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Technical Advances for the Clinical Genomic Evaluation of Sudden Cardiac Death: Verification of Next-Generation Sequencing Panels for Hereditary Cardiovascular Conditions Using Formalin-Fixed Paraffin-Embedded Tissues and Dried Blood Spots [Original Articles]
Conclusions— Similar performance characteristics were observed for next-generation sequencing of FFPET, whole blood, and dried blood spot in the evaluation of inherited CV disorders. Although blood is preferable for genetic analyses, this study offers an alternative when only FFPET is available. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Baudhuin, L. M., Leduc, C., Train, L. J., Avula, R., Kluge, M. L., Kotzer, K. E., Lin, P. T., Ackerman, M. J., Maleszewski, J. J. Tags: Sudden Cardiac Death, Genetics, Cardiomyopathy, Diagnostic Testing Original Articles Source Type: research

Heritability of Atrial Fibrillation [Original Articles]
Conclusions— Genetic variation contributes substantially to AF risk. The risk for AF conferred by genomic variation is similar to that observed for several other cardiovascular diseases. Established AF loci only explain a moderate proportion of disease risk, suggesting that further genetic discovery, with an emphasis on common variation, is warranted to understand the causal genetic basis of AF. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Weng, L.-C., Choi, S. H., Klarin, D., Smith, J. G., Loh, P.-R., Chaffin, M., Roselli, C., Hulme, O. L., Lunetta, K. L., Dupuis, J., Benjamin, E. J., Newton-Cheh, C., Kathiresan, S., Ellinor, P. T., Lubitz, S. A. Tags: Arrhythmias, Atrial Fibrillation, Epidemiology, Genetic, Association Studies, Genetics Original Articles Source Type: research

Metabolic Profiling of Adiponectin Levels in Adults: Mendelian Randomization Analysis [Original Articles]
Conclusions— Our findings indicate that blood adiponectin concentration is more likely to be an epiphenomenon in the context of metabolic disease than a key determinant. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Borges, M. C., Barros, A. J. D., Ferreira, D. L. S., Casas, J. P., Horta, B. L., Kivimaki, M., Kumari, M., Menon, U., Gaunt, T. R., Ben-Shlomo, Y., Freitas, D. F., Oliveira, I. O., Gentry-Maharaj, A., Fourkala, E., Lawlor, D. A., Hingorani, A. D. Tags: Biomarkers, Metabolism, Cardiovascular Disease, Epidemiology, Genetics Original Articles Source Type: research

Toward Genetics-Driven Early Intervention in Dilated Cardiomyopathy: Design and Implementation of the DCM Precision Medicine Study [Methods in Genetics and Clinical Interpretation]
Conclusions— We anticipate that this study will demonstrate that idiopathic DCM has a genetic basis and guide best practices for a genetics-driven approach to early intervention in at-risk relatives. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT03037632. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Kinnamon, D. D., Morales, A., Bowen, D. J., Burke, W., Hershberger, R. E., on behalf of the DCM Consortium* Tags: Clinical Studies, Genetics, Cardiomyopathy, Behavioral/Psychosocial Treatment, Compliance/Adherence Methods in Genetics and Clinical Interpretation Source Type: research

Identity-by-Descent Mapping Identifies Major Locus for Serum Triglycerides in Amerindians Largely Explained by an APOC3 Founder Mutation [Original Articles]
Conclusions— APOC3/APOA5 constitutes a major locus for serum triglycerides in Amerindians, especially the Pimas, and these results provide an empirical example for the concept that population-based linkage analysis is a useful strategy to identify complex trait variants. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Hsueh, W.-C., Nair, A. K., Kobes, S., Chen, P., Goring, H. H. H., Pollin, T. I., Malhotra, A., Knowler, W. C., Baier, L. J., Hanson, R. L. Tags: Lipids and Cholesterol, Genetic, Association Studies, Genetics Original Articles Source Type: research

