Association of lipoprotein(a) with long ‐term mortality following coronary angiography or percutaneous coronary intervention
BackgroundThere is no consistent evidence to suggest the association of plasma lipoprotein(a) (Lp[a]) with long‐term mortality in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI). HypothesisLevel of Lp(a) is associated with long‐term mortality following CAG or PCI. MethodsWe enrolled 1684 patients with plasma Lp(a) data undergoing CAG or PCI between April 2009 and December 2013. The patients were divided into 2 groups: a low‐Lp(a) group (Lp[a]
Source: Clinical Cardiology - April 26, 2017 Category: Cardiology Authors: Zhe Feng, Hua ‐long Li, Wei‐jie Bei, Xiao‐sheng Guo, Kun Wang, Shi‐xin Yi, De‐mou Luo, Xi‐da Li, Shi‐qun Chen, Peng Ran, Peng‐yuan Chen, Sheikh Mohammed Shariful Islam, Ji‐yan Chen, Yong Liu, Ying‐ling Zhou Tags: CLINICAL INVESTIGATIONS Source Type: research

Breast arterial calcification association with coronary artery calcium scoring and implications for cardiovascular risk assessment in women
Breast arterial calcification (BAC) is a type of medial artery calcification that can be seen incidentally on mammography. Studies have suggested association of BAC with cardiovascular risk factors, coronary artery disease (CAD), and cardiovascular morbidity and mortality. Recently published studies have also suggested a modest correlation of BAC with coronary artery calcium (CAC) scoring. Roughly 40 million mammograms are already performed annually in the United States with overlap in patients that undergo CAD screening via CAC scoring. Thus, identification of cardiovascular risk by demonstrating an association between BA...
Source: Clinical Cardiology - April 26, 2017 Category: Cardiology Authors: Angela J. Ryan, Andrew D. Choi, Brian G. Choi, Jannet F. Lewis Tags: REVIEW Source Type: research

Peripheral artery disease and risk of adverse outcomes in heart failure with preserved ejection fraction
Conclusions PAD increases the risk for adverse outcomes in HFpEF and is associated with HF rehospitalization. Practitioners should be aware of the inherent risk associated with PAD in HFpEF. (Source: Clinical Cardiology)
Source: Clinical Cardiology - April 26, 2017 Category: Cardiology Authors: Pratik B. Sandesara, Muhammad Hammadah, Ayman Samman ‐Tahhan, Heval M. Kelli, Wesley T. O'Neal Tags: CLINICAL INVESTIGATIONS Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - April 14, 2017 Category: Cardiology Tags: ISSUE INFORMATION Source Type: research

Procedural success and intra ‐hospital outcome related to left atrial appendage morphology in patients that receive an interventional left atrial appendage closure
ConclusionsIrrespective of the varying morphological presentation of the LAA, the procedural success rates, interventional characteristics, and safety events did not significantly differ among patients receiving an interventional LAA closure. (Source: Clinical Cardiology)
Source: Clinical Cardiology - April 13, 2017 Category: Cardiology Authors: Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Ibrahim El ‐Battrawy, Uzair Ansari, Ishar‐Singh Gill, Martin Borggrefe, Ibrahim Akin Tags: CLINICAL INVESTIGATIONS Source Type: research

Optimal secondary prevention medication use in acute myocardial infarction patients with nonobstructive coronary artery disease is modified by management strategy: insights from the TRIUMPH Registry
BackgroundPatients with acute myocardial infarction (AMI) and nonobstructive coronary artery disease (nonobCAD) may be perceived to be at lower risk for cardiac events, relative to those with obstructive CAD (obCAD), and thus less likely to receive optimal preventive medications in the year following AMI. HypothesisWe aimed to determine if AMI patients with nonobCAD, compared to obCAD, received lower rates of prevention medications in the year following AMI. MethodsWe compared optimal prevention medication use at hospital discharge, 1, 6, and 12 months after hospitalization. Optimal medication use was defined as the receip...
Source: Clinical Cardiology - April 7, 2017 Category: Cardiology Authors: Reynaria Pitts, Stacie L. Daugherty, Fengming Tang, Philip Jones, P. Michael Ho, Thomas T. Tsai, John Spertus, Thomas M. Maddox Tags: QUALITY AND OUTCOMES Source Type: research

Heart rate and outcome in heart failure with reduced ejection fraction: Differences between atrial fibrillation and sinus rhythm —A CIBIS II analysis
ConclusionsIn HFREF patients with AF, a higher heart rate is not associated with increased event rates in contrast to HFREF patients with sinus rhythm. (Source: Clinical Cardiology)
Source: Clinical Cardiology - April 1, 2017 Category: Cardiology Authors: Bart A. Mulder, Kevin Damman, Dirk J. Van Veldhuisen, Isabelle C. Van Gelder, Michiel Rienstra Tags: CLINICAL INVESTIGATIONS Source Type: research

