Letter in response to glucagon-like peptide-1 mediates cardioprotection by remote ischaemic conditioning
We read with interest the study by Basalay et al1 recently published in Cardiovascular Research investigating the mechanism of remote ischaemic conditioning (RIc) signalling. Whilst the results are intriguing, a number of unresolved issues remain when considering RIc in humans. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Source Type: research

Increased canonical WNT/β-catenin signalling and myxomatous valve disease
This editorial refers to ‘Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease’ by A. Hulin et al., doi: 10.1093/cvr/cvw229. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Source Type: research

Osteoglycin’s embracement of VEGF receptor-2 limits angiogenesis and collateralization
This editorial refers to ‘Loss of osteoglycin promotes angiogenesis in limb ischaemia mouse models via modulation of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 signalling pathway’ by Gao et al., pp. 70–80. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Source Type: research

Remote ischemic conditioning: the enigmatic transfer of protection
This editorial refers to ‘Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning’ by Basalay et al., doi: 10.1093/cvr/cvw216. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Source Type: research

Corrigendum
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Tags: Corrigendum Source Type: research

Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy
Conclusions These novel findings demonstrate that the down-regulation of angiomiRs is a major underlying mechanism for the development of microangiopathy in diabetic hearts. Therefore, therapeutic restoration of angiomiRs could become a potential approach to combat the cardiovascular complications of diabetes. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Rawal, S., Munasinghe, P. E., Shindikar, A., Paulin, J., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., Katare, R. Tags: Vascular biology Source Type: research

Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes
Conclusions Ang-1 specifically increases circulating Gr1+ inflammatory monocytes and increases monocyte/macrophage retention in atherosclerotic plaques, thereby contributing to development of atherosclerosis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Fujisawa, T., Wang, K., Niu, X.-L., Egginton, S., Ahmad, S., Hewett, P., Kontos, C. D., Ahmed, A. Tags: Vascular biology Source Type: research

Corrigendum
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Tags: Corrigendum Source Type: research

Loss of osteoglycin promotes angiogenesis in limb ischaemia mouse models via modulation of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 signalling pathway
Conclusions OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF–VEGFR2 signalling and thereby attenuating EC tube formation, proliferation, and migration. Thus, OGN may be a novel therapeutic target for ischaemic vascular diseases. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Wu, Q.-H., Ma, Y., Ruan, C.-C., Yang, Y., Liu, X.-H., Ge, Q., Kong, L.-R., Zhang, J.-W., Yan, C., Gao, P.-J. Tags: Vascular biology Source Type: research

Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression
Conclusion Ticagrelor, unlike clopidogrel, exhibits endothelial-specific antithrombotic properties and blunts arterial thrombus formation. The additional antithrombotic properties displayed by ticagrelor may explain its greater efficacy in reducing thrombotic events in clinical trials. These findings may provide the basis for new indications for ticagrelor. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Reiner, M. F., Akhmedov, A., Stivala, S., Keller, S., Gaul, D. S., Bonetti, N. R., Savarese, G., Glanzmann, M., Zhu, C., Ruf, W., Yang, Z., Matter, C. M., Lüscher, T. F., Camici, G. G., Beer, J. H. Tags: Vascular biology Source Type: research

Remote ischemic conditioning provides humoural cross-species cardioprotection through glycine receptor activation
Aims Remote ischaemic conditioning (RIC) releases a humoural factor able to exert cross-species cardioprotection when plasma dialysate is applied to isolated hearts. However, the exact chemical nature of this factor is currently unknown. Methods and results RIC (4 x 5min femoral occlusion/5min reperfusion) was applied to 10 male pigs, and blood was taken before and after the manoeuvre. Discriminant analysis of 1H-NMR spectra (n = 10–12) obtained from plasma dialysates (12–14 kDa cut-off) allowed to demonstrate a different metabolic profile between control and postRIC samples, with lactate (2.671 ± 0.294...
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Jose Alburquerque-Bejar, J., Barba, I., Valls-Lacalle, L., Ruiz-Meana, M., Pecoraro, M., Rodriguez-Sinovas, A., Garcia-Dorado, D. Tags: Cardiac biology and remodelling Source Type: research

Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease
Conclusions Altogether, these data indicate that Axin2 limits Wnt/β-catenin signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt/β-catenin signalling resulting from loss of Axin2 leads to progressive MVD. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Hulin, A., Moore, V., James, J. M., Yutzey, K. E. Tags: Cardiac biology and remodelling Source Type: research

Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events
Aims Processes in the development of atherosclerotic lesions can lead to plaque rupture or erosion, which can in turn elicit myocardial infarction or ischaemic stroke. The aims of this study were to determine whether Toll-like receptor 7 (TLR7) gene expression levels influence patient outcome and to explore the mechanisms linked to TLR7 expression in atherosclerosis. Methods and results Atherosclerotic plaques were removed by carotid endarterectomy (CEA) and subjected to gene array expression analysis (n = 123). Increased levels of TLR7 transcript in the plaques were associated with better outcome in a follow-up study ove...
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Karadimou, G., Folkersen, L., Berg, M., Perisic, L., Discacciati, A., Roy, J., Hansson, G. K., Persson, J., Paulsson-Berne, G. Tags: Integrative physiology and pathophysiology Source Type: research

Reply: Glucagon-like peptide-1 mediates cardioprotection by remote ischaemic conditioning
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Basalay, M., Mastitskaya, S., Mrochek, A., Ackland, G. L., Arroyo, A. G. d., Sanchez, J., Sjoquist, P.-O., Pernow, J., Gourine, A. V., Gourine, A. Tags: Letters to the Editor Source Type: research

Letter in response to glucagon-like peptide-1 mediates cardioprotection by remote ischaemic conditioning
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Giblett, J. P., Hoole, S. P. Tags: Letters to the Editor Source Type: research

Osteoglycins embracement of VEGF receptor-2 limits angiogenesis and collateralization
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: van Hinsbergh, V. W. M. Tags: Invited Editorials Source Type: research

Increased canonical WNT/{beta}-catenin signalling and myxomatous valve disease
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Chopra, S., Al-Sammarraie, N., Lai, Y., Azhar, M. Tags: Invited Editorials Source Type: research

What mediates the effects of thrombospondin-1 in pulmonary hypertension? New evidence for a dual-pronged role of CD47
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Kuebler, W. M. Tags: Invited Editorials Source Type: research

Remote ischemic conditioning: the enigmatic transfer of protection
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 9, 2017 Category: Cardiology Authors: Heusch, G. Tags: Invited Editorials Source Type: research

Tipifarnib prevents development of hypoxia-induced pulmonary hypertension
ConclusionsOur study demonstrates the importance of protein farnesylation in pulmonary vascular remodelling and provides a rationale for selective targeting of this pathway in pulmonary hypertension. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 5, 2017 Category: Cardiology Source Type: research

A novel protective role for activating transcription factor 3 in the cardiac response to metabolic stress
This editorial refers to ‘ATF3 expression in cardiomyocytes preserves homeostasis in the heart and controls peripheral glucose tolerance’ by R. Kalfon et al., pp. 134–146. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 29, 2016 Category: Cardiology Source Type: research

Tweak up-regulates endothelin-1 system in mouse and human endothelial cells
ConclusionsIn pathological situations such as chronic inflammation, TWEAK could be more harmful through this effect at endothelial level. Pharmacological blockade of this cytokine could prevent the haemodynamic and structural changes related to an increased ET-1 synthesis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 25, 2016 Category: Cardiology Source Type: research

Sphingosine-1-phosphate signalling—a key player in the pathogenesis of Angiotensin II-induced hypertension
ConclusionThe presented results point to a critical involvement of S1P and its signalling axis in the pathogenesis of hypertension. Specifically, SphK2 evolves as key player in immune cell trafficking and vascular dysfunction contributing to the development of overt hypertension. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 21, 2016 Category: Cardiology Source Type: research

SRF/myocardin: a novel molecular axis regulating vascular smooth muscle cell stiffening in hypertension
This editorial refers to ‘Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension’ by Zhou et al., pp. 171–182. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 21, 2016 Category: Cardiology Source Type: research

