Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity and Metformin Treatment in Adult Patients With Type 2 Diabetes Mellitus
ConclusionsOur results suggest that BDNF may be associated with lipid metabolism and that increased production of BDNF may be related to metformin treatment. Moreover, we showed an association between BDNF levels and platelet reactivity; we found that serum BDNF levels in patients with type 2 diabetes who had high platelet reactivity were higher than in subjects with normal platelet reactivity despite antiplatelet therapy.RésuméObjectifsL'objectif de la présente étude était d'examiner l'association des concentrations sériques du facteur neurotrophique dérivé du cervea...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Changing the Conversation: Diabetes Management in Adults with Severe Mental Illnesses and Type 2 Diabetes
ConclusionsThis work offers an alternative conceptualization of diabetes management that moves beyond idealized concepts of self-care to introduce the social realities of patients as they attempt to enact and negotiate medical directives. This understanding encourages a shift toward social and contextual understandings of the lived realities of patients. Attention to how social context informs patients' realities may assist in the development of new patient-oriented grounds for public health strategies and clinical practices and may challenge traditional understandings of compliance and noncompliance.RésuméOb...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Targeted Glycemic Control for Adult Patients with Type 2 Diabetes Mellitus in the Acute Care Setting
Publication date: Available online 8 February 2018Source: Canadian Journal of DiabetesAuthor(s): Ali Pourmand, Maryann Mazer-Amirshahi, Amy Caggiula, Aria Nawab, Christopher Payette, Samuel JohnsonAbstractDiabetes mellitus and complications arising from the disease are a leading cause of morbidity and mortality worldwide. With increasing prevalence over the past 50 years and an estimated 20% of health-care spending dedicated to the disease, diabetes is considered by many to be a true public health emergency. Several protocols and management options exist to maximize glycemic control in the ambulatory setting, but the optim...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Liver Enzymes, Fatty Liver and Type 2 Diabetes Mellitus in a Jinchang Cohort: A Prospective Study in Adults
ConclusionsOur results suggest that the incidence of T2DM in the group with fatty liver is significantly higher than that in the normal population, and the rise of serum AST, GGT and ALT levels are risk factors independent of fatty liver for the development of T2DM after adjusting for confounding factors.RésuméObjectifsOn ignore encore si les enzymes hépatiques ou l’interaction des diverses enzymes hépatiques constituent un prédicteur du diabète sucré de type 2 (DST2), qui est indépendant de la stéatose hépatique.MéthodesUn total de 48&thi...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

We Can Work (It) Out Together: Type 1 Diabetes Boot Camp for Adult Patients and Providers Improves Exercise Self-Efficacy
ConclusionsThese findings suggest that a 4-week education- and exercise-focused program improves DCPs' self-efficacy in providing exercise advice to patients. People with type 1 diabetes did not experience an improvement in exercise self-efficacy; however, the study supports the use of continuous glucose monitoring and the grouping of DCPs and individuals with type 1 diabetes to facilitate experiential learning.RésuméObjectifsCe projet avait pour objectif le recours aux séances d'enseignement et d'exercice pour rehausser le sentiment d'efficacité personnelle dans la pratique de l'exercice chez l...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Patients' with Type 1 and 2 Diabetes Perceptions Towards Current and Advanced Technologies of Blood Glucose Monitoring: a Prospective Study
This study showed that 24.2% (n=50/207) of the participants were asked to monitor their blood glucose between 3-4 times per day when diagnosed, however only 14.0% (n=29/207) were compliant when the study commenced. A further decline in adherence, from diagnosis to study initiation, was seen in participants who had been asked to monitor their blood glucose levels at least five times per day. When questioned about their reasons for poor adherence, 59.2% (n= 123/207) of the cohort indicated that this is due to the painful, uncomfortable and inconvenience nature of testing. In addition, 75.8% (n=157/207) of the participants ex...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

The Association of Potato Intake with Risk for Incident Type 2 Diabetes in Adults
