Long ‐term impacts of hemodialysis on the right ventricle: Assessment via 3‐dimensional speckle‐tracking echocardiography
In this study, RV dysfunction in MHD patients will be revealed and studied in depth by 3DSTE. MethodsEchocardiography was performed on 110 consecutively enrolled individuals: 30 controls and 80 patients with MHD. Conventional echocardiographic parameters and 3DSTE parameters were obtained and compared between groups. Univariate and multivariate logistic regression analysis identified independent predictors of intradialytic hypotension (IDH). ResultsCompared with the control group, RV end‐diastolic volume (RVEDV) was markedly enlarged (46.1 ± 11.8 mL/m2 vs 42.3 ± 8.6&thinsp...
Source: Clinical Cardiology - January 24, 2018 Category: Cardiology Authors: Minmin Sun, Xuesen Cao, Yao Guo, Xiao Tan, Lili Dong, Cuizhen Pan, Xianhong Shu Tags: CLINICAL INVESTIGATIONS Source Type: research

Use of two ‐dimensional speckle tracking echocardiography to predict cardiac events: Comparison of patients with acute myocardial infarction and chronic coronary artery disease
ConclusionsGlobal strain parameters by 2D STE may be useful for the prediction of cardiac events in patients with CAD but add no supplemental information to baseline characteristic and ejection fraction in patients with AMI. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 23, 2018 Category: Cardiology Authors: J örg Scharrenbroich, Sandra Hamada, Andras Keszei, Jörg Schröder, Andreas Napp, Mohammad Almalla, Michael Becker, Ertunc Altiok Tags: CLINICAL INVESTIGATIONS Source Type: research

Clinical and prognostic relationships of pulmonary artery to aorta diameter ratio in patients with heart failure: a cardiac magnetic resonance imaging study
ConclusionsThe PA/Ao ratio is not a useful method to stratify prognosis in patients with HF. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 23, 2018 Category: Cardiology Authors: Pierpaolo Pellicori, Alessia Urbinati, Jufen Zhang, Anil C. Joseph, Pierluigi Costanzo, Elena Lukaschuk, Alessandro Capucci, John G.F. Cleland, Andrew L. Clark Tags: CLINICAL INVESTIGATIONS Source Type: research

Agreement between coding schemas used to identify bleeding ‐related hospitalizations in claims analyses of nonvalvular atrial fibrillation patients
ConclusionsWe observed varying levels of agreement among 3 bleeding‐related hospitalizations schemas in NVAF patients. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 23, 2018 Category: Cardiology Authors: Craig I. Coleman, Tatsiana Vaitsiakhovich, Elaine Nguyen, Erin R. Weeda, Nitesh A. Sood, Thomas J. Bunz, Bernhard Schaefer, Anna ‐Katharina Meinecke, Daniel Eriksson Tags: CLINICAL INVESTIGATIONS Source Type: research

Predictors of arrhythmia recurrence in patients with heart failure undergoing left atrial ablation for atrial fibrillation
BackgroundAtrial fibrillation (AF) ablation is increasingly used in patients with reduced left ventricular ejection fraction (LVEF). The aim of the present study was to evaluate the long‐term results of a single radiofrequency catheter ablation procedure in heart failure (HF) patients with AF. HypothesisWe tested the hypothesis that left atrial ablation is an effective therapeutic modality in patients with heart failure. MethodsOur study included HF patients with LVEF
Source: Clinical Cardiology - January 22, 2018 Category: Cardiology Authors: George Bazoukis, Konstantinos P. Letsas, Gary Tse, Katerina K. Naka, Panagiotis Korantzopoulos, Evangelia Ntzani, Konstantinos Vlachos, Athanasios Saplaouras, Eirini Pagkalidou, Lampros K. Michalis, Antonios Sideris, Michael Efremidis Tags: CLINICAL INVESTIGATIONS Source Type: research

Reassessment of cardiovascular parameters and comorbidities in implantable cardioverter ‐defibrillator patients at the time of first replacement
ConclusionsFocused reassessment of selected patient characteristics at the time of ICD replacement correlates with subsequent mortality and can impact decision making at this point in time. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 22, 2018 Category: Cardiology Authors: Sandra Wuest, Raphael Twerenbold, Michael K ühne, Tobias Reichlin, Christian Sticherling, Stefan Osswald, Beat Schaer Tags: CLINICAL INVESTIGATIONS Source Type: research