Diabetes mellitus is associated with increased acute kidney injury and 1 ‐year mortality after transcatheter aortic valve replacement: A meta‐analysis
Conclusions DM is associated with increased 1‐year mortality and periprocedural AKI in patients undergoing TAVR. The results of this study suggest that DM is a predictor of adverse outcomes in patients undergoing TAVR. (Source: Clinical Cardiology)
Source: Clinical Cardiology - April 1, 2017 Category: Cardiology Authors: George S. Mina, Priyanka Gill, Demiana Soliman, Pratap Reddy, Paari Dominic Tags: CLINICAL INVESTIGATIONS Source Type: research

Interleukin ‐1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D‐HART2)
Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of confirmed HF cases in the United States. However, there are no highly effective evidence‐based treatments currently available for these patients. Inflammation correlates positively with adverse outcomes in HF patients. Interleukin (IL)‐1, a prototypical inflammatory cytokine, has been implicated as a driver of diastolic dysfunction in preclinical animal models and a pilot clinical trial. The Diastolic Heart Failure Anakinra Response Trial 2 (D‐HART2) is a phase 2, 2:1 randomized, double‐blind, placebo‐controlled clinical trial...
Source: Clinical Cardiology - April 1, 2017 Category: Cardiology Authors: Benjamin W. Van Tassell, Leo F. Buckley, Salvatore Carbone, Cory R. Trankle, Justin M. Canada, Dave L. Dixon, Nayef Abouzaki, Claudia Oddi ‐Erdle, Giuseppe Biondi‐Zoccai, Ross Arena, Antonio Abbate Tags: TRIAL DESIGNS Source Type: research

Thromboembolic risk and effect of oral anticoagulation according to atrial fibrillation patterns: A systematic review and meta ‐analysis
The objectives of the meta‐analysis were to investigate different impact on outcomes of pxAF and non‐pxAF, with and without OAC. Two reviewers searched for prospective studies on risk of stroke and systemic embolism (SE) in pxAF and non‐pxAF, with and without OAC. Quality of evidence was assessed according to GRADE approach. Stroke combined with SE was the main outcome. Meta‐regression was performed to evaluate OAC effect on stroke and SE incidence rate. We identified 18 studies. For a total of 239 528 patient‐years of follow‐up. The incidence rate of stroke/SE was 1.6% (95% confidence interval [CI]: 1.3...
Source: Clinical Cardiology - April 1, 2017 Category: Cardiology Authors: Alessio Lilli, Andrea Di Cori, Valerio Zac à Tags: REVIEWS Source Type: research

Prognostic impact of diastolic dysfunction in systolic heart failure —A cross‐project analysis from the German Competence Network Heart Failure
BackgroundWe investigated the modifying role and prognostic importance of diastolic dysfunction (DD) in patients with heart failure and systolic dysfunction (SD). HypothesisThe echocardiographic evaluation of diastolic function in patients with SD provides further prognostic information. MethodsFrom the German Competence Network Heart Failure, 1046 heart failure patients with reduced left ventricular ejection fraction (LVEF;
Source: Clinical Cardiology - April 1, 2017 Category: Cardiology Authors: Claus L üers, Frank Edelmann, Rolf Wachter, Burkert Pieske, Meinhard Mende, Christiane Angermann, Georg Ertl, Hans‐Dirk Düngen, Stefan Störk Tags: CLINICAL INVESTIGATIONS Source Type: research

Association between echocardiographic epicardial fat thickness and circulating endothelial progenitor cell level in patients with stable angina pectoris
This study aimed to investigate association between echocardiographic epicardial fat thickness (EFT) and circulating EPC level. HypothesisEpicardial fat causes inflammation and contributes to progression of CAD. MethodsWe enrolled 213 consecutive patients with stable angina, and EFT was determined by echocardiography. Quantification of EPC markers (defined as CD34 +, CD34 + KDR +, CD34 + KDR + CD133 + cells) in peripheral blood samples was used to measure circulating EPCs. All patients were divided into 3 tertiles according to EFT levels: group 1, low tertile of EFT; group 2, middle tertile of EFT; and group 3, high tertil...
Source: Clinical Cardiology - April 1, 2017 Category: Cardiology Authors: Ting ‐Yung Chang, Chien‐Yi Hsu, Chun‐Chih Chiu, Ruey‐Hsing Chou, Hsin‐Lei Huang, Chin‐Chou Huang, Hsin‐Ban Leu, Po‐Hsun Huang, Jaw‐Wen Chen, Shing‐Jong Lin Tags: CLINICAL INVESTIGATIONS Source Type: research

