Erratum to: Quantitative assessment of background parenchymal enhancement in breast MRI predicts response to risk-reducing salpingo-oophorectomy: preliminary evaluation in a cohort of BRCA1/2 mutation carriers
No description available (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 24, 2015 Category: Cancer & Oncology Authors: Shandong WuSusan WeinsteinMichael DeLeoEmily ConantJinbo ChenSusan DomchekDespina Kontos Source Type: research
Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer
Conclusion:
These studies have revealed a correlation between tumor recurrence and changes of stromal microenvironment accompanied by altered EGFR signaling. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 18, 2015 Category: Cancer & Oncology Authors: Xue HoldmanThomas WelteKimal RajapaksheAdam PondCristian CoarfaQianxing MoShixia HuangSusan HilsenbeckDean EdwardsXiang ZhangJeffrey Rosen Source Type: research
Mammographic density defined by higher than conventional brightness threshold better predicts breast cancer risk for full-field digital mammograms
IntroductionWhen measured using the computer-assisted method CUMULUS, mammographic density adjusted for age and body mass index predicts breast cancer risk. We asked if new mammographic density measures defined by higher brightness thresholds gave better risk predictions.
Methods:
The Korean Breast Cancer Study included 213 women diagnosed with invasive breast cancer and 630 controls matched for age at full-field digital mammogram and menopausal status. Mammographic density was measured using CUMULUS at the conventional threshold (Cumulus), and in effect at two increasingly higher thresholds, which we call Altocumulus and ...
Source: Breast Cancer Research - November 18, 2015 Category: Cancer & Oncology Authors: Tuong NguyenYe AungChristopher EvansChoi Yoon-HoMark JenkinsJoohon SungJohn HopperYun-Mi Song Source Type: research
Effect of physical activity on sex hormones in women: a systematic review and meta-analysis of randomized controlled trials
Conclusions:
Although the effect is relatively modest, physical activity induces a decrease in circulating sex hormones and this effect is not entirely explained by weight loss. The findings emphasize the benefits of physical activity for women. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 5, 2015 Category: Cancer & Oncology Authors: Kaoutar Ennour-IdrissiElizabeth MaunsellCaroline Diorio Source Type: research
Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet
Conclusions:
In obesity-resistant mice, peripubertal HFD is sufficient to irreversibly promote carcinogen-induced tumorigenesis. Increased macrophage recruitment is likely a contributing factor. These results underscore the importance of early life exposures to increased adult cancer risk and are consistent with findings that an HFD in normal weight premenopausal women leads to increased breast cancer risk. Notably, short-latency tumors occurring after peripubertal HFD had characteristics similar to human basal-like breast cancers that predominantly develop in younger women. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 2, 2015 Category: Cancer & Oncology Authors: Mark AupperleeYong ZhaoYing TanYirong ZhuIngeborg LangohrErin KirkJason PironeMelissa TroesterRichard SchwartzSandra Haslam Source Type: research
Multipotent luminal mammary cancer stem cells model tumor heterogeneity
Conclusions:
Since the majority of human tumors are of the luminal subtype, understanding the cell of origin of these tumors and how they relate to other tumor subtypes will impact cancer therapy. Analysis of clonal cell lines derived from different tumor subtypes suggests a developmental hierarchy of MaCSCs, which may provide insights into the progression of human breast cancer. (Source: Breast Cancer Research)
Source: Breast Cancer Research - October 14, 2015 Category: Cancer & Oncology Authors: Lei BaoRobert CardiffPaul SteinbachKaren MesserLesley Ellies Source Type: research
Circulating DNA as biomarker in breast cancer
As the release of tumor-associated DNA into blood circulation is a common event in patients with cancer, screening of plasma or serum DNA may provide information on genetic and epigenetic profiles associated with breast cancer development, progression, and response to therapy. Quantitative testing of circulating DNA can reflect tumor burden, and molecular characterization of circulating DNA can reveal important tumor characteristics relevant to the choice of targeted therapies in individual patients. Contrary to circulating DNA from blood that presents molecular changes in tumor DNA in real time, tissue biopsies can delive...
Source: Breast Cancer Research - October 9, 2015 Category: Cancer & Oncology Authors: Heidi SchwarzenbachKlaus Pantel Source Type: research
Tumor-induced inflammation alters neutrophil phenotype and disease progression
Neutrophils are essential to combat infectious agents but contribute to collateral inflammatory damage. Likewise, neutrophils can kill cancer cells and have been shown to promote malignant growth and metastasis through immunosuppressive functions. Two articles in a recent issue of Nature reveal new mechanisms by which tumors induce changes in neutrophil phenotype through production of inflammatory cytokines. Although the two studies report different outcomes on the effects of neutrophils on tumor growth and metastasis, they delineate novel molecular pathways influencing neutrophil phenotype that may provide new approaches ...
