Identification of a novel mutation in the factor VIII gene causing severe haemophilia A
ConclusionThis novelF8 deletion as a cause of haemophilia A did not result in generation of inhibitory antibodies to Factor VIII treatment and may have impact on (prenatal) diagnosis, genetic counselling, and treatment decisions in the affected family as well as in other families diagnosed with thisF8 mutation. Finally, this novel mutation should be included in the panel of known genetic variants inF8 when searching for the genetic etiology in patients suspected of HEMA. (Source: BMC Hematology)
Source: BMC Hematology - July 31, 2018 Category: Hematology Source Type: research
Demographic characteristics of blood and blood components transfusion recipients and pattern of blood utilization in a tertiary health institution in southern Nigeria
ConclusionsOur study recorded mostly young patients who received mostly whole blood. Most of the patients in the reproductive age group received transfusion for pregnancy and child-birth related cases. (Source: BMC Hematology)
Source: BMC Hematology - July 31, 2018 Category: Hematology Source Type: research
Identification of a novel mutation in the factor VIII gene causing severe haemophilia A
ConclusionThis novelF8 deletion as a cause of haemophilia A did not result in generation of inhibitory antibodies to Factor VIII treatment and may have impact on (prenatal) diagnosis, genetic counselling, and treatment decisions in the affected family as well as in other families diagnosed with thisF8 mutation. Finally, this novel mutation should be included in the panel of known genetic variants inF8 when searching for the genetic etiology in patients suspected of HEMA. (Source: BMC Hematology)
Source: BMC Hematology - July 31, 2018 Category: Hematology Source Type: research
Demographic characteristics of blood and blood components transfusion recipients and pattern of blood utilization in a tertiary health institution in southern Nigeria
ConclusionsOur study recorded mostly young patients who received mostly whole blood. Most of the patients in the reproductive age group received transfusion for pregnancy and child-birth related cases. (Source: BMC Hematology)
Source: BMC Hematology - July 31, 2018 Category: Hematology Source Type: research
Hematological profile of pregnant women at St. Paul ’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
ConclusionSignificant changes in selected hematological parameters between trimesters, and an anemia and thrombocytopenia of mild type were documented in this study. The commonest morphologic features were mostly characteristic features of iron deficiency anemia. These warrant the need for monitoring hematological parameters of pregnant women at any stage of the pregnancy to avoid adverse outcomes. (Source: BMC Hematology)
Source: BMC Hematology - July 9, 2018 Category: Hematology Source Type: research
Anemia and associated factors among children aged 6 –23 months in Damot Sore District, Wolaita Zone, South Ethiopia
ConclusionPrevalence of anemia among children (6 –23 months) was a severe public health problem in the study area. Most important predictors are suboptimal child feeding practices, household food insecurity, and poor diet. Multi-sectoral efforts are needed to improve health and interventions targeting nutrition security are recommended. (Source: BMC Hematology)
Source: BMC Hematology - July 3, 2018 Category: Hematology Source Type: research
Experimental folate deficiency in human subjects: what is the influence of vitamin C status on time taken to develop megaloblastic anaemia?
ConclusionBecause of the importance of folate in one-carbon metabolism, the potential influence of vitamin C intake on the time taken to deplete the liver folate store should be experimentally investigated. (Source: BMC Hematology)
Source: BMC Hematology - June 19, 2018 Category: Hematology Source Type: research
Adapting medical guidelines to be patient-centered using a patient-driven process for individuals with sickle cell disease and their caregivers
ConclusionsIndividuals with SCD and their caregivers want access to guidelines through multiple channels, including technology. Guidelines written for health care providers can be adapted to be patient-centered using Community-engaged research involving providers and patients. These patient-centered guidelines provide a framework for patients to discuss their medical care with their health care providers. (Source: BMC Hematology)
Source: BMC Hematology - June 8, 2018 Category: Hematology Source Type: research
Hemostatic state augmented with platelet indices among Sudanese diabetic septic foot
ConclusionDiabetes mellitus is associated with prothrombotic tendency. Hypercoagulable state in DSF is indicated by shortened PT finding. PDW is a manifesting evidence that proves the presence of more reactive and aggregable platelets in DSF patients. (Source: BMC Hematology)
Source: BMC Hematology - May 11, 2018 Category: Hematology Source Type: research
