Editorial Board
Publication date: August 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1870, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 13, 2018 Category: Cancer & Oncology Source Type: research

Cancer Metabolism: the Known, Unknowns
Publication date: August 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1870, Issue 1Author(s): Chi Van Dang (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 13, 2018 Category: Cancer & Oncology Source Type: research

Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism
Publication date: Available online 6 August 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Michael S. Dahabieh, Erminia Di Pietro, Maïka Jangal, Christophe Goncalves, Michael Witcher, Nancy E. Braverman, Sonia V. del RincónAbstractCancer is irrevocably linked to aberrant metabolic processes. While once considered a vestigial organelle, we now know that peroxisomes play a central role in the metabolism of reactive oxygen species, bile acids, ether phospholipids (e.g. plasmalogens), very-long chain, and branched-chain fatty acids. Immune system evasion is a hallmark of cancer, and p...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 7, 2018 Category: Cancer & Oncology Source Type: research

Mitochondrial dynamics in cancer-induced cachexia
Publication date: Available online 29 July 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Miranda van der Ende, Sander Grefte, Rogier Plas, Jocelijn Meijerink, Renger Witkamp, Jaap Keijer, Klaske van NorrenAbstractCancer-induced cachexia has a negative impact on quality of life and adversely affects therapeutic outcomes and survival rates. It is characterized by, often severe, loss of muscle, with or without loss of fat mass. Insight in the pathophysiology of this complex metabolic syndrome and direct treatment options are still limited, which creates a research demand. Results from recent st...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 29, 2018 Category: Cancer & Oncology Source Type: research

Glutaminase isoenzymes in the metabolic therapy of cancer
Publication date: Available online 24 July 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): José M. Matés, José A. Campos-Sandoval, Javier MárquezAbstractAltered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine metabolism and their expression correlate with malignancy of tumours. The two types of glutaminase isoenzymes, GLS and GLS2, differ in their expression patterns and functional roles: GLS has oncogenic properties and GLS2 has been described as ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 24, 2018 Category: Cancer & Oncology Source Type: research

ARID1A mutant ovarian clear cell carcinoma: A clear target for synthetic lethal strategies
Publication date: Available online 17 July 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Joseph J. Caumanns, G. Bea A. Wisman, Katrien Berns, Ate G.J. van der Zee, Steven de JongAbstractSWI/SNF chromatin remodeling complexes play an important role in the epigenetic regulation of chromatin structure and gene transcription. Mutual exclusive subunits in the SWI/SNF complex include the DNA targeting members ARID1A and ARID1B as well as the ATPases SMARCA2 and SMARCA4. SWI/SNF complexes are predominantly mutated across cancers. The highest mutation incidence is found in ARID1A, primarily consisti...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 18, 2018 Category: Cancer & Oncology Source Type: research

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
Publication date: Available online 11 July 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Debangshu Samanta, Gregg L. SemenzaAbstractCancer cells are characterized by high metabolic demand. The substrates in demand include oxygen, glucose, glutamine and lipids. Oxygen serves as a key substrate in cellular metabolism and bioenergetics. Hypoxia or low oxygen abundance is a common feature of the tumor microenvironment that occurs due to an imbalance in supply and demand. The metabolic response to hypoxia in both cancer cells and stromal cells is orchestrated by hypoxia-inducible factors (HIFs). ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 11, 2018 Category: Cancer & Oncology Source Type: research

Triple negative breast cancer: Key role of Tumor-Associated Macrophages in regulating the activity of anti-PD-1/PD-L1 agents
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Matteo Santoni, Emanuela Romagnoli, Tiziana Saladino, Laura Foghini, Stefania Guarino, Marco Capponi, Massimo Giannini, Paolo Decembrini Cognigni, Gerardo Ferrara, Nicola BattelliAbstractTriple-negative breast cancer (TNBC) is associated with a poor prognosis, due to its aggressive behaviour and lack of effective targeted therapies. Immunocheckpoint inhibitors, such as anti-programmed cell death 1 (PD-1) and anti-PD-ligand(L)1 agents, are in course of investigation in TNBC, used alone or in combinat...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