ConclusionsOur findings indicate that, in Tehranian adults, a moderate intake of dietary total and boiled, but not fried, potatoes may be associated with a lower risk for incident diabetes.RésuméObjectifsDes études antérieures indiquent que le risque de diabète associé à une consommation élevée de pomme de terre diffère selon les populations. Nous avons cherché à étudier les associations entre l'ingestion de pommes de terre sous forme bouillie, frite ou totale et le risque d'incidence de diabète chez les adultes téh&eac...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Endorsement of Diabetes Canada's Alternative Approach for Gestational Diabetes Diagnosis
Publication date: Available online 27 February 2018Source: Canadian Journal of DiabetesAuthor(s): Jason M. Kong (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Serum Vitamin D and Its Upregulated Protein, Thioredoxin Interacting Protein, are Associated with Beta-Cell Dysfunction in Adult Patients with Type 1 and Type 2 Diabetes
ConclusionsOur data showed that vitD and TXNIP were associated with different beta-cell dysfunction markers, indicating their potential abilities to predict the beta-cell status in people with diabetes.RésuméObjectifsLe diabète sucré est caractérisé soit par un défaut total de sécrétion d'insuline, comme dans le diabète de type 1, soit par une dégradation des cellules bêta pancréatiques dans le diabète de type 2. La vitamine D (vitD) et la protéine d'interaction avec la thiorédoxine (TXNIP) ont été m...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Results From a Feasibility Study of Square-Stepping Exercise in Older Adults with Type 2 Diabetes and Self-Reported Cognitive Complaints to Improve Global Cognitive Functioning
ConclusionsSSE should be evaluated further to improve its feasibility in older adults with type 2 diabetes. This study provides preliminary evidence that SSE improves executive function in adults with type 2 diabetes and self-reported cognitive complaints.RésuméObjectifsLes adultes atteints de diabète sucré de type 2 sont à risque accru de démence. Par conséquent, nous avons proposé une initiative appelée programme d'exercice par étapes (SSE) dans le but d'atténuer ce risque. Notre objectif principal était d'évaluer la faisabilit&eac...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Fear of Falling and Balance Confidence in Older Adults With Type 2 Diabetes Mellitus: A Scoping Review
Publication date: Available online 6 March 2018Source: Canadian Journal of DiabetesAuthor(s): Patricia Hewston, Nandini DeshpandeAbstractType 2 diabetes mellitus is highly prevalent in older adults (≥65 years of age) and increases fall risk. Fear of falling and low balance confidence are reported in both fallers and nonfallers and can potentially be more debilitating than a fall itself. Therefore, the objective of this scoping review was to examine and map the current research evidence of balance confidence and fear of falling in older adults with type 2 diabetes. A search of CINAHL, EMBASE and PubMed was conducted. The...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Optimal HbA1c Cut-Off Point for Diagnosis of Type 2 Diabetes in Iranian Adults
Publication date: Available online 12 March 2018Source: Canadian Journal of DiabetesAuthor(s): Farideh Razi, Patricia Khashayar, Robabeh Ghodssi-Ghassemabadi, Mohsen Mehrabzadeh, Maryam Peymani, Fatemeh Bandarian, Ensieh Nasli EsfahaniAbstractObjectiveThe aim of this study was to evaluate the capability of HbA1c as a tool for identifying diabetic and prediabetic Iranian adults.MethodIn a cross-sectional population-based study, 1813 adults comprised of men and women aged 35-75 years without history of diabetes and hemoglobinopathies were included. Fasting blood glucose and HbA1c levels were obtained. According to ADA criter...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Copeptin and Estimated Insulin Sensitivity in Adults with and Without Type 1 Diabetes: CACTI Study
ConclusionCopeptin does not correlate with markers of IR in T1DM, but strongly correlates in non-T1DM. Thus, elevated vasopressin activity and IR appear to be independent risk factors for vascular complications in T1DM. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Association between Elevated C-Reactive Protein Levels and Prediabetes, Particularly Impaired Glucose Tolerance
ConclusionsElevated serum CRP levels are associated with prediabetes, particularly impaired glucose tolerance. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Improving Glycemic Control in Adults and Children with Type 1 Diabetes with the Use of Smart-Phone Based Mobile Applications: a Systematic Review
The objectives of this study were to examine the literature evaluating the use of mobile apps (stand-alone and text messaging/feedback) in T1DM, and to review top-rated mobile apps applicable to T1DM.MethodsMedline, Cochrane and Embase databases were systematically searched to identify studies published from inception to February 2018. Top-rated relevant apps from Google Play Store and Apple App Store were reviewed in July, 2017.ResultsThe literature search yielded 3462 studies. Nine studies evaluated the stand-alone apps. Three showed significant improvement in HbA1C (0.5%, p