Early versus delayed invasive strategy for intermediate ‐ and high‐risk acute coronary syndromes managed without P2Y12 receptor inhibitor pretreatment: Design and rationale of the EARLY randomized trial
According to recent literature, pretreatment with a P2Y12 ADP receptor antagonist before coronary angiography appears no longer suitable in non–ST‐segment elevation acute coronary syndrome (NSTE‐ACS) due to an unfavorable risk–benefit ratio. Optimal delay of the invasive strategy in this specific context is unknown. We hypothesize that without P2Y12 ADP receptor antagonist pretreatment, a very early invasive strategy may be beneficial. The EARLY trial (Early or Delayed Revascularization for Intermediate‐ and High‐Risk Non–ST‐Segment Elevation Acute Coronary Syndromes?) is a prospective, multicen...
Source: Clinical Cardiology - January 22, 2018 Category: Cardiology Authors: Gilles Lemesle, Marc Laine, Mathieu Pankert, Etienne Puymirat, Thomas Cuisset, Ziad Boueri, Luc Maillard, S ébastien Armero, Guillaume Cayla, Laurent Bali, Pascal Motreff, Jean‐Pascal Peyre, Franck Paganelli, François Kerbaul, Antoine Roch, Pierre Mic Tags: TRIAL DESIGNS Source Type: research

Variation in practice patterns and outcomes across United Network for Organ Sharing allocation regions
BackgroundThe number of heart transplants performed is limited by organ availability and is managed by the United Network for Organ Sharing (UNOS). Efforts are underway to make organ disbursement more equitable as demand increases. HypothesisSignificant variation exists in contemporary patterns of care, wait times, and outcomes among patients undergoing heart transplantation across UNOS regions. MethodsWe identified adult patients undergoing first, single‐organ heart transplantation between January 2006 and December 2014 in the UNOS dataset and compared sociodemographic and clinical profiles, wait times, use of mechanica...
Source: Clinical Cardiology - January 22, 2018 Category: Cardiology Authors: Dushyanth Srinivasan, Benjamin Vaccaro, Pooja Rao, Rohit Ghosh, Prashant Warier, Tariq Ahmad, Nihar Desai Tags: CLINICAL INVESTIGATIONS Source Type: research

Association between clinical factors and self ‐underestimation of cardiovascular risk in subjects submitted to a routine health evaluation
BackgroundThe perception of cardiovascular (CV) risk is essential for adoption of healthy behaviors. However, subjects underestimate their own risk. HypothesisClinical characteristics might be associated with self‐underestimation of CV risk. MethodsThis is a retrospective, cross‐sectional study of individuals submitted to routine health evaluation between 2006 and 2012, with calculated lifetime risk score (LRS) indicating intermediate or high risk for CV disease (CVD). Self‐perception of risk was compared with LRS. Logistic regression analysis was performed to test the association between clinical characteristics and...
Source: Clinical Cardiology - January 22, 2018 Category: Cardiology Authors: Thais N. Helou, Raul D. Santos, Antonio G. Laurinavicius, Marcio Sommer Bittencourt, Antonio E.P. Pesaro, Fabio G.M. Franco, Raquel D.O. Concei ção, José A.M. Carvalho, Fernando M.F. Silva, Mauricio Wajngarten, Marcelo Katz Tags: CLINICAL INVESTIGATIONS Source Type: research

Antithrombotic therapy in peripheral artery disease: A review of the EUCLID trial results and current ongoing trials
In addition to risk‐factor modification, antithrombotic therapy is the hallmark of management to reduce cardiovascular ischemic events in patients with peripheral artery disease (PAD). Currently, the guidelines recommend long‐term antiplatelet therapy with aspirin or clopidogrel in this patient population to reduce myocardial infarction, stroke, and vascular death. Past outcomes studies have shown some benefit of ticagrelor, another antiplatelet agent, as compared with clopidogrel in patients with coronary disease and concomitant PAD. However, most recently, the Examining Use of Ticagrelor in Peripheral Artery Disease ...
Source: Clinical Cardiology - January 22, 2018 Category: Cardiology Authors: Rachael Ward, Chandler Long, Manesh R. Patel, William S. Jones Tags: REVIEW Source Type: research

The evolving view of coronary artery calcium and cardiovascular disease risk
Calcification of the coronary artery is a complex pathophysiologic process that is intimately associated with atherosclerosis. Extensive investigation has demonstrated the value of identifying and quantifying coronary artery calcium (CAC) in atherosclerotic cardiovascular disease (CVD) prognostication. However, over the last several years, an increasing body of evidence has suggested that CAC has underappreciated aspects that modulate, and at times attenuate, future CVD risk. The most commonly used measure of CAC, the Agatston unit, effectively models both higher density and higher area of CAC as risk factors for future CV...
Source: Clinical Cardiology - January 22, 2018 Category: Cardiology Authors: Isac C. Thomas, Nketi I. Forbang, Michael H. Criqui Tags: REVIEW Source Type: research

