Patient Perceptions on Facilitating Follow-Up After Heart Failure Hospitalization [Forum for Early Career Clinical Investigation]
Conclusions—
Among this cohort of racially diverse low-income patients hospitalized with HF, an appointment near the patient’s home and a reminder message were the most desired interventions to facilitate follow-up. Further study of similar populations nationwide is warranted. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 14, 2017 Category: Cardiology Authors: Breathett, K., DAmico, R., Adesanya, T. M. A., Hatfield, S., Willis, S., Sturdivant, R. X., Foraker, R. E., Smith, S., Binkley, P., Abraham, W. T., Peterson, P. N. Tags: Heart Failure, Health Services, Quality and Outcomes Forum for Early Career Clinical Investigation Source Type: research
Significance of Ischemic Heart Disease in Patients With Heart Failure and Preserved, Midrange, and Reduced Ejection Fraction: A Nationwide Cohort Study [Original Articles]
Conclusions—
HFmrEF resembled HFrEF rather than HFpEF with regard to both a higher prevalence of IHD and a greater risk of new IHD events. Established IHD was an important prognostic factor across all HF types. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 14, 2017 Category: Cardiology Authors: Vedin, O., Lam, C. S. P., Koh, A. S., Benson, L., Teng, T. H. K., Tay, W. T., Braun, O. O., Savarese, G., Dahlstrom, U., Lund, L. H. Tags: Etiology, Chronic Ischemic Heart Disease, Heart Failure, Myocardial Infarction Original Articles Source Type: research
Precision Medicine for Heart Failure: Lessons From Oncology [Development of Therapeutics for Heart Failure: Expedited Commentary]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 13, 2017 Category: Cardiology Authors: Feldman, A. M., Kontos, C. D., McClung, J. M., Gerhard, G. S., Khalili, K., Cheung, J. Y. Tags: Genetics, Cardiomyopathy, Heart Failure Development of Therapeutics for Heart Failure: Expedited Commentary Source Type: research
Microvascular Paradigm in Heart Failure With Preserved Ejection Fraction: A Quest for Proof of Concept [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 13, 2017 Category: Cardiology Authors: Waddingham, M. T., Paulus, W. J. Tags: Pathophysiology, Cardiomyopathy, Heart Failure Editorial Source Type: research
Decreased KCNE2 Expression Participates in the Development of Cardiac Hypertrophy by Regulation of Calcineurin-NFAT (Nuclear Factor of Activated T Cells) and Mitogen-Activated Protein Kinase Pathways [Original Articles]
Conclusions—
This study demonstrates that cardiac KCNE2 expression is decreased and contributes to the development of hypertrophy via activation of calcineurin–NFAT and mitogen-activated protein kinase pathways. Targeting KCNE2 is a potential therapeutic strategy for the treatment of hypertrophy. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 13, 2017 Category: Cardiology Authors: Liu, W., Deng, J., Ding, W., Wang, G., Shen, Y., Zheng, J., Zhang, X., Luo, Y., Lv, C., Wang, Y., Chen, L., Yan, D., Boudreau, R. L., Song, L.-S., Liu, J. Tags: Cardiomyopathy, Heart Failure, Hypertrophy Original Articles Source Type: research
Pulmonary Hypertension Is Associated With a Higher Risk of Heart Failure Hospitalization and Mortality in Patients With Chronic Kidney Disease: The Jackson Heart Study [Original Articles]
Conclusions—
Among African Americans with chronic kidney disease, PH, which is likely pulmonary venous hypertension, was associated with a higher risk of HF admission and mortality. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 13, 2017 Category: Cardiology Authors: Selvaraj, S., Shah, S. J., Ommerborn, M. J., Clark, C. R., Hall, M. E., Mentz, R. J., Qazi, S., Robbins, J. M., Skelton, T. N., Chen, J., Gaziano, J. M., Djousse, L. Tags: Heart Failure, Pulmonary Hypertension Original Articles Source Type: research
Patient-Reported Health-Related Quality of Life Is a Predictor of Outcomes in Ambulatory Heart Failure Patients Treated With Left Ventricular Assist Device Compared With Medical Management: Results From the ROADMAP Study (Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management) [Original Articles]
Conclusions—
LVAD therapy resulted in improvement of patient health status in heart failure patients with low self-reported hrQoL, but not in patients with acceptable quality of life at the time of LVAD implantation. Patient-reported hrQoL should be integrated into decision making concerning the use and timing of LVAD therapy in heart failure patients who are symptom limited but remain ambulatory.
Clinical Trial Registration—
URL: http://www.ClinicalTrials.gov. Unique identifier: NCT01452802. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 13, 2017 Category: Cardiology Authors: Stehlik, J., Estep, J. D., Selzman, C. H., Rogers, J. G., Spertus, J. A., Shah, K. B., Chuang, J., Farrar, D. J., Starling, R. C., on behalf of the ROADMAP Study Investigators Tags: Risk Factors, Heart Failure, Quality and Outcomes Original Articles Source Type: research
Design and Rationale of the Phase 3 ATTR-ACT Clinical Trial (Tafamidis in Transthyretin Cardiomyopathy Clinical Trial) [Advances in Clinical Trials]
Transthyretin amyloidosis is a rare, life-threatening disease resulting from aggregation and deposition of transthyretin amyloid fibrils in various tissues. There are 2 predominate phenotypic presentations of the disease: transthyretin familial amyloid polyneuropathy, which primarily affects the peripheral nerves, and transthyretin cardiomyopathy (TTR-CM), which primarily affects the heart. However, there is a wide overlap with symptoms at presentation and disease course being highly variable and influenced by the underlying transthyretin mutation, age of the affected individual, sex, and geographic location. Treatment of ...
