The prognostic value of long noncoding RNA Sox2ot expression in various cancers: A systematic review and meta-analysis
Conclusion High lncRNA Sox2ot expression was significantly associated with worse OS, advanced clinical stage, worse tumor differentiation, earlier distant metastasis, and earlier lymph node metastasis in various cancers. LncRNA Sox2ot expression might a promising prognostic factor in various cancers. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

Association between hippuric acid and left ventricular hypertrophy in maintenance hemodialysis patients
Conclusions HA was significantly associated with LVH. HA could be a novel biomarker of left ventricular overload, which is closely associated with an increased risk of death in HD patients. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

Serum CA125 levels predict outcome of interval debulking surgery after neoadjuvant chemotherapy in patients with advanced ovarian cancer
Conclusion Patients who underwent optimal IDS have better prognosis compare to suboptimal IDS. The changes of serum CA125 after neoadjuvant chemotherapy might predict optimal interval debulking surgery in patients with advanced epithelial ovarian cancer. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

Increase in insulin secretion and decrease in muscle degradation by fat-free milk intake are attenuated by physical exercise
Conclusions BCAA-rich fat-free milk intake enhanced insulin secretion and suppressed muscle protein degradation, but these effects are attenuated by exercise accompanied with increase in catecholamine secretion. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

Association between klotho expression and malignancies risk and progression: A meta-analysis
Conclusions Tissue klotho protein expression was associated with a lower risk and progression of malignancies. Klotho may be a protective factor against malignancies risk/progression. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

A monoclonal antibody sandwich ELISA for vitamin D-binding protein (VDBP) is unaffected by Gc-globulin phenotype peptides and actin and demonstrates reduced levels in sepsis and non-sepsis intensive care patients
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Katrina Hong, Christopher M. Florkowski, Matthew P. Doogue, Peter A. Elder, John G. Lewis The measurement of vitamin D-binding protein (VDBP) by immunoassay has been confounded by variable antibody recognition of the Gc1s, Gc1F and Gc2 phenotypes. This has led to spurious conclusions regarding vitamin D status in different ethnic groups. In order to overcome these problems there is a requirement for VDBP antibodies that are unaffected by phenotype status. Here we report the generation and testing of three monoclonal antibodies to VDBP whic...
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

The clinicopathological and prognostic value of long non-coding RNA ZEB1-AS1 in solid tumors: A meta-analysis
Conclusion High expression of ZEB1-AS1 was associated with advanced clinicopathological characteristics, and ZEB1-AS1overexpression may be a potential prognostic biomarker in human cancer. However, more studies involving various tumor types and large sample size are needed. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

Human platelet antigens in disease
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Ying-hao Wen, Ding-Ping Chen Platelets have various functions and participate in primary hemostasis, inflammation, and immune responses. Human platelet antigens (HPAs) are alloantigens expressed on the platelet membrane. Each HPA represent one of six platelet glycoproteins GPIIb, GPIIIa, GPIa, GPIbα, GPIbβ, and CD109, and six biallelic systems are grouped. A single nucleotide polymorphism (SNP) in the gene sequence causes a single amino acid substitution of relevant platelet glycoprotein with the exception of HPA-14bw. High-thro...
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

Methylation of NBPF1 as a novel marker for the detection of plasma cell-free DNA of breast cancer patients
Conclusions These results indicate that hypermethylation of the NBPF1 promoter occurs in a significant proportion of breast tumors and that NBPF1-methylated cfDNA may serve as a potential tumor marker for breast cancer. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

Prognostic and clinicopathological value of CXCL12/SDF1 expression in breast cancer: A meta-analysis
Conclusions This present meta-analysis suggests that CXCL12/SDF1 protein expression is a good prognostic biomarker in breast cancer. In addition, the over-expression of CXCL12/SDF1 protein was associated with positive ER status, negative HER2 status and small tumor size. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

Preoperative lymphocyte-to-monocyte ratio predicts breast cancer outcome: A meta-analysis
Conclusion The preoperative LMR might be a predictive factor of poor prognosis for BC patients. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 29, 2018 Category: Laboratory Medicine Source Type: research

The haptoglobin promoter polymorphism rs5471 is the most definitive genetic determinant of serum haptoglobin level in a Ghanaian population
Conclusions We suggest that rs5471 is a strong genetic determinant of HP levels in Ghanaians, and this seems to be characteristic of Africans. Further investigation using large scale samples will help in understanding the genetic background of individual variability of the serum HP level. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 22, 2018 Category: Laboratory Medicine Source Type: research

