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Different Approaches for Catheter Ablation of Para-Hisian Accessory Pathways: Implications for Mapping and Ablation [Original Articles]
Conclusion— Most para-Hisian APs can be safely and effectively ablated by IVC-A, and ablation in the NCC is not an initial or a preferred approach. The degree of local ventriculoatrial fusion in the para-Hisian region during retrograde AP conduction can differentiate or predict the successful ablation site. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 6, 2017 Category: Cardiology Authors: Liang, M., Wang, Z., Liang, Y., Yang, G., Jin, Z., Sun, M., Han, Y. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology Original Articles Source Type: research

Electrocardiographic Preexcitation and Risk of Cardiovascular Morbidity and Mortality: Results From the Copenhagen ECG Study [Original Articles]
Conclusions— In this large ECG study, individuals with preexcitation had higher hazards of atrial fibrillation and heart failure. The higher hazard of heart failure seemed to be driven by a right anteroseptal accessory pathway. Among elderly people, we found a statistically significant association between preexcitation and a higher hazard of death. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 2, 2017 Category: Cardiology Authors: Skov, M. W., Rasmussen, P. V., Ghouse, J., Hansen, S. M., Graff, C., Olesen, M. S., Pietersen, A., Torp-Pedersen, C., Haunso, S., Kober, L., Svendsen, J. H., Holst, A. G., Nielsen, J. B. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Epidemiology, Heart Failure Original Articles Source Type: research

Outcomes of Ventricular Tachycardia Ablation Using Percutaneous Left Ventricular Assist Devices [Original Articles]
Conclusions— In this large single-center scar-related VT ablation experience, despite the worse clinical status of the patients selected for pLVAD support, clinical outcomes were better than expected and were similar to healthier patients not receiving hemodynamic support. Patients with dilated cardiomyopathy presenting with electrical storm, advanced heart failure, and severe left ventricular dysfunction most frequently received hemodynamic support during VT ablation. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 2, 2017 Category: Cardiology Authors: Kusa, S., Miller, M. A., Whang, W., Enomoto, Y., Panizo, J. G., Iwasawa, J., Choudry, S., Pinney, S., Gomes, A., Langan, N., Koruth, J. S., dAvila, A., Reddy, V. Y., Dukkipati, S. R. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology Original Articles Source Type: research

Induced Pluripotent Stem Cell-Based Treatment of Acquired Heart Block: The Battle for Tomorrow Has Begun! [Editorials]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 12, 2017 Category: Cardiology Authors: Liang, W., Lu, A., Davis, D. R. Tags: Arrhythmias, Cell Therapy, Cellular Reprogramming, Stem Cells, Pacemaker Editorials Source Type: research

Is TGF-{beta}1 (Transforming Growth Factor-{beta}1) an Enabler of Myofibroblast-Cardiomyocyte Cross Talk? [Editorials]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 12, 2017 Category: Cardiology Authors: Kaur, K., Jalife, J. Tags: Arrhythmias, Electrophysiology, Basic Science Research, Fibrosis, Pathophysiology Editorials Source Type: research

Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome [Original Articles]
Conclusions— In Brugada syndrome, AES is commonly located in the right ventricle epicardium and ajmaline exposes its extent and distribution, which is correlated with the degree of coved ST-elevation. AES elimination by radiofrequency ablation results in ECG normalization and VT/VF noninducibility. Substrate-based ablation is effective in potentially eliminating the arrhythmic consequences of this genetic disease. Clinical Trial Registration— URL: https://clinicaltrials.gov. Unique identifier: NCT02641431. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 12, 2017 Category: Cardiology Authors: Pappone, C., Brugada, J., Vicedomini, G., Ciconte, G., Manguso, F., Saviano, M., Vitale, R., Cuko, A., Giannelli, L., Calovic, Z., Conti, M., Pozzi, P., Natalizia, A., Crisa, S., Borrelli, V., Brugada, R., Sarquella-Brugada, G., Guazzi, M., Frigiola, A., Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Sudden Cardiac Death, Ventricular Fibrillation Original Articles Source Type: research

Efficacy of an Anatomical Approach in Radiofrequency Catheter Ablation of Idiopathic Ventricular Arrhythmias Originating From the Left Ventricular Outflow Tract [Original Articles]
Conclusions— When a standard catheter ablation targeting the best electrophysiological measure of idiopathic LVOT VAs was unsuccessful or had to be abandoned because of anatomic obstacles, an anatomic ablation was moderately successful. These idiopathic LVOT VAs with a successful anatomic ablation commonly arose from the intramural LVOT among the left coronary cusp, aortomitral continuity, and epicardium, occasionally the basal left ventricular summit, and rarely the LVOT septum near the His bundle. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 12, 2017 Category: Cardiology Authors: Yamada, T., Yoshida, N., Doppalapudi, H., Litovsky, S. H., McElderry, H. T., Kay, G. N. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator Original Articles Source Type: research

