Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency
ConclusionsIncreasing ketone oxidation rates in failing hearts increases overall energy production without compromising glucose or fatty acid metabolism, albeit without increasing cardiac efficiency. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 19, 2019 Category: Cardiology Source Type: research

In vivo ratiometric optical mapping enables high-resolution cardiac electrophysiology in pig models
ConclusionsIn vivo optical mapping using voltage ratiometry of near-infrared dyes enables high-resolution cardiac electrophysiology in translational pig models. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 7, 2019 Category: Cardiology Source Type: research

Cardiac sodium-dependent glucose cotransporter 1 is a novel mediator of ischaemia/reperfusion injury
ConclusionDuring ischaemia, AMPK up-regulates SGLT1 through ERK, and SGLT1 interacts with EGFR, which in turn increases PKC and Nox2 activity and oxidative stress. SGLT1 may represent a novel therapeutic target for mitigating I/R injury. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 4, 2019 Category: Cardiology Source Type: research

Genome-wide identification of circulating-miRNA expression quantitative trait loci reveals the role of several miRNAs in the regulation of cardiometabolic phenotypes
AbstractAimsTo identify genetic variants that have a regulatory impact on circulating microRNAs (miRNAs) and to connect genetic risk to blood traits/biomarkers through the circulating miRNAs.Methods and resultsLeveraging miRNA-Seq data and the 1000 Genomes imputed genotypes, we carried out genome-wide association analysis for SNPs that regulate the expression of circulating miRNAs in a sample of 710 unrelated subjects of European ancestry. Wherever possible, we used data from the Framingham and the Geuvadis studies to replicate our findings. We found at least one genome-wide significant (P 
Source: Cardiovascular Research - January 31, 2019 Category: Cardiology Source Type: research

The intestine responds to heart failure by enhanced mitochondrial fusion through glucagon-like peptide-1 signalling
ConclusionsIncreased intestinal GLP-1 secretion is an adaptive response to heart failure that is enhanced by miglitol. This could be an effective strategy for treating heart failure through regulation of mitochondrial dynamics. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 10, 2019 Category: Cardiology Source Type: research

Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction
ConclusionOur data demonstrated an early and accelerated cardiac remodelling in AC8TG mice, leading to the development of HF and reduced lifespan. Age-related reorganization of cAMP/PKA signalling can accelerate cardiac ageing, partly through GSK3 α/β phosphorylation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 3, 2019 Category: Cardiology Source Type: research

Inhibition of heat shock protein 70 blocks the development of cardiac hypertrophy by modulating the phosphorylation of histone deacetylase 2
ConclusionThese results demonstrate that HSP70 specifically binds to S394-phosphorylated HDAC2 and maintains its phosphorylation status, which results in HDAC2 activation and the development of cardiac hypertrophy. Inhibition of HSP70 has possible application as a therapeutic. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 28, 2018 Category: Cardiology Source Type: research

Cardiomyocyte-specific loss of RNA polymerase II subunit 5-mediating protein causes myocardial dysfunction and heart failure
ConclusionsRMP plays a protective role in chronic HF. RMP may protect cardiomyocytes from injury by maintaining PGC1 α-dependent mitochondrial biogenesis and function. The results from this study suggest that RMP may be a potential therapeutic agent for treating HF. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 24, 2018 Category: Cardiology Source Type: research

FUNDC2 regulates platelet activation through AKT/GSK-3 β/cGMP axis
ConclusionFUNDC2 positively regulates platelet functions via AKT/GSK-3 β/cGMP signalling pathways, which provides new insight for platelet-related diseases. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 21, 2018 Category: Cardiology Source Type: research

Scientists on the Spot: How the ESC supports basic science in Europe
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 20, 2018 Category: Cardiology Source Type: research

Scientists on the Spot: The past, present, and future of the Council on Basic Cardiovascular Science
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 20, 2018 Category: Cardiology Source Type: research

Scientists on the Spot: Salt, the microbiome, and cardiovascular diseases
ESC Congress 2018 Session:Impact of gut microbiota on cardiovas-cular disease (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 20, 2018 Category: Cardiology Source Type: research

Glucagon-like peptide-1 receptor agonists and cardiovascular disease: from LEADER to EXSCEL
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 20, 2018 Category: Cardiology Source Type: research

Mitochondria and proteostasis: it ’s a kind of MAGIC
(Source: Cardiovascular Research)
Source: Cardiovascular Research - July 20, 2018 Category: Cardiology Source Type: research

