Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide [Original Articles]
Conclusions
This is the first study to evaluate elamipretide in heart failure with reduced ejection fraction and demonstrates that a single infusion of elamipretide is safe and well tolerated. High-dose elamipretide resulted in favorable changes in left ventricular volumes that correlated with peak plasma concentrations, supporting a temporal association and dose–effect relationship. Further study of elamipretide is needed to determine long-term safety and efficacy.
Clinical Trial Registration
URL: https://www.clinicaltrials.gov. Unique identifier: NCT02388464. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 7, 2017 Category: Cardiology Authors: Daubert, M. A., Yow, E., Dunn, G., Marchev, S., Barnhart, H., Douglas, P. S., OConnor, C., Goldstein, S., Udelson, J. E., Sabbah, H. N. Tags: Metabolism, Cardiomyopathy, Heart Failure Original Articles Source Type: research
Detection of Urinary Mulberry Bodies Leads to Diagnosis of Fabry Cardiomyopathy: A Simple Clue in the Urine Sediment [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 4, 2017 Category: Cardiology Authors: Yano, T., Takahashi, R., Yamashita, T., Nagano, N., Ishikawa, A., Sakurai, A., Maruyama, H., Miura, T. Tags: Cardiomyopathy, Hypertrophy Images and Case Reports in Heart Failure Source Type: research
Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor [Original Articles]
Conclusions:
Myh6-sTNF mice with sustained inflammatory signaling develop proteasome dysfunction and impaired autophagic flux that is associated with enhanced mTORC1 activation. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 4, 2017 Category: Cardiology Authors: Hartupee, J., Szalai, G. D., Wang, W., Ma, X., Diwan, A., Mann, D. L. Tags: Basic Science Research, Inflammation, Myocardial Biology, Heart Failure, Inflammatory Heart Disease Original Articles Source Type: research
Correction to: Symptom Diary Use and Improved Survival for Patients With Heart Failure [Correction]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 4, 2017 Category: Cardiology Tags: Correction Source Type: research
The Changing Face of Cardiac Inflammation: New Opportunities in the Management of Myocarditis [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 20, 2017 Category: Cardiology Authors: Cooper, L. T. Tags: Cardiomyopathy, Heart Failure, Inflammatory Heart Disease Editorial Source Type: research
Cardiac Magnetic Resonance Imaging in Myocarditis Reveals Persistent Disease Activity Despite Normalization of Cardiac Enzymes and Inflammatory Parameters at 3-Month Follow-Up [Emerging Investigators]
Conclusions:
This is the first study reporting that cardiac enzymes and inflammatory parameters do not sufficiently reflect LGE in myocarditis. Although a majority of patients with normalizing laboratory markers experienced improved LGE, in a small percentage LGE worsened. These data suggest that cardiac magnetic resonance imaging might add value to currently existing diagnostic tools for risk assessment in myocarditis. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 20, 2017 Category: Cardiology Authors: Berg, J., Kottwitz, J., Baltensperger, N., Kissel, C. K., Lovrinovic, M., Mehra, T., Scherff, F., Schmied, C., Templin, C., Luscher, T. F., Heidecker, B., Manka, R. Tags: Biomarkers, Cardiomyopathy, Inflammatory Heart Disease, Imaging, Magnetic Resonance Imaging (MRI) Emerging Investigators Source Type: research
Pathogenic Role of the Damage-Associated Molecular Patterns S100A8 and S100A9 in Coxsackievirus B3-Induced Myocarditis [Original Articles]
Conclusions:
S100A8 and S100A9 aggravate CVB3-induced myocarditis and might serve as therapeutic targets in inflammatory cardiomyopathies. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 20, 2017 Category: Cardiology Authors: Muller, I., Vogl, T., Pappritz, K., Miteva, K., Savvatis, K., Rohde, D., Most, P., Lassner, D., Pieske, B., Kuhl, U., Van Linthout, S., Tschope, C. Tags: Animal Models of Human Disease, Basic Science Research, Cardiomyopathy Original Articles Source Type: research
Symptom Diary Use and Improved Survival for Patients With Heart Failure [Original Articles]
Conclusions:
In this study of 393 rural patients with HF, we found that greater diary use was associated with longer survival. These findings suggest that greater engagement in self-care behaviors is associated with better HF outcomes.