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Assessing the Levels of L-Carnitine and Total Antioxidant Capacity in Newly Diagnosed and Long-Standing Type II Diabetes
This study was done on 90 adult subjects, which included 30 newly diagnosed, 30 long-standing T2 diabetics, and 30 healthy controls. Plasma samples were used to assay the biochemical parameters.ResultsIn this study, both diabetic groups (newly diagnosed and long-standing T2 diabetics) were significantly different in baseline characteristics, such as age, height, weight, BMI, FBS, Chol, and TG, compared to the healthy controls. Plasma LC levels in newly diagnosed and long-standing T2 diabetic adult patients were significantly lower than healthy controls (P
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Anti-Inflammatory, Antiapoptotic and Proproliferative Effects of Vitis vinifera Seed Ethanolic Extract in the Liver of Streptozotocin-Nicotinamide-Induced Type 2 Diabetes in Male Rats
ConclusionsThe anti-inflammatory, anti-apoptotic and pro-proliferative effects of VVSEE could account for its hepatoprotective actions in diabetes.RésuméObjectifsIl a été établi que la consommation de pépins de raisin de l‘espèce Vitis vinifera améliore la pathologie du foie lors de diabète sucré. Toutefois, on ignore les mécanismes à l'origine de ses effets. Dans la présente étude, les effets anti-inflammatoires, anti-apoptotiques et pro-prolifératifs de l'extrait éthanolique des pépins de raisin de...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Table of Contents
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Editorial Board
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Diabetes and Hypertension: The Low and High Points
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Luc Trudeau, Jeremy Gilbert (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Top 10 Reviewers for 2017
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Predictors of Serum Adiponectin in Patients With Prediabetes and Type 2 Diabetes
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Tomoyuki Kawada (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Response to the Letter to the Editor From Dr. Kawada, “Predictors of Serum Adiponectin in Patients With Prediabetes and Type 2 Diabetes”
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Anindita Banerjee, Vineet Kumar Khemka (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Angiotensin-Converting Enzyme Inhibitors vs. Angiotensin Receptor Blockers for the Treatment of Hypertension in Adults With Type 2 Diabetes: Why We Favour Angiotensin Receptor Blockers
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Thomas A. Mavrakanas, Mark L. LipmanAbstractCardiovascular disease is the principal cause of morbidity and mortality in patients with diabetes mellitus. The incidence or progression of kidney disease is also common in these patients. Several clinical trials have established the efficacy of angiotensin receptor blockers for the prevention of adverse cardiovascular and renal outcomes in this population and are summarized in this review article. Head-to-head comparison of angiotensin receptor blockers with angiotensin-converting enz...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

The Divergent Cardiovascular Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Type 1 Receptor Blockers in Adult Patients With Type 2 Diabetes Mellitus
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Martin H. Strauss, Alistair S. HallAbstractThe renin angiotensin aldosterone system (RAAS) plays a central role in the pathophysiology of hypertension and vascular disease. Angiotensin-converting enzyme inhibitors (ACEi's) suppress angiotensin II (ANG II) concentrations, whereas angiotensin II type 1 (AT1) receptor blockers (ARBs) block the binding of ANG II to AT1 receptors. ACEi's and ARBs are both effective antihypertensive agents and produce similar risk reductions for stroke, a blood pressure-dependent phenomenon. ACEi's als...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Associations Between Sleep Habits and Dysglycemia in Adults in the United States: A Cross-Sectional Analysis
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Katherina C. Chojnacki, Thirumagal Kanagasabai, Michael C. Riddell, Chris I. ArdernAbstractObjectivesTo examine the independent and joint associations between sleep duration and quality with glycated hemoglobin (A1C) levels and dysglycemia in non-institutionalized adults living in the United States.MethodsData from the United States National Health and Nutrition Examination Survey (2005-2008) were used (N=9478; ≥20 years). Information on sleep quantity and quality were derived from the Sleep Disorders Questionnaire and used to...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Blood Pressure Management in Adults With Type 2 Diabetes: Insights From the Diabetes Mellitus Status in Canada (DM-SCAN) Survey