Pretreatment neutrophil-lymphocyte and platelet-lymphocyte ratio predict clinical outcome and prognosis for cervical Cancer
In this study, we aimed to evaluate the predictive and prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in cervical cancer. We retrospectively investigated 616 patients who underwent initial radical hysterectomy with pelvic lymphadenectomy for cervical cancer between July 2012 and December 2014 in China. Their clinical and histopathological markers and complete blood counts were obtained and analyzed. Then we chose the group of 339 of the total 616 patients who were not combined preoperative radiotherapy or chemotherapy for the survival analysis. Prognostic fac...
Source: Clinica Chimica Acta - May 22, 2018 Category: Laboratory Medicine Source Type: research

Enhanced liver fibrosis (ELF) score: Reference ranges, biological variation in healthy subjects, and analytical considerations
Conclusion The reference range of the ELF score overlap with the area defined as moderate fibrosis by the manufacturer. High biological variation of HA was diminished by the natural logarithm in the calculation of the ELF score. The use of the ELF score has suitable analytical and acceptable biological performance characteristics for clinical practice. However, the transfer of results evaluated in healthy persons to the populations with chronic liver diseases deserves caution. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 22, 2018 Category: Laboratory Medicine Source Type: research

Maternal plasma concentrations of macrophage migration inhibitory factor at first trimester as a predictive biomarker of preterm delivery in Chinese women
Conclusions Increased maternal plasma concentrations of MIF at first trimester were associated with increased risk of PTD and might be useful in identifying newborn at risk for PTD for early prevention strategies. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 22, 2018 Category: Laboratory Medicine Source Type: research

Performance of P16/Ki67 dual staining in triaging hr-HPV-positive population during cervical Cancer screening in the younger women
Conclusions This study demonstrated that p16/Ki-67 dual staining represents an effective method for cervical cancer screening. Application of this method could lead to a reduction of unnecessary colposcopy referrals and misdiagnosis. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 22, 2018 Category: Laboratory Medicine Source Type: research

Paraoxonase 1 (PON1)-L55M among common variants in the coding region of the paraoxonase gene family may contribute to the glycemic control in type 2 diabetes
Conclusions Sex should be considered a confounding variable in association studies on the variants PON1-Q192R and PON2-A148G in T2D. Patients sharing the 55 M allele were prone to having good glycemic control. Our findings provide genetic evidence that the PON1-L55M variant may be a factor contributing to glycemic control. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 22, 2018 Category: Laboratory Medicine Source Type: research

Urinary mitochondrial DNA level in non-diabetic chronic kidney diseases
Conclusion Mitochondrial DNA is readily detectable in the urinary supernatant of non-diabetic CKD, and its level correlates with the rate of renal function decline and predicts the risk of doubling of serum creatinine or need of dialysis. Further studies are needed to determine the value of urinary supernatant mtDNA level as a prognostic indicator of non-diabetic CKD (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 21, 2018 Category: Laboratory Medicine Source Type: research

Development and validation of a targeted affinity-enrichment and LC –MS/MS proteomics approach for the therapeutic monitoring of adalimumab
Conclusion Our assay can quantify both sub-therapeutic and therapeutic concentrations of bioavailable adalimumab in patient serum samples. This assay design provides an alternative to isotope-labeled peptides approach currently adopted in targeted proteomics methods. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 19, 2018 Category: Laboratory Medicine Source Type: research

Proteomic approach to profiling immune complex antigens in cerebrospinal fluid samples from patients with central nervous system autoimmune diseases
Conclusions This report is the first to comprehensively identify the antigens incorporated into ICs in CSF. There was limited overlap between the antigens we identified and the CSF proteome or the plasma proteome; therefore, our method can be distinguished from the conventional CSF proteome analysis. Although the sensitivity of disease-specific IC-antigens detected in immune complexome analysis screening, the sensitivity may be improved by developing an ELISA method specifically for detecting the ICs. Immune complexome analysis of CSF may be a new and promising path to biomarker discovery for diagnosis and study for CNS au...
Source: Clinica Chimica Acta - May 18, 2018 Category: Laboratory Medicine Source Type: research

Concentration and value of endocan on outcome in adult patients after severe sepsis
Conclusions Based on our results, serial endocan concentration meets the major requirements for predicting outcome in patients with severe sepsis. An assay of endocan concentration may be a good prognostic biomarker in the clinic for severe sepsis. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 16, 2018 Category: Laboratory Medicine Source Type: research

