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Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
Abnormal regulation and expression of microRNAs (miRNAs) has been documented in various diseases including cancer. The miRNA let-7 (MIRLET7) family controls developmental timing and differentiation. Let-7 loss co... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - August 28, 2019 Category: Internal Medicine Authors: Evgeny Chirshev, Kerby C. Oberg, Yevgeniya J. Ioffe and Juli J. Unternaehrer Tags: Review Source Type: research

New therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota
Transformation and growth of tumor cells are associated with profound alterations in neighbouring cells and their environment, together forming the tumor microenvironment (TME). The TME provides a conducive bu... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - August 27, 2019 Category: Internal Medicine Authors: Babita Agrawal Tags: Review Source Type: research

Systemic treatment for lung carcinoids: from bench to bedside
In the huge spectrum of lung neuroendocrine neoplasms, typical and atypical carcinoids should be considered as a separate biological entity from poorly differentiated forms, harboring peculiar molecular altera... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 4, 2019 Category: Internal Medicine Authors: Mariangela Torniai, Laura Scortichini, Francesca Tronconi, Corrado Rubini, Francesca Morgese, Silvia Rinaldi, Paola Mazzanti and Rossana Berardi Tags: Review Source Type: research

Comparison of the effects of amantadine and ondansetron in treatment of fatigue in patients with multiple sclerosis
Multiple sclerosis (MS) is a common neurological disorder with a variety of manifestations including fatigue. Fatigue may interfere with daily work and activities. Different pharmacological and non-pharmacolog... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 1, 2019 Category: Internal Medicine Authors: Mojtaba Khazaei, Ashkan Karevan, Mohammad Taheri and Soudeh Ghafouri-Fard Tags: Research Source Type: research

The role of liver microenvironment in hepatic metastasis
Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delega... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 1, 2019 Category: Internal Medicine Authors: Tovah Williamson, Nikhila Sultanpuram and Hossein Sendi Tags: Review Source Type: research

The use of leukocytes ’ secretome to individually target biological therapy in autoimmune arthritis: a case report
Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, clas... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 5, 2019 Category: Internal Medicine Authors: Patrice E. Poubelle, Nathalie Pag é, Marie-Pier Longchamps, Natalia Sampaio Moura, David B. Beck, Ivona Aksentijevich, Philippe A. Tessier and Martin Pelletier Tags: Case report Source Type: research

Circulating monocytes and tumor-associated macrophages express recombined immunoglobulins in glioblastoma patients
Glioblastoma is the most common and malignant brain tumor in adults. Glioblastoma is usually fatal 12 –15 months after diagnosis and the current possibilities in therapy are mostly only palliative. Therefore, n... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 3, 2019 Category: Internal Medicine Authors: Svenja Busch, Marina Talamini, Steffen Brenner, Amr Abdulazim, Daniel H änggi, Michael Neumaier, Marcel Seiz-Rosenhagen and Tina Fuchs Tags: Research Source Type: research

The significance of microbiome in personalized medicine
Considering the important role of microbiome, many of current investigations have focused on its beneficial aspects. Although, research explores new dimensions of the impact of microbiome and examines the diff... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 13, 2019 Category: Internal Medicine Authors: Ava Behrouzi, Amir Hossein Nafari and Seyed Davar Siadat Tags: Review Source Type: research

Epigenetics of hepatocellular carcinoma
In recent years, large scale genomics and genome-wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity. Hepatocellular carcinoma, being one of the... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 6, 2019 Category: Internal Medicine Authors: Tan Boon Toh, Jhin Jieh Lim and Edward Kai-Hua Chow Tags: Review Source Type: research

Genetics in primary care: validating a tool to pre-symptomatically assess common disease risk using an Australian questionnaire on family history
A positive family history for diabetes, cardiovascular diseases or various types of cancer increases the relative risk for these diseases by 2 to 5 times compared to people without a positive family history. T... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 2, 2019 Category: Internal Medicine Authors: Elisa J. F. Houwink, Olga R. Hortensius, Kees van Boven, Annet Sollie and Mattijs E. Numans Tags: Research Source Type: research

Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy
The chemical composition of fucoidan, a kind of sulfated polysaccharide mainly derived from brown seaweed, includes a substantial percentage of l-fucose. Fucoidan has various biological and pharmacological activi... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 1, 2019 Category: Internal Medicine Authors: Hsien-Yeh Hsu and Pai-An Hwang Tags: Review Source Type: research

Circulating free DNA concentration as a marker of disease recurrence and metastatic potential in lung cancer
Plasma circulating cell-free (cf) DNA is regarded as a source of tumor DNA. Based on availability of blood tissue for the purposes of early detection of cancer and patients ’ follow-up, several studies have eva... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 18, 2019 Category: Internal Medicine Authors: Hanifeh Mirtavoos-Mahyari, Soudeh Ghafouri-Fard, Adnan Khosravi, Elahe Motevaseli, Zahra Esfahani-Monfared, Sharareh Seifi, Babak Salimi, Vahid Kholghi Oskooei, Mohsen Ghadami and Mohammad Hossein Modarressi Tags: Research Source Type: research

Role of medical and molecular imaging in COPD
Chronic obstructive pulmonary disease (COPD) is expected to climb on the podium of the leading causes of mortality worldwide in the upcoming decade. Clinical diagnosis of COPD has classically relied upon detec... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 15, 2019 Category: Internal Medicine Authors: Lukasz A. Myc, Yun M. Shim, Victor E. Laubach and Julien Dimastromatteo Tags: Review Source Type: research

A non-randomized clinical trial to evaluate the effect of fingolimod on expanded disability status scale score and number of relapses in relapsing-remitting multiple sclerosis patients
Multiple sclerosis (MS) is a chronic disease characterized by demyelination, glial activation and axonal degeneration in the central nervous system. At the present, there is no certain remedy for this disease.... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 8, 2019 Category: Internal Medicine Authors: Mehrdokht Mazdeh, Shahriar Kargar Monhaser, Mohammad Taheri and Soudeh Ghafouri-Fard Tags: Research Source Type: research

Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor microenvironment contains infiltrating immune ce... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 1, 2019 Category: Internal Medicine Authors: S. K. Daniel, K. M. Sullivan, K. P. Labadie and V. G. Pillarisetty Tags: Review Source Type: research