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Jasmine Grenier, Shaun G. Goodman, Lawrence A. Leiter, Anatoly Langer, Hwee Teoh, Deepak L. Bhatt, Alice Y.Y. Cheng, Mary K. Tan, Thomas Ransom, Kim A. Connelly, Andrew T. YanAbstractObjectivesOptimal treatment of blood pressure (BP) and other cardiovascular risk factors, including hyperglycemia, is integral to diabetes management. There are limited data from the primary care setting concerning the contemporary and comprehensive management of type 2 diabetes and other cardiovascular risk factors in relation to guideline-recommend...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Single-Pill Combinations in the Treatment of Hypertension in Adults: Beyond Convenience
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Benoit Imbeault, Michel ValléeAbstractAdequate blood pressure control in patients with hypertension remains the pillar of cardiovascular-event prevention. Smoking cessation, reduced dietary salt intake, physical exercise and weight loss contribute to better blood pressure control and reduced cardiovascular morbidity, but alone, they are often insufficient in doing so, and their success is highly dependent on individual patient motivation. Pharmacologic therapy, thus, remains necessary for most patients, and our conception ...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

An Update on Hypertension in Children With Type 1 Diabetes
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Mallory L. Downie, Emma H. Ulrich, Damien G. NooneAbstractThe prevalence of hypertension in children with type 1 diabetes is reported to be between 6% and 16%. This potentially modifiable cardiovascular risk factor may go undiagnosed and undertreated, particularly in children with type 1 diabetes. Recent updated Canadian clinical practice guidelines recommend blood pressure screening every 2 years in children with type 1 diabetes as well as routine use of ambulatory blood pressure monitoring. Risk factors for hypertension in type...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Nonpharmacological Interventions in the Management of Hypertension in the Adult Population With Type 2 Diabetes Mellitus
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Patricia UrricoAbstractThis review discusses nonpharmacological interventions for the management of hypertension in people with diabetes. Interventions that focus on controlling weight, reducing salt intake, eating according to the Dietary Approaches to Stop Hypertension guidelines, partaking in regular physical activity, ceasing smoking and self-measuring of blood pressure can lower blood pressure in the population with diabetes. Other positive outcomes resulting from these lifestyle changes are improved glycemia levels and card...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Hypertension in Adults With Type 2 Diabetes: A Review of Blood Pressure Measurement Methods, Targets and Therapy
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Lyne Cloutier, Maxime Lamarre-ClicheAbstractHypertension occurs in more than two-thirds of patients with type 2 diabetes. In a retrospective analysis of a Framingham cohort, high blood pressure was associated with a 72% increase in the risk for all-cause death and a 57% increment in the risk for any cardiovascular disease event, making hypertension the strongest driver of cardiovascular outcomes in individuals with diabetes. One of the key aspects of hypertension management is the correct measurement of blood pressure; various ty...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Low Hepcidin in Type 2 Diabetes Mellitus: Examining the Molecular Links and Their Clinical Implications
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Driton Vela, Ramadan B. Sopi, Mitko MladenovAbstractThe relationship between iron and glucose metabolism has been evidenced strongly, but the molecular mediation of this connection is just being revealed. The discovery of hepcidin as the prime controller of iron metabolism has paved the way for understanding the main actors behind this mediation. Recent data suggest that insulin therapy and probably other diabetes drugs can influence hepcidin production, thus influencing the iron load in cells. Correcting iron load through hepcid...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Resistant Hypertension in Adults With Type 1 or 2 Diabetes: A Structured Diagnostic Approach
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Philip A. McFarlaneAbstractPeople with diabetes often have difficulty reaching their blood pressure targets and are labelled as having resistant hypertension. Clinicians often move quickly to screen such people for secondary causes of hypertension; however, such causes are rare, and resistant hypertension usually has other explanations that are significantly more common. By using a structured approach to resistant hypertension, clinicians can assist patients to reach their target blood pressure levels. Step 1 is to determine out-...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Thresholds and Targets for Hypertension Management in Adults With Type 2 Diabetes Should Remain at 130/80 mmHg: What's the Evidence?