Quality of plasma samples and BD Vacutainer Barricor tubes: Effects of centrifugation
Conclusions BD Barricors plasma quality improved with increasing the centrifugation times but already at 4000g/3 min, the suggested centrifugation condition, a significant improvement was achieved. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 15, 2018 Category: Laboratory Medicine Source Type: research

A tag SNP in syncytin-2 3-UTR significantly correlates with the risk of severe preeclampsia
Conclusions These results suggested that genetic predisposition in ERVFRDE-1 may be associated with an increased risk of preeclampsia. This polymorphism is possibly involved in the regulation of syncytin-2 expression in preeclamptic placenta. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 15, 2018 Category: Laboratory Medicine Source Type: research

Losing sight of the Forest for the trees: Why clinical laboratories need to perform their own interference studies
Publication date: August 2018 Source:Clinica Chimica Acta, Volume 483 Author(s): Maximo J. Marin, Xander M.R. van Wijk, Kiang-Teck J. Yeo (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 13, 2018 Category: Laboratory Medicine Source Type: research

Association between viral loads of different oncogenic human papillomavirus types and the degree of cervical lesions in the progression of cervical Cancer
Conclusions The HPV viral load-associated risk for developing into CIN and cervical cancer is likely to be species-dependent and primarily restricted to species 9 (types phylogenetically close to HPV16). (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 13, 2018 Category: Laboratory Medicine Source Type: research

A new sample treatment for asialo-Tf determination with capillary electrophoresis: an added value to the analysis of CDT
Conclusions Asialo-Tf represents an additional value to disialo-Tf as a biomarker of alcohol abuse in forensic toxicology. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 13, 2018 Category: Laboratory Medicine Source Type: research

Review: Apelin in disease
Publication date: August 2018 Source:Clinica Chimica Acta, Volume 483 Author(s): Hanna Antushevich, Maciej Wójcik Apelin, a regulatory peptide, is a ligand of the APJ receptor that belongs to the G protein-coupled receptor family. Apelin and APJ are widely distributed in the body and play potential physiological roles in the cytoprotection of many internal organs. This review article summarizes information about the roles of the apelin/APJ system in neurological, metabolic, hypertension, respiratory, gastrointestinal, hepatic, kidney and cancerous diseases. It is suggested that apelin positively affects the treatme...
Source: Clinica Chimica Acta - May 13, 2018 Category: Laboratory Medicine Source Type: research

Twenty years of European IVD regulations and its aimed traceability - where are we?
Publication date: August 2018 Source:Clinica Chimica Acta, Volume 483 Author(s): Joris R. Delanghe, Marc L. De Buyzere (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 13, 2018 Category: Laboratory Medicine Source Type: research

Oxidative stress markers and thrombomodulin plasma levels in women with early and late severe preeclampsia
Conclusions Longitudinal studies involving pregnant women with risk factors for PE development and including other methods for oxidative stress and endothelial lesion determination should be conducted in order to better evaluate the role of these processes in PE pathogenesis. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 12, 2018 Category: Laboratory Medicine Source Type: research

Long noncoding RNA CYTOR in cancer: A TCGA data review
Conclusion Overall, this study indicates that CYTOR may serve as a prognostic biomarker for cancer patients during the follow-up. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 12, 2018 Category: Laboratory Medicine Source Type: research

Can serum Procalcitonin aid in the diagnosis of blood stream infection in patients on immunosuppressive medications?
Conclusions As PCT levels rise, patients on immunosuppressive agents are less likely to mount a SIRS response, despite having a high probability of BSI. PCT might prove helpful in this setting as immunosuppressive agents do not alter the diagnostic performance of serum PCT in detecting BSI. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 10, 2018 Category: Laboratory Medicine Source Type: research

Simultaneous quantitation of carbohydrate antigen 125 and carcinoembryonic antigen in human serum via time-resolved fluoroimmunoassay
Publication date: August 2018 Source:Clinica Chimica Acta, Volume 483 Author(s): Zhen Huang, Xiang-Ming Zhai, Hao Wang, Qiao-Ting Deng, Kun Li, Bi-Sen Liu, Gang Wang, Tian-Cai Liu In clinical diagnosis of cancer, immunology assay with single tumor marker often lead to a false and missed inspection. A quantitative method with a high degree of accuracy, sensitivity, and effectiveness is required for its diagnosis. We developed a dual-label time-resolved fluoroimmunoassay (TRFIA) to simultaneously detect carbohydrate antigen 125 (CA125) and carcinoembryonic antigen (CEA) in human serum to aid the diagnosis and prognosis of g...
Source: Clinica Chimica Acta - May 10, 2018 Category: Laboratory Medicine Source Type: research

