The 150 most important questions in cancer research and clinical oncology series: Questions 25-30 : Edited by Chinese Journal of Cancer.
Authors: Chinese Journal of Cancer
Abstract
To accelerate our endeavors to overcome cancer, Chinese Journal of Cancer has launched a program of publishing 150 most important questions in cancer research and clinical oncology. In this article, 6 more questions are presented as followed. Question 25: Does imprinting of immune responses to infections early in life predict future risk of childhood and adult cancers? Question 26: How to induce homogeneous tumor antigen expression in a heterogeneous tumor mass to enhance the efficacy of cancer immunotherapy? Question 27: Could we enhance the therapeutic effects ...
Source: Chinese Journal of Cancer - May 7, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China: a hospital-based, multicenter, cross-sectional survey.
CONCLUSIONS: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic, and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective.
PMID: 28454595 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - April 30, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Significance of spatial organization of chromosomes in the progression of acute myeloid leukemia.
Authors: Tian X, Wang Y, Chen D, Ke X, Ma W
PMID: 28427460 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - April 23, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The 150 most important questions in cancer research and clinical oncology series: questions 15-24 : Edited by Chinese Journal of Cancer.
Authors: Chinese Journal of Cancer
Abstract
To accelerate our endeavors to overcome cancer, Chinese Journal of Cancer has launched a program of publishing 150 most important questions in cancer research and clinical oncology. In this article, 10 more questions are presented as follows. Question 15: Can tumor-induced erythrogenesis provide qualified red blood cells for carrying oxygen to distant organs? Question 16: Can we overcome tumor resistance to platinum-containing antineoplastic drugs by activating the sensitivity factors in the tumor? Question 17: How can a cancer cell stay dormant for years? Questi...
Source: Chinese Journal of Cancer - April 8, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Cancer metastasis: issues and challenges.
Authors: Qian CN, Mei Y, Zhang J
Abstract
Metastasis is the major cause of treatment failure in cancer patients and of cancer-related deaths. This editorial discusses how cancer metastasis may be better perceived and controlled. Based on big-data analyses, a collection of 150 important pro-metastatic genes was studied. Using The Cancer Genome Atlas datasets to re-analyze the effect of some previously reported metastatic genes-e.g., JAM2, PPARGC1A, SIK2, and TRAF6-on overall survival of patients with renal and liver cancers, we found that these genes are actually protective factors for patients with cancer....
Source: Chinese Journal of Cancer - April 6, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Rad51 inhibition sensitizes breast cancer stem cells to PARP inhibitor in triple-negative breast cancer.
Authors: Wang D, Du R, Liu S
PMID: 28359295 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - April 2, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The 150 most important questions in cancer research and clinical oncology series: questions 6-14 : Edited by Chinese Journal of Cancer.
Authors: Chinese Journal of Cancer
Abstract
To accelerate our endeavors to overcome cancer, Chinese Journal of Cancer has launched a program of publishing 150 most important questions in cancer research and clinical oncology. In this article, nine more questions are presented as followed. Question 6. Why do nasopharyngeal carcinomas rarely metastasize to the brain? Question 7. Can distant spread of cancer cells be blocked by inhibiting the remodeling of high endothelial venules in the sentinel lymph node? Question 8. What sort of live-imaging techniques can be developed to directly observe the dynamic proc...
Source: Chinese Journal of Cancer - March 31, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Progressive multifocal exophytic pontine glioblastoma: a case report with literature review.
We present a case of a 5-year-old girl with consecutive neurological imaging and other clinical findings indicating progressive multifocal exophytic pontine glioblastoma. Three lesions were reported, of which two were initially presented, and one was developed 2 months later. One lesion demonstrated a progressing exophytic extension in the cistern of the left side of the CPA. The other two lesions were located and confined within the pons. Initial magnetic resonance imaging and positron emission tomography-computed tomography indicated low-grade glioma or inflammatory disease. However, 2 and 3 months later, subsequent ma...
Source: Chinese Journal of Cancer - March 31, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Down-regulation of E-cadherin enhances prostate cancer chemoresistance via Notch signaling.
CONCLUSION: The down-regulation of E-cadherin enhances PCa chemoresistance via Notch signaling, and inhibiting the Notch signaling pathway may reverse PCa chemoresistance.
PMID: 28356132 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 31, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis.
Authors: Xie HY, Shao ZM, Li DQ
Abstract
Distant metastasis to specific target organs is responsible for over 90% of breast cancer-related deaths, but the underlying molecular mechanism is unclear. Mounting evidence suggests that the interplay between breast cancer cells and the target organ microenvironment is the key determinant of organ-specific metastasis of this lethal disease. Here, we highlight new findings and concepts concerning the emerging role of the tumor microenvironment in breast cancer metastasis; we also discuss potential therapeutic intervention strategies aimed at targeting components of...
Source: Chinese Journal of Cancer - March 31, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Clinical treatment considerations in the intensity-modulated radiotherapy era for patients with N0-category nasopharyngeal carcinoma and enlarged neck lymph nodes.
CONCLUSIONS: A BED of 72 Gy to ENLNs is considerably sufficient to provide a clinical benefit to patients with N0-category NPC. Prospective studies are warranted to validate the findings in the present study.
PMID: 28340596 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 28, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Left jackknife position: a novel position for laparoscopic hepatectomy.
CONCLUSIONS: For HCC located in segment VI, VII, or VIII, laparoscopic hepatectomy with this novel position-the left jackknife position-is safe and effective during tumor resection by exposing a sufficient operating field. Trial registration ClinicalTrials.gov ID: NCT02809287.
PMID: 28320486 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 24, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The US Chinese Anti-Cancer Association and the Asian Fund for Cancer Research Recognize Young Chinese Cancer Researchers with the 2016 USCACA-AFCR scholar awards.
Authors: Zhang W, Yan L, Zhang W, Tong Y, Cheng SY
PMID: 28314389 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 23, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Immune mediators in the tumor microenvironment of prostate cancer.
Authors: Dai J, Lu Y, Roca H, Keller JM, Zhang J, McCauley LK, Keller ET
Abstract
Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the tissue in which the tumor originates (e.g., fibroblasts and endothelial cells) or those recruited, through chemotactic or other factors, to the tumor (e.g., circulating immune cells). Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the tumor. Immune cells can...
Source: Chinese Journal of Cancer - March 18, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Corepressor metastasis-associated protein 3 modulates epithelial-to-mesenchymal transition and metastasis.
Authors: Du L, Ning Z, Zhang H, Liu F
Abstract
Worldwide, metastasis is the leading cause of more than 90% of cancer-related deaths. Currently, no specific therapies effectively impede metastasis. Metastatic processes are controlled by complex regulatory networks and transcriptional hierarchy. Corepressor metastasis-associated protein 3 (MTA3) has been confirmed as a novel component of nucleosome remodeling and histone deacetylation (NuRD). Increasing evidence supports the theory that, in the recruitment of transcription factors, coregulators function as master regulators rather than passive passengers. As...
Source: Chinese Journal of Cancer - March 12, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