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Niharika Shahi, Sheldon W. TobeAbstractHypertension and diabetes are common comorbidities and are both modifiable risk factors for cardiovascular disease and death. Lowering blood pressure reduces target organ damage and prevents cardiovascular disease outcomes. The harmonized Canadian clinical practice guidelines for managing hypertension in people with diabetes provides health-behaviour advice and medical therapy recommendations for a threshold blood pressure of 130/80 mmHg and above and to target blood pressure to below...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Framing Obesity as a Health Issue: Differences in Public and Professional Perceptions Between Canada and the United States
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Bonnie L. Kuehl, Sara F.L. Kirk, Nathalie Dumas, Theodore K. Kyle (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Adherence to Guidelines for Inpatient Pharmacologic Management of Type 2 Diabetes in Adults and Glycemic Outcomes
This study assessed the level of adherence to current Canadian practice guidelines for inpatient pharmacologic management of type 2 diabetes and whether it affected the frequency of hyperglycemia or hypoglycemia.MethodsRetrospectively, we assessed the first 3 days of routine inpatient capillary blood glucose measurement (CBGM) records for hyperglycemia (>8 mmol/L fasting,>10 mmol/L nonfasting) and hypoglycemia (
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Masthead
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Placental Expression of Glucose Transporter Proteins in Pregnancies Complicated by Gestational and Pregestational Diabetes Mellitus
Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Paweł Jan Stanirowski, Dariusz Szukiewicz, Monika Pazura-Turowska, Włodzimierz Sawicki, Krzysztof CendrowskiAbstractGestational diabetes mellitus and pregestational diabetes mellitus constitute carbohydrate metabolism disorders, which, if not diagnosed and adequately treated, lead to serious and often life-threatening pregnancy complications. According to a recently formulated hypothesis, some diabetes-related complications, such as fetal macrosomia, may be the result of disturbances in the transplacental transport of nutrients...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Effect of Biochanin a on Retina Level of VEGF, TNF-a and IL-1B in STZ Induced Diabetic Rats
Publication date: Available online 3 April 2018Source: Canadian Journal of DiabetesAuthor(s): Maryam Eskandari Mehrabadi, Zahra Salemi, Saeid Babaie, Mitra PanahiAbstractObjectivesWithout proper medication for the treatment of diabetic retinopathy (DR), retinal cells become malnourished and degenerate, which results to damage in vision cells and can lead to blindness. Flavonoids such as biochanin A (BCA) can directly target different facets of angiogenesis. We assessed the effect of administrating BCA on angiogenic and inflammatory markers in the retina of diabetic rats.MethodsWe selected randomly 2 groups from thirty male...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Population-Level Outcomes with a 2-Step Approach for Gestational Diabetes Screening and Diagnosis - Response
Publication date: Available online 13 April 2018Source: Canadian Journal of DiabetesAuthor(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Factors Influencing Preferences of Adult with Type 2 Diabetes for Diabetes Self-Management Education Interventions
ConclusionsTo optimize the effectiveness of DSME interventions, healthcare providers are encouraged to assess patient's preferences to inform the design of DSME interventions and tailor their implementation to fit the preferences of patients with a range of socio-demographic and clinical profiles. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Safe Use of Metformin in Adults with Type 2 Diabetes and Chronic Kidney Disease – Lower Doses and Sick Day Education Are Essential
Publication date: Available online 25 April 2018Source: Canadian Journal of DiabetesAuthor(s): Lori MacCallum, Peter A. SeniorAbstractMetformin, together with lifestyle intervention, is considered first line for glycemic management in type 2 diabetes. Despite this widespread use, one of the areas of longstanding debate has been whether metformin can be safely used in those with chronic kidney disease (CKD). The concern is the possibility of an increased risk of lactic acidosis resulting from metformin accumulation in those with renal impairment. As options in this patient population are limited and many believe this risk h...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Diabetes Canada Position Statement for People with Types 1 and 2 Diabetes Who Fast During Ramadan
