R-CHOP preceded by blood-brain barrier permeabilization with engineered tumor necrosis factor-{alpha} in primary CNS lymphoma
In conclusion, NGR-hTNF/R-CHOP was safe in these heavily pretreated patients. NGR-hTNF enhanced vascular permeability specifically in tumoral/peritumoral areas, which resulted in fast and sustained responses. (Source: Blood)
Source: Blood - July 17, 2019 Category: Hematology Authors: Ferreri, A. J. M., Calimeri, T., Conte, G. M., Cattaneo, D., Fallanca, F., Ponzoni, M., Scarano, E., Curnis, F., Nonis, A., Lopedote, P., Citterio, G., Politi, L. S., Foppoli, M., Girlanda, S., Sassone, M., Perrone, S., Cecchetti, C., Ciceri, F., Bordigno Tags: Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia
The oncogenic transcription factor TAL1 regulates the transcriptional program in T-ALL. ARID5B is one of the critical downstream targets of TAL1, which further activates the oncogenic regulatory circuit in T-ALL cells. Here, we elucidated the molecular functions of the noncoding RNA, ARID5B-inducing enhancer associated long noncoding RNA (ARIEL), in T-ALL pathogenesis. We demonstrated that ARIEL is specifically activated in TAL1+ T-ALL cases, and its expression is associated with ARID5B enhancer activity. ARIEL recruits mediator proteins to the ARID5B enhancer, promotes enhancer-promoter interactions, and activates the exp...
Source: Blood - July 17, 2019 Category: Hematology Authors: Tan, S. H., Leong, W. Z., Ngoc, P. C. T., Tan, T. K., Bertulfo, F. C., Lim, M. C., An, O., Li, Z., Yeoh, A. E. J., Fullwood, M. J., Tenen, D. G., Sanda, T. Tags: Lymphoid Neoplasia Source Type: research
Vitamin K antagonism impairs the bone marrow microenvironment and hematopoiesis
Vitamin K antagonists (VKAs) have been used in 1% of the world’s population for prophylaxis or treatment of thromboembolic events for 64 years. Impairment of osteoblast function and osteoporosis has been described in patients receiving VKAs. Given the involvement of cells of the bone marrow microenvironment (BMM), such as mesenchymal stem cells (MSCs) and macrophages, as well as other factors such as the extracellular matrix for the maintenance of normal hematopoietic stem cells (HSCs), we investigated a possible effect of VKAs on hematopoiesis via the BMM. Using various transplantation and in vitro assays, we show h...
Source: Blood - July 17, 2019 Category: Hematology Authors: Verma, D., Kumar, R., Pereira, R. S., Karantanou, C., Zanetti, C., Minciacchi, V. R., Fulzele, K., Kunz, K., Hoelper, S., Zia-Chahabi, S., Jabagi, M.-J., Emmerich, J., Dray-Spira, R., Kuhlee, F., Hackmann, K., Schroeck, E., Wenzel, P., Müller, S., Tags: Hematopoiesis and Stem Cells, Thrombosis and Hemostasis Source Type: research
Joint effort to target the orphan of the orphan
(Source: Blood)
Source: Blood - July 17, 2019 Category: Hematology Authors: Wolff, D. Tags: Free Research Articles COMMENTS Source Type: research
Triple-mutant AML: too clever by HLF?
(Source: Blood)
Source: Blood - July 17, 2019 Category: Hematology Authors: Vassiliou, G. S. Tags: Free Research Articles COMMENTS Source Type: research
Is it time to revisit R-CHOP for primary CNS lymphoma?
(Source: Blood)
Source: Blood - July 17, 2019 Category: Hematology Authors: Nayak, L., Batchelor, T. T. Tags: Free Research Articles COMMENTS Source Type: research
Finding ARIEL under the sea of T-ALL circuits
(Source: Blood)
Source: Blood - July 17, 2019 Category: Hematology Authors: Chiang, M. Y. Tags: Free Research Articles COMMENTS Source Type: research
Table of contents. Blood. 2019;133(18):iii-iv.
(Source: Blood)
Source: Blood - July 10, 2019 Category: Hematology Tags: Free Research Articles ERRATUM Source Type: research
Ward-Caviness CK, Huffman JE, Everett K, et al. DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis. Blood. 2018;132(17):1842-1850.