Plasma Proteomics for Epidemiology: Increasing Throughput With Standard-Flow Rates [Original Articles]
Conclusions— The multiplexing capability of LC-MS combined with a standard-flow method increases throughput and reduces the costs of large-scale protein measurements in epidemiological cohorts, but protein rather than peptide standards will be required for defined absolute proteoform quantification. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Yin, X., Baig, F., Haudebourg, E., Blankley, R. T., Gandhi, T., Muller, S., Reiter, L., Hinterwirth, H., Pechlaner, R., Tsimikas, S., Santer, P., Willeit, J., Kiechl, S., Witztum, J. L., Sullivan, A., Mayr, M. Tags: Biomarkers, Proteomics, Epidemiology, Risk Factors Original Articles Source Type: research

Personalized Anticoagulation: Optimizing Warfarin Management Using Genetics and Simulated Clinical Trials [Original Articles]
Conclusions— Under the assumptions of this simulation, patients with atrial fibrillation can be triaged to an optimal warfarin therapy protocol by age and genotype. Clinicians should consider alternative anticoagulation therapy for patients with suboptimal outcomes under any warfarin protocol. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Ravvaz, K., Weissert, J. A., Ruff, C. T., Chi, C.-L., Tonellato, P. J. Tags: Atrial Fibrillation, Translational Studies, Genetics, Quality and Outcomes, Ischemic Stroke Original Articles Source Type: research

Statin Effects on Metabolic Profiles: Data From the PREVEND IT (Prevention of Renal and Vascular End-stage Disease Intervention Trial) [Original Articles]
Conclusions— These randomized clinical trial data demonstrate the widespread effects of pravastatin treatment on lipoprotein subclass profiles and fatty acids. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT03073018. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Kofink, D., Eppinga, R. N., van Gilst, W. H., Bakker, S. J. L., Dullaart, R. P. F., van der Harst, P., Asselbergs, F. W. Tags: Biomarkers, Lipids and Cholesterol, Metabolism, Pharmacology, Treatment Original Articles Source Type: research

MYH7 Rare Variant in a Family With Double-Chambered Left Ventricle [Clinical Genomic Cases]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Wang, J., Zhang, X., Wang, X., Wang, C., Wang, F., Wang, B. Tags: Cardiovascular Disease, Genetics, Cardiomyopathy, Heart Failure Clinical Genomic Cases Source Type: research

Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population [Original Articles]
Conclusions— Common genetic differences affecting the circulating concentration of ANP associated with blood pressure, whereas those affecting BNP did not, highlighting the blood pressure–lowering effect of ANP in the general population. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Salo, P. P., Havulinna, A. S., Tukiainen, T., Raitakari, O., Lehtimaki, T., Kahonen, M., Kettunen, J., Mannikko, M., Eriksson, J. G., Jula, A., Blankenberg, S., Zeller, T., Salomaa, V., Kristiansson, K., Perola, M. Tags: Biomarkers, Cardiovascular Disease, Genetic, Association Studies, Hypertension Original Articles Source Type: research

Familial Ebstein Anomaly: Whole Exome Sequencing Identifies Novel Phenotype Associated With FLNA [Original Articles]
Conclusions— Although congenital heart disease is reported in families with mutations in FLNA, this is the first report of individuals being affected by Ebstein anomaly because of a mutation in this gene and details the concurrent skeletal phenotype observed in this family. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Mercer, C. L., Andreoletti, G., Carroll, A., Salmon, A. P., Temple, I. K., Ennis, S. Tags: Cardiovascular Disease, Genetics, Congenital Heart Disease, Heart Failure Original Articles Source Type: research

Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers [Original Articles]
Conclusions— The truncation mutations were associated with manifestation of cardiac phenotypes in LMNA-related cardiomyopathy, suggesting that genetic analysis might be useful for diagnosis and risk stratification. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Authors: Nishiuchi, S., Makiyama, T., Aiba, T., Nakajima, K., Hirose, S., Kohjitani, H., Yamamoto, Y., Harita, T., Hayano, M., Wuriyanghai, Y., Chen, J., Sasaki, K., Yagihara, N., Ishikawa, T., Onoue, K., Murakoshi, N., Watanabe, I., Ohkubo, K., Watanabe, H., Ohno Tags: Arrhythmias, Sudden Cardiac Death, Genetic, Association Studies, Cardiomyopathy, Heart Failure Original Articles Source Type: research

Correction [Corrections]
(Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - December 13, 2017 Category: Cardiology Tags: Corrections Source Type: research