Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis
Suppressing glutaminolysis does not always induce cancer cell death in glutamine dependent tumors because cells may switch to alternative energy sources. To reveal compensatory metabolic pathways, we investigated the metabolome-wide cellular response to inhibited glutaminolysis in cancer cells. Glutaminolysis inhibition with C.968 suppressed cell proliferation but was insufficient to induce cancer cell death. We found that lipid catabolism was activated as a compensation for glutaminolysis inhibition. (Source: Cancer Letters)
Source: Cancer Letters - May 17, 2018 Category: Cancer & Oncology Authors: Anna Halama, Michal Kulinski, Shaima S. Dib, Shaza B. Zaghlool, Kodappully S. Siveen, Ahmad Iskandarani, Jonas Zierer, Kirti S. Prabhu, Noothan J. Satheesh, Aditya M. Bhagwat, Shahab Uddin, Gabi Kastenm üller, Olivier Elemento, Steven S. Gross, Karsten S Tags: Original Articles Source Type: research
PSMD2 regulates breast cancer cell proliferation and cell cycle progression by modulating p21 and p27 proteasomal degradation
In this study, we investigated the expression profiles of 797 UPS-related genes using HiSeq data from The Cancer Genome Atlas and identified that PSMD2 was markedly upregulated in breast cancer. High PSMD2 expression was significantly correlated with poor prognosis. Gene set enrichment analysis revealed that transcriptome signatures involving proliferation, cell cycle, and apoptosis were critically enriched in specimens with elevated PSMD2. (Source: Cancer Letters)
Source: Cancer Letters - May 17, 2018 Category: Cancer & Oncology Authors: Yunhai Li, Jing Huang, Beilei Zeng, Dejuan Yang, Jiazheng Sun, Xuedong Yin, Mengqi Lu, Zhu Qiu, Weiyan Peng, Tingxiu Xiang, Hongzhong Li, Guosheng Ren Tags: Original Articles Source Type: research
Acquisition of tumorigenic potential and therapeutic resistance in CD133+ subpopulation of prostate cancer cells exhibiting stem-cell like characteristics
The role of CD133 (Prominin-1) as a cancer stem cell marker may be useful for therapeutic approaches and prognostication in prostate cancer patients. We investigated the stem-cell-related function and biological features of a subpopulation of CD133+ cells isolated from established primary human prostate cancer cell lines. The CD133+ cells sorted from human prostate cancer 22Rv1 exhibited high clonogenic and tumorigenic capabilities, sphere forming capacity and serially reinitiated transplantable tumors in NOD-SCID mice. (Source: Cancer Letters)
Source: Cancer Letters - May 15, 2018 Category: Cancer & Oncology Authors: Rajnee Kanwal, Sanjeev Shukla, Ethan Walker, Sanjay Gupta Tags: Original Articles Source Type: research
PTEN PDZ-binding domain suppresses mammary carcinogenesis in the MMTV-PyMT breast cancer model
Phosphatase and tension homolog (PTEN) is a potent tumor suppressor that possesses a PDZ-binding domain (PDZ-BD) at the end of its carboxyl terminus, whose functions during tumorigenesis remains unclear. Here, we crossed a mouse strain with germline deletion of PTEN PDZ-BD with MMTV-PyMT breast cancer model, and found that knockout (KO) mice display normal development of mammary glands, but have both increased breast tumorigenicity and lung metastasis. Orthotopic allograft experiments suggest the loss of PTEN PDZ-BD in breast cancer cells rather than in tumor microenvironment plays a prominent role in increasing tumor burd...