Efficacy of postoperative prophylactic antibiotics in reducing permanent pacemaker infections
BackgroundDespite limited evidence, postoperative prophylactic antibiotics are often used in the setting of permanent pacemaker implantation or replacement. The aim of this study is to investigate the efficacy of postoperative antibiotics. HypothesisPostoperative prophylactic antibiotics may be not clinically useful. MethodsWe recruited 367 consecutive patients undergoing permanent pacemaker implantation or generator replacement at a tertiary referral center. Baseline demographics, clinical characteristics, and procedure information were collected, and all patients received preoperative prophylactic antibiotics. Postoperat...
Source: Clinical Cardiology - April 1, 2017 Category: Cardiology Authors: Wen ‐Huang Lee, Ting‐Chun Huang, Li‐Jen Lin, Po‐Tseng Lee, Chih‐Chan Lin, Cheng‐Han Lee, Ting‐Hsing Chao, Yi‐Heng Li, Ju‐Yi Chen Tags: CLINICAL INVESTIGATIONS Source Type: research

Quantitative segmental analysis of myocardial perfusion to differentiate stress cardiomyopathy from acute myocardial infarction: A myocardial contrast echocardiography study
BackgroundBoth stress cardiomyopathy (SCMP) and acute myocardial infarction (AMI) present with similar clinical symptoms and signs, and apical akinesis. Hypothesis: Quantitative segmental analysis of myocardial contrast echocardiography (MCE) helps to differentiate AMI from SCMP. MethodsReal‐time MCE was performed in 33 consecutive patients who presented with an acute symptom/sign and a new apical akinesis on echocardiography. In 18 left ventricular (LV) myocardial segments, a replenishment curve was obtained in each segment to measure peak plateau myocardial contrast intensity (MCI) (A) and the replenishment curve slope...
Source: Clinical Cardiology - April 1, 2017 Category: Cardiology Authors: Sun ‐Yang Min, Jong‐Min Song, Yewon Shin, Min‐Jung Sin, Dae‐Hee Kim, Duk‐Hyun Kang, Jae‐Kwan Song Tags: CLINICAL INVESTIGATIONS Source Type: research

Platelet reactivity in response to loading dose of atorvastatin or rosuvastatin in patients with stable coronary disease before percutaneous coronary intervention: The STATIPLAT randomized study
ConclusionsLoading dose of atorvastatin (80 mg) or rosuvastatin (40 mg) did not induce significant variation in platelet reactivity in CSA patients with baseline reduced platelet reactivity as in chronic DAPT. Our data confirm that chronic concomitant treatment with low‐dose statins and clopidogrel resulted in significantly lower platelet reactivity compared with clopidogrel alone. (Source: Clinical Cardiology)
Source: Clinical Cardiology - April 1, 2017 Category: Cardiology Authors: Cosmo Godino, Anna Giulia Pavon, Antonio Mangieri, Anna Salerno, Michela Cera, Alberto Monello, Alaide Chieffo, Valeria Magni, Alberto Cappelletti, Alberto Margonato, Antonio Colombo Tags: CLINICAL INVESTIGATIONS Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - March 31, 2017 Category: Cardiology Tags: Issue Information Source Type: research

Response to Letter to the Editor regarding the manuscript “Expression of programmed cell death‐1 and its ligand B7 homolog 1 in peripheral blood lymphocytes from patients with peripartum cardiomyopathy”
(Source: Clinical Cardiology)
Source: Clinical Cardiology - March 24, 2017 Category: Cardiology Authors: Guozhi Xia, Zhongwei Liu, Junkui Wang Tags: LETTER TO THE EDITOR Source Type: research

Cardiac device implantations in obese patients: Success rates and complications
This study analyzed the success rate and complication rates associated with implantation of cardiac implantable electronic devices (CIEDs) in obese patients. HypothesisSuccess rates are lower and complication rates higher in obese patients. MethodsConsecutive patients undergoing CIED implantation between 2011 and 2015 in our hospital were included. Patients were categorized into obese and nonobese groups according to body mass index (BMI); cutoff was 30 kg/m2. Patient characteristics, complication rates, procedural duration, and fluoroscopy data were compared between the 2 groups. ResultsA total of 965 patients (mean age, ...
Source: Clinical Cardiology - March 23, 2017 Category: Cardiology Authors: Philipp Attanasio, Philipp Lacour, Andrea Ernert, Burkert Pieske, Wilhelm Haverkamp, Florian Blaschke, Francesco Dalle Vedove, Martin Huemer Tags: Clinical Investigations Source Type: research

A phase 1 study to evaluate the safety and LDL cholesterol –lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9
ConclusionsOverall, RG7652 elicited substantial and sustained dose‐related LDL‐C reductions with an acceptable safety profile and minimal immunogenicity. (Source: Clinical Cardiology)
Source: Clinical Cardiology - March 22, 2017 Category: Cardiology Authors: Amos Baruch, Diana Luca, Robert S. Kahn, Kyra J. Cowan, Maya Leabman, Nageshwar R. Budha, Cecilia P.C. Chiu, Yan Wu, Daniel Kirchhofer, Andrew Peterson, John C. Davis Jr, Whittemore G. Tingley Tags: CLINICAL INVESTIGATIONS Source Type: research

