Hemodynamic Phenotyping of Pulmonary Hypertension in Left Heart Failure [Advances in Heart Failure]
Increased pulmonary venous pressure secondary to left heart disease is the most common cause of pulmonary hypertension (PH). The diagnosis of PH due to left heart disease relies on a clinical probability assessment followed by the invasive measurements of a mean pulmonary artery pressure (PAP) ≥25 mm Hg and mean wedged PAP (PAWP) >15 mm Hg. A combination of mean PAP and mean PAWP defines postcapillary PH. Postcapillary PH is generally associated with a diastolic pulmonary pressure gradient (diastolic PAP minus mean PAWP) <7 mm Hg, a transpulmonary pressure gradient (mean PAP minus mean PAWP) <12 mm Hg, and pulm...
Source: Circulation: Heart Failure - September 14, 2017 Category: Cardiology Authors: Naeije, R., Gerges, M., Vachiery, J.-L., Caravita, S., Gerges, C., Lang, I. M. Tags: Hemodynamics, Heart Failure, Pulmonary Hypertension Advances in Heart Failure Source Type: research
Diastolic Pressure Difference to Classify Pulmonary Hypertension in the Assessment of Heart Transplant Candidates [Original Articles]
Conclusions:
The DPD calculated in usual practice is underestimated in PH-LHD, which may classify Cpc-PH patients as isolated postcapillary pulmonary hypertension. The QRS-gated DPD reclassifies a subset of PH-LHD patients from isolated postcapillary pulmonary hypertension to Cpc-PH, which is characterized by an adverse hemodynamic profile. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 14, 2017 Category: Cardiology Authors: Wright, S. P., Moayedi, Y., Foroutan, F., Agarwal, S., Paradero, G., Alba, A. C., Baumwol, J., Mak, S. Tags: Heart Failure, Pulmonary Hypertension Original Articles Source Type: research
Preoperative Pectoralis Muscle Quantity and Attenuation by Computed Tomography Are Novel and Powerful Predictors of Mortality After Left Ventricular Assist Device Implantation [Emerging Investigators]
Conclusions:
Pectoralis muscle size and attenuation were powerful predictors of outcomes after LVAD implantation in this data set. This one time, repeatable, internal assessment of patient substrate added valuable prognostic information that was not available on standard preoperative testing. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 14, 2017 Category: Cardiology Authors: Teigen, L. M., John, R., Kuchnia, A. J., Nagel, E. M., Earthman, C. P., Kealhofer, J., Martin, C., Cogswell, R. Tags: Biomarkers, Diet and Nutrition, Heart Failure, Computerized Tomography (CT), Mortality/Survival Emerging Investigators Source Type: research
Decoupling Between Diastolic Pulmonary Artery Pressure and Pulmonary Capillary Wedge Pressure as a Prognostic Factor After Continuous Flow Ventricular Assist Device Implantation [Original Articles]
Conclusions:
The presence of inappropriate decoupling was associated with worse outcomes in patients with LVADs. Prospective, large-scale multicenter studies to validate the result are warranted. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 14, 2017 Category: Cardiology Authors: Imamura, T., Chung, B., Nguyen, A., Rodgers, D., Sayer, G., Adatya, S., Sarswat, N., Kim, G., Raikhelkar, J., Ota, T., Song, T., Juricek, C., Kagan, V., Jeevanandam, V., Mehra, M., Burkhoff, D., Uriel, N. Tags: Heart Failure Original Articles Source Type: research
NOD2 (Nucleotide-Binding Oligomerization Domain 2) Is a Major Pathogenic Mediator of Coxsackievirus B3-Induced Myocarditis [Original Articles]
Conclusions:
NOD2 is an important mediator in the viral uptake and inflammatory response during the pathogenesis of CVB3 myocarditis. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 14, 2017 Category: Cardiology Authors: Tschope, C., Muller, I., Xia, Y., Savvatis, K., Pappritz, K., Pinkert, S., Lassner, D., Heimesaat, M. M., Spillmann, F., Miteva, K., Bereswill, S., Schultheiss, H.-P., Fechner, H., Pieske, B., Kuhl, U., Van Linthout, S. Tags: Basic Science Research, Inflammation, Cardiomyopathy Original Articles Source Type: research
How Many Heart Failure Patients Might We SHIFT to a Lower Heart Rate? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 13, 2017 Category: Cardiology Authors: Eckman, P. M. Tags: Heart Failure Editorial Source Type: research
Ivabradine in Heart Failure: The Representativeness of SHIFT (Systolic Heart Failure Treatment With the IF Inhibitor Ivabradine Trial) in a Broad Population of Patients With Chronic Heart Failure [Original Articles]
Conclusions:
From the Swedish Heart Failure Registry, 14.2% of patients with HF were eligible for ivabradine. These patients more commonly were not receiving target β-blocker dose. Over time, a minority of patients became ineligible and an even smaller minority became eligible. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 13, 2017 Category: Cardiology Authors: Das, D., Savarese, G., Dahlstrom, U., Fu, M., Howlett, J., Ezekowitz, J. A., Lund, L. H. Tags: Clinical Studies, Heart Failure Original Articles Source Type: research
Dipeptidyl Peptidase-4 Inhibitors and Risk of Heart Failure in Patients With Type 2 Diabetes Mellitus: A Population-Based Cohort Study [Original Articles]