Source: Cancer Letters - May 14, 2018 Category: Cancer & Oncology Authors: Mingfei Yan, Yubing Wang, Chi Wai Wong, Penelope Mei-Yu Or, Kin Lok Wong, Lisha Li, Alexander M. Many, Hong Guan, Ui Soon Khoo, Andrew M. Chan Tags: Original Articles Source Type: research
Editorial Board
(Source: Cancer Letters)
Source: Cancer Letters - May 12, 2018 Category: Cancer & Oncology Source Type: research
Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma
Long noncoding RNAs (lncRNA) have been implicated in cancer but most of them remain largely unstudied. Here, we identified a novel NSUN2 methylated lncRNA (NMR), which was significantly upregulated in esophageal squamous cell carcinoma (ESCC), functioned as a key regulator of ESCC tumor metastasis and drug resistance. Upregulation of NMR correlated with tumor metastasis and indicated poor overall survival in ESCC patients. Functionally, NMR could promote tumor cell migration and invasion, inhibit cisplatin-induced apoptosis and increase drug resistance in ESCC cells. (Source: Cancer Letters)
Source: Cancer Letters - May 12, 2018 Category: Cancer & Oncology Authors: Yuan Li, Jiagen Li, Mei Luo, Chengcheng Zhou, Xuejiao Shi, Wenhui Yang, Zhiliang Lu, Zhaoli Chen, Nan Sun, Jie He Tags: Original Articles Source Type: research
Corrigendum to “The Hippo/YAP1 pathway interacts with FGFR1 signaling to maintain stemness in lung cancer” [Canc. Lett. 423 (2018) 36–46]
The authors regret that the acknowledgment section contained incorrect order of grants listed. The correct order is as below: (Source: Cancer Letters)
Source: Cancer Letters - May 10, 2018 Category: Cancer & Oncology Authors: Tingting Lu, Ziming Li, Ying Yang, Wenxiang Ji, Yongfeng Yu, Xiaomin Niu, Qingyu Zeng, Weiliang Xia, Shun Lu Tags: Corrigendum Source Type: research
LncRNA n335586/miR-924/CKMT1A axis contributes to cell migration and invasion in hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide and chronic hepatitis B virus (HBV) infection is a major risk factor for HCC. Emerging evidences indicate that long noncoding RNAs (lncRNAs) play a pivotal role in HCC development, but its contribution to HBV-related HCC remains largely unclear. Differentially expressed lncRNAs in HBV-related HCC tissues were identified by deep sequencing in our previous study. The function of lncRNA n335586, one of most up-regulated lncRNAs in HBV-related HCC, was characterized in the present study. (Source: Cancer Letters)
Source: Cancer Letters - May 10, 2018 Category: Cancer & Oncology Authors: Hongxia Fan, Ping Lv, Ting Mu, Xiaopei Zhao, Yankun Liu, Yujie Feng, Jing Lv, Min Liu, Hua Tang Tags: Original Articles Source Type: research
Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells
Targeting of oncogene-driven replicative stress as therapeutic option for high-risk medullobastoma was assessed using a panel of medulloblastoma cells differing in their c-Myc expression [i.e. group SHH (c-Myc low) vs. group 3 (c-Myc high)]. High c-Myc levels were associated with hypersensitivity to pharmacological Chk1 and ATR inhibition but not to CDK inhibition nor to conventional (genotoxic) anticancer therapeutics. The enhanced sensitivity of group 3 medulloblastoma cells to Chk1 inhibitors likely results from enhanced damage to intracellular organelles, elevated replicative stress and DNA damage and activation of apo...
Source: Cancer Letters - May 10, 2018 Category: Cancer & Oncology Authors: Katharina Kr üger, Katharina Geist, Fabian Stuhldreier, Lena Schumacher, Lena Blümel, Marc Remke, Sebastian Wesselborg, Björn Stork, Nicolaj Klöcker, Stefanie Bormann, Wynand P. Roos, Sebastian Honnen, Gerhard Fritz Tags: Original Articles Source Type: research
Cholesterol inhibits hepatocellular carcinoma invasion and metastasis by promoting CD44 localization in lipid rafts
Cholesterol plays a vital role in modulating the action of membrane proteins critical to cellular function. The effect of serum cholesterol on the prognosis of hepatocellular carcinoma (HCC) patients remains uncertain. Here, we report that high levels of cholesterol predict good survival and low disease recurrence after surgery. Cholesterol could significantly suppress migration and invasion of HCC cells and restrain metastasis of HCC in mice. High levels of cholesterol promoted CD44 translocation into lipid rafts and attenuated CD44-Ezrin binding, which are crucial for cell migration and cancer metastasis. (Source: Cancer Letters)
Source: Cancer Letters - May 8, 2018 Category: Cancer & Oncology Authors: Zhishi Yang, Wenhao Qin, Yao Chen, Bo Yuan, Xiaoling Song, Bibo Wang, Feng Shen, Jing Fu, Hongyang Wang Tags: Original Articles Source Type: research
Transcriptional Repressor Kaiso Promotes Epithelial to Mesenchymal Transition and Metastasis in Prostate Cancer through Direct Regulation of miR-200c
