Radiotherapy with neoadjuvant chemotherapy versus concurrent chemoradiotherapy for ascending-type nasopharyngeal carcinoma: a retrospective comparison of toxicity and prognosis.
CONCLUSIONS: The treatment outcomes of the NACT + RT and CCRT groups were similar; however, CCRT led to higher rates of acute and late toxicities. NACT + RT may therefore be a better treatment strategy for ascending-type NPC.
PMID: 28264724 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 9, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Weekly taxane-anthracycline combination regimen versus tri-weekly anthracycline-based regimen for the treatment of locally advanced breast cancer: a randomized controlled trial.
CONCLUSIONS: In patients with locally advanced breast cancer, weekly PE was not superior to FEC in terms of pCR. However, weekly PE has a higher response rate and superior down-staging effects. On this account, the PE regimen may be considered an alternative option for locally advanced breast cancer. Long-term follow-up data are needed to confirm the efficacy of this regimen on locally advanced breast cancer. Trial registration Chinese clinical trial registry, ChiCTR-TRC-10001043, September 21, 2014.
PMID: 28270181 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 9, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Ailanthone: a new potential drug for castration-resistant prostate cancer.
Authors: Peng S, Yi Z, Liu M
PMID: 28257652 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 6, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Californium-252 neutron brachytherapy combined with external pelvic radiotherapy plus concurrent chemotherapy for cervical cancer: a retrospective clinical study.
CONCLUSION: For patients with cervical cancer, neutron brachytherapy combined with external-beam radiotherapy plus concurrent chemotherapy produces a rapid response and greatly improves local control and long-term survival rates with tolerable adverse effects.
PMID: 28245859 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 3, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Predictive model for 5-year mortality after breast cancer surgery in Taiwan residents.
CONCLUSIONS: Compared with the conventional MLR and Cox models, the ANN model was more accurate in predicting 5-year mortality of breast cancer patients who underwent surgery. The mortality predictors identified in this study can also be used to educate candidates for breast cancer surgery with respect to the course of recovery and health outcomes.
PMID: 28241793 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 2, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Cell cycle-independent roles of p19(INK4d) in human terminal erythropoiesis.
Authors: Han X, Liu J
PMID: 28228163 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - February 24, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prognostic value of alcohol consumption and some other dietary habits for survival in a cohort of Chinese men with lung cancer.
CONCLUSIONS: Occasional consumption of alcohol was a favorable survival factor for Chinese men with lung cancer. However, this survival benefit did not exist for frequent drinkers of alcohol. Chinese men with lung cancer who were frequent consumers of fried or preserved food had a worse prognosis than those who consumed these foods only occasionally.
PMID: 28187735 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - February 13, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Proportion and clinical features of never-smokers with non-small cell lung cancer.
CONCLUSIONS: More than one-third of the Korean patients with NSCLC were never-smokers. NSCLC in never-smokers had different clinical characteristics and major driver mutations and resulted in longer overall survival compared with NSCLC in ever-smokers.
PMID: 28179026 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - February 11, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Id4 promotes cell proliferation in hepatocellular carcinoma.
CONCLUSION: Id4 may be developed as a potent therapeutic agent for the treatment of HCC, but more details about the underlying mechanisms of action are needed.
PMID: 28143562 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - February 3, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The most important questions in cancer research and clinical oncology-Question 2-5. Obesity-related cancers: more questions than answers.
Authors: Venniyoor A
Abstract
Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobacco-related cancers are well characterized and effective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy (metabolically healthy obese, MHO), so which fat deposition (subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogene...
Source: Chinese Journal of Cancer - February 3, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Metformin targets multiple signaling pathways in cancer.
Authors: Lei Y, Yi Y, Liu Y, Liu X, Keller ET, Qian CN, Zhang J, Lu Y
Abstract
Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 diabetes, has become the focus of intense research as a candidate anticancer agent. Here, we discuss the potential of metformin in cancer therapeutics, particularly its functions in multiple signaling pathways, including AMP-activated protein kinase, mammalian target of rapamycin, insulin-like growth factor, c-Jun N-terminal kinase/mitogen-activated protein kinase (p38 MAPK), human epidermal growth factor receptor-2, and n...
Source: Chinese Journal of Cancer - January 28, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
For robust big data analyses: a collection of 150 important pro-metastatic genes.
Authors: Mei Y, Yang JP, Qian CN
Abstract
Metastasis is the greatest contributor to cancer-related death. In the era of precision medicine, it is essential to predict and to prevent the spread of cancer cells to significantly improve patient survival. Thanks to the application of a variety of high-throughput technologies, accumulating big data enables researchers and clinicians to identify aggressive tumors as well as patients with a high risk of cancer metastasis. However, there have been few large-scale gene collection studies to enable metastasis-related analyses. In the last several years, emerging eff...
Source: Chinese Journal of Cancer - January 24, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study.
CONCLUSIONS: ASPP1 might be involved in the progression of ESCC, and ASPP2 was a potential prognostic biomarker of ESCC and should be evaluated in future studies.
PMID: 28103919 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 22, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma.
CONCLUSIONS: MWA is as safe and effective as RFA in treating very-early-stage HCC, supporting MWA as a first-line treatment option for this disease.
PMID: 28103953 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 22, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The most important questions in cancer research and clinical oncology : Question 1. Could the vertical transmission of human papilloma virus (HPV) infection account for the cause, characteristics, and epidemiology of HPV-positive oropharyngeal carcinoma, non-smoking East Asian female lung adenocarcinoma, and/or East Asian triple-negative breast carcinoma?
Authors: Wee JT, Poh SS
Abstract
Specific research foci: (1) Mouse models of gamma-herpes virus-68 (γHV-68) and polyomavirus (PyV) infections during neonatal versus adult life. (2) For human papilloma virus (HPV)-positive oropharyngeal carcinoma (OPC)-(a) Asking the question: Is oral sex a powerful carcinogen? (b) Examining the evidence for the vertical transmission of HPV infection. (c) Examining the relationship between HPV and Epstein-Barr virus (EBV) infections and nasopharyngeal cancer (NPC) in West European, East European, and East Asian countries. (d) Examining the association between HPV-positive ...
Source: Chinese Journal of Cancer - January 19, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