Any Associations Between the Timing of the Peak QTc Prolongation, Depth of the Admission T ‐Wave Inversions, and Extent/Intensity of Myocardial Edema in Patients With Takotsubo Syndrome?
(Source: Clinical Cardiology)
Source: Clinical Cardiology - January 18, 2018 Category: Cardiology Authors: John E. Madias Tags: LETTER TO THE EDITOR Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - January 18, 2018 Category: Cardiology Tags: ISSUE INFORMATION Source Type: research

Drug ‐Coated Balloons for De‐Novo Lesions in Small Coronary Arteries: Rationale and Design of BASKET‐SMALL 2
BackgroundThe treatment of coronary small vessel disease (SVD) remains an unresolved issue. Drug‐eluting stents (DES) have limited efficacy due to increased rates of instent‐restenosis, mainly caused by late lumen loss. Drug‐coated balloons (DCB) are a promising technique since native vessels remain structurally unchanged. MethodsBASKET‐SMALL 2 is a multicenter, randomized, controlled, non‐inferiority trial of DCB vs. DES in native SVD for clinical endpoints. 758 patients with de‐novo lesions in vessels
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: Nicole Gilgen, Ahmed Farah, Bruno Scheller, Marc ‐Alexander Ohlow, Norman Mangner, Daniel Weilenmann, Jochen Wöhrle, Peiman Jamshidi, Gregor Leibundgut, Sven Möbius‐Winkler, Robert Zweiker, Florian Krackhardt, Christian Butter, Leonhard Bruch, Chris Tags: TRIAL DESIGNS Source Type: research

Sustained Sex ‐based Treatment Differences in Acute Coronary Syndrome Care: Insights from the American Heart Association Get With the Guidelines Coronary Artery Disease Registry
BackgroundSex‐based differences in acute coronary syndrome (ACS) mortality may attenuate with age due to better symptom recognition and prompt care.HypothesisAge is a modifier of temporal trends in sex‐based differences in ACS care. MethodsAmong 104,817 eligible patients with ACS enrolled in the AHA GWTG‐CAD registry between 2003‐2008, care and in‐hospital mortality were evaluated stratified by sex and age (
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: Jacob A. Udell, Gregg C. Fonarow, Thomas M. Maddox, Christopher P. Cannon, W. Frank Peacock, Warren K. Laskey, Maria V. Grau ‐Sepulveda, Eric E. Smith, Adrian F. Hernandez, Eric D. Peterson, Deepak L. Bhatt, Tags: CLINICAL INVESTIGATIONS Source Type: research

Importance of Baseline Heart Rate as a Predictor of Cardiac Functional Recovery in Newly Diagnosed Heart Failure with Reduced Ejection Fraction
ConclusionThe novel findings of our analysis reveal the only predictor of LVR in this study was a low baseline HR. Early modulation of heart rate in newly diagnosed HF patients may increase the rates of LVR. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: Ali Valika, Kim Paprockas, Dana Villines, Maria Rosa Costanzo Tags: CLINICAL INVESTIGATIONS Source Type: research

The role of imaging in women with ischemic heart disease
Substantial advances and insights in medical technology and treatment strategies, and the focus on sex‐specific research have contributed to a reduction in cardiovascular mortality in women. Despite these advances, ischemic heart disease (IHD) remains the leading cause of cardiovascular morbidity and mortality of women in the Western world. Advances in cardiovascular imaging, over the past 4 decades, have significantly improved the evaluation and management of the full spectrum of coronary atherosclerosis, which contributes to ischemic heart disease. The development of contemporary and novel diagnostic imaging techniques...
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: Niti R. Aggarwal, Rachel M. Bond, Jennifer H. Mieres Tags: REVIEW Source Type: research

Why names matter for women: MINOCA/INOCA (myocardial infarction/ischemia and no obstructive coronary artery disease)
The syndromes of myocardial infarction/myocardial ischemia with No Obstructive Coronary Artery Disease (MINOCA/INOCA) are increasingly evident. A majority of these patients have coronary microvascular dysfunction. These patients have elevated risk for a cardiovascular event (including acute coronary syndrome, myocardial infarction, stroke, and repeated cardiovascular procedures) and appear to be at higher risk for development of heart failure with preserved ejection fraction. Terminology such as coronary artery disease or coronary heart disease is often synonymous with obstructive atherosclerosis in the clinician's mind, l...
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: Christine Pacheco Claudio, Odayme Quesada, Carl J. Pepine, C. Noel Bairey Merz Tags: REVIEW Source Type: research

