Carvedilol induces biased β1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility
ConclusionThese observations present a novel β1AR-NOS3 signalling pathway to promote cardiac inotropy in the heart, indicating that this signalling paradigm may be targeted in therapy of heart diseases with reduced ejection fraction. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 21, 2020 Category: Cardiology Source Type: research
Cardiac cellularity is dependent upon biological sex and is regulated by gonadal hormones
ConclusionThis work shows that the constituent cell types of the mouse heart are hormone-dependent and that the cardiac cellular landscapes are distinct in females and males, remain plastic, and can be rapidly modulated by endocrine factors. These observations have implications for strategies aiming to therapeutically alter cardiac cellular heterogeneity and underscore the importance of considering biological sex for studies examining cardiac physiology and stress responses. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 17, 2020 Category: Cardiology Source Type: research
Dyslipidaemia and regulatory T-cell migration: an immunometabolic connection?
This editorial refers to ‘Diet-induced dyslipidaemia induces metabolic and migratory adaptations in regulatory T cells’ by J. Amersfoortet al., pp.1309 –1324. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 17, 2020 Category: Cardiology Source Type: research
Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system
ConclusionSIRT5 promotes arterial thrombosis by modulating fibrinolysis through endothelial PAI-1 expression. Hence, SIRT5 may be an interesting therapeutic target in the context of atherothrombotic events. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 15, 2020 Category: Cardiology Source Type: research
Pleiotropic actions of factor Xa inhibition in cardiovascular prevention: mechanistic insights and implications for anti-thrombotic treatment
AbstractAtherosclerosis is a chronic inflammatory disease in which atherothrombotic complications lead to cardiovascular morbidity and mortality. At advanced stages, myocardial infarction, ischaemic stroke, and peripheral artery disease, including major adverse limb events, are caused either by acute occlusive atherothrombosis or by thromboembolism. Endothelial dysfunction, vascular smooth muscle cell activation, and vascular inflammation are essential in the development of acute cardiovascular events. Effects of the coagulation system on vascular biology extend beyond thrombosis. Under physiological conditions, coagulatio...
Source: Cardiovascular Research - September 15, 2020 Category: Cardiology Source Type: research
Adoptive transfer of CX3CR1 transduced-T regulatory cells improves homing to the atherosclerotic plaques and dampens atherosclerosis progression
ConclusionACT with vasculotropic Tregs appears as a promising strategy to selectively target immune activation in the atherosclerotic plaque. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 15, 2020 Category: Cardiology Source Type: research
Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction
ConclusionAltogether, this work unveils a key role for IRX5 in the regulation of human ventricular depolarization and cardiac electrical conduction, providing therefore new insights into our understanding of cardiac diseases. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 8, 2020 Category: Cardiology Source Type: research
ESC Advocacy (2018 –2020): contributing to the ESC mission of reducing the burden of cardiovascular disease
ESCAdvocacyCardiovascularBurdenCommittee (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 8, 2020 Category: Cardiology Source Type: research
Impact of protein glycosylation on lipoprotein metabolism and atherosclerosis
AbstractProtein glycosylation is a post-translational modification consisting in the enzymatic attachment of carbohydrate chains to specific residues of the protein sequence. Several types of glycosylation have been described, withN-glycosylation andO-glycosylation being the most common types impacting on crucial biological processes, such as protein synthesis, trafficking, localization, and function. Genetic defects in genes involved in protein glycosylation may result in altered production and activity of several proteins, with a broad range of clinical manifestations, including dyslipidaemia and atherosclerosis. A large...
Source: Cardiovascular Research - September 4, 2020 Category: Cardiology Source Type: research
The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction
ConclusionsWe developed a mouse model that recapitulates the human HFpEF disease, providing a novel opportunity to study disease pathogenesis and the development of enhanced therapeutic approaches. We furthermore show that attenuation of cardiometabolic dysregulation may represent a novel therapeutic target for the treatment of HFpEF. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 1, 2020 Category: Cardiology Source Type: research
Role of interleukin-23/interleukin-17 axis in T-cell-mediated actions in hypertension
AbstractCurrent knowledge suggests that hypertension is in part mediated by immune mechanisms. Both interleukin (IL)-23 and IL-17 are up-regulated in several experimental hypertensive rodent models, as well as in hypertensive humans in observational studies. Recent preclinical studies have shown that either IL-23 or IL-17A treatment induce blood pressure elevation. However, the IL-23/IL-17 axis has not been a major therapeutic target in hypertension, unlike in other autoimmune diseases. In this review, we summarize current knowledge on the role of these cytokines in immune mechanisms contributing to hypertension, and discu...
Source: Cardiovascular Research - September 1, 2020 Category: Cardiology Source Type: research
Pathophysiology of atrial fibrillation and chronic kidney disease
AbstractAtrial fibrillation (AF) and chronic kidney disease (CKD) are closely related conditions with shared risk factors. The growing prevalence of both AF and CKD indicates that more patients will suffer from concurrent conditions. There are various complex interlinking mechanisms with important implications for the management of these patients. Furthermore, there is uncertainty regarding the use of oral anticoagulation (OAC) in AF and CKD that is reflected by a lack of consensus between international guidelines. Therefore, the importance of understanding the implications of co-existing AF and CKD should not be underesti...
Source: Cardiovascular Research - September 1, 2020 Category: Cardiology Source Type: research
A combined microRNA and target protein-based panel for predicting the probability and severity of uraemic vascular calcification: a translational study
Conclusion Using a translational approach, we discovered a novel panel of biomarkers for gauging the probability/severity of uraemic VC based on miRNAs/target proteins, which improved the diagnostic accuracy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 31, 2020 Category: Cardiology Source Type: research
The inflammation-resolution promoting molecule resolvin-D1 prevents atrial proarrhythmic remodelling in experimental right heart disease
ConclusionThe inflammation-resolution enhancing molecule RvD1 prevents AF-promoting RA remodelling, while suppressing inflammatory changes and fibrotic/electrical remodelling, in RHD. Resolvins show potential promise in combating atrial arrhythmogenic remodelling by suppressing ongoing inflammatory signalling. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 31, 2020 Category: Cardiology Source Type: research
Leaders in Cardiovascular Research: Filippo Crea
Watch the interview here: https://youtu.be/myCo6U4o7Ts (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 31, 2020 Category: Cardiology Source Type: research