Predictors and variability of drug ‐eluting vs bare‐metal stent selection in contemporary percutaneous coronary intervention: Insights from the PRISM study
Drug‐eluting stents (DES) reduce risk of in‐stent restenosis after percutaneous coronary intervention (PCI) but require dual antiplatelet therapy (DAPT) for a longer term than bare‐metal stents (BMS). Few studies have examined clinical predictors of DES vs BMS, and variability in provider selection between DES and BMS in clinical practice has not been well described. These insights can inform our understanding of current practice and may identify opportunities to improve decision‐making stent selection decinsion‐making. In a multicenter registry, 3295 consecutive patients underwent PCI by 158 interventional cardi...
Source: Clinical Cardiology - March 15, 2017 Category: Cardiology Authors: Ali Shafiq, Kensey Gosch, Amit P. Amin, Henry H. Ting, John A. Spertus, Adam C. Salisbury Tags: QUALITY AND OUTCOMES Source Type: research

Coronary artery calcification is common on nongated chest computed tomography imaging
ConclusionsA high prevalence of coronary calcification was found in non‐gated chest CT scans performed for non‐cardiac indications. In one‐third, coronary calcification was not mentioned in the clinical report when actually present. In this population of patients with cardiac risk factors, standard reporting of the presence of coronary calcification may provide an opportunity for risk factor modification. (Source: Clinical Cardiology)
Source: Clinical Cardiology - March 15, 2017 Category: Cardiology Authors: Revathi Balakrishnan, Brian Nguyen, Roy Raad, Robert Donnino, David P. Naidich, Jill E. Jacobs, Harmony R. Reynolds Tags: CLINICAL INVESTIGATIONS Source Type: research

Rationale and design of REDUCE ‐IT: Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial
Residual cardiovascular risk persists despite statins, yet outcome studies of lipid‐targeted therapies beyond low‐density lipoprotein cholesterol (LDL‐C) have not demonstrated added benefit. Triglyceride elevation is an independent risk factor for cardiovascular events. High‐dose eicosapentaenoic acid (EPA) reduces triglyceride‐rich lipoproteins without raising LDL‐C. Omega‐3s have postulated pleiotropic cardioprotective benefits beyond triglyceride‐lowering. To date, no large, multinational, randomized clinical trial has proved that lowering triglycerides on top of statin therapy improves cardiovascular ou...
Source: Clinical Cardiology - March 14, 2017 Category: Cardiology Authors: Deepak L. Bhatt, Ph. Gabriel Steg, Eliot A. Brinton, Terry A. Jacobson, Michael Miller, Jean ‐Claude Tardif, Steven B. Ketchum, Ralph T. Doyle, Sabina A. Murphy, Paresh N. Soni, Rene A. Braeckman, Rebecca A. Juliano, Christie M. Ballantyne, Tags: TRIAL DESIGNS Source Type: research

Short ‐ and long‐term clinical predictors of pharmacological cardioversion of persistent atrial fibrillation by dofetilide: A retrospective cohort study of 160 patients
We examined age, sex, race, hypertension, diabetes, smoking, dyslipidemia, CAD, left ventricular ejection fraction (LVEF), creatinine, BMI and concomitant use of calcium channel blockers (CCB), β‐blockers in a multivariable logistic regression model. We also examined the same predictors in Cox regression model for AF‐related readmission within 1 year of follow‐up. Results13.5% individuals did not convert to SR on dofetilide. 55.6% converted on the first dose and 83.1% converted by the fourth dose. In multivariable logistic models, dyslipidemia (OR: 2.4, CI: 1.12‐5.16) and LVEF (OR: 3.83,CI: 1.37‐10.8) were a...
Source: Clinical Cardiology - March 13, 2017 Category: Cardiology Authors: Hafeez Ul Hassan Virk, Waqas T. Qureshi, Nayani Makkar, Joseph Bastawrose, Nektarios Souvaliotis, Joshua Aziz, Emad Aziz Tags: CLINICAL INVESTIGATIONS Source Type: research

Predictors and long ‐term outcome of super‐responders to cardiac resynchronization therapy
BackgroundThe level of improvement in left ventricular ejection fraction (LVEF) in super‐responders to cardiac resynchronization therapy (CRT) is exceptional. However, the long‐term prognosis remains unknown in a large population. HypothesisWhether super‐responders haven good long‐term outcomes. MethodsWe registered 347 patients with primary CRT‐D indication. Super‐response was defined by LVEF>50% at follow‐up echocardiogram. Best‐subset regression analysis identified predictors of super‐response. Endpoints were major adverse cardiac events (MACE; eg, all‐cause mortality or heart failure hospitalizat...
Source: Clinical Cardiology - March 13, 2017 Category: Cardiology Authors: Abdul Ghani, Peter Paul H.M. Delnoy, Ahmet Adiyaman, Jan Paul Ottervanger, Anand R. Ramdat Misier, Jaap Jan J. Smit, Arif Elvan Tags: Clinical Investigations Source Type: research

