Evolving Story of Clinical Trials in Hypertrophic Cardiomyopathy [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - January 10, 2018 Category: Cardiology Authors: Elliott, P. M. Tags: Cardiomyopathy, Hypertrophy, Treatment Editorial Source Type: research
Intersection of Pulmonary Hypertension and Right Ventricular Dysfunction in Patients on Left Ventricular Assist Device Support: Is There a Role for Pulmonary Vasodilators? [Advances in Mechanical Circulatory Support]
Left ventricular assist devices (LVADs) improve survival and quality of life in patients with advanced heart failure. Despite these benefits, combined post- and precapillary pulmonary hypertension can be particularly problematic in patients on LVAD support, often exacerbating right ventricular (RV) dysfunction. Both persistently elevated pulmonary vascular resistance and RV dysfunction are associated with adverse outcomes, including death after LVAD. These observations have led to significant interest in the use of pulmonary vasodilators to treat pulmonary hypertension and preserve RV function among LVAD-supported patients...
Source: Circulation: Heart Failure - January 10, 2018 Category: Cardiology Authors: Sparrow, C. T., LaRue, S. J., Schilling, J. D. Tags: Heart Failure Advances in Mechanical Circulatory Support Source Type: research
Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy: The RESTYLE-HCM Randomized, Double-Blind, Placebo-Controlled Study [Original Articles]
Conclusions
In patients with nonobstructive HCM, ranolazine showed no overall effect on exercise performance, plasma prohormone brain natriuretic peptide levels, diastolic function, or quality of life. The drug showed an excellent safety profile and was associated with reduced premature ventricular complex burden. Late sodium current inhibition does not seem to improve functional capacity in HCM.
Clinical Trial Registration:
URL: https://www.clinicaltrialsregister.eu. Unique identifier: 2011-004507-20 (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - January 10, 2018 Category: Cardiology Authors: Olivotto, I., Camici, P. G., Merlini, P. A., Rapezzi, C., Patten, M., Climent, V., Sinagra, G., Tomberli, B., Marin, F., Ehlermann, P., Maier, L. S., Fornaro, A., Jacobshagen, C., Ganau, A., Moretti, L., Hernandez Madrid, A., Coppini, R., Reggiardo, G., P Tags: Clinical Studies, Cardiomyopathy Original Articles Source Type: research
Exercise Hemodynamic and Functional Capacity After Mitral Valve Replacement in Patients With Ischemic Mitral Regurgitation: A Comparison of Mechanical Versus Biological Prostheses [Original Articles]
Conclusions
In patients with ischemic mitral regurgitation, bioprostheses are associated with worse hemodynamic performance and reduced functional capacity, when compared with MVRm. Randomized studies with longer follow-up including quality of life and survival data are required to confirm these results. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - January 10, 2018 Category: Cardiology Authors: Fino, C., Iacovoni, A., Pibarot, P., Pepper, J. R., Ferrero, P., Merlo, M., Galletti, L., Caputo, M., Ferrazzi, P., Anagnostopoulos, C., Cugola, D., Senni, M., Bellavia, D., Magne, J. Tags: Chronic Ischemic Heart Disease, Valvular Heart Disease, Cardiovascular Surgery, Quality and Outcomes Original Articles Source Type: research
Skeletal Muscle Compensation for Cardiac Muscle Insufficiency in Heart Failure and Reduced Ejection Fraction [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - January 9, 2018 Category: Cardiology Authors: Reddy, Y. N. V., Obokata, M., Haykowsky, M. J., Borlaug, B. A. Tags: Exercise, Cardiomyopathy, Heart Failure Images and Case Reports in Heart Failure Source Type: research
Acute and Chronic Increases of Circulating FSTL1 Normalize Energy Substrate Metabolism in Pacing-Induced Heart Failure [Original Articles]
Conclusions
These findings support a novel function for FSTL1 and provide the first direct evidence that a circulating cardiokine/myokine can alter myocardial and systemic energy substrate metabolism, in vivo. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - January 9, 2018 Category: Cardiology Authors: Seki, M., Powers, J. C., Maruyama, S., Zuriaga, M. A., Wu, C.-L., Kurishima, C., Kim, L., Johnson, J., Poidomani, A., Wang, T., Munoz, E., Rajan, S., Park, J. Y., Walsh, K., Recchia, F. A. Tags: Animal Models of Human Disease, Growth Factors/Cytokines, Metabolism, Heart Failure Original Articles Source Type: research
The Heart Transplant Waiting List and the Interplay of Policy and Practice: In Search of Fairness [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 15, 2017 Category: Cardiology Authors: Stehlik, J., Wever-Pinzon, O. Tags: Transplantation, Mortality/Survival Editorial Source Type: research