The key role of extracellular vesicles in the metastatic process
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Hongyun Zhao, Abhinav Achreja, Elisabetta Iessi, Mariantonia Logozzi, Davide Mizzoni, Rossella Di Raimo, Deepak Nagrath, Stefano FaisAbstractExtracellular vesicles (EVs), including exosomes, have a key role in the paracrine communication between organs and compartments. EVs shuttle virtually all types of biomolecules such as proteins, lipids, nucleic acids, metabolites and even pharmacological compounds. Their ability to transfer their biomolecular cargo into target cells enables EVs to play a key r...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Long pentraxin 3: A novel multifaceted player in cancer
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Arianna Giacomini, Gaia Cristina Ghedini, Marco Presta, Roberto RoncaAbstractSince its discovery in 1992, long pentraxin 3 (PTX3) has been characterized as soluble patter recognition receptor, a key player of the innate immunity arm with non-redundant functions in pathogen recognition and inflammatory responses. As a component of the extra-cellular matrix milieu, PTX3 has been implicated also in wound healing/tissue remodeling, cardiovascular diseases, fertility, and infectious diseases. Consequentl...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Genetic host factors in Helicobacter pylori-induced carcinogenesis: Emerging new paradigms
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Michiel C. Mommersteeg, Jun Yu, Maikel P. Peppelenbosch, Gwenny M. FuhlerAbstractHelicobacter Pylori is a gram negative rod shaped microaerophilic bacterium that colonizes the stomach of approximately half the world's population. Infection with c may cause chronic gastritis which via a quite well described process known as Correas cascade can progress through sequential development of atrophic gastritis, intestinal metaplasia and dysplasia to gastric cancer. H. pylori is currently the only bacterium...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Ryszard Olinski, Daniel Gackowski, Marcus S. CookeAbstractThe DNA of all living cells undergoes continuous structural and chemical alteration, which may be derived from exogenous sources, or endogenous, metabolic pathways, such as cellular respiration, replication and DNA demethylation. It has been estimated that approximately 70,000 DNA lesions may be generated per day in a single cell, and this has been linked to a wide variety of diseases, including cancer. However, it is puzzling why potentially...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Functional analysis of Cullin 3 E3 ligases in tumorigenesis
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Ji Cheng, Jianping Guo, Zhiwei Wang, Brian J. North, Kaixiong Tao, Xiangpeng Dai, Wenyi WeiAbstractCullin 3-RING ligases (CRL3) play pivotal roles in the regulation of various physiological and pathological processes, including neoplastic events. The substrate adaptors of CRL3 typically contain a BTB domain that mediates the interaction between Cullin 3 and target substrates to promote their ubiquitination and subsequent degradation. The biological implications of CRL3 adaptor proteins have been wel...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Deubiquitylating enzymes as cancer stem cell therapeutics
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Saba Haq, Bharathi Suresh, Suresh RamakrishnaAbstractThe focus of basic and applied research on core stem cell transcription factors has paved the way to initial delineation of their characteristics, their regulatory mechanisms, and the applicability of their regulatory proteins for protein-induced pluripotent stem cells (protein-IPSC) generation and in further clinical settings. Striking parallels have been observed between cancer stem cells (CSCs) and stem cells. For the maintenance of stem cells ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Fusion genes: A promising tool combating against cancer
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Xiaofeng Dai, Rutaganda Theobard, Hongye Cheng, Mengtao Xing, Jianying ZhangAbstractThe driving roles of fusion genes during tumorigenesis have been recognized for decades, with efficacies demonstrated in clinical diagnosis and targeted therapy. With advances in sequencing technologies and computational biology, a surge in the identification of fusion genes has been witnessed during the past decade. The discovery and presence of splicing based fusions in normal tissues have challenged our canonical co...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Bartosz Wawrzynow, Alicja Zylicz, Maciej ZyliczAbstractOrganized networks of heat shock proteins, which possess molecular chaperone activity, protect cells from abrupt environmental changes. Additionally, molecular chaperones are essential during stress-free periods, where they moderate housekeeping functions. During tumorigenesis, these chaperone networks are extensively remodeled in such a way that they are advantageous to the transforming cell. Molecular chaperones by buffering critical elements of...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Catherine J. Libby, Anh Nhat Tran, Sarah E. Scott, Corinne Griguer, Anita B. HjelmelandAbstractDe-regulated cellular energetics is an emerging hallmark of cancer with alterations to glycolysis, oxidative phosphorylation, the pentose phosphate pathway, lipid oxidation and synthesis and amino acid metabolism. Understanding and targeting of metabolic reprogramming in cancers may yield new treatment options, but metabolic heterogeneity and plasticity complicate this strategy. One highly heterogeneous canc...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): I. Marques-Aleixo, E. Santos-Alves, P.J. Oliveira, P.I. Moreira, J. Magalhães, A. AscensãoAbstractDoxorubicin (DOX) is a widely used antineoplastic agent for a wide range of cancers, including hematological malignancies, soft tissue sarcomas and solid tumors. However, DOX exhibits a dose-related toxicity that results in life-threatening cardiomyopathy. In addition to the heart, there is evidence that DOX toxicity extends to other organs. This general toxicity seems to be related to mitoc...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Reformation in chimeric antigen receptor based cancer immunotherapy: Redirecting natural killer cell
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Chu Lin, Jun ZhangAbstractNatural killer (NK) cells are an important subset of lymphocytes which play a critical role in host immunity against cancers. With MHC-independent recognition, short lifespan and potent cytotoxicity, NK cells make a promising candidate for chimeric antigen receptor (CAR)-engineered cancer immunotherapy. Due to innate biological properties of NK cells, CAR-NK may outperform CAR-T therapy in terms of less side effects and more universal access, which may become a great reformat...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