Urinary [TIMP ‐2] × [IGFBP7] for risk prediction of acute kidney injury in decompensated heart failure
ConclusionsUrinary [TIMP‐2] × [IGFBP7] is a promising marker for AKI risk assessment in patients with ADHF. (Source: Clinical Cardiology)
Source: Clinical Cardiology - March 9, 2017 Category: Cardiology Authors: Moritz Schanz, Jing Shi, Christoph Wasser, Mark Dominik Alscher, Martin Kimmel Tags: CLINICAL INVESTIGATIONS Source Type: research

Prevalence and clinical significance of left bundle branch block according to classical or strict definition criteria in permanent pacemaker patients
BackgroundPrevious studies have shown that the presence of left bundle branch block (LBBB) is associated with an increased risk of cardiac mortality and heart failure (HF). Recently, new criteria to define strict LBBB have been proposed: QRS duration ≥140 ms for men and ≥130 ms for women, along with mid‐QRS notching or slurring in ≥2 contiguous leads. HypothesisWe assessed the prevalence and prognostic significance of LBBB according to classical (QRS duration ≥120ms) and strict criteria in permanent pacemaker patients. MethodsWe retrospectively enrolled 723 consecutive patients who had undergone single‐ or ...
Source: Clinical Cardiology - March 9, 2017 Category: Cardiology Authors: Andrea Mazza, Maria Grazia Bendini, Raffaele De Cristofaro, Mariolina Lovecchio, Sergio Valsecchi, Massimo Leggio, Giuseppe Boriani Tags: CLINICAL INVESTIGATIONS Source Type: research

The protective effects of a novel fitness ‐fatness index on all‐cause mortality among adults with cardiovascular disease
ConclusionsIn this national sample, increased FFI was associated with reduced risk of all‐cause mortality; this association was driven by the beneficial effects of fitness. This underscores the importance of tailored cardiac rehabilitation programs designed to promote fitness, in particular, among cardiac populations. (Source: Clinical Cardiology)
Source: Clinical Cardiology - March 9, 2017 Category: Cardiology Authors: Emily Frith, Paul D. Loprinzi Tags: CLINICAL INVESTIGATIONS Source Type: research

Alcohol and cardiovascular disease in the geriatric population
There has been little focus on the effects of alcohol on the elderly. Although the cardiovascular benefits of moderate alcohol consumption could be of the greatest benefit in this group, so might be the detrimental effects of abuse. In this article, we review available data on the effects of alcohol consumption on cardiovascular disease, cardiomyopathy, arrhythmias, hypertension, and vascular function in older adults. Alcohol consumption has increased in the US population age 65 years and older in the last decade, as has monthly heavy episodic drinking in older alcohol consumers. Studies of alcohol consumption in older sub...
Source: Clinical Cardiology - March 9, 2017 Category: Cardiology Authors: Aditi Kalla, Vincent M. Figueredo Tags: REVIEW Source Type: research

Left ventricular global longitudinal strain predicts mortality and heart failure admissions in African American patients
BackgroundSeveral studies have demonstrated the importance of left ventricular (LV) global longitudinal strain (GLS) as a reliable prognostic indicator in patients with heart failure (HF). These studies have included few African American (AA) patients, despite the growing prevalence and severity of HF in this patient population. Hypothesis LV GLS predicts long‐term HF admission and all‐cause mortality in AA patients with chronic HF on optimal guideline‐directed medical therapy (GDMT). MethodsWe enrolled 207 AA adults, age 56 ± 14.5 years, with New York Heart Association (NYHA) class I thro...
Source: Clinical Cardiology - March 7, 2017 Category: Cardiology Authors: Mayank M. Kansal, Ibrahim N. Mansour, Sahar Ismail, Adam Bress, Grace Wu, Omer Mirza, Rahul Marpadga, Hana Gheith, Yoonsang Kim, Yien Li, Larisa Cavallari, Thomas D. Stamos Tags: CLINICAL INVESTIGATION Source Type: research

Silent atrial fibrillation: epidemiology, diagnosis, and clinical impact
Silent or subclinical asymptomatic atrial fibrillation (SAF) has currently gained wide interest in the epidemiologic, neurologic, and cardiovascular communities. It is well known that the electrophysiological and mechanical effects of symptomatic and silent atrial fibrillation (AF) are the same. It is probable that because “AF begets AF,” progression from paroxysmal to persistent or permanent AF might be more rapid in patients with long‐term unrecognized and untreated SAF, because no treatment is sought by or provided to such patients. Moreover, SAF is common and has significant clinical implications. The cli...
Source: Clinical Cardiology - March 7, 2017 Category: Cardiology Authors: Polychronis E. Dilaveris, Harold L. Kennedy Tags: Review Source Type: research

