The effect of weight change on changes in breast density measures over menopause in a breast cancer screening cohort
IntroductionHigh weight and high percent mammographic breast density are both breast cancer risk factors, but are negatively correlated. Therefore we wanted to obtain more insight in this apparent paradox.
Methods:
We investigated in a longitudinal study how weight change over menopause is related to changes in mammographic breast features. 591 participants of the EPIC-NL cohort, were divided into 3 groups according their prospectively measured weight change over menopause: 1) weight loss (> −3.0 %), 2) stable weight (between −3.0 % and +3.0 %) and 3) weight gain (>3.0 %). SPSS GLM univariate analysis was used to d...
Source: Breast Cancer Research - May 30, 2015 Category: Cancer & Oncology Authors: Johanna WandersMarije BakkerWouter VeldhuisPetra PeetersCarla van Gils Source Type: research
Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response
Conclusions:
Serial gene expression analysis revealed candidate immune and proliferation pathways associated with response and recurrence. Larger studies incorporating the approach described here are warranted to identify predictive and prognostic biomarkers in the NAC setting for specific targeted therapies.Clinical trial registrationThe I-SPY 1 TRIAL was registered on April 9, 2002 as NCT00033397. (Source: Breast Cancer Research)
Source: Breast Cancer Research - May 29, 2015 Category: Cancer & Oncology Authors: Mark MagbanuaDenise WolfChristina YauSarah DavisJulia CrothersAlfred AuChristopher HaqqChad LivasyHope RugoLaura EssermanJohn ParkLaura van¿t VeerI-SPY 1 TRIAL Investigators Source Type: research
Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures
Conclusions:
Collectively, the pilot data is consistent with the notion that increased blood is supplied to breast cancers, and it also suggests that less conversion of oxy- to deoxy-hemoglobin occurs in more proliferative cancers. Overall, the observations corroborate expectations that macroscopic measurements of breast cancer physiology using DOT and DCS can reveal microscopic pathological properties of breast cancer and hold potential to complement pathological biomarker information. (Source: Breast Cancer Research)
Source: Breast Cancer Research - May 27, 2015 Category: Cancer & Oncology Authors: So ChungMichael FeldmanDaniel MartinezHelen KimMary PuttDavid BuschJulia TchouBrian CzernieckiMitchell SchnallMark RosenAngela DeMicheleArjun YodhRegine Choe Source Type: research
Anti-HER2 CD4+ T-helper type 1 response is a novel immune correlate to pathologic response following neoadjuvant therapy in HER2-positive breast cancer
We examined differences in anti-HER2 Th1 responses between pCR and non-pCR patients to identify modifiable immune correlates to pathologic response following neoadjuvant T + C.
Methods:
Anti-HER2 Th1 responses in 87 HER2pos-IBC patients were examined using peripheral blood mononuclear cells pulsed with 6 HER2-derived class II peptides via IFN-γ ELISPOT. Th1 response metrics were anti-HER2 responsivity, repertoire (number of reactive peptides), and cumulative response across 6 peptides (spot-forming cells [SFC]/106 cells). Anti-HER2 Th1 responses of non-pCR patients (n = 4) receiving adjuvant HER2-pulsed type 1-pol...
Source: Breast Cancer Research - May 23, 2015 Category: Cancer & Oncology Authors: Jashodeep DattaErik BerkShuwen XuElizabeth FitzpatrickCinthia RosemblitLea LowenfeldNoah GoodmanDavid LewisPaul ZhangCarla FisherRobert RosesAngela DeMicheleBrian Czerniecki Source Type: research
IL-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis
Conclusions:
We demonstrated that IL-15 has a role in mammary cancer immunosurveillance and that IL-15-regulated NK and CD8+ memory cells play a role in long-lasting immunoprevention, further supporting the potential use of IL-15 as adjuvant in immunological strategies against tumors. (Source: Breast Cancer Research)
Source: Breast Cancer Research - May 22, 2015 Category: Cancer & Oncology Authors: Stefania CrociPatrizia NanniArianna PalladiniGiordano NicolettiValentina GrossoGiorgia BenegiamoLorena LanduzziAlessia LamolinaraMarianna IanzanoDario RanieriMassimiliano Dall¿OraManuela IezziCarla De GiovanniPier-Luigi Lollini Source Type: research
Anti-CCL2: building a reservoir or opening the floodgates to metastasis?