A new side to an old coin: dynamin related protein-1 with benefits in the heart
This editorial refers to ‘A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration’ by Zhang et al., pp. 160–170. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 21, 2016 Category: Cardiology Source Type: research

Akap-mediated signalling: the importance of being in the right place at the right time
This editorial refers to ‘Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve’ by Li et al., pp. 147–159. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 21, 2016 Category: Cardiology Source Type: research

Remote ischaemic conditioning reduces infarct size in animal in vivo models of ischaemia-reperfusion injury: a systematic review and meta-analysis
AimsThe potential of remote ischaemic conditioning (RIC) to ameliorate myocardial ischaemia-reperfusion injury (IRI) remains controversial. We aimed to analyse the pre-clinical evidence base to ascertain the overall effect and variability of RIC in animal in vivo models of myocardial IRI. Furthermore, we aimed to investigate the impact of different study protocols on the protective utility of RIC in animal models and identify gaps in our understanding of this promising therapeutic strategy.Methods and resultsOur primary outcome measure was the difference in mean infarct size between RIC and control groups in in vivo models...
Source: Cardiovascular Research - December 17, 2016 Category: Cardiology Source Type: research

Circulating 'lncRNA OTTHUMT00000387022 from monocytes as a novel biomarker for coronary artery disease
Aims Long non-coding RNAs (lncRNAs) have been found to be involved in the pathogenesis of coronary artery disease (CAD). However, it remains to be established whether or not circulating lncRNAs can serve as biomarkers of CAD. Methods and results Using a microarray-based lncRNA expression profiling, we found 86 lncRNAs that were differentially expressed in circulating peripheral blood monocytes and plasma from 15 CAD patients and 15 control subjects. After choosing a consistent criterion (average normalized intensity ≥7 with significance
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: Cai, Y., Yang, Y., Chen, X., Wu, G., Zhang, X., Liu, Y., Yu, J., Wang, X., Fu, J., Li, C., Jose, P. A., Zeng, C., Zhou, L. Tags: Vascular biology Source Type: research

Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function
Conclusions We demonstrated that LPP3 is a negative regulator of inflammatory cytokines, leucocyte adhesion, cell survival, and migration in HAECs, suggesting a protective role of LPP3 against endothelial dysfunction in humans. Both the catalytic and the RGD functional domains were involved and S1P, but not LPA, might be the endogenous substrate of LPP3. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: Touat-Hamici, Z., Weidmann, H., Blum, Y., Proust, C., Durand, H., Iannacci, F., Codoni, V., Gaignard, P., Therond, P., Civelek, M., Karabina, S. A., Lusis, A. J., Cambien, F., Ninio, E. Tags: Vascular biology Source Type: research

Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase
Aims Stent deployment causes endothelial cells (EC) denudation, which promotes in-stent restenosis and thrombosis. Thus endothelial regrowth in stented arteries is an important therapeutic goal. Stent struts modify local hemodynamics, however the effects of flow perturbation on EC injury and repair are incompletely understood. By studying the effects of stent struts on flow and EC migration, we identified an intervention that promotes endothelial repair in stented arteries. Methods and Results In vitro and in vivo models were developed to monitor endothelialization under flow and the influence of stent struts. A 2D parall...
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: Hsiao, S. T., Spencer, T., Boldock, L., Prosseda, S. D., Xanthis, I., Tovar-Lopez, F. J., Van Beusekom, H. M. M., Khamis, R. Y., Foin, N., Bowden, N., Hussain, A., Rothman, A., Ridger, V., Halliday, I., Perrault, C., Gunn, J., Evans, P. C. Tags: Vascular biology Source Type: research

Endothelial cell-derived pentraxin 3 limits the vasoreparative therapeutic potential of circulating angiogenic cells
Conclusion Endothelium, when exposed to HD CACs, releases PTX3 which markedly impairs the vascular regenerative response in an autocrine manner. Therefore, CAC density and accompanying release of angiocrine PTX3 are critical considerations when using these cells as a cell therapy for ischaemic disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: ONeill, C. L., Guduric-Fuchs, J., Chambers, S. E. J., ODoherty, M., Bottazzi, B., Stitt, A. W., Medina, R. J. Tags: Vascular biology Source Type: research

Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning
Conclusions These data strongly suggest that GLP-1 functions as a humoral factor of remote ischaemic conditioning cardioprotection. This phenomenon requires intact vagal innervation of the visceral organs and recruitment of GLP-1R-mediated signalling. Cardioprotection induced by GLP-1R activation is mediated by a mechanism involving M3 muscarinic receptors. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: Basalay, M. V., Mastitskaya, S., Mrochek, A., Ackland, G. L., del Arroyo, A. G., Sanchez, J., Sjoquist, P.-O., Pernow, J., Gourine, A. V., Gourine, A. Tags: Cardiac biology and remodelling Source Type: research

High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature
Conclusion Our results highlight EC-to-cardiomyocyte transfer of heparanase to modulate the cardiomyocyte cell death signature. This mechanism was observed in the acutely diabetic heart, and its interruption following chronic diabetes may contribute towards the development of diabetic cardiomyopathy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: Wang, F., Jia, J., Lal, N., Zhang, D., Chiu, A. P.-L., Wan, A., Vlodavsky, I., Hussein, B., Rodrigues, B. Tags: Cardiac biology and remodelling Source Type: research

Magnetic resonance imaging of infarct-induced canonical wingless/integrated (Wnt)/{beta}-catenin/T-cell factor pathway activation, in vivo
Conclusions The TCF/Lef promoter-hFTH construct is a novel and reliable MRI reporter gene for in vivo detection of the canonical Wnt/β-catenin/TCF activation state in response to cardiac injury and therapeutic interventions. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: Matteucci, M., Casieri, V., Gabisonia, K., Aquaro, G. D., Agostini, S., Pollio, G., Diamanti, D., Rossi, M., Travagli, M., Porcari, V., Recchia, F. A., Lionetti, V. Tags: Cardiac biology and remodelling Source Type: research

C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function
Aims B-type natriuretic peptide (BNP)–natriuretic peptide receptor A (NPR-A) receptor signalling inhibits cardiac sympathetic neurotransmission, although C-type natriuretic peptide (CNP) is the predominant neuropeptide of the nervous system with expression in the heart and vasculature. We hypothesized that CNP acts similarly to BNP, and that transgenic rats (TGRs) with neuron-specific overexpression of a dominant negative NPR-B receptor would develop heightened sympathetic drive. Methods and results Mean arterial pressure and heart rate (HR) were significantly (P
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: Buttgereit, J., Shanks, J., Li, D., Hao, G., Athwal, A., Langenickel, T. H., Wright, H., da Costa Goncalves, A. C., Monti, J., Plehm, R., Popova, E., Qadri, F., Lapidus, I., Ryan, B., Özcelik, C., Paterson, D. J., Bader, M., Herring, N. Tags: Cardiac biology and remodelling Source Type: research

Systems biology--opportunities and challenges: the application of proteomics to study the cardiovascular extracellular matrix
Systems biology approaches including proteomics are becoming more widely used in cardiovascular research. In this review article, we focus on the application of proteomics to the cardiac extracellular matrix (ECM). ECM remodelling is a hallmark of many cardiovascular diseases. Proteomic techniques using mass spectrometry (MS) provide a platform for the comprehensive analysis of ECM proteins without a priori assumptions. Proteomics overcomes various constraints inherent to conventional antibody detection. On the other hand, studies that use whole tissue lysates for proteomic analysis mask the identification of the less abun...
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: Barallobre-Barreiro, J., Lynch, M., Yin, X., Mayr, M. Tags: Review Source Type: research

'A picture is worth a thousand words: image highlights from Cardiovascular Research
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: Gal, D., Sipido, K. R., Vandevelde, W. Tags: Invited Editorials Source Type: research

Natriuretic peptides and peripheral autonomic neurotransmission: back to the A, B, and Cs.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: Ajijola, O. A., Shivkumar, K., Habecker, B. A. Tags: Invited Editorials Source Type: research

Innovative reporter gene imaging techniques making inroads to biology
(Source: Cardiovascular Research)
Source: Cardiovascular Research - December 15, 2016 Category: Cardiology Authors: Zhao, M. Tags: Invited Editorials Source Type: research