What the Women's Health Initiative has taught us about menopausal hormone therapy
Our understanding of the complex relationship between menopausal hormone therapy (MHT) and cardiovascular disease (CVD) risk has been informed by detailed analyses in the Women's Health Initiative (WHI), the largest randomized, placebo‐controlled trial evaluating MHT in postmenopausal women. Although the WHI demonstrated increased risk of CVD events with MHT in the overall cohort, subsequent secondary analyses demonstrated that these risks were influenced by the woman's age and time since menopause, with lower absolute risks and hazard ratios for younger than older women. As MHT is the most effective treatment for the va...
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: Rebecca C. Chester, Juliana M. Kling, JoAnn E. Manson Tags: REVIEW Source Type: research

Sex differences in heart failure
Heart failure (HF) numbers continue to grow in the United States and approximately 50% of patients living with HF are women. For the provider, it is critical to understand the role that gender plays in recognition, diagnosis, and management. The purpose of this literature review is to highlight the prevalence of heart failure in women and discuss gender variations in epidemiology, symptoms, pharmacology, and treatment as well as examine the representation of women in clinical trials. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: Evann Eisenberg, Katherine E. Di Palo, Ileana L. Pi ña Tags: REVIEW Source Type: research

How do we attract and retain women in cardiology?
The recruitment and advancement of women in cardiology is an important priority for the cardiology community. Despite improvements in sex disparities over the last 2 decades, women remain a small minority in cardiology. Recent studies have revealed key obstacles facing female cardiologists including radiation exposure, family responsibilities, unequal financial compensations, and lack of career advancement. To attract and retain more women into the field of cardiology, the cardiology community, including professional society leaders, division chiefs, and program directors, must all work to overcome these barriers. (Source:...
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: Emily S. Lau, Malissa J. Wood Tags: REVIEW Source Type: research

Type I Wenckebach second ‐degree AV block: A matter of definition
(Source: Clinical Cardiology)
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: S. Serge Barold Tags: EDITORIAL Source Type: research

Effect of type D personality on smoking status and their combined impact on outcome after acute myocardial infarction
ConclusionsType D personality and smoking status increase the risk of cardiac events. An emotionally stressed personality and persistence of smoking after the first cardiac event, and mostly their mutual influence, indicate a population at high cardiovascular risk. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: Egidio Imbalzano, Marco Vatrano, Sebastiano Quartuccio, Roberto Ceravolo, Vincenzo Antonio Ciconte, Paola Rotella, Renato Pardeo, Giovanni Trapani, Pasquale De Fazio, Cristina Segura ‐Garcia, Rossella Costantino, Antonino Saitta, Giuseppe Mandraffino Tags: CLINICAL INVESTIGATIONS Source Type: research

Peripartum cardiomyopathy: Status 2018
Peripartum cardiomyopathy is a rare cardiac condition, overall. However, in certain populations can be found frequently enough and the signs, symptoms, and management should be readily understood. Here we provide an updated overview of this topic. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: Divya Gupta, Nanette K. Wenger Tags: REVIEW Source Type: research

You've come a long way, baby
(Source: Clinical Cardiology)
Source: Clinical Cardiology - January 1, 2018 Category: Cardiology Authors: Martha Gulati, Nanette K. Wenger Tags: REVIEW Source Type: research

Acute kidney injury post –transcatheter aortic valve replacement
The objective of this concise review was to identify the prevalence and the impact of AKI following TAVR on patient outcomes by including the most recent literature in our search. After a thorough search on MEDLINE, Google Scholar, and PubMed, we included all literature relevant to AKI following TAVR. We found that AKI was caused by a variety of reasons, such as hemodynamic instability during rapid pacing, blood transfusion, periprocedural embolization, and use of contrast medium, to name a few. In patients who developed AKI following TAVR, 30‐day and 1‐year mortality were increased. Further, in these patients, length ...
Source: Clinical Cardiology - December 18, 2017 Category: Cardiology Authors: Pradhum Ram, Kenechukwu Mezue, Gregg Pressman, Janani Rangaswami Tags: REVIEW Source Type: research

