kunzke, T., Sbiera, S., Kircher, S., Feuchtinger, A., Aichler, M., Herterich, S., Ronchi, C. L., Weigand, I., Schlegel, N., Waldmann, J., Candida Villares Fragoso, M., Whitsett, T. G., Gill, A. J., Fassnacht, M., Walch, A., Kroiss, M. Tags: Cancer Diagnostics (since 2002) Source Type: research
Circulating Tumor Cells as a Prognostic Factor in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: The CIRCUTEC Prospective Study [Cancer Diagnostics]
CONCLUSIONS:
CTCs can be detected before and during chemotherapy in patients with rHNSCC. D0–D7 CTC kinetics evaluated with EPISPOTEGFR are associated with the response to treatment. This study indicates that CTCs can be used as a real-time liquid biopsy to monitor the early response to chemotherapy in rHNSCC.
ClinicalTrials.gov Identifier:
NCT02119559 (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Garrel, R., Mazel, M., Perriard, F., Vinches, M., Cayrefourcq, L., Guigay, J., Digue, L., Aubry, K., Alfonsi, M., Delord, J.-P., Lallemant, B., Even, C., Daures, J.-P., Landais, P., Cupissol, D., Alix-Panabieres, C. Tags: Cancer Diagnostics (since 2002) Source Type: research
Effect of Lipoprotein(a) on the Diagnosis of Familial Hypercholesterolemia: Does It Make a Difference in the Clinic? [Lipids, Lipoproteins, and Cardiovascular Risk Factors]
CONCLUSIONS:
Adjusting LDL cholesterol concentration for Lp(a) cholesterol improves the diagnostic accuracy of DLCN and SB criteria, especially with Lp(a) >1.0 g/L and LDL cholesterol <251 mg/dL (<6.5 mmol/L). Lp(a) should be measured in all patients suspected of having FH. (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Chan, D. C., Pang, J., Hooper, A. J., Bell, D. A., Burnett, J. R., Watts, G. F. Tags: Lipids, Lipoproteins, and Cardiovascular Risk Factors Source Type: research
Urinary Amino-Terminal Pro-C-Type Natriuretic Peptide: A Novel Marker of Chronic Kidney Disease in Diabetes [Proteomics and Protein Markers]
CONCLUSIONS:
Characterization of the products of proCNP in urine confirmed the presence of NTproCNP. In spot random urine from study participants with DM, NCR is inversely associated with estimated glomerular filtration rate. In contrast to ACR, NCR reflects nonvascular factors that likely include renal inflammation and fibrosis. (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Prickett, T. C. R., Lunt, H., Warwick, J., Heenan, H. F., Espiner, E. A. Tags: Proteomics and Protein Markers Source Type: research
Detection of Neprilysin-Derived BNP Fragments in the Circulation: Possible Insights for Targeted Neprilysin Inhibition Therapy for Heart Failure [Proteomics and Protein Markers]
CONCLUSIONS:
BNP-neo17 formation is NEP dependent. Considering that BNP-neo17 is generated from the active form of BNP by NEP, we speculate that BNP-neo17 may reflect both the NEP activity and natriuretic potential and serve for HF therapy guidance. (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Feygina, E. E., Artemieva, M. M., Postnikov, A. B., Tamm, N. N., Bloshchitsyna, M. N., Medvedeva, N. A., Katrukha, A. G., Semenov, A. G. Tags: Proteomics and Protein Markers Source Type: research
Biomarkers for Predicting Response to Immunotherapy with Immune Checkpoint Inhibitors in Cancer Patients [Review]
BACKGROUND:
Immunotherapy, especially the use of immune checkpoint inhibitors, has revolutionized the management of several different cancer types in recent years. However, for most types of cancer, only a minority of patients experience a durable response. Furthermore, administration of immunotherapy can result in serious adverse reactions. Thus, for the most efficient and effective use of immunotherapy, accurate predictive biomarkers that have undergone analytical and clinical validation are necessary.
CONTENT:
Among the most widely investigated predictive biomarkers for immunotherapy are programmed death-ligand 1 (PD-L...
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Duffy, M. J., Crown, J. Tags: Cancer Diagnostics (since 2002) Review Source Type: research
Educational Recommendations on Selected Analytical and Clinical Aspects of Natriuretic Peptides with a Focus on Heart Failure: A Report from the IFCC Committee on Clinical Applications of Cardiac Bio-Markers [Special Report]
The IFCC Committee on Clinical Applications of Cardiac Bio-Markers (C-CB) has directives and initiatives focused on providing evidence-based educational resources to aid and improve understanding around key analytical and clinical aspects of cardiac biomarkers used in clinical practice and the research setting. As a task force, we have previously published position statements and recommendations focused on use and analytical aspects of high-sensitivity cardiac troponin assays. The current educational document is the first from the C-CB highlighting important biochemical, analytical, and clinical aspects as they relate to t...
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Kavsak, P. A., Lam, C. S. P., Saenger, A. K., Jaffe, A. S., Collinson, P., Pulkki, K., Omland, T., Lefevre, G., Body, R., Ordonez-Llanos, J., Apple, F. S. Tags: Proteomics and Protein Markers Special Report Source Type: research
Commentary [Clinical Case Study]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Wolska, A., Remaley, A. T. Tags: Clinical Case Study Source Type: research
