A novel complete blood count ‐based score to screen for myelodysplastic syndrome in cytopenic patients
SummaryThe diagnosis of myelodysplastic syndromes (MDS) is often challenging, time ‐ and resource‐consuming. A thorough analysis of complete blood count (CBC) parameters could, however, help to screen for MDS among other causes of cytopenia. To test this hypothesis, 109 newly‐diagnosed MDS patients and 399 cytopenic patients older than 50 years with confirmed absence of MDS were enrolled in a prospective study. Multiparametric analysis highlighted three CBC parameters that were significantly different between the two cohorts: mean corpuscular volume, absolute neutrophil count and median neutrophil complexity and wid...
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Robin Boutault,
Pierre Peterlin,
Marouane Boubaya,
Katja Sockel,
Patrice Chevallier,
Alice Garnier,
Thierry Guillaume,
Amandine Le Bourgeois,
Camille Debord,
Catherine Godon,
Yannick Le Bris,
Olivier Theisen,
Frank Kroschinsky,
Philippe Morea Tags: Research Paper Source Type: research
Cumulative anthracycline exposure and risk of cardiotoxicity; a Danish nationwide cohort study of 2440 lymphoma patients treated with or without anthracyclines
We examined cardiotoxicity in adult patients with diffuse large B‐cell lymphoma and follicular lymphoma undergoing first‐line immunochemotherapy from 2000–2012. In total, 2440 patients without previous heart disease were identified from the Danish Lymphoma Registry, of which 1994 (81·7%) were treated with anthracycline‐containing chemotherapy [R‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone) or R‐CHOEP (R‐CHOP + etoposide)] and 446 (18·3%) were treated without anthracyclines (reference group). Compared to the refe rence group, the adjusted hazard ratio of CHF after 3–5 cycles o...
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Joachim Baech,
Steen M. Hansen,
Peter E. Lund,
Peter Soegaard,
Peter de Nully Brown,
Jacob Haaber,
Judit J ørgensen,
Jørn Starklint,
Pär Josefsson,
Christian B. Poulsen,
Maja B. Juul,
Christian Torp‐Pedersen,
Tarec C. El‐Galaly Tags: Research Paper Source Type: research
Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia. A NOPHO ‐DBH‐AML study
SummaryData on occurrence, genetic characteristics and prognostic impact of complex and monosomal karyotype (CK/MK) in children with acute myeloid leukaemia (AML) are scarce. We studied CK and MK in a large unselected cohort of childhood AML patients diagnosed and treated according to Nordic Society for Paediatric Haematology and Oncology (NOPHO) ‐AML protocols 1993–2015. In total, 800 patients withde novoAML were included. CK was found in 122 (15%) and MK in 41 (5%) patients. CK and MK patients were young (median age 2 ·1 and 3·3 years, respectively) and frequently had FAB M7 morphology (24% and 22%, respectively)....
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Ninna Bager,
Kristian L. Juul ‐Dam,
Julie D. Sandahl,
Jonas Abrahamsson,
Berna Beverloo,
Eveline S. J. M. Bont,
Shau‐Yin Ha,
Kirsi Jahnukainen,
Ólafur G. Jónsson,
Gertjan L. Kaspers,
Zhanna Kovalova,
Birgitte Lausen,
Barbara De Moerloose Tags: Research Paper Source Type: research
Sequential B ‐lymphoid and myeloid blastic transformation of Philadelphia chromosome‐negative myeloproliferative neoplasm
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Aileen Y. Hu,
Ting Zhou Tags: Images in Haematology Source Type: research
Long survival in patients with Waldenstr öm macroglobulinaemia diagnosed at a young age
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Amaara Babwah,
Joshua Gustine,
Kirsten Meid,
Toni Dubeau,
Lian Xu,
Guang Yang,
Zachary R. Hunter,
Steven P. Treon,
Jorge J. Castillo Tags: Correspondence Source Type: research
A retrospective multicentre study of COCKLE, an oral chemotherapy regimen, as palliative treatment for high grade lymphoma
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Bernard Maybury,
George Kimpton,
Sophie Otton Tags: Correspondence Source Type: research
Clinical outcomes in chronic lymphocytic leukaemia associated with expression of CD5, a negative regulator of B ‐cell receptor signalling
SummaryChronic lymphocytic leukaemia (CLL) is characterized by expression of CD5 on clonal B cells, and is partly driven by activated B ‐cell receptor (BCR) signalling. While CD5 is known to be a negative regulator of BCR signalling, it is unknown if variability in CD5 expression exists among patients and whether CLL cell CD5 expression affects CLL clinical outcomes. We assessed the extent to which CD5 expression is correlated wit h clinical outcomes, and whether this information adds to currently used prognostic markers. We evaluated CD5 expression from 1275 blood samples, established prognostic markers and time to even...
