Implications of vessel co-option in sorafenib-resistant hepatocellular carcinoma.
Authors: Kuczynski EA, Kerbel RS
Abstract
The reason why tumors generally have a modest or transient response to antiangiogenic therapy is not well understood. This poses a major challenge for sorafenib treatment of advanced hepatocellular carcinoma (HCC) where alternate therapies are lacking. We recently published a paper entitled "Co-option of liver vessels and not sprouting angiogenesis drives acquired sorafenib resistance in hepatocellular carcinoma" in the Journal of the National Cancer Institute, providing a potential explanation for this limited benefit. We found that in mice bearing HCCs that had a...
Source: Chinese Journal of Cancer - November 28, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Development and validation of a nomogram for predicting the survival of patients with non-metastatic nasopharyngeal carcinoma after curative treatment.
CONCLUSION: We developed and validated a novel nomogram that outperformed the TNM staging system in predicting the OS of non-metastatic NPC patients who underwent curative therapy.
PMID: 27887636 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 28, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prognostic value and predictive threshold of tumor volume for patients with locally advanced nasopharyngeal carcinoma receiving intensity-modulated radiotherapy.
CONCLUSION: In patients with locally advanced NPC, GTV-P >46.4 mL is an independent unfavorable prognostic indicator for survival after IMRT, with a prognostic value superior to that of T category.
PMID: 27852284 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 19, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis.
CONCLUSIONS: The current evidence suggests that PDCD4 down-regulation is involved in the progression of several types of solid tumor and is a potential marker for solid tumor prognoses. Its clinical usefulness should be confirmed by large-scale prospective studies.
PMID: 27852288 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 19, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Treatment implications of posterior fossa ependymoma subgroups.
Authors: Ramaswamy V, Taylor MD
Abstract
Posterior fossa ependymoma comprises two distinct molecular entities, ependymoma_posterior fossa A (EPN_PFA) and ependymoma_posterior fossa B (EPN_PFB), with differentiable gene expression profiles. As yet, the response of the two entities to treatment is unclear. To determine the relationship between the two molecular subgroups of posterior fossa ependymoma and treatment, we studied a cohort of 820 patients with molecularly profiled, clinically annotated posterior fossa ependymomas. We found that the strongest predictor of poor outcome in patients with posterior fo...
Source: Chinese Journal of Cancer - November 18, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma.
Authors: Li WF, Chen L, Sun Y, Ma J
Abstract
The value of adding induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) for the treatment of locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear. In our recent article entitled "Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial" published in the Lancet Oncology, we reported the results of a phase III, multicenter, randomized controlled trial comparing cisplatin, 5-fluorouracil,...
Source: Chinese Journal of Cancer - November 18, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
A combination therapy for KRAS-mutant lung cancer by targeting synthetic lethal partners of mutant KRAS.
Authors: Pang X, Liu M
Abstract
The KRAS gene is frequently mutated in multiple cancer types, but it fell off the drug discovery radar for many years because of its inherent "undruggable" structure and undefined biological properties. As reported in the paper entitled "Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK" in Nature Communications, we performed a synthetic lethal screening with a combinatorial strategy on a panel of clinical drugs; we found that combined inhibition of polo-like kinase 1 and RhoA/Rho kinase markedly suppressed tumor growth in mice. An ...
Source: Chinese Journal of Cancer - November 1, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Radiation-induced osteosarcoma of the maxilla and mandible after radiotherapy for nasopharyngeal carcinoma.
CONCLUSIONS: RISOM after radiotherapy for NPC is aggressive and often eludes early detection and timely intervention. Surgery combined with postoperative chemotherapy might be an effective treatment to improve patient survival.
PMID: 27729091 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 14, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
What do oncologists need to know about biosimilar products?
Authors: Leung LK, Mok K, Liu C, Chan SL
Abstract
Many biologic products have improved the outcomes of cancer patients, but the costs can substantially burden healthcare systems. Biosimilar products can potentially reduce drug costs and increase patient access to beneficial treatments. Approval of a biosimilar product relies on the demonstration of "comparability" or "no clinically meaningful differences" as compared to its reference biologic product. Biosimilar products for erythropoietin, granulocyte colony-stimulating factor, trastuzumab, and rituximab are already available, and the regulatory processes...
Source: Chinese Journal of Cancer - October 14, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
ABO blood group is a predictor of survival in patients with laryngeal cancer.
CONCLUSIONS: The ABO blood group is associated with survival in patients with laryngeal cancer. Patients with blood group O had significantly shorter OS than patients with other ABO blood groups.
PMID: 27733208 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 14, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Overuse of colorectal cancer screening services in the United States and its implications.
Authors: Bian J
Abstract
As a standard way for prevention and early detection of colorectal cancer (CRC), colonoscopy has been used for CRC screening in the United States for more than one decade. An article entitled "Assessing Colorectal Cancer Screening Adherence of Medicare Fee-For-Service Beneficiaries Age 76 to 95 Years" recently published at the Journal of Oncology Practice reports the trends in overuse of CRC screening services among average-risk elderly populations at the age of 76-95 years. Several reasons for overusing colonoscopy have been postulated, and some strategies for reducing overuse of...
Source: Chinese Journal of Cancer - September 19, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
New risk factors and new tendency for central nervous system relapse in patients with diffuse large B-cell lymphoma: a retrospective study.
CONCLUSIONS: In the present study, rituximab decreased the CNS relapse rate of DLBCL, whereas intrathecal chemotherapy prophylaxis alone was not sufficient for preventing CNS relapse. Serum levels of ALB and ALP, and the time to complete remission were new independent predictive factors for CNS relapse in the patients with DLBCL. In the patients received R-CHOP regimen, a trend of increased CNS relapse was found to be associated with extranodal lesions.
PMID: 27624700 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 16, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Phase II open-label study of recombinant circularly permuted TRAIL as a single-agent treatment for relapsed or refractory multiple myeloma.
CONCLUSIONS: CPT as a single agent can elicit a response in patients with RRMM and is well tolerated. Further clinical investigation is warranted. Trial Registration ChiCTR-ONC-12002065 http://www.chictr.org/cn.
PMID: 27608772 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 11, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Associations of genetic polymorphisms of the transporters organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1), and ATP-binding cassette subfamily C member 2 (ABCC2) with platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients.
CONCLUSION: OCT2 rs316019, MATE1 rs2289669, and ABCC2 rs717620 might be potential clinical markers for predicting chemotherapy toxicity and response induced by platinum-based treatment in NSCLC patients. Trial registration Chinese Clinical Trial Registry ChiCTR-RNC-12002892.
PMID: 27590272 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 5, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
What did Sun Yat-sen really die of? A re-assessment of his illness and the cause of his death.
Authors: Barth RF, Chen J
Abstract
This year is the 150th anniversary of the birth of Sun Yat-sen (November 12, 1866) and the 91st year following his death (March 12, 1925). It generally has been believed that the cause of his death was "liver cancer." However, as indicated in the official autopsy report, dated March 13, 1925, of the Peking Union Medical College Hospital (PUMCH) in Beijing, the cause of his death in reality was an adenocarcinoma of the gallbladder with direct extension to the liver and diaphragm as well as widespread metastases to the peritoneal cavity. This important piece of information ...
Source: Chinese Journal of Cancer - September 4, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