Scientific updates on the interaction of genes, epigenetics, and multicellularity in cardiovascular diseases: the Working Group of Myocardial Function of the ESC
Myocardial diseases such as myocardial infarction are directly linked to vascular pathology including endothelial dysfunction, inflammation, and thrombosis. Also in heart failure with reduced or with preserved ejection fraction, macro- and microvascular dysfunction either in the heart itself but also in the periphery is directly or indirectly related to myocardial hypertrophy, remodelling, and progression of heart failure. Multicellularity in the heart and vascular system and countless variable cell –cell interactions at all levels contribute to cardiovascular (patho)physiology. Interactions e.g. of cardiomyocytes wi...
Source: Cardiovascular Research - July 9, 2018 Category: Cardiology Source Type: research

Unravelling immune cell complexity in atherosclerosis
This editorial refers to ‘Immune cell sensus in murine atherosclerosis: cytometry by time of flight illuminates vascular myeloid cell diversity’ by J.E. Coleet al., pp.1360 –1371. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 23, 2018 Category: Cardiology Source Type: research

Prof Niels Voigt talks to Prof Stanley Nattel about advances in atrial fibrillation research and career insights
Professor Nattel discusses the future of atrial fibrillation (AF) research and his career insights as one of the leading physician-scientists in AF research. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 21, 2018 Category: Cardiology Source Type: research

Teaching cardiovascular medicine to machines
Dr. Pablo Lamata is a Wellcome Trust Senior Fellow in Basical Biomedical Science and a Reader in Computational Cardiology at King's College of London. His research interest focuses in the combination of imaging and computational modelling technologies to improve the management of cardiovascular diseases. His team (http://cmib.website/) develops solutions to stratify subjects according to the remodelling of cardiac anatomy, to characterise the performance of the heart during diastole, and to assess non-invasively the pressure driving blood flow in the central circulatory system. He is the coordinator of the EU consortium &l...
Source: Cardiovascular Research - June 21, 2018 Category: Cardiology Source Type: research

The ASPRE pre-eclampsia trial: implications for basic research and clinical practice
Basky Thilaganathan was appointed Director of Fetal Medicine at St George ’s Hospital in 1999 and Professor of Fetal Medicine in 2008. His research interests are focused on Maternal-Fetal medicine, with a particular interest on maternal cardiac function, placental function, fetal growth, and pre-eclampsia (TED talk:http://bit.ly/2i1SqDk). He completed his post-graduate training at King ’s College London and St Bartholomew’s Hospitals, culminating in his Membership of the Royal College of Obstetricians and Gynaecologists (1995), MD in Fetal Medicine (1996), and Certificate of Completion of Training (1998)....
Source: Cardiovascular Research - June 21, 2018 Category: Cardiology Source Type: research

Circadian clock: each tissue has its own rhythm
Albano C. Meli received his PhD in Neurobiology at the Faculty of Pharmacy in Montpellier (France) in 2007. He then worked as a postdoctoral research scientist at Columbia University Medical Center in New York City (USA) for 4 years where he got mainly trained in basic cardiology. He was granted a European Marie-Curie Fellowship (2011) and a European Society of Cardiology grant (2012) to build up a team on human pluripotent stem cell-derived cardiomyocytes at Masaryk University Faculty of Medicine in Brno (Czech Republic). Albano was recruited as a permanent researcher by the French National Institute for Health and Medica...
Source: Cardiovascular Research - June 21, 2018 Category: Cardiology Source Type: research

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology
This article is part of the Mini Review Series from the Varenna 2017 meeting of the Working Group of Myocardial Function of the European Society of Cardiology. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 15, 2018 Category: Cardiology Source Type: research

Role of endothelial and macrophage tetrahydrobiopterin in development and progression of atherosclerosis: BH4 puzzle solved?
This editorial refers to ‘Roles for endothelial cell and macrophageGch1 and tetrahydrobiopterin in atherosclerosis progression ’ by G. Douglaset al., pp.1385 –1399. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 5, 2018 Category: Cardiology Source Type: research

Obesity-induced cardiac dysfunction: pre-natal vs. post-natal nurture
This editorial refers to ‘Maternal diet-induced obesity programmes cardiac dysfunction in male mice independently of post-weaning diet’ by E. Locheet al., pp.1372 –1384. (Source: Cardiovascular Research)
Source: Cardiovascular Research - June 5, 2018 Category: Cardiology Source Type: research

Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence
AbstractStatin therapy reduces cardiovascular events in patients with, or at risk of, atherosclerotic cardiovascular disease. However, statins are underutilized in patients for whom they are indicated and are frequently discontinued. Discontinuation may be the result of statin-associated muscle symptoms (SAMS), which encompass a broad spectrum of clinical phenotypes from myalgia to severe myopathy. As with many adverse drug reactions (ADRs), inter-individual variability in susceptibility to SAMS is due, at least in part, to differences in host genetics. The genetic basis for SAMS has been investigated in candidate gene stu...
Source: Cardiovascular Research - June 5, 2018 Category: Cardiology Source Type: research

Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology
This article is part of the Mini Review Series from the Varenna 2017 meeting of the Working Group of Myocardial Function of the European Society of Cardiology. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research

Non-coding RNAs in vascular disease – from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology
This article is part of the Mini Review Series from the Varenna 2017 meeting of the Working Group of Myocardial Function of the European Society of Cardiology. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research

Beyond longevity: novel roles of Sirtuin-3 in thrombosis
This editorial refers to ‘Loss ofSirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity ’ by D.S. Gaulet al., pp.1178 –1188. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research

Urocortin 2: will a drug targeting both the vasculature and the right ventricle be the future of pulmonary hypertension therapy?
This editorial refers to ‘Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension’ by R. Adãoet al., pp.1165 –1177. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research

Molecular events that lead to cardiomyocyte binucleation
This editorial refers to ‘Cardiomyocyte binucleation is associated with aberrant mitotic microtubule distribution, mislocalization of RhoA and IQGAP3, as well as defective actomyosin ring anchorage and cleavage furrow ingression’ by M. Leoneet al., pp.1115 –1131. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research

Dr Anke Smits talks to Professor Johann Wojta on the benefits for young investigators at FCVB 2018
Watch the interview here:http://www.youtube.com/watch?v=MGWCGnkLoCg (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research

Recognizing young investigators at Frontiers in Cardiovascular Biology 2018
Dr Heather Y. Small, BSc(Hons) MRes PhD is Senior Managing Editor ofCardiovascular Research. She is based in the Journal ’s Editorial Office within the Institute of Cardiovascular and Medical Sciences at the University of Glasgow, UK. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research

Catheter ablation of atrial fibrillation and outcomes in heart failure patients: seeking the treasure in the CASTLE
(Source: Cardiovascular Research)
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research

Macrophages: new players in cardiac ageing?
Dr. Tobias Bruegmann is working group leader at the Institute of Physiology I at the University of Bonn and chairmen of the Young physiologists, the group for young scientists within the German Physiological Society. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research

Modelling the complexity of heart failure with preserved ejection fraction
This editorial refers to ‘Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening’ by O. Soropet al., pp.954 –964. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 8, 2018 Category: Cardiology Source Type: research

Immune cell census in murine atherosclerosis: cytometry by time of flight illuminates vascular myeloid cell diversity
ConclusionsA CyTOF-based comprehensive mapping of the immune cell subsets within atherosclerotic aortas from ApoE−/− mice offers tools for myeloid cell discrimination within the vascular compartment and it reveals that high fat feeding skews the myeloid cell repertoire toward inflammatory monocyte-macrophage populations rather than resident macrophage phenotypes and cDC2 during atherogenesis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 2, 2018 Category: Cardiology Source Type: research

Adiponectin determines farnesoid X receptor agonism-mediated cardioprotection against post-infarction remodelling and dysfunction
In this study, we aimed to elucidate the role of long-term FXR activation on post-MI cardiac remodelling and dysfunction.Methods and resultsMice underwent either MI surgery or sham operation. At 1  week after MI, both sham and MI mice were gavaged with 25 mg/kg/d of a synthetic FXR agonist (GW4064) or a vehicle control for 7 weeks, and cardiac performance was assessed by consecutive echocardiography studies. Administration of GW4064 significantly increased left ventricular ejection frac tion at 4 weeks and 8 weeks after MI (bothP 
Source: Cardiovascular Research - April 30, 2018 Category: Cardiology Source Type: research

Biodegradable coronary scaffolds: their future and clinical and technological challenges
AbstractAngioplasty and stenting are standard treatment options for both stabile occlusive coronary artery disease and acute myocardial infarctions. Over the last years, several biodegradable stent systems have entered pre-clinical and clinical evaluation and into clinical practice. A strong supporting scaffold is necessary after angioplasty to prevent elastic recoil of the vessel but in the long term a permanent metallic stent will only impair normal physiology of the artery wall. Thus, the main advantage of a resorbable system is the potential for better vessel recovery and function in the long term. The new stent system...
Source: Cardiovascular Research - April 30, 2018 Category: Cardiology Source Type: research

Anthracycline cardiotoxicity: looking for new therapeutic approaches targeting cell senescence?
This editorial refers to ‘Co-administration of resveratrol with doxorubicin in young mice attenuates detrimental late-occurring cardiovascular changes’ by N. Matsumuraet al., pp.1350 –1359. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 28, 2018 Category: Cardiology Source Type: research

Fatty acids are the best fuel for overloaded hearts
This editorial refers to ‘Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice’ by Y. Umbarawanet al., pp.1132 –1144. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 27, 2018 Category: Cardiology Source Type: research