High Mobility Group A (HMGA) proteins: Molecular instigators of breast cancer onset and progression
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Riccardo Sgarra, Silvia Pegoraro, Gloria Ros, Carlotta Penzo, Eusebio Chiefari, Daniela Foti, Antonio Brunetti, Guidalberto ManfiolettiAbstractCancer heterogeneity is one of the factors that constitute an obstacle towards an efficient targeting of this multifaceted disease. Molecular information can help in classifying cancer subtypes and in providing clinicians with novel targeted therapeutic opportunities. In this regard, classification of breast cancer into intrinsic subtypes based on molecular pro...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

HOX cluster-embedded micro-RNAs and cancer
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Sebastian Fantini, Valentina Salsi, Vincenzo Zappavigna (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Molecular classification as prognostic factor and guide for treatment decision of pancreatic cancer
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): David J. Birnbaum, François Bertucci, Pascal Finetti, Daniel Birnbaum, Emilie MamessierAbstractClinico-pathological factors fail to consistently predict the outcome after pancreatic resection for pancreatic ductal adenocarcinoma (PDAC). PDACs show a high level of inter- and intra- tumor genetic heterogeneity. A molecular classification should help sort patients into less heterogeneous and more appropriate groups regarding the metastatic risk and the therapeutic response, with the consequences o...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Protein restriction and cancer
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Jie Yin, Wenkai Ren, Xingguo Huang, Tiejun Li, Yulong YinAbstractProtein restriction without malnutrition is currently an effective nutritional intervention known to prevent diseases and promote health span from yeast to human. Recently, low protein diets are reported to be associated with lowered cancer incidence and mortality risk of cancers in human. In murine models, protein restriction inhibits tumor growth via mTOR signaling pathway. IGF-1, amino acid metabolic programing, FGF21, and autophagy m...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Oligonucleotide aptamers against tyrosine kinase receptors: Prospect for anticancer applications
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Simona Camorani, Elvira Crescenzi, Monica Fedele, Laura CerchiaAbstractTransmembrane receptor tyrosine kinases (RTKs) play crucial roles in cancer cell proliferation, survival, migration and differentiation. Area of intense research is searching for effective anticancer therapies targeting these receptors and, to date, several monoclonal antibodies and small-molecule tyrosine kinase inhibitors have entered the clinic. However, some of these drugs show limited efficacy and give rise to acquired resista...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