Heart Rhythm Society: expert consensus statements —part 2
One of the most important roles for professional societies in medicine is assembling multiple stakeholders and experts to develop documents that can help guide and define policies and strategies for best medical care. Each year the Heart Rhythm Society (HRS) develops several consensus documents that address critical clinical subjects that have been identified by input from HRS members and HRS committees. Over the past 5 years, HRS has produced documents with multiple professional societies from around the world, and although the topics chosen for exploration center around arrhythmia management, the reviews and recommendati...
Source: Clinical Cardiology - March 7, 2017 Category: Cardiology Authors: Susie Sennhauser, Rishi Anand, Fred Kusumoto, Nora Goldschlager Tags: Review Source Type: research

Heart Rhythm Society: expert consensus statements —part 1
One of the most important roles for professional societies in medicine is assembling multiple stakeholders and experts to develop documents that can help guide and define policies and strategies for best medical care. Each year the Heart Rhythm Society (HRS) develops several consensus documents that address critical clinical subjects that have been identified by input from HRS members and HRS committees. Over the past 5 years, HRS has produced documents with multiple professional societies from around the world, and although the topics chosen for exploration center around arrhythmia management, the reviews and recommendati...
Source: Clinical Cardiology - March 7, 2017 Category: Cardiology Authors: Susie Sennhauser, Rishi Anand, Fred Kusumoto, Nora Goldschlager Tags: Review Source Type: research

Scared for the scar: fearsome impact of acute cardiovascular disease on perceived kinesiophobia (fear of movement)
BackgroundTo assess levels of kinesiophobia (fear of movement) in patients hospitalized for acute cardiovascular disease. HypothesisIncreased levels of kinesiophobia can be found in subjects hospitalized for acute cardiovascular disease. MethodsSeventy‐four consecutive patients admitted for acute coronary syndrome and 58 for acute heart failure were enrolled in the study and assessed by the Tampa Scale for the evaluation of kinesiophobia. Subjects were compared with a reference population with stable coronary artery disease and healthy controls. ResultsNo significant differences were found between acute coronary syndrome...
Source: Clinical Cardiology - March 7, 2017 Category: Cardiology Authors: Natale D. Brunetti, Antonio Guerra, Riccardo Ieva, Michele Correale, Francesco Santoro, Nicola Tarantino, Matteo Di Biase Tags: CLINICAL INVESTIGATIONS Source Type: research

The relationship between cardio ‐ankle vascular index and subclinical atherosclerosis evaluated by cardiac computed tomographic angiography
ConclusionsWe demonstrated that CAVI had a significant relationship with subclinical coronary atherosclerosis evaluated by CCTA, especially in relation to plaque burden and plaque extent, but not severe stenosis. Thus, CAVI may reflect coronary atherosclerosis burden more than severity. (Source: Clinical Cardiology)
Source: Clinical Cardiology - March 7, 2017 Category: Cardiology Authors: Suguru Matsumoto, Rine Nakanishi, Yanting Luo, Michael Kim, Anas Alani, Negin Nezarat, Christopher Dailing, Matthew J. Budoff Tags: CLINICAL INVESTIGATIONS Source Type: research

Controversies in postoperative atrial fibrillation after noncardiothoracic surgery: clinical and research implications
Post operative atrial fibrillation after non‐cardiothoracic surgery is an increasingly common problem. There is little high quality data to guide clinicians in risk prediction as well as short term and long term management. There appears to be a significant risk of recurrent atrial fibrillation and stroke but effective screening strategies have not been tested. In this commentary, we delineate various controversies in the management of post operative atrial fibrillation and briefly review the available evidence. Prospective studies in this clinically important area of cardiology should be encouraged. (Source: Clinical Cardiology)
Source: Clinical Cardiology - March 7, 2017 Category: Cardiology Authors: Srikanth Vallurupalli, Anusha Shanbhag, Jawahar L. Mehta Tags: Reviews Source Type: research

Long ‐term outcomes with aspiration thrombectomy for patients undergoing primary percutaneous coronary intervention: A meta‐analysis of randomized trials
Randomized clinical trials that examined long‐term clinical outcomes of routine aspiration thrombectomy prior to primary percutaneous coronary intervention (PCI) in patients with acute ST‐segment elevation myocardial infarction have yielded different results. We hypothesized that the routine use of manual thrombus aspiration prior to primary PCI lacks long‐term clinical benefits. Electronic databases were searched for randomized trials comparing routine aspiration thrombectomy and conventional PCI. We included only trials that reported clinical outcomes beyond 6 months. The primary outcome was all‐cause mortality, ...
Source: Clinical Cardiology - March 1, 2017 Category: Cardiology Authors: Akram Y. Elgendy, Islam Y. Elgendy, Ahmed N. Mahmoud, Anthony A. Bavry Tags: REVIEWS Source Type: research

