Bacteria as a double-action sword in cancer
Publication date: Available online 23 June 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Atieh Yaghoubi, Majid Khazaei, Saba Jalili, Seyed Mahdi Hasanian, Amir Avan, Saman Soleimanpour, William C. Cho (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 24, 2020 Category: Cancer & Oncology Source Type: research

Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor’s arsenal
Publication date: Available online 21 June 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): ClaraS. Mundry, Kirsten C. Eberle, Pankaj K. Singh, Michael A. Hollingsworth, Kamiya Mehla (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 22, 2020 Category: Cancer & Oncology Source Type: research

Immunomodulatory effects of ablation therapy on tumors: Potentials for combination with immunotherapy
Publication date: Available online 15 June 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ling Qian, Hua Shenye, Jing Xie, Zhiqiang Meng (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 17, 2020 Category: Cancer & Oncology Source Type: research

Priming the tumor immune microenvironment with chemo(radio)therapy: A systematic review across tumor types
Publication date: Available online 12 June 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Tom van den Ende, Héctor G. van den Boorn, Nadine M. Hoonhout, Faridi S. van Etten-Jamaludin, Sybren L. Meijer, Sarah Derks, Tanja D. de Gruijl, Maarten F. Bijlsma, Martijn G.H. van Oijen, Hanneke W.M. van Laarhoven (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 14, 2020 Category: Cancer & Oncology Source Type: research

Cardiovascular risks and toxicity - The Achilles heel of androgen deprivation therapy in prostate cancer patients
Publication date: Available online 11 June 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Sakthivel Muniyan, Lei Xi, Kaustubh Datta, Anindita Das, Benjamin A. Teply, Surinder K. Batra, Rakesh C. Kukreja (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 12, 2020 Category: Cancer & Oncology Source Type: research

Killing the “BAD”: Challenges for immunotherapy in pancreatic cancer
Publication date: Available online 9 June 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Tian-Jiao Li, Wen-Quan Wang, Xian-Jun Yu, Liang Liu (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 9, 2020 Category: Cancer & Oncology Source Type: research

New insights on sorafenib resistance in liver cancer with correlation of individualized therapy
Publication date: Available online 6 June 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Zhang Cheng, Jiang Wei-Qi, Ding Jin (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 6, 2020 Category: Cancer & Oncology Source Type: research

Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
Publication date: Available online 31 May 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Elham Hatami, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 31, 2020 Category: Cancer & Oncology Source Type: research

Emerging functions and clinical prospects of connexins and pannexins in melanoma
Publication date: Available online 24 May 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Adrián Varela-Vázquez, Amanda Guitián-Caamaño, Paula Carpintero-Fernandez, Eduardo Fonseca, Samar Sayedyahossein, Trond Aasen, Silvia Penuela, María D. Mayán (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 25, 2020 Category: Cancer & Oncology Source Type: research

CRISPR screen in mechanism and target discovery for cancer immunotherapy
Publication date: August 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1874, Issue 1Author(s): Dan Liu, Xuan Zhao, Anqun Tang, Xiyue Xu, Shuci Liu, Li Zha, Wen Ma, Junnian Zheng, Ming Shi (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 22, 2020 Category: Cancer & Oncology Source Type: research

Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions
Publication date: Available online 18 May 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Lavanya Ponnusamy, Sathanraj Natarajan, Karthik Thangaraj, Ravi Manoharan (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 19, 2020 Category: Cancer & Oncology Source Type: research

Potential of CRISPR screen in target discovery for cancer immunotherapy
Publication date: Available online 13 May 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Dan Liu, Xuan Zhao, Anqun Tang, Xiyue Xu, Shuci Liu, Li Zha, Wen Ma, Junnian Zheng, Ming Shi (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 13, 2020 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: April 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1873, Issue 2Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 11, 2020 Category: Cancer & Oncology Source Type: research

FOX transcription factor family in hepatocellular carcinoma
Publication date: Available online 11 May 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Zhongqin Gong, Jianqing Yu, Shucai Yang, Paul B.S. Lai, George Gong Chen (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 11, 2020 Category: Cancer & Oncology Source Type: research