Neutralisation of macrophage chemoattractant C-C chemokine ligand 2 (CCL2) has shown reduced metastasis and enhanced survival in numerous experimental models of tumorigenesis. However, important new findings reported in Nature by Momo Bentires-Alj’s laboratory demonstrate that withdrawal of anti-CCL2 treatment accelerates lung metastasis and death in mice. The study highlights the need to consider longer term consequences of therapeutic intervention of metastatic disease, especially with regard to transient interference with the tumour microenvironment. (Source: Breast Cancer Research)
Source: Breast Cancer Research - May 21, 2015 Category: Cancer & Oncology Authors: Jessica HitchcockChristine Watson Source Type: research
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for GPER in mediating tamoxifen resistance through CAF-derived fibronectin and β1-integrin signaling pathway in tumor cells
Conclusions:
GPER/EGFR/ERK signaling upregulates β1-integrin expression and activates downstream kinases, which contributes to CAF-induced cell migration and EMT, in MCF-7R cells. GPER probably contributes to tamoxifen resistance via interaction with the tumor microenvironment in a β1-integrin dependent pattern. Thus, β1-integrin may be a potential target to improve anti-hormone therapy responses in breast cancer patients. (Source: Breast Cancer Research)
Source: Breast Cancer Research - May 21, 2015 Category: Cancer & Oncology Authors: Jie YuanManran LiuLi YangGang TuQing ZhuMaoshan ChenHong ChengHaojun LuoWeijie FuZhenhua LiGuanglun Yang Source Type: research
Quantitative assessment of background parenchymal enhancement in breast MRI predicts response to risk-reducing salpingo-oophorectomy: preliminary evaluation in a cohort of BRCA1/2 mutation carriers
We present a fully-automated method for deriving quantitative measures of background parenchymal enhancement (BPE) from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and perform a preliminary evaluation of these measures to assess the effect of risk-reducing salpingo-oophorectomy (RRSO) in a cohort of BReast CAncer susceptibility gene 1/2 (BRCA1/2) mutation carriers.
Methods:
Breast DCE-MRI data from 50 BRCA1/2 carriers were retrospectively analyzed under the Health Insurance Portability and Accountability Act (HIPAA) and institutional review board approval. Both the absolute (| |) and relative ( ...
Source: Breast Cancer Research - May 19, 2015 Category: Cancer & Oncology Authors: Shandong WuSusan WeinsteinMichael DeLeoEmily ConantJinbo ChenSusan DomchekDespina Kontos Source Type: research
Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery
Conclusion:
The therapeutic effects of breast cancer magnetic hyperthermia could be strongly enhanced by the combination of MF66 functionalized with N6L and DOX and magnetic hyperthermia. Our approach combines two ways of tumor cell killing (magnetic hyperthermia and chemotherapy) and represents a straightforward strategy for translation into the clinical practice when injecting nanoparticles intratumorally. (Source: Breast Cancer Research)
Source: Breast Cancer Research - May 13, 2015 Category: Cancer & Oncology Authors: Susanne KossatzJulia GrandkePierre CouleaudAlfonso LatorreAntonio AiresKieran Crosbie-StauntonRobert LudwigHeidi DähringVolker EtteltAna Lazaro-CarrilloMacarena CaleroMaha SaderJosé CourtyYuri VolkovAdriele Prina-MelloAngeles VillanuevaÁlvaro SomozaAit Source Type: research
Omega-3 fatty acids for breast cancer prevention and survivorship
Women with evidence of high intake ratios of the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) relative to the omega-6 arachidonic acid have been found to have a reduced risk of breast cancer compared with those with low ratios in some but not all case–control and cohort studies. If increasing EPA and DHA relative to arachidonic acid is effective in reducing breast cancer risk, likely mechanisms include reduction in proinflammatory lipid derivatives, inhibition of nuclear factor-κB-induced cytokine production, and decreased growth factor receptor signaling as a result of alteratio...