The era of cardiovascular epigenetics: histone deacetylases and vascular inflammation
This editorial refers to ‘HDAC4 regulates vascular inflammation via activation of autophagy,’ by D. Yanget al., pp. 1016 –1028. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 27, 2018 Category: Cardiology Source Type: research

The American College of Cardiology 2018; a Starbuckian ODYSSEY and a Black Barbershop
Matt Daniels is currently a Wellcome Trust Intermediate Fellow (WT098519MA) and Honorary Consultant Cardiologist in the Cardiovascular Medicine Department at Oxford University and a specially appointed visiting Professor in the University of Osaka, Japan. In Oxford, he leads the Stem cell-derived models of inherited heart disease group making novelin vitro disease models and phenotyping tools based on light emitting proteins and microscopy. His clinical practice includes clinical trials of medical devices, digital health platforms and novel therapeutics. He is an expert in Inherited Cardiac Conditions, percutaneous structu...
Source: Cardiovascular Research - April 20, 2018 Category: Cardiology Source Type: research

Dr Giacomo Rossitto interviews Professor Rhian Touyz, on the translational applications of vascular smooth muscle cell biology in cardiovascular disease
Watch the interview here:https://www.youtube.com/watch?v=pJ_hKhog2SY (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 20, 2018 Category: Cardiology Source Type: research

Trained immunity and cardiovascular disease: is it time for translation to humans?
Commentary on: ‘Metabolic induction of trained immunity through the mevalonate pathway’ by Bekkeringet al.,Cell 20187; (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 20, 2018 Category: Cardiology Source Type: research

The future of myocardial injury biomarkers in cardiovascular disease: looking beyond cardiac troponins
Mike Marber is a physician scientist with basic research interests in the processes causing heart cell death and clinical interests in patient care during and after acute myocardial infarction. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 20, 2018 Category: Cardiology Source Type: research

High-sensitivity troponin: a barometer for cardiac health
Dr Kuan Ken Lee is a British Heart Foundation Clinical Research Fellow at the University of Edinburgh Centre for Cardiovascular Science and Specialty Trainee in Cardiology in the South East of Scotland. His research aims to improve our understanding of how high-sensitivity cardiac troponin can improve our risk stratification and selection of patients with acute chest pain for further investigation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 20, 2018 Category: Cardiology Source Type: research

Epigenetic control of lipid metabolism: implications for lifespan and healthspan
Dr. Gabriele G. Schiattarella is a researcher at the University of Texas Southwestern Medical Center in Dallas, TX, USA. He received his MD in 2009 from the University Federico II of Naples (Italy). After completing a fellowship in Cardiology at the same university (2015) and matriculating in a PhD programme in Experimental Medicine, he moved to UT Southwestern Medical Center where he completed his PhD programme. Dr. Schiattarella ’s background is in medicine, experimental cardiology and cellular/molecular biology, with specific training and expertise in murine models of cardiovascular disease and preclinical assessm...
Source: Cardiovascular Research - April 20, 2018 Category: Cardiology Source Type: research

Protein geranylgeranylation: a possible new player in congenital heart defects
This editorial refers to ‘Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart’ by Z. Chenet al., pp.965 –978. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 19, 2018 Category: Cardiology Source Type: research

The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis
AbstractThe mineralocorticoid receptor (MR) is a member of the nuclear receptor steroid-binding family. The classical MR ligand aldosterone controls electrolyte and fluid homeostasis after binding in renal epithelial cells. However, more recent evidence suggests that activation of extrarenal MRs by aldosterone negatively impacts cardiovascular health independent of its effects on blood pressure: high levels of aldosterone associate with an increased cardiovascular event rate, where MR antagonists exert beneficial effects on cardiovascular mortality. The most important cause for cardiovascular events is atherosclerosis that...
Source: Cardiovascular Research - April 16, 2018 Category: Cardiology Source Type: research

Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation
ConclusionWe here show for the first time that HFpEF-AF (but not chronic AF without HF) is associated with marked impairment of platelet NO responses due to sGC dysfunction and nitrite circumvents the ‘platelet NO resistance’ phenomenon in human HFpEF, at least partly, by acting as a direct sGC activator independent of NO. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 12, 2018 Category: Cardiology Source Type: research

Personalizing therapy for atrial fibrillation: the role of stem cell and in silico disease models
AbstractAtrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with substantial morbidity. There is considerable inter-patient variability in the pathologic processes that promote AF, and this variability likely has a significant genetic basis. Clinically this is reflected by the observation that anti-arrhythmic drugs and interventional procedures have highly variable efficacy, and this highlights the need for adopting a more efficacious personalized approach. We explore recent advancements in bothin silico and stem cell disease models that set the stage for a personalized approach. Specifically w...
Source: Cardiovascular Research - April 10, 2018 Category: Cardiology Source Type: research