Noninvasive predictors of perioperative atrial arrhythmias in patients with tetralogy of Fallot undergoing pulmonary valve replacement
BackgroundPatients with tetralogy of Fallot (TOF) have increased risk of atrial arrhythmias. HypothesisA measure of atrial dispersion, the P‐wave vector magnitude (Pvm), can identify patients at risk for perioperative atrial flutter (AFL) or intra‐atrial re‐entrant tachycardia (IART) in a large TOF cohort. MethodsWe performed a blinded, retrospective analysis of 158 TOF patients undergoing pulmonary valve replacement between 1997 and 2015. History of AFL/IART was documented using electrocardiogram, Holter monitor, exercise stress test, implanted cardiac device, and electrophysiology study. P‐R intervals, Pvm, QRS d...
Source: Clinical Cardiology - March 1, 2017 Category: Cardiology Authors: Daniel Cortez, Waseem Barham, Emily Ruckdeschel, Nandita Sharma, Anthony C. McCanta, Johannes von Alvensleben, William H. Sauer, Kathryn K. Collins, Joseph Kay, Sonali Patel, Duy T. Nguyen Tags: CLINICAL INVESTIGATIONS Source Type: research

Issue Information
(Source: Clinical Cardiology)
Source: Clinical Cardiology - February 27, 2017 Category: Cardiology Tags: Issue Information Source Type: research

Design and rationale of the EBBINGHAUS trial: A phase 3, double ‐blind, placebo‐controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid‐lowering therapy—A cognitive study of patients enrolled in the FOURIER trial
Some observational studies raised concern that statins may cause memory impairment, leading to a US Food and Drug Administration warning. Similar questions were raised regarding proprotein convertase subtilisin/kexin‐type 9 inhibitors (PCSK9i) and neurocognitive function. No prospectively designed study has evaluated the relationship between long‐term PCSK9i use and cognition changes. Patients with prior cardiovascular disease treated with maximally tolerated statin enrolled in FOURIER (the randomized, double‐blind, placebo‐controlled cardiovascular outcome study of the PCSK9i evolocumab) could participate in this ...
Source: Clinical Cardiology - February 15, 2017 Category: Cardiology Authors: Robert P. Giugliano, Francois Mach, Kenton Zavitz, Christopher Kurtz, Jingjing Schneider, Huei Wang, Anthony Keech, Terje R. Pedersen, Marc S. Sabatine, Peter S. Sever, Narimon Honarpour, Scott M. Wasserman, Brian R. Ott, Tags: TRIAL DESIGNS Source Type: research

Intracardiac echocardiography for verification for left atrial appendage thrombus presence detected by transesophageal echocardiography: the ActionICE II study
ConclusionsWith TEE, a false positive of an LAA thrombus may be indicated, especially when a thrombus is described as soft rather than solid. Our study suggests that ICE may be a valuable option for verification of a TEE‐based diagnosis of a thrombus. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 12, 2017 Category: Cardiology Authors: Jakub Baran, Beata Zaborska, Roman Piotrowski, Malgorzata Sikora ‐Frąc, Ewa Pilichowska‐Paszkiet, Piotr Kułakowski Tags: CLINICAL INVESTIGATIONS Source Type: research

ST ‐elevation acute myocardial infarction in pregnancy: 2016 update
This article reviews the literature relating to the pathophysiology of AMI in pregnant patients and the challenges in diagnosis and treatment of ST‐elevation myocardial infarction (STEMI) in this unique population. From a cardiologist, maternal–fetal medicine specialist, and anesthesiologist's perspective, we provide recommendations for the diagnosis and management of STEMI occurring during pregnancy. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 12, 2017 Category: Cardiology Authors: Sahar Ismail, Cynthia Wong, Priya Rajan, Mladen  I. Vidovich Tags: REVIEW Source Type: research

The influence of chemotherapy on the right ventricle: did we forget something?
ConclusionsChemotherapy induces the impairment of RV structure, function, and mechanics by different complex mechanisms. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 12, 2017 Category: Cardiology Authors: Marijana Tadic, Cesare Cuspidi, Dagmara Hering, Lucia Venneri, Oleksandr Danylenko Tags: REVIEW Source Type: research

The clinical utility of normal findings on noninvasive cardiac assessment in the prediction of atrial fibrillation
ConclusionsNormal findings on routine noninvasive cardiac assessment identify persons in whom the risk of AF is low. Further studies are needed to explore the utility of this profile regarding the decision to implement certain risk factor modification strategies in older adults to reduce AF burden. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 12, 2017 Category: Cardiology Authors: Sanjay Venkatesh, Wesley T. O'Neal, Stephen T. Broughton, Amit J. Shah, Elsayed Z. Soliman Tags: CLINICAL INVESTIGATIONS Source Type: research