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Daphne R. Friedman,
Eross Guadalupe,
Alicia Volkheimer,
Joseph O. Moore,
J. Brice Weinberg Tags: Research Paper Source Type: research
Growth disturbances in children and adolescents receiving long ‐term tyrosine kinase inhibitor therapy for Chronic Myeloid Leukaemia or Philadelphia Chromosome‐positive Acute Lymphoblastic Leukaemia
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Himalee S. Sabnis,
Caroline Keenum,
Rebecca W. Lewis,
Briana Patterson,
John Bergsagel,
Karen E. Effinger,
Emily Silverman,
Ann C. Mertens,
Sharon M. Castellino Tags: Correspondence Source Type: research
Additive effect of sirolimus and hydroxycarbamide on fetal haemoglobin level in kidney transplant patients with sickle cell disease
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Adil A. Al ‐Khatti,
Ahmed M. Alkhunaizi Tags: Correspondence Source Type: research
Auer rods in neutrophils in bone marrow and peripheral blood in mixed phenotype acute leukaemia in a child
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Samia Kabbage,
Roberto Cupaiolo,
Laurence Rozen,
Anne Demulder Tags: Images in Haematology Source Type: research
Efficacy of bendamustine and rituximab in splenic marginal zone lymphoma: results from the phase II BRISMA/IELSG36 study
In conclusion, B‐R resulted in a very effective first‐line regimen for SMZL. Based on the results achieved in the BRISMA trial, B‐R should be considered when a chemotherapy combination with rituximab is deemed necessary for symptomatic SMZL patients. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Emilio Iannitto,
Monica Bellei,
Sandy Amorim,
Andr és J. M. Ferreri,
Luigi Marcheselli,
Marina Cesaretti,
Corinne Haioun,
Salvatrice Mancuso,
Krimo Bouabdallah,
Remy Gressin,
Claudio Tripodo,
Alexandra Traverse‐Glehen,
Lucile Baseggio,
Sim Tags: Research Paper Source Type: research
Time to progression of mantle cell lymphoma after high ‐dose cytarabine‐based regimens defines patients risk for death
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Carlo Visco,
Maria C. Tisi,
Andrea Evangelista,
Alice Di Rocco,
Anna ‐Katharina Zoellner,
Vittorio R. Zilioli,
Stefan Hohaus,
Roberta Sciarra,
Alessandro Re,
Cristina Tecchio,
Annalisa Chiappella,
Lucia Morello,
Guido Gini,
Luca Nassi,
Tom Tags: Correspondence Source Type: research
Diagnosis of Hodgkin lymphoma in the modern era
SummaryThe Hodgkin lymphomas are a family of unique lymphoma subtypes, in which the nature of the neoplastic cell was enigmatic for many years. Much of the mystery has been solved, with all forms now considered to be of B ‐cell origin, in most cases of germinal centre derivation. Today we recognize Hodgkin lymphoma as an eponym that encompasses multiple entities. One of the unifying themes is the major contribution from the tumour microenvironment. Both the character of the neoplastic cells and the nature of the im mune environment are critical to accurate diagnosis. Moreover, an understanding of the molecular alteration...
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Hao ‐Wei Wang,
Jayalakshmi P. Balakrishna,
Stefania Pittaluga,
Elaine S. Jaffe Tags: Review Source Type: research
Acquired ichthyosis as a paraneoplastic feature of ALK ‐negative anaplastic large cell lymphoma
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Georgi Valchev,
Tsvetan Alaikov,
Velizar Shivarov Tags: Images in Haematology Source Type: research
Cytokine release syndrome and neurotoxicity after CD19 chimeric antigen receptor ‐modified (CAR‐) T cell therapy
SummaryChimeric antigen receptor ‐modified (CAR)‐T cells have demonstrated impressive results in the treatment of haematological malignancies. However, cytokine release syndrome (CRS) and neurotoxicity are common toxicities which are potentially life‐threatening in severe cases. Risk factors for CRS and neurotoxicity identifi ed so far include disease burden, lymphodepletion intensity and CAR‐T cell dose administered. Risk‐adapted dosing, with lower CAR‐T cell doses administered to B‐cell acute lymphoblastic leukaemia patients with high marrow blast counts, has been successful at decreasing severe CRS rates i...
Source: British Journal of Haematology - November 8, 2018 Category: Hematology Authors: Kevin A. Hay Tags: Review Source Type: research