Prognostic and clinical significance of histone deacetylase 1 expression in breast cancer: A meta-analysis
Conclusion Overall, our meta-analysis demonstrated an association between increased HDAC1 expression and better OS in Asian breast cancer patients. In addition, HDAC1 over-expression correlated with positive ER and negative HER2 expression in breast cancer. However, researches in large patients' randomised controlled trials (RCTs) are needed to confirm the results. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 10, 2018 Category: Laboratory Medicine Source Type: research

Serum human epididymis secretory protein 4 as a potential biomarker of renal fibrosis in kidney transplantation recipients
Conclusions Serum HE4 was increased in kidney transplant recipients with decreased kidney function and renal fibrosis and was correlated with the severity of the disease, suggesting that HE4 has the potential to be used as a novel clinical biomarker for evaluating kidney function and predicting renal fibrosis in kidney transplant recipients. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 10, 2018 Category: Laboratory Medicine Source Type: research

Pyrosequencing-based quantitative measurement of CALR mutation allele burdens and their clinical implications in patients with myeloproliferative neoplasms
Conclusions Pyrosequencing was a useful rapid sequencing method to determine the burden of CALR mutations. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 8, 2018 Category: Laboratory Medicine Source Type: research

High-mobility group box 1 protein (HMGB1) gene polymorphisms and cancer susceptibility: A comprehensive meta-analysis
Conclusion This is the first meta-analysis exploring the association of four HMGB1 polymorphisms with cancer. Although polymorphism rs1045411 emerged as a risk candidate, additional studies are suggested to confirm these findings. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 8, 2018 Category: Laboratory Medicine Source Type: research

Prognostic value of PEG10 in Asian solid tumors: A meta-analysis
Conclusions PEG10 expression is associated with advanced clinicopathological characteristics and can be used as a prognostic biomarker in patients with solid tumors. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 8, 2018 Category: Laboratory Medicine Source Type: research

PCSK9: A potential regulator of apoE/apoER2 against inflammation in atherosclerosis?
Publication date: August 2018 Source:Clinica Chimica Acta, Volume 483 Author(s): Xue-qin Bai, Juan Peng, Mei-mei Wang, Jun Xiao, Qiong Xiang, Zhong Ren, Hong-yan Wen, Zhi-sheng Jiang, Zhi-han Tang, Lu-shan Liu Atherosclerosis is characterized by chronic inflammation and lipid accumulation in arterial walls, resulting in several vascular events. Proprotein convertase subtilisin kexin 9 (PCSK9), a serine protease, has a pivotal role in the degradation of hepatic low-density lipoprotein receptor (LDLR). It can increase plasma concentrations of low-density lipoprotein cholesterol and affect lipid metabolism. Recently, PCSK9 h...
Source: Clinica Chimica Acta - May 8, 2018 Category: Laboratory Medicine Source Type: research

The combination of 5 serum markers compared to FibroScan to predict significant liver fibrosis in patients with chronic hepatitis B virus
Conclusion The combination of the 5 serum markers and FibroScan performed equally well in predicting significant fibrosis. The combination of the 5 serum markers is a reliable noninvasive method to predict significant liver fibrosis in patients with CHB. So, it provide another choice rather than FibroScan in predicting significant liver fibrosis. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 3, 2018 Category: Laboratory Medicine Source Type: research

Development of an enzymatic assay to measure lactate in perchloric acid-precipitated cerebrospinal fluid
Conclusions CSF lactate can be measured with accuracy and precision using the same perchloric-acid treated sample that is used for pyruvate. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 3, 2018 Category: Laboratory Medicine Source Type: research

Serum FBLN1 and STK31 as biomarkers of colorectal cancer and their ability to noninvasively differentiate colorectal cancer from benign polyps
Conclusion FBLN1 and STK31 can be possible screening and differentiating biomarkers of CRC. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 3, 2018 Category: Laboratory Medicine Source Type: research