Response to Expression of Programmed Cell Death ‐1 and Its Ligand B7 Homolog 1 in Peripheral Blood Lymphocytes From Patients With Peripartum Cardiomyopathy
(Source: Clinical Cardiology)
Source: Clinical Cardiology - February 1, 2017 Category: Cardiology Authors: Mihai Capilna, Diana Opincariu, Erzsebet Lazar Tags: LETTER TO THE EDITOR Source Type: research

Rationale and design of a multicenter, international and collaborative Coronary Artery Aneurysm Registry (CAAR)
Coronary artery aneurysm is defined as a coronary dilation that exceeds the diameter of adjacent segments or the diameter of the patient's largest normal coronary vessel by 1.5×. It is an uncommon disease that has been diagnosed with increasing frequency since the widespread appearance of coronary angiography. The published incidence varies from 1.5% to 5%, suggesting male dominance and a predilection for the right coronary artery. Although several causes have been described, atherosclerosis accounts for ≥50% of coronary aneurysms in adults. Reported complications include thrombosis and distal embolization, ruptur...
Source: Clinical Cardiology - February 1, 2017 Category: Cardiology Authors: Iv án J. Núñez‐Gil, Luis Nombela‐Franco, Rodrigo Bagur, Mario Bollati, Enrico Cerrato, Emilio Alfonso, Christoph Liebetrau, José María De la Torre Hernandez, Benjamín Camacho, Rafael Mila, Ignacio J. Amat‐Santos, Fernando Alfonso, Ramón Rodr Tags: CLINICAL INVESTIGATIONS Source Type: research

Ventricular arrhythmias in patients with newly diagnosed nonischemic cardiomyopathy: Insights from the PROLONG study
ConclusionsPatients with newly diagnosed NICM and LVEF ≤35% show an elevated risk of ventricular tachycardia/fibrillation during initiation and optimization of heart failure therapy. To prevent sudden cardiac death, WCD should be considered in patients with newly diagnosed NICM with severely reduced LVEF. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 1, 2017 Category: Cardiology Authors: David Duncker, Thorben K önig, Stephan Hohmann, Johann Bauersachs, Christian Veltmann Tags: CLINICAL INVESTIGATIONS Source Type: research

PCSK9 inhibitor access barriers —issues and recommendations: Improving the access process for patients, clinicians and payers
This article reviews findings recognized and solutions suggested by experts during these discussions. The article is a product of the ASPC, along with each author writing as an individual and endorsed by the AACE. (Source: Clinical Cardiology)
Source: Clinical Cardiology - February 1, 2017 Category: Cardiology Authors: Seth J. Baum, Peter P. Toth, James A. Underberg, Paul Jellinger, Joyce Ross, Katherine Wilemon Tags: REVIEW Source Type: research

Adaptations following an intermittent hypoxia ‐hyperoxia training in coronary artery disease patients: a controlled study
ConclusionsIn CAD patients, an IHHT program is associated with improved exercise tolerance, healthier risks factors profile, and a better quality of life. Our study also suggests that IHHT is as effective as an 8‐week standard rehabilitation program. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 31, 2017 Category: Cardiology Authors: Oleg Glazachev, Phylipp Kopylov, Davide Susta, Elena Dudnik, Elena Zagaynaya Tags: CLINICAL INVESTIGATIONS Source Type: research

Trends and outcomes of infective endocarditis in patients on dialysis
We examined outcomes of 44 816 patients with IE on dialysis and 202 547 patients with IE not on dialysis from the Nationwide Inpatient Sample database from 2006 thorough 2011. Dialysis patients were younger (59 ± 15 years vs 62 ± 18 years) and more likely to be female (47% vs 40%) and African‐American (47% vs 40%; all P
Source: Clinical Cardiology - January 31, 2017 Category: Cardiology Authors: Nirmanmoh Bhatia, Sahil Agrawal, Aakash Garg, Divyanshu Mohananey, Abhishek Sharma, Manyoo Agarwal, Lohit Garg, Nikhil Agrawal, Amitoj Singh, Sudip Nanda, Jamshid Shirani Tags: QUALITY AND OUTCOMES Source Type: research

Is there a prognostic relevance of electrophysiological studies in bundle branch block patients?
ConclusionsOur present study suggests that an indication for pacemaker implantation based solely on a diagnostic EP study with prolongation of the HV interval is not justified. (Source: Clinical Cardiology)
Source: Clinical Cardiology - January 31, 2017 Category: Cardiology Authors: Harilaos Bogossian, Gerrit Frommeyer, Kornelius G öbbert, Fuad Hasan, Quy Suu Nguyen, Ilias Ninios, Dejan Mijic, Dirk Bandorski, Reinhard Hoeltgen, Melchior Seyfarth, Bernd Lemke, Lars Eckardt, Markus Zarse Tags: CLINICAL INVESTIGATIONS Source Type: research