Chinese Journal of Natural Medicines This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hematopoietic effect of small molecular fraction of Polygoni multiflori Radix Praeparata in cyclophosphamide-induced anemia mice
In conclusion, the SMF of PMRP promoted the recovery of hematopoietic function in a CTX-induced anemia mouse, which can support SMF to be used as an adjunct to chemotherapy to counteract its side effects. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - September 11, 2019 Category: Complementary Medicine Source Type: research

Three new bioactive flavonoid glycosides from Viscum album
Publication date: July 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 7Author(s): Jia-Kun DAI, Duo CAO, Cui-Hua LI, Jing GAO, Meng-Qing LI, Na FAN, Ya-Hui WEI, Zheng-Liang SUN, Meng-Yang HOUABSTRACTTwo new flavonoid glycosides, named viscumneoside XII (1), and viscumneoside XIII (2); a new dihydrogen flavonoid glycoside product named viscumneoside XIV (3), were isolated from the aerial part of Viscum album, along with seven known compounds (4−10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory ...
Source: Chinese Journal of Natural Medicines - September 11, 2019 Category: Complementary Medicine Source Type: research

Determination of five neurotransmitters in the rat brain for the study of the hypnotic effects of Ziziphi Spinosae Semen aqueous extract on insomnia rat model by UPLC-MS/MS
Publication date: July 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 7Author(s): Yan YAN, Qiang LI, Hui-Zhi DU, Chen-Xi SHEN, Ai-Ping LI, Xiang-Ping PEI, Chen-Hui DU, Xue-Mei QINABSTRACTZiziphi Spinosae Semen (ZSS) has been used for treatment of insomnia in China for centuries. To reveal the influence of insomnia on the levels of the neurotransmitters including serotonin (5-HT), glutamic acid (Glu), γ-aminobutyric acid (GABA), noradrenaline (NE) and dopamine (DA), and to study the role of ZSS aqueous extract in the treatment of insomnia, an UPLC-ESI- MS/MS method was developed and validated for simult...
Source: Chinese Journal of Natural Medicines - September 11, 2019 Category: Complementary Medicine Source Type: research

Microcos paniculata: a review on its botany, traditional uses, phytochemistry and pharmacology
Publication date: August 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 8Author(s): Ying-Qun JIANG, E-Hu LIUAbstractThe shrub Microcos paniulata (MPL; Tiliaceae), distributed in south China, south and southeast Asia, yields a phytomedicine used to treat heat stroke, fever, dyspepsia, diarrhea, insect bites and jaundice. Phytochemical investigations on different parts of MPL indicate the presence of flavonoids, alkaloids, triterpenoids and organic acids. The MPL leaves, fruits, barks and roots extracts showed antidiarrheal, antimicrobial and insecticidal, anti-inflammation, hepatoprotective, cardiovascul...
Source: Chinese Journal of Natural Medicines - August 30, 2019 Category: Complementary Medicine Source Type: research

Differential expression of the TwHMGS gene and its effect on triptolide biosynthesis in Tripterygium wilfordii
Publication date: August 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 8Author(s): Yu-Ru TONG, Yi-Feng ZHANG, Yu-Jun ZHAO, Tian-Yuan HU, Jia-Dian WANG, Lu-Qi HUANG, Wei GAOAbstract3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) is the first committed enzyme in the MVA pathway and involved in the biosynthesis of terpenes in Tripterygium wilfordii. The full-length cDNA and a 515 bp RNAi target fragment of TwHMGS were ligated into the pH7WG2D and pK7GWIWG2D vectors to respectively overexpress and silence, TwHMGS was overexpressed and silenced in T. wilfordii suspension cells using biolistic-gun mediated tr...
Source: Chinese Journal of Natural Medicines - August 30, 2019 Category: Complementary Medicine Source Type: research

Species identification of poisonous medicinal plant using DNA barcoding
Publication date: August 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 8Author(s): Miao LIU, Xi-Wen LI, Bao-Sheng LIAO, Lu LUO, Yue-Ying RENAbstractThe aim is to select a universal DNA barcode for identifying all poisonous medicinal plants in Chinese pharmacopoeia and their poisonous related species or adulterants. We chose 4 commonly used regions as candidate DNA barcodes (ITS2, psbA-trnH, matK and rbcL) and compared their identification efficiency in 106 species from 27 families and 65 genera totally. Data analysis was performed including the information of sequence alignment, inter/intra-specific ge...
Source: Chinese Journal of Natural Medicines - August 30, 2019 Category: Complementary Medicine Source Type: research

A novel protease-activated receptor 1 inhibitor from the leech Whitmania pigra
In conclusion,a novel PAR1 inhibitor pigrin was found from the leech Whitmania pigra. This study helped to elucidate the mechanism of the leech for the treatment of cardiovascular disorder. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - August 30, 2019 Category: Complementary Medicine Source Type: research

