---
Cellular Microbiology,Volume 20, Issue 4, April 2018. (Source: Cellular Microbiology)
Source: Cellular Microbiology - December 22, 2017 Category: Microbiology Source Type: research
Modelling persistent Mycoplasma pneumoniae infection of human airway epithelium
Abstract
Mycoplasma pneumoniae is a human respiratory tract pathogen causing acute and chronic airway disease states that can include long‐term carriage and extrapulmonary spread. The mechanisms of persistence and migration beyond the conducting airways, however, remain poorly understood. We previously described an acute exposure model using normal human bronchial epithelium (NHBE) in air–liquid interface culture, showing that M. pneumoniae gliding motility is essential for initial colonisation and subsequent spread, including localisation to epithelial cell junctions. We extended those observations here, characterizi...
Source: Cellular Microbiology - December 22, 2017 Category: Microbiology Authors: Oliver A. Prince, Thomas M. Krunkosky, Edward S. Sheppard, Duncan C. Krause Tags: RESEARCH ARTICLE Source Type: research
Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversal
Abstract
Gliding motility and cell traversal by the Plasmodium ookinete and sporozoite invasive stages allow penetration of cellular barriers to establish infection of the mosquito vector and mammalian host, respectively. Motility and traversal are not observed in red cell infectious merozoites, and we have previously classified genes that are expressed in sporozoites but not merozoites (S genes) in order to identify proteins involved in these processes. The S4 gene has been described as critical for Cell Traversal of Ookinetes and Sporozoites (CelTOS), yet knockout parasites (s4/celtos¯) do not generate robust salivary g...
Source: Cellular Microbiology - December 19, 2017 Category: Microbiology Authors: Ryan W.J. Steel, Ying Pei, Nelly Camargo, Alexis Kaushansky, Dorender A. Dankwa, Thomas Martinson, Thao Nguyen, Will Betz, Hayley Cardamone, Vladimir Vigdorovich, Nicholas Dambrauskas, Sara Carbonetti, Ashley M. Vaughan, Noah D. Sather, Stefan H.I. Kappe Tags: RESEARCH ARTICLE Source Type: research
The entry of Salmonella in a distinct tight compartment revealed at high temporal and ultrastructural resolution
Abstract
Salmonella enterica induces membrane ruffling and genesis of macropinosomes during its interactions with epithelial cells. This is achieved through the type three secretion system‐1 (T3SS‐1), which first mediates bacterial attachment to host cells and then injects bacterial effector proteins to alter host behavior. Next, Salmonella enters into the targeted cell within an early membrane‐bound compartment that matures into a slow growing, replicative niche called the Salmonella Containing Vacuole (SCV). Alternatively, the pathogen disrupts the membrane of the early compartment and replicate at high rate in the...
Source: Cellular Microbiology - December 18, 2017 Category: Microbiology Authors: Jennifer Fredlund, Jos é Carlos Santos, Virginie Stévenin, Allon Weiner, Patricia Latour‐Lambert, Katya Rechav, Adeline Mallet, Jacomine Krijnse‐Locker, Michael Elbaum, Jost Enninga Tags: RESEARCH ARTICLE Source Type: research
Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversal
Cellular Microbiology,Volume 20, Issue 4, April 2018. (Source: Cellular Microbiology)
Source: Cellular Microbiology - December 18, 2017 Category: Microbiology Source Type: research
The entry of Salmonella in a distinct tight compartment revealed at high temporal and ultrastructural resolution
Cellular Microbiology,Volume 20, Issue 4, April 2018. (Source: Cellular Microbiology)
Source: Cellular Microbiology - December 18, 2017 Category: Microbiology Source Type: research
---
Cellular Microbiology,Volume 20, Issue 4, April 2018. (Source: Cellular Microbiology)
Source: Cellular Microbiology - December 18, 2017 Category: Microbiology Source Type: research
Thank you to our Reviewers
(Source: Cellular Microbiology)
Source: Cellular Microbiology - December 12, 2017 Category: Microbiology Tags: TOP REVIEWERS LIST Source Type: research
Issue Information
No abstract is available for this article. (Source: Cellular Microbiology)
Source: Cellular Microbiology - December 12, 2017 Category: Microbiology Tags: ISSUE INFORMATION Source Type: research
Treponema denticola increases MMP ‐2 expression and activation in the periodontium via reversible DNA and histone modifications
Cellular Microbiology,Volume 20, Issue 4, April 2018. (Source: Cellular Microbiology)
Source: Cellular Microbiology - December 4, 2017 Category: Microbiology Source Type: research
---
Cellular Microbiology,Volume 20, Issue 4, April 2018. (Source: Cellular Microbiology)
Source: Cellular Microbiology - December 4, 2017 Category: Microbiology Source Type: research
The bile salt sodium taurocholate induces Campylobacter jejuni outer membrane vesicle production and increases OMV ‐associated proteolytic activity.
