Inadequate Reporting of Analytical Characteristics of Biomarkers Used in Clinical Research: A Threat to Interpretation and Replication of Study Findings [Current Issues in Laboratory Medicine]
CONCLUSIONS:
Reporting of the analytical performance of biomarker measurements is variable and often absent from published clinical studies. We suggest that readers need fuller reporting of analytical characteristics to interpret study results, assess generalizability of conclusions, and compare results among clinical studies. (Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Sun, Q., Welsh, K. J., Bruns, D. E., Sacks, D. B., Zhao, Z. Tags: Current Issues in Laboratory Medicine Source Type: research
A Novel Online Calculator Based on Serum Biomarkers to Detect Hepatocellular Carcinoma among Patients with Hepatitis B [Cancer Diagnostics]
CONCLUSIONS:
Our results demonstrated that a web-based calculator including age, sex, AFP, and PIVKA-II accurately predicted the presence of HCC in patients with CHB.
ClinicalTrials.gov Identifier:
NCT03047603 (Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Yang, T., Xing, H., Wang, G., Wang, N., Liu, M., Yan, C., Li, H., Wei, L., Li, S., Fan, Z., Shi, M., Chen, W., Cai, S., Pawlik, T. M., Soh, A., Beshiri, A., Lau, W. Y., Wu, M., Zheng, Y., Shen, F. Tags: Cancer Diagnostics (since 2002) Source Type: research
Clinical Utility of Procalcitonin in the Diagnosis of Pneumonia [Infectious Disease]
CONCLUSIONS:
In patients presenting with dyspnea, diagnostic accuracy of procalcitonin for pneumonia is only moderate and lower than that of interleukin 6 and CRP. The clinical utility of procalcitonin was lower than expected.
SUMMARY:
Pneumonia has diverse and often unspecific symptoms. As the role of biomarkers in the diagnosis of pneumonia remains controversial, it is often difficult to distinguish pneumonia from other illnesses causing shortness of breath. The current study prospectively enrolled unselected patients presenting with acute dyspnea and directly compared the diagnostic accuracy of procalcitonin, interleuk...
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Wussler, D., Kozhuharov, N., Tavares Oliveira, M., Bossa, A., Sabti, Z., Nowak, A., Murray, K., du Fay de Lavallaz, J., Badertscher, P., Twerenbold, R., Shrestha, S., Flores, D., Nestelberger, T., Walter, J., Boeddinghaus, J., Zimmermann, T., Koechlin, L. Tags: Infectious Disease Source Type: research
Discovering Cross-Reactivity in Urine Drug Screening Immunoassays through Large-Scale Analysis of Electronic Health Records [Informatics and Statistics]
CONCLUSIONS:
Our findings can help laboratorians and providers interpret presumptive positive UDS results. Our data-driven approach can serve as a model for high-throughput discovery of substances that interfere with laboratory tests. (Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Hughey, J. J., Colby, J. M. Tags: Informatics and Statistics Source Type: research
Effects of One Year of Vitamin D and Marine Omega-3 Fatty Acid Supplementation on Biomarkers of Systemic Inflammation in Older US Adults [Clinical Immunology]
CONCLUSIONS:
In this large sample from a population-based randomized controlled trial, neither vitamin D nor n-3 FA supplementation over 1 year decreased these biomarkers of inflammation.
ClinicalTrials.gov Identifier:
NCT01169259; NCT01351805 (Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Costenbader, K. H., MacFarlane, L. A., Lee, I.-M., Buring, J. E., Mora, S., Bubes, V., Kotler, G., Camargo, C. A., Manson, J. E., Cook, N. R. Tags: Clinical Immunology Source Type: research
Ethics for Laboratory Medicine [Review]
CONCLUSIONS:
Although many clinical laboratorians do not see or treat patients, they must be held accountable to the highest ethical and professional behavior. Recognition and understanding of ethical issues are essential to ethical practice of laboratory medicine. (Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Gronowski, A. M., Budelier, M. M., Campbell, S. M. Tags: Other Areas of Clinical Chemistry Review Source Type: research
Commentary [Clinical Case Study]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Edwards, P. T., Harpavat, S. Tags: Clinical Case Study Source Type: research
Persistent Jaundice and Multiple Fractures in a Newborn [Clinical Case Study]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Owens, D. J., Williamson, T. W., Kenwright, K. M. Tags: General Clinical Chemistry, Clinical Case Studies Clinical Case Study Source Type: research
Perspectives on the Changing Landscape of Measuring Cardiovascular Risk Related to LDL [Q&A]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: El-Khoury, J. M., Remaley, A. T., Nordestgaard, B. G., Kaufman, H. W., Mora, S., Cao, J., Meeusen, J. W. Tags: Lipids, Lipoproteins, and Cardiovascular Risk Factors Q & amp;A Source Type: research
Noninvasive Prenatal Testing and Detection of Occult Maternal Malignancies [Perspective]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Lenaerts, L., Jatsenko, T., Amant, F., Robert Vermeesch, J. Tags: Cancer Diagnostics (since 2002), Perspective Source Type: research
Dried Blood Spots May Improve Detection of Blood Doping [Editorials]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Cox, H. D. Tags: Molecular Diagnostics and Genetics Editorials Source Type: research
Laboratory Measurement's Contribution to the Replication and Application Crisis in Clinical Research [Editorials]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Bossuyt, P. M. Tags: Editorials Source Type: research
Population-Specific Screening for Hepatocellular Carcinoma [Editorials]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Pittman, M. E. Tags: Cancer Diagnostics (since 2002) Editorials Source Type: research
Procalcitonin's Adjunct Role in the Diagnosis and Management of Pneumonia [Editorials]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Peck Palmer, O. M. G. Tags: Infectious Disease Editorials Source Type: research