QTc dispersion and Cornell duration product can predict 10 ‐year outcomes in hypertensive patients with left ventricular hypertrophy
BackgroundPersistent and adequate treatment of patients with arterial hypertension leads to more favorable disease outcome. HypothesisAside for the present left ventricular hypertrophy (LVH), there are other non‐invasive parameters which can represent additional predictors of unfavorable prognosis in patients with essential arterial hypertension during the 10‐year follow‐up. MethodsA hypertensive group with LVH (124 patients; age 57.0 ± 8.0; 84 males and 40 females) was included in the study and examined noninvasively. Patients used regular medication therapy during the follow‐up period. Result...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Dragan B. Djordjevi ć, Ivan S. Tasić, Svetlana I. Kostić, Bojana N. Stamenković, Aleksandar D. Djordjević, Dragan B. Lović Tags: CLINICAL INVESTIGATIONS Source Type: research

High ‐volume forced diuresis with matched hydration using the RenalGuard System to prevent contrast‐induced nephropathy: A meta‐analysis of randomized trials
BackgroundContrast‐induced nephropathy (CIN) is a well‐recognized complication of coronary angiography that is associated with poor outcomes. Several small randomized controlled trials (RCTs) have recently shown that in patients with chronic kidney disease (CKD), furosemide‐induced forced diuresis with matched hydration using the RenalGuard system can prevent its occurrence. However, individual studies have been underpowered and thus cannot show significant differences in major clinical endpoints. HypothesisForced diuresis with matched hydration using the RenalGuard system improves clinical outcomes in patients under...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Rahman Shah, Sarah J. Wood, Sajjad A. Khan, Amina Chaudhry, M. Rehan Khan, Mohamed S. Morsy Tags: CLINICAL INVESTIGATIONS Source Type: research

Lithium ‐induced electrocardiographic changes: A complete review
Lithium has been used for the treatment of bipolar disorder for more than 6 decades. Reports of cardiac side effects resulting in both benign electrocardiographic (ECG) changes and near fatal arrhythmias have been reported in the literature. A systematic literature search was conducted on 2 electronic databases—PubMed and Medline—for the time period between January 1970 and March 2016 using the key word “lithium,” along with “electrocardiography” or “ECG.” All articles and their references were then screened by title for relevance by 2 authors and a librarian. A total of 406 ...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Nikhil Mehta, Robert Vannozzi Tags: REVIEW Source Type: research

Cardiovascular safety of NSAIDs: Additional insights after PRECISION and point of view
Increasing numbers of patients with arthritis use nonsteroidal anti‐inflammatory drugs (NSAIDs), some for long periods. The relative cardiovascular safety of NSAID use is of considerable concern, particularly among patients with or at risk of cardiovascular disease. Until recently, the evidence base was limited to older trials with small sample sizes. The large‐scale Prospective Randomized Evaluation of Celecoxib Integrated Safety vs Ibuprofen or Naproxen (PRECISION) trial and a recent Bayesian meta‐analysis of individual patient data in nearly a half‐million patients were undertaken to address some of the existing...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Carl J. Pepine, Paul A. Gurbel Tags: REVIEW Source Type: research

Isometric handgrip echocardiography: A noninvasive stress test to assess left ventricular diastolic function
ConclusionsIHE is a simple, effective tool for evaluating diastolic function during simulated activities of daily living. (Source: Clinical Cardiology)
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: T. Jake Samuel, Rhys Beaudry, Mark J. Haykowsky, Satyam Sarma, Suwon Park, Thomas Dombrowsky, Paul S. Bhella, Michael D. Nelson Tags: CLINICAL INVESTIGATIONS Source Type: research

Appropriateness vs value: Echocardiography in primary care
ConclusionsTo ensure the greatest value and optimize use of diagnostic testing, it may be necessary to develop a more comprehensive set of guidelines to assist clinicians to readily identify patient populations at low, moderate, and high risk for the presence of disease and provide educational interventions, including feedback regarding individual ordering behaviors. (Source: Clinical Cardiology)
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Amy Bethge, Oana Penciu, Salma Baksh, Swapnil Parve, Jessika Lobraico, Andrew M. Keller Tags: CLINICAL INVESTIGATIONS Source Type: research

Culprit plaque characteristics in women vs men with a first ST ‐segment elevation myocardial infarction: In vivo optical coherence tomography insights
ConclusionsAmong patients presenting with a first STEMI, there were no differences in culprit plaque features between women and men. (Source: Clinical Cardiology)
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Rong Sun, Liping Sun, Yandong Fu, Huimin Liu, Maoen Xu, Xuefeng Ren, Huai Yu, Hui Dong, Yang Liu, Yinchun Zhu, Jinwei Tian, Bo Yu Tags: CLINICAL INVESTIGATIONS Source Type: research