In this study, we established that the transcriptional repressor Kaiso directly binds methylated regions of the miR-200 family, and this is reversed with 5-aza treatment. sh-Kaiso PC-3 cells display increased miR-200-a/b/c, miR-141, and miR-429 expression, with miR-200c demonstrating the most significant increase. Interestingly, overexpression of EGFR or treatment with EGF decreases miR-200c expression and this is reversed after treatment with EGFR specific kinase inhibitor PD153035. (Source: Cancer Letters)
Source: Cancer Letters - May 8, 2018 Category: Cancer & Oncology Authors: Abisola Abisoye-Ogunniyan, Huxian Lin, Anghesom Ghebremedhin, Ahmad Salam, Balasubramanyam Karanam, Shaniece Theodore, Jacqueline Jones-Trich, Melissa Davis, William Grizzle, Honghe Wang, Clayton Yates Tags: Original Articles Source Type: research
SMYD3 controls a Wnt-responsive epigenetic switch for ASCL2 activation and cancer stem cell maintenance
Tumor growth is fueled by subset of cells with stem cell properties (Cancer stem cells, CSCs). While persistent activation of Wnt/ β-catenin signaling confers CSC properties, it remains unclear how epigenetic modifications regulate Wnt target genes to dictate their self-renewal. Here, we report a novel Wnt-responsive epigenetic switch for CSC maintenance through activating the stem cell transcription factor ASCL2 in gastric ca rcinoma (GC). We characterize ASCL2-expressing (ASCL2+) GC cells as a subset of Wnt-responsive CSCs that depend on ASCL2 for self-renewal. (Source: Cancer Letters)
Source: Cancer Letters - May 7, 2018 Category: Cancer & Oncology Authors: Tao Wang, Hong Wu, Sha Liu, Zengjie Lei, Zhongyi Qin, Liangzhi Wen, Kai-jun Liu, Xing-wei Wang, Yan Guo, Qin Liu, Lei Liu, Jun Wang, Li Lin, Chengyi Mao, Xiangfeng Zhu, Hualiang Xiao, Xiuwu Bian, Dongfeng Chen, Chuan Xu, Bin Wang Tags: Original Articles Source Type: research
CD31 regulates metastasis by inducing epithelial –mesenchymal transition in hepatocellular carcinoma via the ITGB1-FAK-Akt signaling pathway
Platelet endothelial cell adhesion molecule-1 (PECAM-1 or CD31) is a well-known marker of endothelial cells and a key factor for adhesion and accumulation of platelets. CD31 plays roles in cell proliferation, apoptosis, migration, and cellular immunity. CD31 is also expressed on tumor cells, such as breast cancer cells and non-Hodgkin's lymphomas, and contributes to tumor cell invasion. Here, our experiments show that CD31 promotes metastasis by inducing the epithelial –mesenchymal transition in hepatocellular carcinoma by up-regulating integrin β1 via the FAK/Akt signaling pathway. (Source: Cancer Letters)
Source: Cancer Letters - May 7, 2018 Category: Cancer & Oncology Authors: Yuan-Yuan Zhang, Ling-Qun Kong, Xiao-Dong Zhu, Hao Cai, Cheng-Hao Wang, Wen-Kai Shi, Man-Qing Cao, Xiao-Long Li, Kang-Shuai Li, Shi-Zhe Zhang, Zong-Tao Chai, Jian-Yang Ao, Bo-Gen Ye, Hui-Chuan Sun Tags: Original Articles Source Type: research
Indoleamine 2,3-dioxygenase 1 inhibition targets anti-PD1-resistant lung tumors by blocking myeloid-derived suppressor cells
Indoleamine 2,3-dioxygenase 1 (IDO1), involved in the catabolism of tryptophan (Trp) to kynurenine (Kyn) is an important regulator of tumor-mediated immunosuppression implicated in resistance to anti-PD1 immunotherapy. We investigated the role of IDO1 in an anti-PD1-resistant lung cancer model (344SQ_R) compared to the parental 344SQ tumors (344SQ_P). IDO1 was overexpressed in tumor-infiltrating leukocytes, and plasma Kyn levels were increased, in 344SQ_R vs. 344SQ_P. The IDO1 inhibitor INCB023843 retarded tumor growth and reduced lung metastases in 344SQ_R. (Source: Cancer Letters)
Source: Cancer Letters - May 7, 2018 Category: Cancer & Oncology Authors: Ailin Li, Hampartsoum B. Barsoumian, Jonathan E. Schoenhals, Taylor R. Cushman, Mauricio S. Caetano, Xiaohong Wang, David R. Valdecanas, Sharareh Niknam, Ahmed I. Younes, Guang Li, Wendy A. Woodward, Maria Angelica Cortez, James W. Welsh Tags: Original Articles Source Type: research
Fucoidan Upregulates TLR4/CHOP-Mediated Caspase-3 and PARP Activation to Enhance Cisplatin-Induced Cytotoxicity in Human Lung Cancer Cells
In this study, we found that sequential therapy, i.e., cisplatin followed by fucoidan, reduced tumor volume in an LLC1-bearing C57BL/6 mouse model. Using a series of combined therapeutic experiments, we found that the inhibition rate of the sequential treatment (cisplatin →fucoidan) was 50 ∼ 75%. However, the inhibition rate of the sequential treatment, with fucoidan pretreatment, was increased to 75 ∼ 85%. (Source: Cancer Letters)
Source: Cancer Letters - May 7, 2018 Category: Cancer & Oncology Authors: Hsien-Yeh Hsu, Tung-Yi Lin, Chun-Hao Hu, David Ta Fu Shu, Mei-Kuang Lu Tags: Original Articles Source Type: research