ILT4 functions as a potential checkpoint molecule for tumor immunotherapy
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Aiqin Gao, Yuping Sun, Guangyong PengAbstractImmune checkpoint blockade therapy targeting CTLA4 and PD-1/PD-L1 is a promising strategy in the treatment of different types of cancers. However, the clinical success rates of these therapies are still moderate and varied among cancer types. Therefore, identification of alternative and novel checkpoint molecules or interrupting tolerogenic pathways is urgently needed for successful tumor immunotherapy. Immunoglobulin-like transcript 4 (ILT4) is as an immun...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Nervous system and primary liver cancer
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Seogsong Jeong, Bo Zheng, Hongyang Wang, Qiang Xia, Lei ChenAbstractRecent advances have found irregular activities of the nervous system-associated factors in the development and progression of primary liver cancer. These factors contributed in the regulation of migration, proliferation, and apoptosis of cancer cells, and took a role in modulating invasion, metastasis, and recurrence after curative treatment. In clinical researches, neural-related factors were found to be significant prognostic facto...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

The role of compartmentalized signaling pathways in the control of mitochondrial activities in cancer cells
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Laura Rinaldi, Rossella Delle Donne, Domenica Borzacchiello, Luigi Insabato, Antonio FelicielloAbstractMitochondria are the powerhouse organelles present in all eukaryotic cells. They play a fundamental role in cell respiration, survival and metabolism. Stimulation of G-protein coupled receptors (GPCRs) by dedicated ligands and consequent activation of the cAMP·PKA pathway finely couple energy production and metabolism to cell growth and survival. Compartmentalization of PKA signaling at mitoch...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Phosphate toxicity and tumorigenesis
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Ronald B. Brown, Mohammed S. RazzaqueAbstractIn this article, we briefly summarized evidence that cellular phosphate burden from phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells express more phosphate cotransporters and store more inorganic phosphate than normal cells, and dysregulated phosphate homeostasis is associated with the genesis of various human tumors. High dietary phosphate consumption causes the growth of lung and skin tumors in experimental animal ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Microcalcifications in breast cancer: From pathophysiology to diagnosis and prognosis
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): S. O'Grady, M.P. MorganAbstractThe implementation of mammographic screening programmes in many countries has been linked to a marked increase in early detection and improved prognosis for breast cancer patients. Breast tumours can be detected by assessing several features in mammographic images but one of the most common are the presence of small deposits of calcium known as microcalcifications, which in many cases may be the only detectable sign of a breast tumour. In addition to their efficacy in th...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

RGD cadherins and α2β1 integrin in cancer metastasis: A dangerous liaison
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): J. Ignacio Casal, Rubén A. BartoloméAbstractWe propose a new cadherin family classification comprising epithelial cadherins (cadherin 17 [CDH17], cadherin 16, VE-cadherin, cadherin 6 and cadherin 20) containing RGD motifs within their sequences. Expression of some RGD cadherins is associated with aggressive forms of cancer during the late stages of metastasis, and CDH17 and VE-cadherin have emerged as critical actors in cancer metastasis. After binding to α2β1 integrin, these ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastoma
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Diana A. Aderetti, Vashendriya V.V. Hira, Remco J. Molenaar, Cornelis J.F. van NoordenAbstractGlioblastoma is the most lethal primary brain tumor and poor survival of glioblastoma patients is attributed to the presence of glioma stem cells (GSCs). These therapy-resistant, quiescent and pluripotent cells reside in GSC niches, which are specific microenvironments that protect GSCs against radiotherapy and chemotherapy. We previously showed the existence of hypoxic peri-arteriolar GSC niches in glioblast...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