Dendrobium sonia polysaccharide regulates immunity and restores the dysbiosis of the gut microbiota of the cyclophosphamide-induced immunosuppressed mice
Publication date: August 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 8Author(s): Wei LIU, Ran YAN, Liang ZHANGAbstractTo recognize the potential medicinal value of the Dendrobium sonia, polysaccharide (DSP) was extracted, purified, and investigated for its immunomodulatory activity. In vitro, DSP was shown to enhance the viability (MTT assay) and phagocytosis of macrophages. In cyclophosphamide-induced immunosuppressed mice, DSP increased serum levels of TNF-α, IL-6 and IFN-γ (enzyme-linked immunosorbent assay, ELISA), and ameliorated the imbalance of the community of gut microbiota as detected by ...
Source: Chinese Journal of Natural Medicines - August 30, 2019 Category: Complementary Medicine Source Type: research

Investigation into perturbed nucleoside metabolism and cell cycle for elucidating the cytotoxicity effect of resveratrol on human lung adenocarcinoma epithelial cells
Publication date: August 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 8Author(s): Zheng LI, Qian-Qian CHEN, Christopher Wai Kei LAM, Jian-Ru GUO, Wei-Jia ZHANG, Cai-Yun WANG, Vincent Kam Wai WONG, Mei-Cun YAO, Wei ZHANGAbstractIn an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol (RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in signif...
Source: Chinese Journal of Natural Medicines - August 30, 2019 Category: Complementary Medicine Source Type: research

Effect of loureirin A against Candida albicans biofilms
Publication date: August 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 8Author(s): Mei-Yu LIN, Zhong-Lan YUAN, Dan-Dan HU, Gan-Hai HU, Ri-Li ZHANG, Hua ZHONG, Lan YAN, Yuan-Ying JIANG, Juan SU, Yan WANGAbstractLoureirin A is a major active component of Draconis sanguis, a traditional Chinese medicine. This work aimed to investigate the activity of loureirin A against Candida albicans biofilms. 2, 3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT)reduction assay and scanning electron microscopy were used to investigate the anti-biofilm effect. Minimal inhibitory concentration t...
Source: Chinese Journal of Natural Medicines - August 30, 2019 Category: Complementary Medicine Source Type: research

Five new polyhydroxylated furostanol saponins from the rhizomes of Tupistra chinensis
Publication date: August 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 8Author(s): Yu-Ze LI, Bei SONG, Xu-Dong ZHENG, Wen-Li HUANG, Hua-Wei ZHANG, Yi JIANG, Zheng-Gang YUE, Xiao-Mei SONG, Jian-Li LIUAbstractFive new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J–N (1–5), together with four known furostanol saponins (6–9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 val...
Source: Chinese Journal of Natural Medicines - August 30, 2019 Category: Complementary Medicine Source Type: research

Profiling and identification of aqueous extract of Cordyceps sinensis by ultra-high performance liquid chromatography tandem quadrupole-orbitrap mass spectrometry
This study presents a systematic characterization method based on a rapid chromatographic separation (8 min) on a polar-modified C18 (Waters Cortecs T3) column of aqueous extract of Cordyceps sinensis. UHPLC-HRMS method was used to profile components in both untargeted and targeted manners by full MS/PIL/dd-MS2 acquisition approach. The components were identified or tentatively identified by reference standards comparison, fragmentation rules elucidation and available databases search. A total of 91 components, including 10 nucleobases, 20 nucleosides, 39 dipeptides, 18 amino acids and derivatives and 4 other components, w...
Source: Chinese Journal of Natural Medicines - August 30, 2019 Category: Complementary Medicine Source Type: research

The mechanisms of traditional Chinese medicine underlying the prevention and treatment of atherosclerosis
Publication date: June 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 6Author(s): Ting-Ting LI, Zhi-Bin WANG, Yang LI, Feng CAO, Bing-You YANG, Hai-Xue KUANGAbstractAtherosclerosis (AS) is a chronic inflammatory disease associated with high morbidity and mortality. The incidence of AS is increasing in the last decades. So development of safe and effective therapeutics for treating AS has become prominently important. Although there are numerous chemical drugs available for treating AS, some drugs are not effective and some have serious side effects. Traditional Chinese medicine (TCM) has a long history ...
Source: Chinese Journal of Natural Medicines - June 29, 2019 Category: Complementary Medicine Source Type: research

3′-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels
This study reveals a pain-alleviating mechanism of dietary isoflavones and may provide a convenient avenue to alleviate pain. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - June 29, 2019 Category: Complementary Medicine Source Type: research

Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions
Publication date: June 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 6Author(s): Tae-Kyeong Lee, Joon Ha Park, Ji Hyeon Ahn, Hyunjung Kim, Minah Song, Jae-Chul Lee, Jong Dai Kim, Yong Hwan Jeon, Jung Hoon Choi, Choong Hyun Lee, In Koo Hwang, Bing-Chun YAN, Moo-Ho Won, Il Jun KangAbstractTo examine the effects of Populus tomentiglandulosa (PT) extract on the expressions of antioxidant enzymes and neurotrophic factors in the cornu ammonis 1 (CA1) region of the hippocampus at 5 min after inducing transient global cerebral ischemia (TGCI) in gerbils, TGCI was induced by occlusion of common carotid arteries...
Source: Chinese Journal of Natural Medicines - June 29, 2019 Category: Complementary Medicine Source Type: research