Use of acetazolamide in the treatment of patients with refractory congestive heart failure
ConclusionIn a cohort of patients with refractory CHF treated with an intensive diuretic treatment, the addition of acetazolamide was associated with improvement in functional class and surrogates of fluid overload. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 29, 2018 Category: Cardiology Authors: Julio N úñez,
Raquel Heredia,
Ana Payá,
Ignacio Sanchis,
Susana Prado,
Gema Miñana,
Enrique Santas,
Rafael Espriella,
Eduardo Núñez,
Juan Sanchis,
Antoni Bayés‐Genís Tags: SHORT COMMUNICATION Source Type: research
Beneficial effects of tolvaptan on atrial remodeling induced by chronic intermittent hypoxia in rats
ConclusionsCIH ‐induced significant atrial remodeling in our rat model, which was attenuated by tolvaptan. These changes may be explained due to alterations in miR‐21/Spry1/ERK/MMP‐9, miR‐21/PTEN/PI3K/AKT, and NF‐κB pathways by tolvaptan. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 29, 2018 Category: Cardiology Authors: Kai Zhang,
Zuowang Ma,
Weiding Wang,
Ruimeng Liu,
Yue Zhang,
Meng Yuan,
Guangping Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Effect of Multi ‐Disciplinary Cardiac Rehabilitation on the Response to Cardiac Resynchronization Therapy
Cardiovascular Therapeutics,Volume 0, Issue ja, -Not available-. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 21, 2018 Category: Cardiology Authors: Pieter Martens
,
Guy Jacobs
,
Matthias Dupont
,
Wilfried Mullens Source Type: research
MicroRNA ‐27a mediates the Wnt/β‐catenin pathway to affect the myocardial fibrosis in rats with chronic heart failure
ConclusionDown ‐regulation of miR‐27a may inhibit the Wnt/β‐catenin pathway to reduce the deposition of myocardial collagen, prevent myocardial fibrosis and improve cardiac function.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 20, 2018 Category: Cardiology Authors: Ya ‐Se Zhuang,
Ying‐Ying Liao,
Bo‐Yi Liu,
Zhi‐Cheng Fang,
Li Chen,
Li Min,
Wei Chen Tags: Original Research Article Source Type: research
MicroRNA ‐27a mediates the Wnt/β‐catenin pathway to affect the myocardial fibrosis in rats with chronic heart failure
Cardiovascular Therapeutics,Volume 0, Issue ja, -Not available-. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 20, 2018 Category: Cardiology Authors: Ya ‐Se Zhuang
,
Ying‐Ying Liao
,
Bo‐Yi Liu
,
Zhi‐Cheng Fang
,
Li Chen
,
Li Min
,
Wei Chen Source Type: research
Issue Information
Cardiovascular Therapeutics, Volume 36, Issue 5, October 2018. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 12, 2018 Category: Cardiology Tags: ISSUE INFORMATION Source Type: research
Statins and substantially increased ALT values at baseline
Cardiovascular Therapeutics, Volume 36, Issue 5, October 2018. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 12, 2018 Category: Cardiology Authors: Vasilios G. Athyros,
Niki Katsiki,
Dimitri P. Mikhailidis Tags: LETTER TO THE EDITOR Source Type: research
TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic, and pressure ‐induced stress in mice
ConclusionsBile acids, specifically TGR5 agonists, induce cytoprotective changes in the heart and improve myocardial response to physiologic, inotropic, and hemodynamic stress in mice. TGR5 plays a critical role in myocardial adaptability, and TGR5 activation may represent a potentially attractive treatment option in heart failure. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 12, 2018 Category: Cardiology Authors: Zeena Eblimit,
Sundararajah Thevananther,
Saul J. Karpen,
Heinrich Taegtmeyer,
David D. Moore,
Luciano Adorini,
Daniel J. Penny,
Moreshwar S. Desai Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Trimetazidine suppresses oxidative stress, inhibits MMP ‐2 and MMP‐9 expression, and prevents cardiac rupture in mice with myocardial infarction
ConclusionsOur findings indicate that TMZ suppresses oxidative stress, inhibits MMP ‐2 and MMP‐9 expression, and prevents CR in mice with MI. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 12, 2018 Category: Cardiology Authors: Wei Gong,
Youcai Ma,
Aobo Li,
Han Shi,
Shaoping Nie Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Cost ‐effectiveness analysis of biodegradable polymer versus durable polymer drug‐eluting stents incorporating real‐world evidence
