Characteristics, quality of life and control of respiratory allergic diseases caused by house dust mites (HDMs) in Spain: a cross-sectional study
AbstractThis multicentre, cross-sectional study conducted in Spain assessed the clinical characteristics and quality of life of patients who were aged 14 –55 years and had allergic rhinitis and/or asthma, which was due to house dust mite sensitisation, for at least 2 years. Overall, 296 patients were included; 60% had allergic rhinitis (mostly persistent moderate-to-severe) and 40% had rhinitis and asthma (mostly intermittent or mild-to-persisten t). Patients with rhinitis had moderately reduced quality of life, which was significantly worse in adults than adolescents. The impact of asthma on quality of life was less p...
Source: Clinical and Translational Allergy - August 5, 2019 Category: Allergy & Immunology Source Type: research
Eosinophilic disorders: evaluation of current classification and diagnostic criteria, proposal of a practical diagnostic algorithm
AbstractEosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and complex cases, with fatal outcome. Interest in this group of disorders has increased during the last two decades, with consistent progress made regarding understanding of molecular mechanisms, refining of diagnostic criteria, classification and evaluation of therapeutic options. There are still many gaps and difficulties in evaluating eosinophilic syndromes and diseases in medical practice. The disease prognosis...
Source: Clinical and Translational Allergy - July 24, 2019 Category: Allergy & Immunology Source Type: research
Elderly versus younger patients with hereditary angioedema type I/II: patient characteristics and safety analysis from the Icatibant Outcome Survey
ConclusionsElderly patients with C1-INH-HAE were significantly older at diagnosis and had greater delay in diagnosis than younger patients. Elderly patients contributed to approximately 10% of the icatibant-treated attacks. Our analysis found similar AE rates (overall and possibly/probably related) in icatibant-treated elderly versus younger patients, despite the fact that elderly patients had significantly more comorbidities and were receiving a greater number of concomitant medications. Our analysis did not identify any new or unexpected safety concerns. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 18, 2019 Category: Allergy & Immunology Source Type: research
Increased platelet activating factor levels in chronic spontaneous urticaria predicts refractoriness to antihistamine treatment: an observational study
ConclusionsCompared with NCs, CSU patients, particularly those with H1RA refractoriness, showed significant increases in serum PAF levels and decreases in PAF-AH. Therapies modulating PAF and PAF-AH levels could be effective in patients with CSU refractory to antihistamines. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 16, 2019 Category: Allergy & Immunology Source Type: research
High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
AbstractAntihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36%) of antihistamine refractory cases was observed. Forty percent of patients on antihistamine prophylaxis suffered from 1 or more angioedema attacks per month. Our findings stress the need for additional treatment options for recurrent idiopathic angioedema. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 11, 2019 Category: Allergy & Immunology Source Type: research
Molecular clustering of genes related to the atopic syndrome: Towards a more tailored approach and personalized medicine?
ConclusionsThis study shows a model to define clusters within the atopic syndrome based on gene expression profiles of immune cell lineages. Our results support the hypothesis that both genetic mechanisms and immune dysregulation play a role in the pathogenesis. It also opens up the possibility for novel therapeutic targets and a more tailored approach towards personalized medicine. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 9, 2019 Category: Allergy & Immunology Source Type: research
Comparison of two multiplex arrays in the diagnostics of allergy
The objective of this analysis was to compare the multiplex ImmunoCAP ISAC (Thermo Fisher Scientific, Sweden) and the multiplex Alex Allergy Explorer (Macro Array Diagnostics GmbH, Austria) platform on specific IgE to grass pollen (Phl p 1, Phl p 5), tree pollen (Bet v 1), house dust mites (Der p 1, Der p 2) and cat (Fel d 1) allergens in allergic patients. Our findings demonstrate a good correlation of presently used methods to detect serum sIgE. Multiplex testing of allergen-specific IgE can be the method of choice for a prospective component-resolved diagnosis of type I allergy, and the basis for the design and mon...
Source: Clinical and Translational Allergy - July 7, 2019 Category: Allergy & Immunology Source Type: research
Sesame oleosins are minor allergens
ConclusionSesame oleosins are minor allergens and appear to have no additonal value in diagnosing sesame allergy in adults based on sIgE and sIgG detection. There is a high need for additional diagnostic tools in those patients to minimize the number of required food challenges. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 27, 2019 Category: Allergy & Immunology Source Type: research
Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis
ConclusionsThis long-term cohort study, investigating the outcome after surgery in CRSwNP, showed that, despite the low number of patients, 78.9% of patients with CRSwNP were subject to recurrence of the disease and 36.8% to revision surgery over a 12-year period. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 13, 2019 Category: Allergy & Immunology Source Type: research
Subcutaneous immunotherapy with depigmented-polymerized allergen extracts: a systematic review and meta-analysis
ConclusionsCompared to placebo, AIT with DPAEs is effective in patients with pollen- or HDM-induced rhinoconjunctivitis with or without allergic asthma and improves health-related quality of life. It does not differ significantly in safety and tolerability. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 4, 2019 Category: Allergy & Immunology Source Type: research
A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow ’s milk allergic infants: a randomized controlled trial
ConclusionsThe AAF including specific synbiotics effectively modulates the gut microbiota and its metabolic activity in non-IgE mediated CMA infants bringing it close to a healthy breastfed profile.Trial registration Registered on 1 May 2013 with Netherlands Trial Register Number NTR3979. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 30, 2019 Category: Allergy & Immunology Source Type: research
Identification of immunodominant IgE binding epitopes of Der p 24, a major allergen of Dermatophagoides pteronyssinus
ConclusionsWe identified Der p 24 as a major HDM allergen with strong IgE binding activity via an immunodominant IgE epitope in the N-terminal 32-residue region, which triggers IgE production in vivo. The identified Der p 24 epitope may support HDM allergy diagnosis and treatment. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 22, 2019 Category: Allergy & Immunology Source Type: research
Clinical and serological follow-up of patients with WDEIA
AbstractThe clinical threshold in wheat-dependent, exercise-induced anaphylaxis seems to be lowered in patients on wheat free diet, whereas the opposite is seen in patients on regular wheat intake. Therefore, a recommendation of wheat consumption, if considered safe to the patient based on case-history and challenge results, could be advised. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 15, 2019 Category: Allergy & Immunology Source Type: research
Psychosocial working conditions, asthma self-management at work and asthma morbidity: a cross-sectional study
ConclusionsAdverse psychosocial working conditions are associated with poorer asthma self-management behaviour at work and with increased asthma morbidity. The latter association may be mediated by asthma self-management behaviour.Trial registration German Clinical Trials Register, registration number: DRK S00011309, date of registration: 22.12.2016. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 8, 2019 Category: Allergy & Immunology Source Type: research
Skin microdialysis: methods, applications and future opportunities —an EAACI position paper
AbstractSkin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Therefore, an EAACI Task Force on SMD was formed to disseminate knowledge about the technique and its many applications. This position p...
Source: Clinical and Translational Allergy - April 9, 2019 Category: Allergy & Immunology Source Type: research