Conclusions:
Our findings suggest that DPP-4i use did not increase the risk of HF compared with sulfonylurea. In addition, the risks for cardiovascular outcomes were not elevated in DPP-4i–treated patients compared with sulfonylurea-treated patients. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 12, 2017 Category: Cardiology Authors: Kim, Y.-G., Yoon, D., Park, S., Han, S. J., Kim, D. J., Lee, K.-W., Park, R. W., Kim, H. J. Tags: Cardiovascular Disease, Diabetes, Type 2, Heart Failure Original Articles Source Type: research
Impact of Incident Heart Failure on Body Composition Over Time in the Health, Aging, and Body Composition Study Population [Original Articles]
Conclusions:
Incident HF in older adults was associated with disproportionate loss of lean mass, particularly among men. Prognostic implications are significant, with key sex-specific inferences on physical function, frailty, disability, and pharmacodynamics that all merit further investigation. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 12, 2017 Category: Cardiology Authors: Forman, D. E., Santanasto, A. J., Boudreau, R., Harris, T., Kanaya, A. M., Satterfield, S., Simonsick, E. M., Butler, J., Kizer, J. R., Newman, A. B. Tags: Heart Failure Original Articles Source Type: research
Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo [Original Articles]
Conclusions:
Hyperphosphorylation of this serine in cTnI C terminus impacts heart function by depressing diastolic function at baseline and limiting systolic reserve under physiological stresses. However, paradoxically, it preserves heart function after ischemia/reperfusion injury, potentially by decreasing proteolysis of cTnI. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 12, 2017 Category: Cardiology Authors: Li, Y., Zhu, G., Paolocci, N., Zhang, P., Takahashi, C., Okumus, N., Heravi, A., Keceli, G., Ramirez-Correa, G., Kass, D. A., Murphy, A. M. Tags: Basic Science Research, Hemodynamics, Myocardial Biology, Pathophysiology, Heart Failure Original Articles Source Type: research
Heart Failure Is Common and Under-Recognized in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia [Original Articles]
Conclusions:
HF symptoms, especially exertional dyspnea, are common in ARVC/D; yet, classic left-sided signs are typically absent and less than half have evidence of volume overload. Given the unique predominately right-sided phenotype, a large portion of patients with HF may be under-recognized. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 5, 2017 Category: Cardiology Authors: Gilotra, N. A., Bhonsale, A., James, C. A., te Riele, A. S. J., Murray, B., Tichnell, C., Sawant, A., Ong, C. S., Judge, D. P., Russell, S. D., Calkins, H., Tedford, R. J. Tags: Arrhythmias, Cardiomyopathy, Heart Failure Original Articles Source Type: research
Outflow Graft Occlusion of the HeartMate 3 Left Ventricular Assist Device [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 29, 2017 Category: Cardiology Authors: Duero Posada, J. G., Moayedi, Y., Alhussein, M., Rodger, M., Alvarez, J., Wintersperger, B. J., Ross, H. J., Butany, J., Billia, F., Rao, V. Tags: Cardiomyopathy, Heart Failure, Cardiovascular Surgery, Transplantation Images and Case Reports in Heart Failure Source Type: research
Goldilocks Dilemma of Dose Titration in Heart Failure With Reduced Ejection Fraction: Too Little, Too Much, or Just Right? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 8, 2017 Category: Cardiology Authors: Allen, L. A., Fang, J. C. Tags: Heart Failure Editorial Source Type: research
Progenitor Cells and Clinical Outcomes in Patients With Heart Failure [Original Articles]
Conclusions
PC levels are lower in patients with HF, and lower PC counts are strongly and independently predictive of mortality. Strategies to increase PCs and exogenous stem cell therapies designed to improve regenerative capacity in HF, especially, in HF with preserved ejection fraction, need to be further explored. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 8, 2017 Category: Cardiology Authors: Samman Tahhan, A., Hammadah, M., Sandesara, P. B., Hayek, S. S., Kalogeropoulos, A. P., Alkhoder, A., Mohamed Kelli, H., Topel, M., Ghasemzadeh, N., Chivukula, K., Ko, Y.-A., Aida, H., Hesaroieh, I., Mahar, E., Kim, J. H., Wilson, P., Shaw, L., Vaccarino, Tags: Stem Cells, Heart Failure, Mortality/Survival Original Articles Source Type: research
Dose of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers and Outcomes in Heart Failure: A Meta-Analysis [Original Articles]
Conclusions
In patients with HF with reduced ejection fraction, compared with lower doses, higher doses of ACEI and ARB significantly though modestly improved the composite end point of all-cause mortality or HF hospitalization without significantly increasing the chances of discontinuation. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 8, 2017 Category: Cardiology Authors: Khan, M. S., Fonarow, G. C., Ahmed, A., Greene, S. J., Vaduganathan, M., Khan, H., Marti, C., Gheorghiade, M., Butler, J. Tags: Heart Failure Original Articles Source Type: research