In this study, the effect of ST on C. jejuni OMVs was investigated. Physiological concentrations of ST do not have an inhibitory effect on C. jejuni growth until the early stationary phase. Co‐culture of C. jejuni with 0.1% or 0.2% (w/v) ST stimulates OMV production, increasing both lipid and protein concentrations. C. jejuni ST‐OMVs possess increased proteolytic activity and exhibit a different protein profile compared to OMVs isolated in the absence of ST. ST‐OMVs exhibit enhanced cytotoxicity and immunogenicity to T84 IECs and enhanced killing of Galleria mellonella larvae. ST increases the level of mRNA transcrip...
Source: Cellular Microbiology - December 4, 2017 Category: Microbiology Authors: Abdi Elmi, Amber Dorey, Eleanor Watson, Heena Jagatia, Neil F. Inglis, Ozan Gundogdu, Mona Bajaj ‐Elliott, Brendan W. Wren, David G.E. Smith, Nick Dorrell Tags: RESEARCH ARTICLE Source Type: research
Treponema denticola increases MMP ‐2 expression and activation in the periodontium via reversible DNA and histone modifications
Abstract
Host‐derived matrix metalloproteinases (MMPs) and bacterial proteases mediate destruction of extracellular matrices and supporting alveolar bone in periodontitis. The Treponema denticola dentilisin protease induces MMP‐2 expression and activation in periodontal ligament (PDL) cells, and dentilisin‐mediated activation of pro‐MMP‐2 is required for cellular fibronectin degradation. Here we report that T. denticola regulates MMP‐2 expression through epigenetic modifications in the periodontium. PDL cells were treated with epigenetic enzyme inhibitors before or after T. denticola challenge. Fibronectin frag...
Source: Cellular Microbiology - December 1, 2017 Category: Microbiology Authors: Islam M. Ateia, Pimchanok Sutthiboonyapan, Pachiyappan Kamarajan, Taocong Jin, Valentina Godovikova, Yvonne L. Kapila, J. Christopher Fenno Tags: RESEARCH ARTICLE Source Type: research
The Human Blood ‐Brain Barrier Internalizes Cryptococcus neoformans via the EphA2‐Tyrosine Kinase Receptor
Abstract
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life‐threatening meningitis most commonly in populations with impaired immunity. Here we resolved the transcriptome of the human brain endothelium challenged with C. neoformans to establish whether C. neoformans invades the CNS by co‐opting particular signaling pathways as a means to promote its own entry. Among the 5 major pathways targeted by C. neoformans, the EPH‐EphrinA1 (EphA2) tyrosine kinase receptor‐signaling pathway was examined further. Silencing the EphA2 receptor transcript in a human brain endothelial cell line or blockin...
Source: Cellular Microbiology - December 1, 2017 Category: Microbiology Authors: Phylicia A. Aaron, Mantana Jamklang, John P. Uhrig, Angie Gelli Tags: RESEARCH ARTICLE Source Type: research