ConclusionsThis is the first Canadian position statement on the topic of Ramadan fasting and diabetes. It was developed by an expert faculty and endorsed by Diabetes Canada, and provides guidance about pharmacotherapy and glucose monitoring for health-care providers so that they can assist Canadian Muslims living with diabetes to observe fasting during Ramadan safely.RésuméObjectifLe jeûne de l'aube au crépuscule pendant le Ramadan, incluant une abstinence d'eau et de nourriture, est l'un des piliers de l'islam et est observé par la majorité des musulmans. La plupart des recherches ...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Cystic Fibrosis Related Diabetes Screening in Adults: a Gap Analysis & Evaluation of A1C Accuracy
Publication date: Available online 2 May 2018Source: Canadian Journal of DiabetesAuthor(s): Julie A. Gilmour, Jenna Sykes, Edward Etchells, Elizabeth TullisAbstractOBJECTIVEWe sought to identify the gap in Cystic Fibrosis Related Diabetes (CFRD) screening, using an Oral Glucose Tolerance Test (OGTT), within our tertiary care clinic. Our second aim was to identify the A1C threshold that optimizes sensitivity and specificity for predicting CFRD and Impaired Glucose Tolerance (IGT).RESEARCH DESIGN AND METHODSThis retrospective study used data housed within the Toronto Cystic Fibrosis (CF) database. The study population includ...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Evaluation of a Patient Care Planning Intervention to Improve Appointment Attendance in Adults Following Bariatric Surgery, a Treatment for Obesity and Type 2 Diabetes
ConclusionsIn summary, this QI intervention was able to improve patient-centred care and clinic efficiency through the use of advanced care planning as evaluated by appointment attendance data and patient satisfaction surveys. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Associations between Depressive Symptoms and Indices of Obesity in Adults with Prediabetes and Normal Blood Glucose Levels: Results From the Emotional Health and Wellbeing Study
ConclusionsDepressive symptoms were more strongly associated with indices of obesity in people with prediabetes than in people with normal blood glucose levels. Depressive symptoms may be a barrier to weight management in people with prediabetes. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Atrial Fibrillation is Associated with Impaired Atrial Mitochondrial Energetics and Supercomplex Formation in Adults with Type 2 Diabetes
Publication date: Available online 31 May 2018Source: Canadian Journal of DiabetesAuthor(s): Georges N. Kanaan, David Patten, Calum Redpath, Mary-Ellen HarperAbstractBackgroundType 2 diabetes mellitus (T2DM) is a chronic progressive disease associated with increased risk for cardiovascular diseases (CVDs) and with impaired mitochondrial metabolism in cardiac and skeletal muscles. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with significant morbidity and mortality. T2DM is also one of the prevalent concomitant diseases in patients with AF. During AF, myocardial energy demand is...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Pediatric Type 1 Diabetes: Patients' and Caregivers' Perceptions of Glycemic Control
ConclusionsPatients and caregivers had accurate knowledge of ideal BG range but were less knowledgeable about the meaning of A1C levels and ideal A1C targets. Nevertheless, whether glycemic control was perceived as an A1C measurement or a BG range, A1C levels trended lower for patients when both they and their caregivers had accurate perceptions of glycemic control.RésuméObjectifs1) Décrire la perception des enfants et des adolescents atteints du DT1 et de leurs soignants sur les mesures liées à la régulation glycémique (les concentrations de l'hémoglobine [A1c] ...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Eating Behaviours and Prevalence of Gastroesophageal Reflux Disease in Japanese Adult Patients With Type 2 Diabetes Mellitus: The Dogo Study
ConclusionsLate-night dinner may be positively associated with GERD in Japanese patients with type 2 diabetes.RésuméObjectifsDans la population générale, le souper tardif est associé de manière positive au reflux gastro-œsophagien (RGO) pathologique. Aucune donnée probante n'existe au sujet de la relation entre les comportements alimentaires et le RGO chez les patients atteints du diabète sucré de type 2, pourtant la prévalence du RGO chez les patients atteints du diabète de type 2 est plus élevée que chez les patientsnon diab&...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Is Type 2 Diabetes in Adults Associated With Impaired Capacity for Weight Loss?
Publication date: June 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 3Author(s): Ghadi Antoun, Majid Nikpay, Ruth McPherson, Mary-Ellen Harper, Robert Dent (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research