Gender differences in the association between discharge hemoglobin and 12 ‐month mortality after acute myocardial infarction
BackgroundAnemia at discharge in patients with acute myocardial infarction is associated with poor prognosis; whether this differs in women and men or if there is a threshold value at which these relationships change is unknown. HypothesisWomen have a lower discharge hemoglobin (Hb) at which outcomes worsen. MethodsWe identified patients with acute myocardial infarction in the TRIUMPH registry between 2005 and 2008. In multivariable models, we evaluated the relationship between discharge Hb and 12‐month mortality and tested whether this relationship varied by gender. We assessed whether the relationship with discharge Hb...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Lauren E. Thompson, Frederick A. Masoudi, Kensey L. Gosch, Pamela N. Peterson, Philip G. Jones, Adam C. Salisbury, Mikhail Kosiborod, Stacie L. Daugherty Tags: CLINICAL INVESTIGATIONS Source Type: research

Prevalence and predictors of elevated high ‐sensitivity C‐reactive protein in post–myocardial infarction patients: Insights from the VIRGO and TRIUMPH registries
Elevated high‐sensitivity C‐reactive protein (hs‐CRP) is associated with worse cardiovascular outcomes in patients with acute myocardial infarction (AMI), but little is known about the distribution of hs‐CRP levels and predictors of elevated hs‐CRP after AMI in the real world. Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH) and Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) are prospective AMI registries in the United States that assessed hs‐CRP levels 30 days after AMI. TRIUMPH additionally asse...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Mohammed Qintar, Puza P. Sharma, Yashashwi Pokharel, Yuanyuan Tang, Yuan Lu, Philip Jones, Rachel P. Dreyer, John A. Spertus Tags: QUALITY AND OUTCOMES Source Type: research

Impact of obstructive sleep apnea on cardiovascular outcomes in patients with acute symptomatic pulmonary embolism: Rationale and methodology for the POPE study
In normotensive patients with acute symptomatic pulmonary embolism (PE), the effect of undiagnosed obstructive sleep apnea (OSA) on cardiovascular (CV) outcomes lacks clarity. The Prognostic Significance of Obstructive Sleep Apnea in Patients With Acute Symptomatic Pulmonary Embolism (POPE) study is a multicenter, observational study designed to prospectively assess the prognostic significance of concomitant OSA in hemodynamically stable outpatients with acute symptomatic PE. Adult patients with acute stable PE are eligible. Recruited patients undergo an overnight sleep study using a level III portable diagnostic device wi...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Eva Ma ñas, Esther Barbero, Diana Chiluiza, Aldara García, Raquel Morillo, Deisy Barrios, Miguel Ángel Martínez‐García, Alicia Albalat, Irene Cano, David Jiménez, Tags: TRIAL DESIGNS Source Type: research

Rationale and design of the long ‐Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post–myocardial infarction patients (TIGRIS) study
The long‐term progression of coronary artery disease as defined by the natural disease course years after a myocardial infarction (MI) is an important but poorly studied area of clinical research. The long‐Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post–myocardial infarction patients (TIGRIS) study was designed to address this knowledge gap by evaluating patient management and clinical outcomes following MI in different regions worldwide. TIGRIS (ClinicalTrials.gov Identifier: NCT01866904) is a multicenter, observational, prospective, longitudinal stud...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Dirk Westermann, Shaun G. Goodman, Jos é C. Nicolau, Gema Requena, Andrew Maguire, Ji Yan Chen, Christopher B. Granger, Richard Grieve, Stuart J. Pocock, Stefan Blankenberg, Ana Maria Vega, Satoshi Yasuda, Tabassome Simon, David Brieger, Tags: CLINICAL INVESTIGATIONS Source Type: research

Impact of coronary artery disease in patients undergoing transcatheter aortic valve replacement: Insights from the FRANCE ‐2 registry
BackgroundCoronary artery disease (CAD) is common in patients undergoing transcatheter aortic valve replacement (TAVR). However, the impact of CAD distribution before TAVR on short‐ and long‐term prognosis remains unclear. HypothesisWe hypothesized that the long‐term clinical impact differs according to CAD distribution in patients undergoing TAVR using the FRench Aortic National CoreValve and Edwards (FRANCE‐2) registry. MethodsFRANCE‐2 is a national French registry including all consecutive TAVR performed between 2010 and 2012 in 34 centers. Three‐year mortality was assessed in relation to CAD status. CAD was...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Etienne Puymirat, Romain Didier, H élène Eltchaninoff, Bernard Lung, Jean‐Philippe Collet, Dominique Himbert, Eric Durand, Alain Leguerrier, Pascal Leprince, Jean Fajadet, Emmanuel Teiger, Karine Chevreul, Michel Lièvre, Didier Tchetché, Florence Le Tags: CLINICAL INVESTIGATIONS Source Type: research