Source: Breast Cancer Research - May 4, 2015 Category: Cancer & Oncology Authors: Carol FabianBruce KimlerStephen Hursting Source Type: research
Metformin increases survival in hormone receptor-positive, Her2-positive breast cancer patients with diabetes
IntroductionMetformin use has recently been observed to decrease both the rate and mortality of breast cancer. Our study was aim to determine whether metformin use is associated with survival in diabetic breast cancer patients by breast cancer subtype and systemic treatment
Methods:
Data from the Asan Medical Center Breast Cancer Database from 1997 to 2007 were analyzed. The study cohort comprised 6,967 nondiabetic patients, 202 diabetic patients treated with metformin, and 184 diabetic patients that did not receive metformin. Patients who were divided into three groups by diabetes status and metformin use were also divide...
Source: Breast Cancer Research - May 3, 2015 Category: Cancer & Oncology Authors: Hee KimHyunwook KwonJong LeeHwa KimSae LeeHee ParkGuiyun SohnYura LeeBeom KohJong YuByung SonSei Ahn Source Type: research
Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early stage hormone negative breast cancer
IntroductionThe serine/threonine protein kinase ataxia telangiectasia mutated (ATM) is critical in maintaining genomic integrity. Upon DNA double-strand breaks, ATM phosphorylates key downstream proteins including p53 and BRCA1/2, thereby orchestrating complex signaling pathways involved in cell cycle arrest, DNA repair, senescence and apoptosis. Although sporadic mutation of ATM occurs rarely in breast cancer, the status of its protein expression and its clinical significance in breast cancer remain not well established. Our study was designed to investigate the influence of ATM protein in both tumor and cancer-associated...
Source: Breast Cancer Research - May 3, 2015 Category: Cancer & Oncology Authors: Xiaolan FengHaocheng LiMichelle DeanHolly WilsonElizabeth KornagaEmeka EnwerePatricia TangAlexander PatersonSusan Lees-MillerAnthony MaglioccoGwyn Bebb Source Type: research
Benefits and harms of mammography screening
Mammography screening for breast cancer is widely available in many countries. Initially praised as a universal achievement to improve women's health and to reduce the burden of breast cancer, the benefits and harms of mammography screening have been debated heatedly in the past years. This review discusses the benefits and harms of mammography screening in light of findings from randomized trials and from more recent observational studies performed in the era of modern diagnostics and treatment. The main benefit of mammography screening is reduction of breast-cancer related death. Relative reductions vary from about 15 to...
Source: Breast Cancer Research - May 1, 2015 Category: Cancer & Oncology Authors: Magnus LøbergMette LousdalMichael BretthauerMette Kalager Source Type: research
An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers
Conclusions:
This study illustrates how original approaches like the phylogeny-based method we used can empower classical molecular epidemiological studies aimed at identifying association or risk modification effects. (Source: Breast Cancer Research)
Source: Breast Cancer Research - April 25, 2015 Category: Cancer & Oncology Authors: Sophie BleinClaire BardelVincent DanjeanLesley McGuffogSue HealeyDaniel BarrowdaleAndrew LeeJoe DennisKaroline KuchenbaeckerPenny SoucyMary TerryWendy ChungDavid GoldgarSaundra BuysRamunas JanaviciusLaima TihomirovaNadine TungCecilia DorflingElizabeth van Source Type: research
Adipose cells promote resistance of breast cancer cells to trastuzumab-mediated antibody-dependent cellular cytotoxicity
Conclusions:
Collectively, our findings underline the importance of adipose tissue in the resistance to trastuzumab, and suggest that approaches targeting the adipocyte-cancer cell crosstalk may help sensitize cancer cells to trastuzumab-based therapy. (Source: Breast Cancer Research)
Source: Breast Cancer Research - April 24, 2015 Category: Cancer & Oncology Authors: Minh DuongAurore CleretEva-Laure MateraKamel ChettabDoriane MathéSandrine Valsesia-WittmannBéatrice ClémenceauCharles Dumontet Source Type: research