LC-Q-TOF-MS based plasma metabolomic profile of subclinical pelvic inflammatory disease: A pilot study
Conclusion Through an LC-Q-TOF-MS based metabolomic analysis on subclinical PID, this study reports the potential plasma biomarkers which may be helpful for its non-invasive diagnosis. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 3, 2018 Category: Laboratory Medicine Source Type: research

Signalling mechanism(s) of epithelial –mesenchymal transition and cancer stem cells in tumour therapeutic resistance
Publication date: August 2018 Source:Clinica Chimica Acta, Volume 483 Author(s): Zhihong Cai, Yijing Cao, Yichen Luo, Haobin Hu, Hui Ling Epithelial-mesenchymal transition (EMT) leads to tumour progression, including tumour metastasis, disease recurrence and therapy resistance. Cancer stem cells (CSCs) are a small group of cells that have the ability to undergo self-renewal and heterogeneous differentiation, which play a key role in the occurrence and development of cancer. EMT can promote tumour cells to develop stem cell characteristics, which makes tumours more difficult to treat. Therefore, exploring the role of EMT a...
Source: Clinica Chimica Acta - May 3, 2018 Category: Laboratory Medicine Source Type: research

Diagnostic and therapeutic profiles of serum bile acids in women with intrahepatic cholestasis of pregnancy-a pseudo-targeted metabolomics study
Conclusions The profiles of serum bile acids in women with ICP became more clear under the UDCA therapy, and were fully recovered after the delivery. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 2, 2018 Category: Laboratory Medicine Source Type: research

Levels of serum high mobility group box 1 were independently associated with cardiovascular risk in patients undergoing coronary angiography
Conclusions In patients undergoing coronary angiography with no history of diabetes, levels of serum HMGB1 were positively associated with 10-year CHD risk, independent of patients' undiagnosed abnormal glucose regulation. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 2, 2018 Category: Laboratory Medicine Source Type: research

Visual detection of miRNA using peroxidase-like catalytic activity of DNA-CuNCs and methylene blue as indicator
In this study, we developed a colorimetric method which is primarily based on the limited amount of redox in response to the miRNA target analyte binding for the determination of the miRNA, which is used as a biomarker to confirm the clinical diagnosis of cancers such as breast cancer. This method is on the basis of the peroxidase-like property of DNA templated copper nanoclusters (DNA-CuNCs). In this research, it was found that the DNA (poly T) stabilized green emitting CuNCs which exhibited enzyme-like peroxidase activity. After hybridization of miRNA with DNA-CuNCs probe and duplex formation, CuNCs catalyzed the oxidati...
Source: Clinica Chimica Acta - April 30, 2018 Category: Laboratory Medicine Source Type: research

Preanalytical phase: Effects of water ingestion during fasting on routine hematological parameters in a small cohort of young women
Conclusion Ingestion of 300 ml water 1 h before blood extraction does not alter the hematological parameters studied. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - April 30, 2018 Category: Laboratory Medicine Source Type: research

Serum chloride as a novel marker for adding prognostic information of mortality in chronic heart failure
Conclusions In a Chinese Han population, admission serum chloride concentrations are inversely associated with all-cause mortality of CHF patients and provide incremental prognostic information of serum sodium. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - April 27, 2018 Category: Laboratory Medicine Source Type: research

A metabolomics study on the immunosuppressive effect of Tripterygium hypoglaucum (Levl.) Hutch in mice: The discovery of pathway differences in serum metabolites
Publication date: August 2018 Source:Clinica Chimica Acta, Volume 483 Author(s): Yanlei Guo, Yongde Wang, Xuan Shi, Weihan Qin, Xiaomei Zhang, Jiahong Xu, Xiaoling Liu, Dajian Yang, Yong Yang Tripterygium hypoglaucum (Levl.) Hutch (THH), a typical traditional Chinese medicine, is widely used in clinical practice for the treatment of rheumatoid arthritis, systemic lupus erythematous, and other connective tissue and autoimmune diseases. However, most related researches focused on the pharmacological effects of THH, while less attention has been paid to the immunosuppressive mechanism. The present study aims to determine the...
Source: Clinica Chimica Acta - April 26, 2018 Category: Laboratory Medicine Source Type: research

Sustained or higher levels of growth factors in platelet-rich plasma during 7-day storage
Conclusions During the storage in blood bank, platelet counts and 7 growth factors sustained or reached higher level than L-PRP obtained on first day. Multiple injections of stored PRPs could become applicable by our protocol. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - April 26, 2018 Category: Laboratory Medicine Source Type: research