Clinical Trial Registration:
URL: https://www.clinicaltrials.gov. Unique Identifier: NCT00415545. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 20, 2017 Category: Cardiology Authors: Park, L. G., Dracup, K., Whooley, M. A., McCulloch, C., Jin, C., Moser, D. K., Clark, R. A., Pelter, M. M., Biddle, M., Howie Esquivel, J. Tags: Heart Failure Original Articles Source Type: research
Is There a Sweet Spot for Left Ventricular Assist Devices and Diabetes Mellitus? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 15, 2017 Category: Cardiology Authors: Young, J. B., Vest, A. R. Tags: Heart Failure Editorial Source Type: research
Multicenter Evaluation of Octreotide as Secondary Prophylaxis in Patients With Left Ventricular Assist Devices and Gastrointestinal Bleeding [Original Research Articles]
Conclusions
Patients with continuous-flow left ventricular assist device receiving secondary prophylaxis with octreotide had a significantly lower GI bleed recurrence compared with historical controls not treated with octreotide. Additional prospective studies are needed to confirm these data. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 15, 2017 Category: Cardiology Authors: Shah, K. B., Gunda, S., Emani, S., Kanwar, M. K., Uriel, N., Colombo, P. C., Uber, P. A., Sears, M. L., Chuang, J., Farrar, D. J., Brophy, D. F., Smallfield, G. B. Tags: Cardiomyopathy, Cardiovascular Surgery Original Research Articles Source Type: research
Unique Pattern of Aortic Regurgitation Caused by Rupture Into the Left Ventricular Interleaflet Triangle of a Sinus Valsalva Aneurysm Involving the Left Coronary Cusp [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 15, 2017 Category: Cardiology Authors: Mochizuki, Y., Iwahashi, K., Nakagiri, K., Shite, J. Tags: Heart Failure, Valvular Heart Disease, Aneurysm Images and Case Reports in Heart Failure Source Type: research
Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure: Results From REDHART (Recently Decompensated Heart Failure Anakinra Response Trial) [Original Research Articles]
Conclusions
No change in peak Vo2 occurred at 2 weeks in patients with recently decompensated systolic HF treated with anakinra, whereas an improvement was seen in those patients in whom anakinra was continued for 12 weeks. Additional larger studies are needed to validate the effects of prolonged anakinra on peak Vo2 and rehospitalization for HF.
Clinical Trial Registration
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01936909. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 15, 2017 Category: Cardiology Authors: Van Tassell, B. W., Canada, J., Carbone, S., Trankle, C., Buckley, L., Oddi Erdle, C., Abouzaki, N. A., Dixon, D., Kadariya, D., Christopher, S., Schatz, A., Regan, J., Viscusi, M., Del Buono, M., Melchior, R., Mankad, P., Lu, J., Sculthorpe, R., Biondi-Z Tags: Inflammation, Translational Studies, Heart Failure Original Research Articles Source Type: research
Contemporary Characteristics and Outcomes in Chagasic Heart Failure Compared With Other Nonischemic and Ischemic Cardiomyopathy [Original Research Articles]
Conclusions
Despite younger age, less comorbidity, and comprehensive use of conventional HF therapies, patients with Chagasic HF with reduced ejection fraction continue to have worse quality of life and higher hospitalization and mortality rates compared with other etiologies.
Clinical Trial Registration
PARADIGM-HF: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01035255; ATMOSPHERE: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00853658. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 15, 2017 Category: Cardiology Authors: Shen, L., Ramires, F., Martinez, F., Bodanese, L. C., Echeverria, L. E., Gomez, E. A., Abraham, W. T., Dickstein, K., Kober, L., Packer, M., Rouleau, J. L., Solomon, S. D., Swedberg, K., Zile, M. R., Jhund, P. S., Gimpelewicz, C. R., McMurray, J. J. V., o Tags: Heart Failure Original Research Articles Source Type: research
Impact of Diabetes Mellitus on Outcomes in Patients Supported With Left Ventricular Assist Devices: A Single Institutional 9-Year Experience [Original Research Articles]
Conclusions
DM is associated with increased rates of all-cause mortality and major adverse events despite favorable glycemic control after LVAD implantation. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 15, 2017 Category: Cardiology Authors: Asleh, R., Briasoulis, A., Schettle, S. D., Tchantchaleishvili, V., Pereira, N. L., Edwards, B. S., Clavell, A. L., Maltais, S., Joyce, D. L., Joyce, L. D., Daly, R. C., Kushwaha, S. S., Stulak, J. M. Tags: Diabetes, Type 2, Heart Failure, Complications, Mortality/Survival Original Research Articles Source Type: research
Notice of Retraction [Retraction]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 15, 2017 Category: Cardiology Tags: Retraction Source Type: research
