Clinical and Translational Medicine Clinical and Translational Medicine RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies
There is growing interest in identifying predictive biomarkers for inhibitors of programmed cell death protein 1 receptor (PD-1), programmed death ligand 1 (PD-L1), and cytotoxic T-lymphocyte associated protei... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 18, 2019 Category: Internal Medicine Authors: Jun Gong, Alexander Chehrazi-Raffle, Veronica Placencio-Hickok, Michelle Guan, Andrew Hendifar and Ravi Salgia Tags: Review Source Type: research

Impact of fatty acid binding protein 5-deficiency on COPD exacerbations and cigarette smoke-induced inflammatory response to bacterial infection
Although cigarette smoking (CS) is by far the most important risk factor of chronic obstructive pulmonary disease (COPD), repeated and sustained infections are clearly linked to disease pathogenesis and are re... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 15, 2019 Category: Internal Medicine Authors: Deviyani M. Rao, Della T. Phan, Michelle J. Choo, Michael R. Weaver, Rebecca E. Oberley-Deegan, Russell P. Bowler and Fabienne Gally Tags: Research Source Type: research

Cell membrane protein functionalization of nanoparticles as a new tumor-targeting strategy
Nanoparticles have seen considerable popularity as effective tools for drug delivery. However, non-specific targeting continues to remain a challenge. Recently, biomimetic nanoparticles have emerged as an inno... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 15, 2019 Category: Internal Medicine Authors: Anna Pasto, Federica Giordano, Michael Evangelopoulos, Alberto Amadori and Ennio Tasciotti Tags: Review Source Type: research

Comparison of administration of clopidogrel with aspirin versus aspirin alone in prevention of secondary stroke after transient ischemic attack
Patients with transient ischemic attack (TIA) or minor stroke are at risk of strokes. One of the precautionary measures to reduce risk of stroke in these patients is administration of antiplatelet drugs. (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 4, 2019 Category: Internal Medicine Authors: Mojtaba Khazaei, Fateme Ghasemian, Mehrdokht Mazdeh, Mohammad Taheri and Soudeh Ghafouri-Fard Tags: Research Source Type: research

Expression of Concern to: Clinical study of Gene-Eden-VIR/Novirin in genital herpes: suppressive treatment safely decreases the duration of outbreaks in both severe and mild cases
The Editor of this journal has published this Expression of Concern to alert readers that, following publication of the article [1], it came to light that there were undeclared competing interests that have a ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 6, 2019 Category: Internal Medicine Authors: Hanan Polansky, Edan Itzkovitz and Adrian Javaherian Tags: Correction Source Type: research

EGFR plasma mutation in prediction models for resistance with EGFR TKI and survival of non-small cell lung cancer
This study aims to clarify the prognostic role of epidermal growth factor receptor (EGFR) mutations in plasma of non-small cell lung cancer (NSCLC) for resistance to tyrosine kinase inhibitor (TKI), in correlatio... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 19, 2019 Category: Internal Medicine Authors: Thang Thanh Phan, Bich-Thu Tran, Son Truong Nguyen, Toan Trong Ho, Hang Thuy Nguyen, Vu Thuong Le and Anh Tuan Le Tags: Research Source Type: research

The effect of omega-3 fatty acids on clinical and paraclinical features of intractable epileptic patients: a triple blind randomized clinical trial
Long chain omega-3 fatty acids (omega-3 FAs) supplements have been shown to exert beneficial effects in patients with epilepsy through elevation of seizure thresholds and dampening of inflammatory responses. I... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 16, 2019 Category: Internal Medicine Authors: Shaghayegh Omrani, Mohammad Taheri, Mir Davood Omrani, Shahram Arsang-Jang and Soudeh Ghafouri-Fard Tags: Research Source Type: research

Pancreatic cancer microenvironment: a current dilemma
Pancreatic cancer is one of the leading causes of cancer-related death in the United States and survival outcomes remain dismal despite significant advances in molecular diagnostics and therapeutics in clinica... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 15, 2019 Category: Internal Medicine Authors: Burak Uzunparmak and Ibrahim Halil Sahin Tags: Review Source Type: research

Clinical features of Sj ögren’s syndrome patients with autoantibodies against interferons
Sj ögren’s syndrome (SS) is an autoimmune disease characterized by immune attack on the salivary and lacrimal glands. Given the known cytokine activation and type I interferon gene expression signature found in... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 3, 2019 Category: Internal Medicine Authors: Peter D. Burbelo, Sarah Browne, Steve M. Holland, Michael J. Iadarola and Ilias Alevizos Tags: Research Source Type: research

The role of environmental exposure to non-cigarette smoke in lung disease
Chronic exposure to household indoor smoke and outdoor air pollution is a major contributor to global morbidity and mortality. The majority of these deaths occur in low and middle ‐income countries. Children, w... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 5, 2018 Category: Internal Medicine Authors: Rajendra KC, Shakti D. Shukla, Sanjay S. Gautam, Philip M. Hansbro and Ronan F. O ’Toole Tags: Review Source Type: research

The effect of natalizumab on disability score and relapse rate of multiple sclerosis patients: a prospective cohort study
Multiple sclerosis (MS) is a progressive immune-related disorder of the central nervous system leading to destruction of myelin sheaths. Natalizumab is a humanized monoclonal antibody against the cell adhesion... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 30, 2018 Category: Internal Medicine Authors: Mehrdokht Mazdeh, Shno Hosseini, Mohammad Taheri and Soudeh Ghafouri-Fard Tags: Research Source Type: research

Pros and cons of mouse models for studying osteoarthritis
Osteoarthritis (OA) is one of the most common chronic conditions in the world today. It results in breakdown of cartilage in joints and causes the patient to experience intense pain and even disability. The pa... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 21, 2018 Category: Internal Medicine Authors: Santul Bapat, Daniel Hubbard, Akul Munjal, Monte Hunter and Sadanand Fulzele Tags: Review Source Type: research

Oncolytic viruses and checkpoint inhibitors: combination therapy in clinical trials
Advances in the understanding of cancer immunotherapy and the development of multiple checkpoint inhibitors have dramatically changed the current landscape of cancer treatment. Recent large-scale phase III tri... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 14, 2018 Category: Internal Medicine Authors: Christopher J. LaRocca and Susanne G. Warner Tags: Review Source Type: research

Development and clinical assessment of new objective adherence markers for four microbicide delivery systems used in HIV prevention studies
Adherence is critical for successful topical, vaginally delivered anti-retroviral (ARV)-based HIV pre-exposure prophylaxis (PrEP). Quantitating systemic or tissue ARV levels through LC –MS/MS is currently viewe... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 7, 2018 Category: Internal Medicine Authors: Terry A. Jacot, Meredith R. Clark, Oluwatosin E. Adedipe, Susan Godbout, Abby G. Peele, Susan Ju, Jill L. Schwartz, Andrea R. Thurman and Gustavo F. Doncel Tags: Research Source Type: research

Cell toxicity mechanism and biomarker
Cell toxicity may result in organ dysfunction and cause severe health problem. Recent studies revealed many toxicants may induced the over production of Nitric oxide, reactive oxygen species and the subsequent... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 29, 2018 Category: Internal Medicine Authors: Yong Zhang Tags: Review Source Type: research