Source: Circulation: Heart Failure - June 13, 2017 Category: Cardiology Authors: Maurer, M. S., Elliott, P., Merlini, G., Shah, S. J., Cruz, M. W., Flynn, A., Gundapaneni, B., Hahn, C., Riley, S., Schwartz, J., Sultan, M. B., Rapezzi, C., on behalf of the ATTR-ACT Study Investigators Tags: Clinical Studies Advances in Clinical Trials Source Type: research
Endothelial Senescence Contributes to Heart Failure With Preserved Ejection Fraction in an Aging Mouse Model [Original Articles]
Conclusions—
SAM develop endothelial dysfunction. Adding a high-salt, high-fat diet accelerates endothelial senescence and instigates endothelial inflammation. This coincides with hemodynamic and structural changes typical of HFpEF. Targeting endothelial senescence could be a new therapeutic avenue in HFpEF. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 13, 2017 Category: Cardiology Authors: Gevaert, A. B., Shakeri, H., Leloup, A. J., Van Hove, C. E., De Meyer, G. R. Y., Vrints, C. J., Lemmens, K., Van Craenenbroeck, E. M. Tags: Heart Failure Original Articles Source Type: research
Sex Differences in Mortality Based on United Network for Organ Sharing Status While Awaiting Heart Transplantation [Original Articles]
Conclusions—
When stratified by initial UNOS status, women had a higher mortality than men as UNOS status 1 and a lower mortality as UNOS status 2. With >20 sex interactions for mortality and transplantation, further evaluation is warranted to form a more equitable allocation system. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 13, 2017 Category: Cardiology Authors: Hsich, E. M., Blackstone, E. H., Thuita, L., McNamara, D. M., Rogers, J. G., Ishwaran, H., Schold, J. D. Tags: Heart Failure, Transplantation Original Articles Source Type: research
2017 ACC/AHA/HFSA/ISHLT/ACP Advanced Training Statement on Advanced Heart Failure and Transplant Cardiology (Revision of the ACCF/AHA/ACP/HFSA/ISHLT 2010 Clinical Competence Statement on Management of Patients With Advanced Heart Failure and Cardiac Transplant): A Report of the ACC Competency Management Committee [ACC/AHA/HFSA/ISHLT/ACP Advanced Training Statement]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 12, 2017 Category: Cardiology Authors: Jessup, M., Drazner, M. H., Book, W., Cleveland, J. C., Dauber, I., Farkas, S., Ginwalla, M., Katz, J. N., Kirkwood, P., Kittleson, M. M., Marine, J. E., Mather, P., Morris, A. A., Polk, D. M., Sakr, A., Schlendorf, K. H., Vorovich, E. E. Tags: Statements and Guidelines ACC/AHA/HFSA/ISHLT/ACP Advanced Training Statement Source Type: research
Accelerometer-Measured Daily Activity in Heart Failure With Preserved Ejection Fraction: Clinical Correlates and Association With Standard Heart Failure Severity Indices [Original Articles]
Conclusions—
Daily activity is a measure of HF-related and global functional status in HF with preserved ejection fraction. As compared with intermittently assessed standard HF assessments, change in daily activity may provide unique information about the impact of HF interventions on functional status.
Clinical Trial Registration—
URL: https://www.clinicaltrials.gov/. Unique identifier: NCT02053493 (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 6, 2017 Category: Cardiology Authors: Snipelisky, D., Kelly, J., Levine, J. A., Koepp, G. A., Anstrom, K. J., McNulty, S. E., Zakeri, R., Felker, G. M., Hernandez, A. F., Braunwald, E., Redfield, M. M. Tags: Lifestyle, Heart Failure Original Articles Source Type: research
Impact of Preeclampsia on Clinical and Functional Outcomes in Women With Peripartum Cardiomyopathy [Original Articles]
Conclusions—
PPCM with concomitant preeclampsia is associated with increased morbidity and mortality and different patterns of LV remodeling and recovery of LV function when compared with patients with PPCM that is not complicated by preeclampsia. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 1, 2017 Category: Cardiology Authors: Lindley, K. J., Conner, S. N., Cahill, A. G., Novak, E., Mann, D. L. Tags: Pregnancy, Cardiomyopathy, Preeclampsia Original Articles Source Type: research
Cardiorespiratory Fitness and Reclassification of Risk for Incidence of Heart Failure: The Veterans Exercise Testing Study [Original Articles]
Conclusions—
CRF is strongly, inversely, and independently associated with the incidence of HF in veterans referred for exercise testing. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 1, 2017 Category: Cardiology Authors: Myers, J., Kokkinos, P., Chan, K., Dandekar, E., Yilmaz, B., Nagare, A., Faselis, C., Soofi,, M. Tags: Epidemiology, Exercise Original Articles Source Type: research
Abnormal Global Longitudinal Strain Predicts Future Deterioration of Left Ventricular Function in Heart Failure Patients With a Recovered Left Ventricular Ejection Fraction [Original Articles]
Conclusions—
In patients with a recovered LVEF, an abnormal GLS predicts the likelihood of having a decreased LVEF during follow-up, whereas a normal GLS predicts the likelihood of stable LVEF during recovery. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 30, 2017 Category: Cardiology Authors: Adamo, L., Perry, A., Novak, E., Makan, M., Lindman, B. R., Mann, D. L. Tags: Clinical Studies, Contractile Function, Myocardial Biology, Cardiomyopathy, Heart Failure Original Articles Source Type: research