A landscape of circular RNA expression in the human heart
ConclusionsOur data provide a detailed circRNA expression landscape in hearts. There is a high-abundance of specific cardiac-expressed circRNA. These findings open up a new avenue for future investigation into this emerging class of RNA. (Source: Cardiovascular Research)
Source: Cardiovascular Research - December 6, 2016 Category: Cardiology Source Type: research

A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration
ConclusionThese results uncover a novel non-canonical function of the fission protein, DRP1 in maintaining or positively stimulating mitochondrial respiration, bioenergetics and ROS signalling in adult cardiomyocyte, which is likely independent of morphological changes. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 27, 2016 Category: Cardiology Source Type: research

Corrigendum
to: Expression and function of IL-1R8 (TIR8/SIGIRR): a regulatory member of the IL-1 receptor family in platelets [Cardiovasc Res 2016; 111 (4): 373–384] (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 17, 2016 Category: Cardiology Source Type: research

Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve
ConclusionsThese findings define a critical role for AKAP150 in regulating Ca2+ cycling and myocardial ionotropy following pathological stress, suggesting the AKAP150 signalling pathway may serve as a novel therapeutic target for heart failure. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2016 Category: Cardiology Source Type: research

Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression
ConclusionTicagrelor, unlike clopidogrel, exhibits endothelial-specific antithrombotic properties and blunts arterial thrombus formation. The additional antithrombotic properties displayed by ticagrelor may explain its greater efficacy in reducing thrombotic events in clinical trials. These findings may provide the basis for new indications for ticagrelor. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 15, 2016 Category: Cardiology Source Type: research

Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events
AimsProcesses in the development of atherosclerotic lesions can lead to plaque rupture or erosion, which can in turn elicit myocardial infarction or ischaemic stroke. The aims of this study were to determine whether Toll-like receptor 7 (TLR7) gene expression levels influence patient outcome and to explore the mechanisms linked to TLR7 expression in atherosclerosis.Methods and resultsAtherosclerotic plaques were removed by carotid endarterectomy (CEA) and subjected to gene array expression analysis (n = 123). Increased levels of TLR7 transcript in the plaques were associated with better outcome in a follow-up...
Source: Cardiovascular Research - November 15, 2016 Category: Cardiology Source Type: research

What mediates the effects of thrombospondin-1 in pulmonary hypertension? New evidence for a dual-pronged role of CD47
This editorial refers to ‘TSP1–CD47 signalling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction’ by Natasha M. Rogers et al. pp. 15–29. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 15, 2016 Category: Cardiology Source Type: research

ATF3 expression in cardiomyocytes preserves homeostasis in the heart and controls peripheral glucose tolerance
ConclusionsCardiac ATF3 has a protective role in dampening the HFD-induced cardiac remodeling processes. ATF3 exerts both local and systemic effects related to T2D-induced cardiomyopathy. This study provides a strong relationship between heart remodeling processes and blood glucose homeostasis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 7, 2016 Category: Cardiology Source Type: research

Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease
ConclusionsAltogether, these data indicate that Axin2 limits Wnt/β-catenin signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt/β-catenin signalling resulting from loss of Axin2 leads to progressive MVD. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 7, 2016 Category: Cardiology Source Type: research

Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension
AimsIncreased aortic stiffness is a fundamental manifestation of hypertension. However, the molecular mechanisms involved remain largely unknown. We tested the hypothesis that abnormal intrinsic vascular smooth muscle cell (VSMC) mechanical properties in large arteries, but not in distal arteries, contribute to the pathogenesis of aortic stiffening in hypertension, mediated by the serum response factor (SRF)/myocardin signalling pathway.Methods and resultsFour month old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were studied. Using atomic force microscopy, significant VSMC stiffenin...
Source: Cardiovascular Research - October 23, 2016 Category: Cardiology Source Type: research

Loss of osteoglycin promotes angiogenesis in limb ischaemia mouse models via modulation of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 signalling pathway
ConclusionsOGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF–VEGFR2 signalling and thereby attenuating EC tube formation, proliferation, and migration. Thus, OGN may be a novel therapeutic target for ischaemic vascular diseases. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 23, 2016 Category: Cardiology Source Type: research