Platinum Drug Sensitivity Polymorphisms in Stage III Non-small Cell Lung Cancer With Invasion of Mediastinal Lymph Nodes
Conclusion: These polymorphisms contribute to inter-individual sensibility to chemotherapy response. Interrogation of these genetic variations may have potential applicability when deciding the treatment strategy for patients with stage III NSCLC (N2). (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: NASTASE, A., LUPO, A., LASZLO, V., DAMOTTE, D., DIMA, S., CANNY, E., ALIFANO, M., POPESCU, I., KLEPETKO, W., GRIGOROIU, M. Tags: Experimental Studies Source Type: research
Expression Patterns of CD44 and AREG Under Treatment With Selective Tyrosine Kinase Inhibitors in HPV+ and HPV- Squamous Cell Carcinoma
Conclusion: The selective drug treatment options significantly influenced the expression of CD44 and AREG in HPV– and HPV+ tumor cells, constituting the need for personalized treatment options. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: KANSY, B., ADERHOLD, C., HUBER, L., LUDWIG, S., BIRK, R., LAMMERT, A., LANG, S., ROTTER, N., KRAMER, B. Tags: Experimental Studies Source Type: research
The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk
Conclusion: The T allele of ERCC1 rs11615 jointly with smoking habits may contribute to a higher lung cancer risk in Taiwan. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: CHEN, L.-H., SHEN, T.-C., LI, C.-H., CHIU, K.-L., HSIAU, Y.-C., WANG, Y.-C., GONG, C.-L., WANG, Z.-H., CHANG, W.-S., TSAI, C.-W., HSIA, T.-C., BAU, D.-T. Tags: Experimental Studies Source Type: research
Cytogenetic and Molecular Study of an Adult Sclerosing Rhabdomyosarcoma of the Extremity: MYOD1-mutation and Clonal Evolution
Conclusion: To our knowledge, this is the first adult MYOD1-mutant sclerosing rhabdomyosarcoma studied cytogenetically. The only other reported sclerosing rhabdomyosarcoma with MYOD1 mutation and abnormal karyotype was pediatric. Since these tumors are highly aggressive, further studies unravelling their cytogenetic and molecular characteristics are warranted. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: GORUNOVA, L., BJERKEHAGEN, B., MICCI, F., HEIM, S., PANAGOPOULOS, I. Tags: Experimental Studies Source Type: research
Fusion of the Lumican (LUM) Gene With the Ubiquitin Specific Peptidase 6 (USP6) Gene in an Aneurysmal Bone Cyst Carrying a t(12;17)(q21;p13) Chromosome Translocation
Conclusion: We report a novel t(12;17)(q21;p13) chromosome translocation which gave rise to a LUM-USP6 fusion in an aneurysmal bone cyst. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., ANDERSEN, K., LOBMAIER, I., LUND-IVERSEN, M., MICCI, F., HEIM, S. Tags: Experimental Studies Source Type: research
Characterization of Kinase Expression Related to Increased Migration of PC-3M Cells Using Global Comparative Phosphoproteome Analysis
Conclusion: PAK2, SLK, MST4, MAP2K2, and ARAF are kinases that are potentially associated with the progression of increased migration in PC-3M cells and may represent molecule regulators or drug targets for highly metastatic PCa therapy. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: GAO, Y., HA, Y.-S., KWON, T. G., CHO, Y.-C., LEE, S., LEE, J. N. Tags: Experimental Studies Source Type: research
Multisite Tumor Sampling Reveals Extensive Heterogeneity of Tumor and Host Immune Response in Ovarian Cancer
Conclusion: Clinically relevant morphological and host immune-response IPH appear to be the norm in OVCA. This may complicate efforts to decipher sensitivity of the tumor to certain treatment modalities from a single pre-operative biopsy. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: LAKIS, S., KOTOULA, V., KOLIOU, G.-A., EFSTRATIOU, I., CHRISAFI, S., PAPANIKOLAOU, A., ZEBEKAKIS, P., FOUNTZILAS, G. Tags: Experimental Studies Source Type: research
Combination of ERK2 and STAT3 Inhibitors Promotes Anticancer Effects on Acute Lymphoblastic Leukemia Cells
Conclusion: Our findings provide a rationale for combined inhibition of RAS/RAF/MEK/ERK and STAT3 pathways in order to enhance anticancer effects against acute lymphoblastic leukemia cells. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: JASEK-GAJDA, E., JURKOWSKA, H., JASIŃSKA, M., LITWIN, J. A., LIS, G. J. Tags: Experimental Studies Source Type: research