Mitral-Aortic Flow Reversal in Cardiac Resynchronization Therapy: Coupling With Ejection and Impact of Variations in Atrioventricular Delay [Original Articles]
Conclusions— Perfect coupling between mitral-aortic flow reversal and ejection flow in the left ventricle occurs at optimal AVD. As a result, full blood momentum in the outflow tract is used to facilitate early ejection. This can be measured and provides a new method for AVD optimization. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 12, 2017 Category: Cardiology Authors: Rodriguez Munoz, D., Moya Mur, J. L., Moreno, J., Fernandez-Golfin, C., Franco, E., Berlot, B., Monteagudo, J. M., Matia Frances, R., Hernandez Madrid, A., Zamorano, J. L. Tags: Hemodynamics, Heart Failure, Echocardiography, Pacemaker Original Articles Source Type: research

Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation [Original Articles]
Conclusions— The spatial resolution of AF data can significantly affect the interpretation of the underlying AF mechanism. Therefore, the interpretation of human AF data must be taken in the context of the spatial resolution of the recordings. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 12, 2017 Category: Cardiology Authors: Roney, C. H., Cantwell, C. D., Bayer, J. D., Qureshi, N. A., Lim, P. B., Tweedy, J. H., Kanagaratnam, P., Peters, N. S., Vigmond, E. J., Ng, F. S. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Computational Biology Original Articles Source Type: research

Effect of Digoxin Use Among Medicaid Enrollees With Atrial Fibrillation [Original Articles]
Conclusions— Our study demonstrates an overall increased risk of hospitalizations and mortality with digoxin use but no racial/ethnic differences in outcomes were observed. Further studies including minority populations are needed to critically evaluate these associations. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 12, 2017 Category: Cardiology Authors: Adedinsewo, D., Xu, J., Agasthi, P., Oderinde, A., Adekeye, O., Sachdeva, R., Rust, G., Onwuanyi, A. Tags: Arrhythmias, Epidemiology, Race and Ethnicity, Mortality/Survival Original Articles Source Type: research

TGF-{beta}1 (Transforming Growth Factor-{beta}1) Plays a Pivotal Role in Cardiac Myofibroblast Arrhythmogenicity [Original Articles]
Conclusions— TGF-β1 profoundly alters the electrophysiological phenotype of cardiac myofibroblasts. Apart from possibly contributing to the control of cell function in general, the changes proved to be pivotal for proarrhythmic myofibroblast–cardiomyocyte crosstalk in vitro, which suggests that TGF-β1 may play a potentially important role in arrhythmogenesis of the fibrotic heart. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 12, 2017 Category: Cardiology Authors: Salvarani, N., Maguy, A., De Simone, S. A., Miragoli, M., Jousset, F., Rohr, S. Tags: Arrhythmias, Basic Science Research, Fibrosis, Growth Factors/Cytokines, Ion Channels/Membrane Transport Original Articles Source Type: research

Induced Pluripotent Stem Cell-Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function [Original Articles]
Conclusions— iPSC-CMs can integrate into host myocardium and create a biological pacemaker. Although this is a promising development, rate and rhythm of the iPSC-CMs pacemakers remain to be optimized. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 12, 2017 Category: Cardiology Authors: Chauveau, S., Anyukhovsky, E. P., Ben-Ari, M., Naor, S., Jiang, Y.-P., Danilo, P., Rahim, T., Burke, S., Qiu, X., Potapova, I. A., Doronin, S. V., Brink, P. R., Binah, O., Cohen, I. S., Rosen, M. R. Tags: Arrhythmias, Electrophysiology, Animal Models of Human Disease, Basic Science Research Original Articles Source Type: research

Conquest of Ventricular Tachycardia: Insights Into Mechanisms, Innovations in Management: Contribution of Mark E. Josephson, MD, to Clinical Electrophysiology [Advances in Arrhythmia and Electrophysiology]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 9, 2017 Category: Cardiology Authors: Shenasa, M., Miller, J. M., Callans, D. J., Almendral, J. M., Marchlinski, F. E., Buxton, A. E. Tags: Arrhythmias, Electrophysiology Advances in Arrhythmia and Electrophysiology Source Type: research

Acute and Long-Term Effects of Full-Power Electroporation Ablation Directly on the Porcine Esophagus [Original Article]
Conclusions— Esophageal architecture remains unaffected 2 months after irreversible electroporation, purposely targeting the adventitia. Irreversible electroporation seems to be a safe modality for catheter ablation near the esophagus. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 9, 2017 Category: Cardiology Authors: Neven, K., van Es, R., van Driel, V., van Wessel, H., Fidder, H., Vink, A., Doevendans, P., Wittkampf, F. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Complications Original Article Source Type: research

Response by Michowitz and Belhassen to Letter Regarding Article, "Familial Occurrence of Atrioventricular Nodal Reentrant Tachycardia" [Correspondence]
(Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - May 4, 2017 Category: Cardiology Authors: Michowitz, Y., Belhassen, B. Tags: Electrophysiology Correspondence Source Type: research