Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis
In this study, we found that YD0514 significantly inhibited proliferation, motility, and adhesion of metastatic breast cancer cell lines MDA-MB-231, GI101, GILM2, and GILM3. (Source: Cancer Letters)
Source: Cancer Letters - March 26, 2018 Category: Cancer & Oncology Authors: Dengfeng Li, Hong Wang, Ye Ding, Ziwei Zhang, Zhi Zheng, Jiabin Dong, Hyejin Kim, Xiaojing Meng, Qianjun Zhou, Jia Zhou, Lin Fang, Qiang Shen Tags: Original Articles Source Type: research
Immunogenicity and antitumor activity of the superlytic λF7 phage nanoparticles displaying a HER2/neu-derived peptide AE37 in a tumor model of BALB/c mice
In this study, the AE37 (Ii-Key/HER-2/neu 776 –790) peptide derived from HER2 (human epidermal growth factor receptor protein) was used as a fused peptide to the lambda phage (λF7) coat protein gpD, and the phage nanoparticles were used to induce antitumor immunogenicity in a TUBO model of breast cancer in mice. Mice were immunized with the AE37 peptide displaying phage, λF7 (gpD::AE37) every 2-week intervals over 6-weeks, then the generated immune responses were evaluated. (Source: Cancer Letters)
Source: Cancer Letters - March 26, 2018 Category: Cancer & Oncology Authors: Nastaran Barati, Atefeh Razazan, Jessica Nicastro, Roderick Slavcev, Atefeh Arab, Fatemeh Mosaffa, Amin Reza Nikpoor, Ali Badiee, Mahmoud Reza Jaafari, Javad Behravan Tags: Original Articles Source Type: research
Basement membrane destruction by pancreatic stellate cells leads to local invasion in pancreatic ductal adenocarcinoma
Stroma invasion is an important step in pancreatic cancer progression. However, how pancreatic ductal adenocarcinoma (PDAC) with ductal structure invades the surrounding stroma has not been clear. Here, we elucidated the mechanism of stromal invasion of PDAC, using organoids. From resected PDAC specimens, we established human PDAC organoids, which developed ductal and basement membrane (BM) structures. When the organoids were co-cultured with pancreatic stellate cells (PSCs) in a collagen matrix, organoids lost their BM and ductal structures, and invaded collagen matrix more frequently than did mono-cultured organoids. (So...
Source: Cancer Letters - March 26, 2018 Category: Cancer & Oncology Authors: Kazuhiro Koikawa, Kenoki Ohuchida, Yohei Ando, Shin Kibe, Hiromichi Nakayama, Shin Takesue, Sho Endo, Toshiya Abe, Takashi Okumura, Chika Iwamoto, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Eishi Nagai, Kazuhiro Mizumoto, Makoto Hash Tags: Original Articles Source Type: research
Immuno-modulators enhance antigen-specific immunity and anti-tumor effects of mesothelin-specific chimeric DNA vaccine through promoting DC maturation
As a tumor antigen, mesothelin (MSLN) can be identified in various malignancies. MSLN is potential for antigen-specific cancer vaccines. We generated a novel chimeric DNA vaccine using antigen-specific connective tissue growth factor lined with MSLN (CTGF/MSLN). The anti-tumor effects of the CTGF/MSLN DNA vaccine combined with anti-CD40 Ab and toll-like receptor 3 ligand –poly(I:C) were validated in an MSLN-expressing model. CTGF/MSLN DNA with anti-CD40Ab and poly(I:C) vaccinated mice demonstrated potent anti-tumor effects with longer survival and less tumor volumes. (Source: Cancer Letters)
Source: Cancer Letters - March 26, 2018 Category: Cancer & Oncology Authors: Yu-Li Chen, Ming-Cheng Chang, Ying-Cheng Chiang, Han-Wei Lin, Nai-Yun Sun, Chi-An Chen, Wei-Zen Sun, Wen-Fang Cheng Tags: Original Articles Source Type: research
Pro-apoptotic Bax promotes mesenchymal-epithelial transition by binding to respiratory complex-I and antagonizing the malignant actions of pro-survival Bcl-2 proteins
The plasticity of solid tumors between the epithelial and mesenchymal states critically influences their malignant progression and metastasis. The epithelial-mesenchymal transition (EMT), which supports cancer cell invasion and metastasis, is promoted by pro-survival members (e.g., Bcl-2 and Bcl-XL) of the Bcl-2 protein family, which are well-known key apoptosis regulators. We found that Bcl-w, another pro-survival member, promotes EMT by increasing respiratory complex-I activity and reactive oxygen species (ROS) levels. (Source: Cancer Letters)
Source: Cancer Letters - March 26, 2018 Category: Cancer & Oncology Authors: Eun Mi Kim, Chan-Hun Jung, Jie-Young Song, Jong Kuk Park, Hong-Duck Um Tags: Original Articles Source Type: research
Squalene epoxidase as a promising metabolic target in cancer treatment
Oncogenic alteration of the cholesterol synthesis pathway is a recognized mechanism of metabolic adaptation. In the present review, we focus on squalene epoxidase (SE), one of the two rate-limiting enzymes in cholesterol synthesis, retracing its history since its discovery as an antimycotic target to its description as an emerging metabolic oncogene by amplification with clinical relevance in cancer. We review the published literature assessing the association between SE over-expression and poor prognosis in this disease. (Source: Cancer Letters)
Source: Cancer Letters - March 26, 2018 Category: Cancer & Oncology Authors: Gabriella Cirmena, Paola Franceschelli, Edoardo Isnaldi, Lorenzo Ferrando, Marilena De Mariano, Alberto Ballestrero, Gabriele Zoppoli Tags: Mini-review Source Type: research
Retraction notice to “SRI36160 is a specific inhibitor of Wnt/ < beta > -catenin signaling in human pancreatic and colorectal cancer cells ” [Canc. Lett. 389C (2017) 41–48]