Effects of Acute Phase Intensive Electrical Muscle Stimulation in Frail Elderly Patients With Acute Heart Failure (ACTIVE ‐EMS): Rationale and protocol for a multicenter randomized controlled trial
In elderly patients with acute heart failure (AHF), clinical outcome is adversely affected by frailty. Although a number of potentially effective interventions for frailty have been reported, little is known about the effects of rehabilitation programs in frail elderly AHF patients. We postulated that addition of electrical muscle stimulation (EMS), which induces muscle contraction without requiring patient volition, to early rehabilitation would be efficacious in frail elderly AHF patients. The ACTIVE‐EMS (Effects of Acute Phase Intensive Electrical Muscle Stimulation in Frail Elderly Patients With AHF; UMIN000019551) t...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Shinya Tanaka, Kentaro Kamiya, Yuya Matsue, Ryusuke Yonezawa, Hiroshi Saito, Nobuaki Hamazaki, Ryota Matsuzawa, Kohei Nozaki, Kazuki Wakaume, Yoshiko Endo, Emi Maekawa, Minako Yamaoka ‐Tojo, Takaaki Shiono, Takayuki Inomata, Takashi Masuda, Junya Ako Tags: TRIAL DESIGNS Source Type: research

Left atrial function and mortality in the oldest old
ConclusionsThis study demonstrated that elderly subjects aged 85 to 86 years with significantly impaired LA function had increased 5‐year mortality independently of indices of LA volume. (Source: Clinical Cardiology)
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: David Leibowitz, Jonathan Koslowsky, Dan Gilon, Jeremy M. Jacobs, Irit Stessman ‐Lande, Jochanan Stessman Tags: CLINICAL INVESTIGATIONS Source Type: research

Clinical efficacy of irrigated catheter application of amiodarone during ablation of persistent atrial fibrillation
BackgroundPharmacological treatment during ablation of persistent atrial fibrillation (AF) is common, but utility of irrigated catheter application of amiodarone during ablation of persistent AF remains unclear. HypothesisIrrigated catheter application of amiodarone improves quality of ablation and long‐term outcomes. MethodsWe enrolled 90 persistent AF patients who underwent catheter ablation. Patients were randomized to the amiodarone group (n = 45) or control group (n = 45). All patients underwent stepwise ablation beginning with isolation of the pulmonary veins. Next, we performed ablation...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Xingfu Huang, Yanjia Chen, Yuli Huang, Hongxin Zhao, Yanyu Chen, Liwei He, Shenrong Liu, Vikram Shee, Dingli Xu, Jian Peng Tags: CLINICAL INVESTIGATIONS Source Type: research

Chronic kidney disease and coronary artery calcification in the Brazilian Longitudinal Study of Adult Health (ELSA ‐Brasil)
BackgroundChronic kidney disease is a worldwide public health concern due to the increased prevalence the high fatalities related to heart disease in this population. Among novel cardiovascular risk markers, the coronary artery calcification score (CAC) emerged as an independent predictor of cardiovascular events. HypothesisWe aimed to test if glomerular filtration rate or albuminuria are independently associated with coronary calcification. MethodsThe Brazilian Longitudinal Study of Adult Health is a cohort of men and women aged 35 to 74 years old addressing cardiovascular diseases. We analyzed the association of C...
Source: Clinical Cardiology - December 15, 2017 Category: Cardiology Authors: Cheng Suh ‐Chiou, Rosa M. Moysés, Marcio S. Bittencourt, Isabela M. Bensenor, Paulo A. Lotufo Tags: CLINICAL INVESTIGATIONS Source Type: research

Atrial fibrillation and risk of cardiovascular events and mortality in patients with symptomatic peripheral artery disease: A meta ‐analysis of prospective studies
ConclusionsAF is associated with increased risk of mortality and MACE in symptomatic PAD. (Source: Clinical Cardiology)
Source: Clinical Cardiology - December 15, 2017 Category: Cardiology Authors: Mislav Vrsalovi ć, Ana Vrsalović Presečki Tags: CLINICAL INVESTIGATIONS Source Type: research