(Source: Blood)
Source: Blood - July 10, 2019 Category: Hematology Tags: Free Research Articles ERRATUM Source Type: research
Unusual histiocytes in a pleural effusion: signature of a rare disease
(Source: Blood)
Source: Blood - July 10, 2019 Category: Hematology Authors: El Khoury, C., Farhat, H. Tags: Free Research Articles, Stem Cells in Hematology, Phagocytes, Granulocytes, and Myelopoiesis BLOOD WORK Source Type: research
Marked lymphocytosis and atypical cells with a cleft nucleus in a 1-month-old child
(Source: Blood)
Source: Blood - July 10, 2019 Category: Hematology Authors: Rieu, J.-B., Vergez, F. Tags: Hematopoiesis and Stem Cells, Free Research Articles, BloodWork BLOOD WORK Source Type: research
Haploidentical hematopoietic cell and kidney transplantation for hematological malignancies and end-stage renal failure
At Massachusetts General Hospital, we pioneered simultaneous hematopoietic cell (HCT)/kidney transplantation from HLA-identical related donors for the treatment of hematological malignancies with end-stage renal failure. We have now extended this to HLA-haploidentical donors in a pilot trial. Six recipients, 5 of whom were conditioned with fludarabine, cyclophosphamide, and total-body irradiation, underwent combined HCT/kidney transplantation from haploidentical donors; graft-versus-host disease (GVHD) prophylaxis included post-HCT cyclophosphamide, tacrolimus, and mycophenolate mofetil. One patient died as a result of com...
Source: Blood - July 10, 2019 Category: Hematology Authors: Chen, Y.-B., Elias, N., Heher, E., McCune, J. S., Collier, K., Li, S., Del Rio, C., El-Jawahri, A., Williams, W., Tolkoff-Rubin, N., Fishman, J. A., McAfee, S., Dey, B. R., DeFilipp, Z., ODonnell, P. V., Cosimi, A. B., Sachs, D., Kawai, T., Spitzer, T. R. Tags: Transplantation, Brief Reports Source Type: research
Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms
In this study of 113 MPN patients, we aimed to comprehensively characterize the mutational landscape of the granulocyte transcriptome using RNA sequencing data and subsequently examine the applicability of immunotherapeutic strategies for MPN patients. Following implementation of customized workflows and data filtering, we identified a total of 13 (12/13 novel) gene fusions, 231 nonsynonymous single nucleotide variants, and 21 insertions and deletions in 106 of 113 patients. We found a high frequency of SF3B1-mutated primary myelofibrosis patients (14%) with distinct 3' splicing patterns, many of these with a protein-alter...
Source: Blood - July 10, 2019 Category: Hematology Authors: Schischlik, F., Jäger, R., Rosebrock, F., Hug, E., Schuster, M., Holly, R., Fuchs, E., Milosevic Feenstra, J. D., Bogner, E., Gisslinger, B., Schalling, M., Rumi, E., Pietra, D., Fischer, G., Fae, I., Vulliard, L., Menche, J., Haferlach, T., Megge Tags: Immunobiology and Immunotherapy, Myeloid Neoplasia Source Type: research
Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes
Myeloid neoplasms, including myelodysplastic syndromes (MDS), are genetically heterogeneous disorders driven by clonal acquisition of somatic mutations in hematopoietic stem and progenitor cells (HPCs). The order of premalignant mutations and their impact on HPC self-renewal and differentiation remain poorly understood. We show that episomal reprogramming of MDS patient samples generates induced pluripotent stem cells from single premalignant cells with a partial complement of mutations, directly informing the temporal order of mutations in the individual patient. Reprogramming preferentially captured early subclones with ...
Source: Blood - July 10, 2019 Category: Hematology Authors: Hsu, J., Reilly, A., Hayes, B. J., Clough, C. A., Konnick, E. Q., Torok-Storb, B., Gulsuner, S., Wu, D., Becker, P. S., Keel, S. B., Abkowitz, J. L., Doulatov, S. Tags: Hematopoiesis and Stem Cells, Myeloid Neoplasia Source Type: research
A novel model of controlling PD-L1 expression in ALK+ anaplastic large cell lymphoma revealed by CRISPR screening
The success of programmed cell death protein 1 (PD-1)/PD-L1-based immunotherapy highlights the critical role played by PD-L1 in cancer progression and reveals an urgent need to develop new approaches to attenuate PD-L1 function by gaining insight into how its expression is controlled. Anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphoma (ALK+ ALCL) expresses a high level of PD-L1 as a result of the constitutive activation of multiple oncogenic signaling pathways downstream of ALK activity, making it an excellent model in which to define the signaling processes responsible for PD-L1 upregulation in tumor...
Source: Blood - July 10, 2019 Category: Hematology Authors: Zhang, J.-P., Song, Z., Wang, H.-B., Lang, L., Yang, Y.-Z., Xiao, W., Webster, D. E., Wei, W., Barta, S. K., Kadin, M. E., Staudt, L. M., Nakagawa, M., Yang, Y. Tags: Immunobiology and Immunotherapy, Lymphoid Neoplasia Source Type: research