An epi(c)genetic war: Pathogens, cancer and human genome
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Deepa Rajagopalan, Sudhakar JhaAbstractCancer is characterized by inter- and intra-tumor heterogeneity and this is also observed in the context of cancers caused by pathogens. Nearly 20% of all cancers are attributable to pathogenic organisms. Pathogenic infections result in deregulation of gene expression both by genetic and epigenetic mechanisms, thereby causing malignant transformation. Another characteristic of pathogen-induced cancers is the occurrence of chronic inflammation due to activation of...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Molecular heterogeneity in diffuse large B-cell lymphoma and its implications in clinical diagnosis and treatment
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Lingchuan Guo, Pei Lin, Hui Xiong, Shichun Tu, Gang ChenAbstractOver half of patients with diffuse large B-cell lymphoma (DLBCL) can be cured by standard R-CHOP treatment (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). However, the remaining patients are refractory and ultimately succumb to progressive or relapsed disease. During the past decade, there has been significant progress in the understanding of molecular mechanisms in DLBCL, largely owing to collaborative efforts in...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Obesity linking to hepatocellular carcinoma: A global view
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Lu Gan, Zhenjiang Liu, Chao SunAbstractHepatocellular carcinoma (HCC) is the commonest primary liver cancer and the second leading cause of cancer death worldwide. Obesity is rapidly becoming pandemic and associated with increased carcinogenesis. In this review, we describe the obesity-related factors that influence the development of HCC. We provide evidence of strong links between neural regulation, endocrine and HCC in obesity. We discuss recent advances in our understanding of how adipose tissue a...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Yasuhiro Saito, Ridhdhi R. Desai, Senthil K. MuthuswamyAbstractCell polarity is a fundamental property used to generate asymmetry and structure in all cells. Cancer is associated with loss of cell and tissue structure. While observations made in model system such as Drosophila, identify polarity regulators as tumor suppressors that cause inappropriate cell division, studies in mammalian epithelia do not always support such a causative contribution. Our analysis of published cancer dataset shows that m...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Circulating tumor cell-derived organoids: Current challenges and promises in medical research and precision medicine
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Prakash P. Praharaj, Sujit K. Bhutia, Sunitha Nagrath, Rhonda L. Bitting, Gagan DeepAbstractTraditional 2D cell cultures do not accurately recapitulate tumor heterogeneity, and insufficient human cell lines are available. Patient-derived xenograft (PDX) models more closely mimic clinical tumor heterogeneity, but are not useful for high-throughput drug screening. Recently, patient-derived organoid cultures have emerged as a novel technique to fill this critical need. Organoids maintain tumor tissue het...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

EphB4: A promising target for upper aerodigestive malignancies
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Ravi Salgia, Prakash Kulkarni, Prakash S. GillAbstractThe erythropoietin-producing hepatocellular carcinoma (Eph) receptors are the largest family of receptor tyrosine kinases (RTKs) that include two major subclasses, EphA and EphB. They form an important cell communication system with critical and diverse roles in a variety of biological processes during embryonic development. However, dysregulation of the Eph/ephrin interactions is implicated in cancer contributing to tumour growth, metastasis, and ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Colorectal cancer prevention: Immune modulation taking the stage
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Rochelle Fletcher, Yi-Jun Wang, Robert E. Schoen, Olivera J. Finn, Jian Yu, Lin ZhangAbstractPrevention or early detection is one of the most promising strategies against colorectal cancer (CRC), the second leading cause of cancer death in the US. Recent studies indicate that antitumor immunity plays a key role in CRC prevention. Accumulating evidence suggests that immunosurveillance represents a critical barrier that emerging tumor cells have to overcome in order to sustain the course of tumor develo...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance
Publication date: Available online 24 April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Douglas E. Biancur, Alec C. KimmelmanAbstractPancreatic ductal adenocarcinoma (PDA) is an aggressive cancer that is highly refractory to the current standards of care. The difficulty in treating this disease is due to a number of different factors, including altered metabolism. In PDA, the metabolic rewiring favors anabolic reactions which supply the cancer cell with necessary cellular building blocks for unconstrained growth. Furthermore, PDA cells display high levels of basal autophagy and macropinocy...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Metabolic reprogramming of the tumor microenvironment by p62 and its partners
Publication date: Available online 25 April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Miguel Reina-Campos, Phillip M. Shelton, Maria T. Diaz-Meco, Jorge MoscatAbstractThe concerted metabolic reprogramming across cancer and normal cellular compartments of the tumor microenvironment can favor tumorigenesis by increasing the survival and proliferating capacities of transformed cells. p62 has emerged as a critical signaling adaptor, beyond its role in autophagy, by playing an intricate context-dependent role in metabolic reprogramming of the cell types of the tumor and stroma, which shapes t...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Applications of metabolomics to study cancer metabolism
Publication date: Available online 25 April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Akash K. Kaushik, Ralph J. DeBerardinisAbstractReprogrammed metabolism supports tumor growth and provides a potential source of therapeutic targets and disease biomarkers. Mass spectrometry-based metabolomics has emerged as a broadly informative technique for profiling metabolic features associated with specific oncogenotypes, disease progression, therapeutic liabilities and other clinically relevant aspects of tumor biology. In this review, we introduce the applications of metabolomics to study deregul...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Inorganic phosphate transporters in cancer: Functions, molecular mechanisms and possible clinical applications
Publication date: Available online 9 May 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Marco Antônio Lacerda-Abreu, Thais Russo-Abrahão, Robson de Queiroz Monteiro, Franklin David Rumjanek, José Roberto Meyer-FernandesAbstractInorganic phosphate is one of the most essential nutrients for the maintenance of cell life. Because of its essential role in nutrient supplementation, the study of plasma membrane inorganic phosphate transporters in cancer biology has received much attention in recent years. Several studies suggest that these transporters are up-regulated in tumor c...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