ConclusionsBiodegradable polymer drug ‐eluting stents were cost‐effective compared with DP‐DES in patients with coronary artery disease at 1 year and 5 years after PCI. It is worth noting that the cost of stents had a significant impact on the findings. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 12, 2018 Category: Cardiology Authors: Monica Teng,
Ying Jiao Zhao,
Ai Leng Khoo,
Rajiv Ananthakrishna,
Tiong Cheng Yeo,
Boon Peng Lim,
Mark Y. Chan,
Joshua P. Loh Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Safety and efficacy of nonvitamin K antagonist oral anticoagulants during catheter ablation of atrial fibrillation: A systematic review and meta ‐analysis
ConclusionsUse of NOACs compared to VKAs significantly reduced the risk of bleeding in patients with AF ablation. Similarly, the risk of bleeding was lower with uninterrupted NOACs than with uninterrupted VKAs, and with interrupted NOACs than with interrupted VKAs. The rate of thromboembolic complications was extremely low in both study groups without any differences. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 12, 2018 Category: Cardiology Authors: Zhen Ge,
Michela Faggioni,
Usman Baber,
Samantha Sartori,
Sabato Sorrentino,
Serdar Farhan,
Jaya Chandrasekhar,
Birgit Vogel,
Abdul Qadeer,
Jonathan Halperin,
Vivek Reddy,
Srinivas Dukkipati,
George Dangas,
Roxana Mehran Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Vascular endothelial growth factor gene transfer therapy for coronary artery disease: A systematic review and meta ‐analysis
ConclusionsVascular endothelial growth factor gene therapy appears to be safe and effective regarding serious cardiac events, with greater benefit when using adenoviral vectors. This meta ‐analysis highlights the need for further exploration in these areas. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 12, 2018 Category: Cardiology Authors: Rong Yuan,
Qiqi Xin,
Weili Shi,
Wei Liu,
Simon ‐M. Lee,
Puiman Hoi,
Lin Li,
Jun Zhao,
Weihong Cong,
Keji Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Predicting long ‐term ischemic events using routine clinical parameters in patients with coronary artery disease: The OPT‐CAD risk score
ConclusionsAmong CAD patients, a risk score based on 10 baseline clinical variables performed better than the GRACE risk score in predicting long ‐term ischemic events. However, further research is needed to assess the value of the OPT‐CAD score in guiding the management of antiplatelet therapy for patients with CAD. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 12, 2018 Category: Cardiology Authors: Yaling Han,
Jiyan Chen,
Miaohan Qiu,
Yi Li,
Jing Li,
Yingqing Feng,
Jian Qiu,
Liang Meng,
Yihong Sun,
Guizhou Tao,
Zhaohui Wu,
Chunyu Yang,
Jincheng Guo,
Kui Pu,
Shaoliang Chen,
Xiaozeng Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Predictors and consequences of postdischarge gastrointestinal bleeding after percutaneous coronary intervention
ConclusionIn this large cohort of real ‐world patients after PCI, postdischarge GIB was not significantly associated with MACCE up to 2 years of follow‐up but lead to an increase in DAPT cessation, and DAPT cessation was strongly associated with 2‐year mortality. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 12, 2018 Category: Cardiology Authors: Pei Zhu,
Xiaofang Tang,
Jingjing Xu,
Ying Song,
Ru Liu,
Yin Zhang,
Lijian Gao,
Zhan Gao,
Jue Chen,
Yuejin Yang,
Runlin Gao,
Bo Xu,
Jinqing Yuan Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Obstacles to mineralocorticoid receptor antagonists in a community ‐based heart failure population
ConclusionsThe reasons why MRA are underutilized were mainly because of contraindications. However, the data suggest that physicians are overly cautious about moderately reduced kidney function. There seems to be a 10% ‐18% avoidable undertreatment with MRA, especially for elderly patients that are admitted to the hospital for other reasons than heart failure. This suggests that patients with heart failure would benefit from routine follow‐up at a cardiology clinic. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 12, 2018 Category: Cardiology Authors: Anna Jonsson,
Helena Norberg,
Ellinor Bergdahl,
Krister Lindmark Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
