Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients
ConclusionsSensitization to skin resident fungi includingMalassezia globosa is uncommon in European CholU patients, but is associated with atopy and pronounced wheal formation upon dermal contact with their own sweat.Trial registration German Clinical Trials Registry DRKS-ID: DRKS00004277 (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 31, 2020 Category: Allergy & Immunology Source Type: research
Viral infections and wheezing –asthma inception in childhood: is there a role for immunomodulation by oral bacterial lysates?
AbstractSevere and recurrent infections of the respiratory tract in early childhood constitute major risk factors for the development of bronchial hyper-responsiveness and obstructive respiratory diseases in later life. In the first years of life, the vast majority of respiratory tract infections (RTI) leading to wheezing and asthma are of a viral origin and severity and recurrence are the consequence of a greater exposure to infectious agents in a period when the immune system is still relatively immature. Therefore, boosting the efficiency of the host immune response against viral infections seems to be a rational preven...
Source: Clinical and Translational Allergy - May 29, 2020 Category: Allergy & Immunology Source Type: research
Is diet partly responsible for differences in COVID-19 death rates between and within countries?
AbstractReported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be sign...
Source: Clinical and Translational Allergy - May 26, 2020 Category: Allergy & Immunology Source Type: research
Male sex is strongly associated with IgE-sensitization to airborne but not food allergens: results up to age 24 years from the BAMSE birth cohort
ConclusionIgE-sensitization to airborne allergens increases with age up to young adulthood, whereas sensitization to food allergens seems to level off. Male sex is strongly associated with IgE-sensitization to airborne allergens from early childhood up to young adulthood. In contrast, there is little evidence for associations between sex and IgE-sensitization to foods. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 24, 2020 Category: Allergy & Immunology Source Type: research
EAACI anaphylaxis guidelines: systematic review protocol
(Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 19, 2020 Category: Allergy & Immunology Source Type: research
COST Action ‘ImpARAS’: what have we learnt to improve food allergy risk assessment. A summary of a 4 year networking consortium
AbstractThe growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources such as insects, algae and duckweed and using new processing techniques. Consumer exposure to these novel or processed proteins, could cause new food allergies, exacerbating a public health issue which is already directly affecting an estimated 20 million Europeans. Introduction of novel foods should not add to the burden of food allergy and this calls for a reliable, harmonised, evidence-based and validated a...
Source: Clinical and Translational Allergy - May 17, 2020 Category: Allergy & Immunology Source Type: research
EAACI Task force Clinical epidemiology of anaphylaxis: experts ’ perspective on the use of adrenaline autoinjectors in Europe
ConclusionOur data confirm the lack of consensus regarding the number of AAIs to prescribe. Despite the European Medical Agency recommendation, the majority of allergy experts prescribed one autoinjector per patient. However, under distinct circumstances (e.g. mastocytosis, asthma, excess body weight, a history of severe anaphylaxis, or restricted access to immediate emergency), experts tended to prescribe more AAIs, which is in accordance with the European Academy of Allergy and Clinical Immunology guidelines. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 10, 2020 Category: Allergy & Immunology Source Type: research
Clinical trials in allergen immunotherapy in the age group of children and adolescents: current concepts and future needs
AbstractAllergen immunotherapy (AIT) is the only treatment option available for allergic patients with disease-modifying intention. Both efficacy and safety has been demonstrated for multiple trials in children, adolescents and adults. Though regulatory requirements for marketing authorization have been clearly outlined and an increasing number of high quality trials has been initiated, multiple concepts and details in study design may be further elaborated, harmonized and improved. An international group of experts in the field of AIT has thoroughly reviewed and discussed current concepts and provided an outlook on furthe...
Source: Clinical and Translational Allergy - April 23, 2020 Category: Allergy & Immunology Source Type: research
Impact on quality of life and safety of sublingual and subcutaneous immunotherapy in children with severe house dust mite and pollen-associated allergic rhinoconjunctivitis
ConclusionsPollen SCIT and pollen and HDM SLIT all lead to significant improvements in QoL. The risk of anaphylaxis is low, but SCIT is associates with a 1 in 5 chance of asthma flares in the days after its administration. Discontinuation of therapy is more frequent in older, polysensitised children, and those undergoing HDM immunotherapy. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - April 19, 2020 Category: Allergy & Immunology Source Type: research
Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes
ConclusionAddition of NI with a sea-water solution to regular treatment improved AR symptom control. CARAT questionnaires and MASK application can be useful outcome tools in real-life studies. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 12, 2020 Category: Allergy & Immunology Source Type: research
Development of a model care pathway for the management of Hymenoptera venom allergy: evidence-based key interventions and indicators
ConclusionA set of 123 key interventions and of six process indicators were found to be appropriate for the development and standardization of the clinical content of the Hymenoptera venom allergy care pathway. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 3, 2020 Category: Allergy & Immunology Source Type: research
Study of atopic multimorbidity in subjects with rhinitis using multiplex allergen component analysis
ConclusionIgE polysensitization, to perennial and seasonal allergens, and levels of total IgE seem to be the main determinants of atopic multimorbidity in subjects with rhinitis. This indicates that disease-modifying treatment that targets IgE sensitization may be of value when decreasing the risk of developing atopic multimorbidity. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 20, 2020 Category: Allergy & Immunology Source Type: research
Eczema phenotypes and risk of allergic and respiratory conditions in school age children
ConclusionEczema phenotypes were differentially associated with risks of respiratory and allergic conditions in school-aged children. Children with early transient and persistent eczema might benefit from more intense follow-up for early identification and treatment of asthma and allergies. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 18, 2020 Category: Allergy & Immunology Source Type: research
Modified protocol of omalizumab treatment to prevent carboplatin-induced drug hypersensitivity reactions: a case study
AbstractCarboplatin administration can usually be safely continued via a so-called desensitisation protocol when hypersensitivity reactions arise. Severe break-through reactions that occur early during desensitisation are likely to be IgE-mediated; in that case, addition of omalizumab premedication should be strongly considered. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - January 28, 2020 Category: Allergy & Immunology Source Type: research
Healthy people in healthy premises: the Finnish Indoor Air and Health Programme 2018 –2028
AbstractClean and fresh indoor air supports health and well-being. However, indoor air can contain pollutants that can cause a variety of symptoms and reduce well-being. Individual exposure agents can also increase the risk of certain diseases. Finns have taken major steps to improve the quality of indoor air for several decades. The primary focus of these activities has been the prevention and reduction of exposure to poor indoor air quality through guidance and regulation directing remediation of damaged buildings. Nevertheless, reported symptoms related to poor indoor air quality are common in Finland. In addition to ex...
Source: Clinical and Translational Allergy - January 16, 2020 Category: Allergy & Immunology Source Type: research