MYC-induced metabolic stress and tumorigenesis
Publication date: Available online 20 May 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Adam J. Wolpaw, Chi V. DangAbstractThe MYC oncogene is commonly altered across human cancers. Distinct from the normal MYC proto-oncogene, which is under tight transcriptional, translational, and post-translational control, deregulated oncogenic MYC drives imbalanced, non-linear amplification of transcription that results in oncogenic ‘stress.’ The term ‘stress’ had been a euphemism for our lack of mechanistic understanding, but synthesis of many studies over the past decade provid...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context
This article is part of a Special Issue entitled: Cancer Metabolism edited by Dr. Chi Van Dang. (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Androgen blockade based clinical trials landscape in triple negative breast cancer
Publication date: Available online 25 May 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Yaqin Shi, Fang Yang, Doudou Huang, Xiaoxiang GuanAbstractAndrogen receptor (AR) targeted treatment has shown promising preliminary results in triple negative breast cancer (TNBC). Identification of AR-associated signaling pathways is of great significance for in-depth understanding of their roles in pathogenesis of TNBC. To meet this objective, preclinical and clinical studies were conducted to clarify the biological interactions of AR signaling and combination strategies based on AR-targeted therapy. Bi...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Mitochondria in cancer metabolism, an organelle whose time has come?
Publication date: Available online 26 May 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Rebecca G. Anderson, Lais P. Ghiraldeli, Timothy S. PardeeAbstractMitochondria have long been controversial organelles in cancer. Early discoveries in cancer metabolism placed much emphasis on cytosolic contributions. Initial debate focused on if mitochondria had a role in cancer formation and progression at all. More recently the contributions of mitochondria to cancer development and progression have become firmly established. This has led to the identification of novel targets and inhibitors being stud...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

MicroRNAs as potential liquid biopsy biomarkers in colorectal cancer: A systematic review
Publication date: Available online 29 May 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Yuji Toiyama, Yoshinaga Okugawa, James Fleshman, C. Richard Boland, Ajay GoelAbstractEmerging evidence has demonstrated the feasibility of circulating miRNAs as robust non-invasive biomarkers for the diagnosis in colorectal cancer. The use of circulating miRNAs for the early detection of colorectal cancer (CRC) is of particular interest as it can offer a potential complementary approach to screening colonoscopy. However, the development of circulating miRNAs as “liquid biopsy” biomarkers for d...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Control of metabolism by p53 – Cancer and beyond
Publication date: Available online 5 June 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Christiaan F. Labuschagne, Fabio Zani, Karen H. VousdenAbstractp53 is an important tumour suppressor gene, with loss of p53 contributing to the development of most human cancers. However, the activation of p53 in response to stress signals underpins a role for p53 in diverse aspects of health and disease. Activities of p53 that regulate metabolism can play a role in maintaining homeostasis and protecting cells from damage – so preventing disease development. By contrast, either loss or over-activati...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research