Outcome of octogenarians with atrial fibrillation undergoing percutaneous coronary intervention: insights from the AFCAS registry
BackgroundMore evidence is needed on the optimal antithrombotic regimen in elderly patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). HypothesisOctogenarian patients (aged ≥80 years) with AF who underwent PCI have worse 12‐month clinical outcome, compared with younger patients. MethodsWe performed a post‐hoc analysis of data from the prospective, multicenter AFCAS registry, which enrolled consecutive patients with AF who underwent PCI and stenting. Outcome measures included major adverse cardiac/cerebrovascular events (MACCE; all‐cause death, myocardial infarction, repeat r...
Source: Clinical Cardiology - December 15, 2017 Category: Cardiology Authors: Heli M. Lahtela, Aissa Bah, Tuomas Kiviniemi, Wail Nammas, Axel Schlitt, Andrea Rubboli, Pasi P. Karjalainen, Marco Proietti, Juha E.K. Hartikainen, Gregory Y.H. Lip, K.E. Juhani Airaksinen Tags: CLINICAL INVESTIGATIONS Source Type: research

The long ‐term prognostic value of highly sensitive cardiac troponin I in patients with acute pulmonary embolism
ConclusionsIn patients with acute PE, detectable cTnI is predictive of long‐term mortality, particularly among patients who were identified as low risk according to PESI score. (Source: Clinical Cardiology)
Source: Clinical Cardiology - December 15, 2017 Category: Cardiology Authors: Katherine Lee Chuy, Emad Uddin Hakemi, Tareq Alyousef, Geetanjali Dang, Rami Doukky Tags: CLINICAL INVESTIGATIONS Source Type: research

Target achievement with maximal statin ‐based lipid‐lowering therapy in Korean patients with familial hypercholesterolemia: A study supported by the Korean Society of Lipid and Atherosclerosis
BackgroundData on treatment results of lipid‐lowering therapy (LLT) in familial hypercholesterolemia (FH) are limited, particularly in Asian patients. HypothesisWe sought to evaluate the target achievement rate and associated variables in Korean patients with FH after maximal statin‐based LLT. MethodsWe enrolled 146 patients with heterozygous FH, and 90 patients were finally analyzed. Patients were initially prescribed rosuvastatin 10 mg or atorvastatin 20 mg, and the regimen was adjusted to achieve the low‐density lipoprotein cholesterol (LDL‐C) target of 100 mg/dL. The primary evaluation poin...
Source: Clinical Cardiology - December 14, 2017 Category: Cardiology Authors: Jaewon Oh, Chan Joo Lee, Doo Il Kim, Moo ‐Yong Rhee, Byoung‐Kwon Lee, Youngkeun Ahn, Byung Ryul Cho, Jeong‐Taek Woo, Seung‐Ho Hur, Jin‐Ok Jeong, Yangsoo Jang, Sang‐Hak Lee Tags: CLINICAL INVESTIGATIONS Source Type: research

An unusual myopericarditis
(Source: Clinical Cardiology)
Source: Clinical Cardiology - December 8, 2017 Category: Cardiology Authors: Clotilde Bailleul, Etienne Puymirat Tags: LETTER TO THE EDITOR Source Type: research

Response to Fragmented QRS Complex Predicts Contrast ‐Induced Nephropathy and In‐Hospital Mortality After Primary Percutaneous Coronary Intervention in Patients With ST‐Segment Elevation Myocardial Infarction
(Source: Clinical Cardiology)
Source: Clinical Cardiology - December 8, 2017 Category: Cardiology Authors: Andreea Barcan, Zsuzsanna Suciu, Imre Benedek Tags: LETTER TO THE EDITOR Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - December 8, 2017 Category: Cardiology Tags: ISSUE INFORMATION Source Type: research

Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial
ConclusionsPatients with CD in ROCKET AF had similar risk of stroke/SE compared with patients without CD. Additionally, there was no interaction between CD and the treatment effect of rivaroxaban or warfarin for stroke prevention or safety endpoints. (Source: Clinical Cardiology)
Source: Clinical Cardiology - December 1, 2017 Category: Cardiology Authors: Ajar Kochar, Anne S. Hellkamp, Yuliya Lokhnygina, W. Schuyler Jones, Richard C. Becker, Scott D. Berkowitz, G ünter Breithardt, Keith A.A. Fox, Jonathan L. Halperin, Graeme J. Hankey, Kenneth W. Mahaffey, Christopher C. Nessel, Daniel E. Singer, Jonathan Tags: CLINICAL INVESTIGATIONS Source Type: research