Hemodynamics of Fontan Failure: The Role of Pulmonary Vascular Disease [Original Articles]
Conclusions
When coupled with low cardiac index, even mild elevations in PVRI identify patients at high risk of Fontan failure. This suggests that pulmonary vascular disease is a key mechanism underlying Fontan failure and supports further studies to understand the pathophysiology and target treatments to pulmonary vascular tone in this population. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 15, 2017 Category: Cardiology Authors: Egbe, A. C., Connolly, H. M., Miranda, W. R., Ammash, N. M., Hagler, D. J., Veldtman, G. R., Borlaug, B. A. Tags: Congenital Heart Disease Original Articles Source Type: research
Trends in the Use of Inotropes to List Adult Heart Transplant Candidates at Status 1A [Original Articles]
Conclusions
After the wider geographic sharing of hearts in 2006, transplant programs used multiple inotropes to list candidates at status 1A more frequently with progressively lower doses. Concurrently, the status 1A inotrope candidate waitlist outcomes improved substantially. These trends suggest that overtreatment with multiple inotropes contributes to the current critical excess of status 1A candidates. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 15, 2017 Category: Cardiology Authors: Parker, W. F., Garrity, E. R., Fedson, S., Churpek, M. M. Tags: Heart Failure, Transplantation, Ethics and Policy Original Articles Source Type: research
Cardiac-Specific Bdh1 Overexpression Ameliorates Oxidative Stress and Cardiac Remodeling in Pressure Overload-Induced Heart Failure [Original Articles]
Conclusions
We demonstrated that ketone body oxidation increased in failing hearts, and increased ketone body utilization decreased oxidative stress and protected against heart failure. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 14, 2017 Category: Cardiology Authors: Uchihashi, M., Hoshino, A., Okawa, Y., Ariyoshi, M., Kaimoto, S., Tateishi, S., Ono, K., Yamanaka, R., Hato, D., Fushimura, Y., Honda, S., Fukai, K., Higuchi, Y., Ogata, T., Iwai-Kanai, E., Matoba, S. Tags: Heart Failure, Remodeling Original Articles Source Type: research
Predicting Risk in Patients Hospitalized for Acute Decompensated Heart Failure and Preserved Ejection Fraction: The Atherosclerosis Risk in Communities Study Heart Failure Community Surveillance [Original Articles]
Conclusions
Mortality after acute decompensation in patients with heart failure with preserved ejection fraction is high, with one third of patients dying within a year. A prediction tool may allow for greater discrimination of the highest risk patients.
Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00005131 (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 14, 2017 Category: Cardiology Authors: Thorvaldsen, T., Claggett, B. L., Shah, A., Cheng, S., Agarwal, S. K., Wruck, L. M., Chang, P. P., Rosamond, W. D., Lewis, E. F., Desai, A. S., Lund, L. H., Solomon, S. D. Tags: Risk Factors, Heart Failure, Mortality/Survival Original Articles Source Type: research
Peer Review of a Manuscript Submission: A How-To Guide for Effective and Efficient Commentary [On My Mind]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 13, 2017 Category: Cardiology Authors: Allen, L. A., Ho, P. M. Tags: Ethics and Policy On My Mind Source Type: research
Breaking the Law of Small Numbers [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 13, 2017 Category: Cardiology Authors: Pang, P. S., Weaver, C. S. Tags: Heart Failure Editorial Source Type: research
Short-Term Outcomes and Factors Associated With Adverse Events Among Adults Discharged From the Emergency Department After Treatment for Acute Heart Failure [Original Articles]
Conclusions
We identified selected hospital and patient characteristics associated with short-term adverse outcomes. Further understanding of these factors may optimize safe outpatient management in ED-treated patients with heart failure. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 13, 2017 Category: Cardiology Authors: Sax, D. R., Mark, D. G., Hsia, R. Y., Tan, T. C., Tabada, G. H., Go, A. S. Tags: Epidemiology, Risk Factors, Heart Failure, Health Services Original Articles Source Type: research
Targeting Myocardial Energetics in the Failing Heart: Are We There Yet? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - December 7, 2017 Category: Cardiology Authors: Mann, D. L. Tags: Clinical Studies, Metabolism, Oxidant Stress Editorial Source Type: research