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). (Source: Cancer Letters)
Source: Cancer Letters - March 23, 2018 Category: Cancer & Oncology Authors: Yonghe Li, Patsy G. Oliver, Wenyan Lu, Vibha Pathak, Sivaram Sridharan, Corinne E. Augelli-Szafran, Donald J. Buchsbaum, Mark J. Suto Source Type: research
Retraction notice to “A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells”
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). (Source: Cancer Letters)
Source: Cancer Letters - March 23, 2018 Category: Cancer & Oncology Authors: Pramod P. Mehta, Pei-Pei Kung, Shinji Yamazaki, Marlena Walls, Andrea Shen, Leslie Nguyen, Michael R. Gehring, Gerrit Los, Tod Smeal, Min-Jean Yin Source Type: research
Retraction notice to “MiR-143 inhibits tumor cell proliferation and invasion by targeting STAT3 in esophageal squamous cell carcinoma”
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). (Source: Cancer Letters)
Source: Cancer Letters - March 23, 2018 Category: Cancer & Oncology Authors: Jia Liu, Yu Mao, Dakai Zhang, Shengnan Hao, Zicheng Zhang, Zhenjiang Li, Baosheng Li Source Type: research
Editorial Board
(Source: Cancer Letters)
Source: Cancer Letters - March 23, 2018 Category: Cancer & Oncology Source Type: research
CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance
CXCR4 surface expression is considered an independent prognostic factor for disease relapse and survival in acute myeloid leukemia (AML) patients. Herein, we investigated targetable autophagy-related mechanisms of CXCR4 for AML therapy. Our experiments show that activation of CXCR4 signaling in AML cells increases autophagic activity and decreases cytarabine-induced apoptosis. Accordingly, combined use of autophagy inhibitors significantly increased the sensitivity of AML cells to cytarabine in vitro and in vivo. (Source: Cancer Letters)
Source: Cancer Letters - March 22, 2018 Category: Cancer & Oncology Authors: Xiaojia Hu, Shuang Mei, Wenfang Meng, Shihang Xue, Lejian Jiang, Yang Yang, Lanlan Hui, Ye Chen, Min-Xin Guan Tags: Original Articles Source Type: research
Anti-CD73 and anti-OX40 immunotherapy coupled with a novel biocompatible enzyme prodrug system for the treatment of recurrent, metastatic ovarian cancer
Approximately 75% of ovarian cancer is diagnosed once metastasis to the peritoneal cavity has occurred. A large proportion of patients eventually develop platinum-resistive tumors, which are considered terminal. In order to provide an alternative a novel fusion protein, mCTH-ANXA5, has been developed for the treatment of recurrent, metastatic ovarian cancer. The fusion protein combines annexin V (ANXA5), an ovarian tumor and tumor vasculature targeting protein, with mutated cystathionine gamma-lyase (mCTH), an enzyme that converts selenomethionine (SeMet) into toxic methylselenol, which generates reactive oxygen species an...
Source: Cancer Letters - March 22, 2018 Category: Cancer & Oncology Authors: Needa A. Virani, Elangovan Thavathiru, Patrick McKernan, Kathleen Moore, Doris M. Benbrook, Roger G. Harrison Tags: Original Articles Source Type: research
Corrigendum to “Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells” [Canc. Lett. 412 (2018) 297-307]
The authors regret and apologize for their unintentional omission of acknowledgments for financial support given by the Korean Society of Ginseng. The ‘Acknowledgment’ is as follows: (Source: Cancer Letters)
Source: Cancer Letters - March 22, 2018 Category: Cancer & Oncology Authors: Huong Thuy Le, Huy Truong Nguyen, Hye-Young Min, Seung Yeob Hyun, Soonbum Kwon, Yeongcheol Lee, Thi Hong Van Le, Jeeyeon Lee, Jeong Hill Park, Ho-Young Lee Tags: Corrigendum Source Type: research
CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance
CXCR4 surface expression is considered an independent prognostic factor for disease relapse and survival in acute myeloid leukemia (AML) patients. Herein, we investigated targetable autophagy-related mechanisms of CXCR4 for AML therapy. Our experiments show that activation of CXCR4 signaling in AML cells increases autophagic activity and decreases cytarabine-induced apoptosis. Accordingly, combined use of autophagy inhibitors significantly increased the sensitivity of AML cells to cytarabine in vitro and in vivo. (Source: Cancer Letters)
Source: Cancer Letters - March 22, 2018 Category: Cancer & Oncology Authors: Xiaojia Hu, Shuang Mei, Wenfang Meng, Shihang Xue, Jiang Lejian, Yang Yang, Lanlan Hui, Ye Chen, Min-Xin Guan Tags: Original Articles Source Type: research
XRCC3 contributes to temozolomide resistance of glioblastoma cells by promoting DNA double-strand break repair
Glioblastoma is the most frequent and aggressive form of high-grade malignant glioma. Due to the dismal prognosis faced by patients suffering from this disease, there is a need for identifying new targets that might improve therapy. The aim of this study was to determine the contribution of the DNA double-strand break (DSB) repair protein X-ray repair cross-complementing 3 (XRCC3) to the resistance of glioma cells to the chemotherapeutic drug temozolomide. Analysis of a publicly available database, E-GEOD-4290, showed that gliomas overexpress XRCC3 (NM_005432) compared to normal brain tissue. (Source: Cancer Letters)
Source: Cancer Letters - March 22, 2018 Category: Cancer & Oncology Authors: Wynand Paul Roos, Larissa Frohnapfel, Steve Quiros, Florian Ringel, Bernd Kaina Tags: Original Articles Source Type: research