STRA6 Expression Serves as a Prognostic Biomarker of Gastric Cancer
Conclusion: Patients with high levels of STRA6 mRNA experienced significantly worse clinical outcomes, indicating that STRA6 may serve as a diagnostic and prognostic biomarker of GC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: NAKAMURA, S., KANDA, M., SHIMIZU, D., SAWAKI, K., TANAKA, C., HATTORI, N., HAYASHI, M., YAMADA, S., NAKAYAMA, G., OMAE, K., KOIKE, M., KODERA, Y. Tags: Experimental Studies Source Type: research
Recurrent Fusion of the GRB2 Associated Binding Protein 1 (GAB1) Gene With ABL Proto-oncogene 1 (ABL1) in Benign Pediatric Soft Tissue Tumors
Conclusion: GAB1-ABL1 is a recurrent fusion gene in benign pediatric tumors. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., ANDERSEN, K., TAFJORD, S., LUND-IVERSEN, M., LOBMAIER, I., MICCI, F., HEIM, S. Tags: Experimental Studies Source Type: research
Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase
Conclusion: These findings demonstrate that: 1) The "Warburg effect" is dispensable, 2) loss of the LDHAB gene is not only inconsequential to viability but fosters greater mitochondrial energy, and 3) drugs that target LDHA/B are likely to be ineffective without a plausible combination second drug target. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: MAZZIO, E., BADISA, R., MACK, N., CASSIM, S., ZDRALEVIC, M., POUYSSEGUR, J., SOLIMAN, K. F. A. Tags: Experimental Studies Source Type: research
microRNAs and Corresponding Targets Involved in Metastasis of Colorectal Cancer in Preclinical In Vivo Models
The high death toll of colorectal cancer patients is due to metastatic disease which is difficult to treat. The liver is the preferred site of metastasis, followed by the lungs and peritoneum. In order to identify new targets and new modalities of intervention we surveyed the literature for microRNAs (miRs) which modulate metastasis of colorectal cancer in preclinical in vivo models. We identified 12 up-regulated and 19 down-regulated miRs corresponding to the latter criterium. The vast majority (n=16) of identified miRs are involved in modulation of epithelial-mesenchymal transition (EMT). Other categories of metastasis-r...
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: WEIDLE, U. H., BRINKMANN, U., AUSLAENDER, S. Tags: Reviews Source Type: research
Circulating Tumor DNA in Biliary Tract Cancer: Current Evidence and Future Perspectives
Peripheral blood of cancer patients "physiologically" presents cells and cellular components deriving from primary or metastatic sites, including circulating tumor cells (CTCs), circulating free DNA (cfDNA) and exosomes containing proteins, lipids and nucleic acids. The term circulating tumor DNA (ctDNA) indicates the part of cfDNA which derives from primary tumors and/or metastatic sites, carrying tumor-specific genetic or epigenetic alterations. Analysis of ctDNA has enormous potential applications in all stages of cancer management, including earlier diagnosis of cancer, identification of driver alterations, monitoring ...
Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: RIZZO, A., RICCI, A. D., TAVOLARI, S., BRANDI, G. Tags: Reviews Source Type: research
Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma
Conclusion: LTL was shorter in the G3 subgroup compared to the G2 and G1 subgroups of LSCC patients. TERT rs401681 and its C/T and T/T genotypes were associated with decreased odds of overall LSCC development. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 22, 2020 Category: Cancer & Oncology Authors: VAICIULIS, P., LIUTKEVICIENE, R., LIUTKEVICIUS, V., VILKEVICIUTE, A., GEDVILAITE, G., ULOZA, V. Tags: Article Source Type: research
Long Noncoding RNA ANROC on the INK4 Locus Functions to Suppress Cell Proliferation
Conclusion: ANROC functions to suppress cell cycle progression by suppressing cyclin B1 expression, thus inhibiting cell proliferation. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 22, 2020 Category: Cancer & Oncology Authors: KOTAKE, Y., TSURUDA, T. Tags: Article Source Type: research