Source: Breast Cancer Research - October 6, 2015 Category: Cancer & Oncology Authors: Charaf Benarafa Source Type: research
Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response
Conclusions:
In this homogenous cohort of TNBCs few recurrent mutations were found. However, PIK3CA mutations were associated with BRCA proficiency, which can have clinical consequences in the near future. (Source: Breast Cancer Research)
Source: Breast Cancer Research - October 3, 2015 Category: Cancer & Oncology Authors: Esther LipsMagali MichautMarlous HoogstraatLennart MulderNicolle BesselinkMarco KoudijsEdwin CuppenEmile VoestRene BernardsPetra NederlofJelle WesselingSjoerd RodenhuisLodewyk WesselsOn behalf of the Center for Personalized Cancer Treatment Source Type: research
Transformation of enriched mammary cell populations with polyomavirus middle T antigen influences tumor subtype and metastatic potential
Conclusions:
Expression of PyMT within different mammary cell populations influences tumor histology, molecular subtype, and metastatic potential. The data demonstrate that luminal CD133+ cells give rise to less metastatic tumors, luminal CD133− cells preferentially establish basal tumors, and the cell of origin for squamous metaplasia likely resides in the basal and stem cell populations. (Source: Breast Cancer Research)
Source: Breast Cancer Research - October 1, 2015 Category: Cancer & Oncology Authors: Daria DrobyshevaBrittni SmithMaria McDowellKatrin GuillenHuseyin EkizBryan Welm Source Type: research
The relationship between quantitative human epidermal growth factor receptor 2 gene expression by the 21-gene reverse transcriptase polymerase chain reaction assay and adjuvant trastuzumab benefit in Alliance N9831
IntroductionThe N9831 trial demonstrated the efficacy of adjuvant trastuzumab for patients with human epidermal growth factor receptor 2 (HER2) locally positive tumors by protein or gene analysis. We used the 21-gene assay to examine the association of quantitative HER2 messenger RNA (mRNA) gene expression and benefit from trastuzumab.
Methods:
N9831 tested the addition of trastuzumab to chemotherapy in stage I–III HER2-positive breast cancer. For two of the arms of the trial, doxorubicin and cyclophosphamide followed by paclitaxel (AC-T) and doxorubicin and cyclophosphamide followed by paclitaxel and trastuzumab concurr...
Source: Breast Cancer Research - October 1, 2015 Category: Cancer & Oncology Authors: Edith PerezFrederick BaehnerSteven ButlerE. ThompsonAmylou DueckFarid JamshidianDiana CherbavazCarl YoshizawaSteven ShakPeter KaufmanNancy DavidsonJulie GralowYan AsmannKarla Ballman Source Type: research
Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor-negative breast cancer
Conclusions:
These findings suggest that TLR4 is expressed in a functional form in ER/PR-negative breast cancers. Studies regarding TLR4-antagonist therapies should be focusing on ER/PR-negative breast cancer particularly. (Source: Breast Cancer Research)
Source: Breast Cancer Research - September 22, 2015 Category: Cancer & Oncology Authors: Meliha MehmetiRoni AllaouiCaroline BergenfelzLao SaalStephen EthierMartin JohanssonKarin JirströmKarin Leandersson Source Type: research
An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer
Conclusions:
Our study demonstrates how ecological methods applied to the tumor microenvironment using routine histology can provide reproducible, quantitative biomarkers for identifying high-risk breast cancer patients. We found that the clinical value of immune-cancer interaction patterns is highly subtype-specific but substantial and independent to known clinicopathologic variables that mostly focused on cancer itself. Our approach can be developed into computer-assisted prediction based on histology samples that are already routinely collected. (Source: Breast Cancer Research)
Source: Breast Cancer Research - September 22, 2015 Category: Cancer & Oncology Authors: Carlo MaleyKonrad KoelbleRachael NatrajanAthena AktipisYinyin Yuan Source Type: research
The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial
IntroductionObese breast cancer patients have worse prognosis than normal weight patients, but the level at which obesity is prognostically unfavorable is unclear.
Methods:
This retrospective analysis was performed using data from the SUCCESS A trial, in which 3754 patients with high-risk early breast cancer were randomized to anthracycline- and taxane-based chemotherapy with or without gemcitabine. Patients were classified as underweight/normal weight (body mass index (BMI) (Source: Breast Cancer Research)
Source: Breast Cancer Research - September 18, 2015 Category: Cancer & Oncology Authors: Peter WidschwendterThomas FriedlLukas SchwentnerNikolaus DeGregorioBernadette JaegerAmelie SchrammInga BekesMiriam DenizKrisztian LatoTobias WeissenbacherBernd KostUlrich AndergassenJulia JueckstockJulia NeugebauerElisabeth TrappPeter FaschingMatthias Bec Source Type: research
ALK alteration is a frequent event in aggressive breast cancers
IntroductionBreast cancer is the most common female malignancy worldwide and, despite improvements in treatment modalities, there are increased chances of recurrence and metastasis in a substantial number of cases and it remains one of the major causes of mortality among female cancer patients. Anaplastic lymphoma kinase (ALK) gene has been found to be altered in several solid and hematologic tumors. We aimed to comprehensively study the prevalence of ALK expression, and changes in copy number and translocation in a large cohort of breast cancer cases in a Middle Eastern population.
Methods:
ALK protein expression was inve...
Source: Breast Cancer Research - September 17, 2015 Category: Cancer & Oncology Authors: Abdul SirajShaham BegZeenath JehanSarita PrabhakaranMaqbool AhmedAzhar R.HussainFouad Al-DayelAsma TulbahDahish AjarimKhawla Al-Kuraya Source Type: research