Nucleic acid nanotechnology for cancer treatment
Publication date: Available online 11 May 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Jun-O Jin, Gyurin Kim, Juyoung Hwang, Kyung Ho Han, Minseok Kwak, Peter C.W. Lee (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 11, 2020 Category: Cancer & Oncology Source Type: research

Enzyme-based autophagy in anti-neoplastic management: From molecular mechanisms to clinical therapeutics
Publication date: Available online 24 April 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Amir Ajoolabady, Ayuob Aghanejad, Yagunag Bi, Yingmei Zhang, H.A. Hamid Aslkhodapasand, Alireza Abhari, Jun Ren (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 25, 2020 Category: Cancer & Oncology Source Type: research

Molecular subtyping in pancreatic neuroendocrine neoplasms: New insights into clinical, pathological unmet needs and challenges
Publication date: Available online 25 April 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Jie Yan, Shuangni Yu, Congwei Jia, Min Li, Jie Chen (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 25, 2020 Category: Cancer & Oncology Source Type: research

Functionally analyzing the important roles of hepatocyte nuclear factor 3 (FoxA) in tumorigenesis
Publication date: Available online 20 April 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Bing Gao, Wei Xie, Xueji Wu, Lei Wang, Jianping Guo (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 21, 2020 Category: Cancer & Oncology Source Type: research

Odyssey of trefoil factors in cancer: Diagnostic and therapeutic implications
Publication date: Available online 13 April 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Rahat Jahan, Ashu Shah, Sophia G. Kisling, Muzafar A. Macha, Sarah Thayer, Surinder K. Batra, Sukhwinder Kaur (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 15, 2020 Category: Cancer & Oncology Source Type: research

Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions
Publication date: April 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1873, Issue 2Author(s): Jawed A. Siddiqui, Ramesh Pothuraju, Maneesh Jain, Surinder K. Batra, Mohd W. Nasser (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 9, 2020 Category: Cancer & Oncology Source Type: research

The rise of T-type channels in melanoma progression and chemotherapeutic resistance
Publication date: Available online 7 April 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Lía Alza, Anna Visa, Judit Herreros, Carles Cantí (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 9, 2020 Category: Cancer & Oncology Source Type: research

Circulating tumour DNA: A new biomarker to monitor resistance in NSCLC patients treated with EGFR-TKIs
Publication date: Available online 8 April 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Zhenli Diao, Yanxi Han, Rui Zhang, Jinming Li (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 9, 2020 Category: Cancer & Oncology Source Type: research

Targeting tumor microenvironment in ovarian cancer: Premise and promise
Publication date: Available online 29 March 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Yuting Jiang, Chengdi Wang, Shengtao Zhou (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 31, 2020 Category: Cancer & Oncology Source Type: research

RON receptor tyrosine kinase in pancreatic ductal adenocarcinoma: Pathogenic mechanism in malignancy and pharmaceutical target for therapy
Publication date: Available online 29 March 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Hang-Ping Yao, Rachel Hudson, Ming-Hai Wang (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 30, 2020 Category: Cancer & Oncology Source Type: research

Advances in cancer cachexia: Intersections between affected organs, mediators, and pharmacological interventions
Publication date: Available online 25 March 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Jawed A. Siddiqui, Ramesh Pothuraju, Maneesh Jain, Surinder K. Batra, Mohd W. Nasser (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 25, 2020 Category: Cancer & Oncology Source Type: research

Fibrosis and cancer: A strained relationship
Publication date: April 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1873, Issue 2Author(s): Bram Piersma, M.K. Hayward, Valerie M. Weaver (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 18, 2020 Category: Cancer & Oncology Source Type: research

Caspase-8: The double-edged sword
Publication date: Available online 5 March 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ranadip Mandal, Joan Compte Barrón, Izabela Kostova, Sven Becker, Klaus Strebhardt (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 6, 2020 Category: Cancer & Oncology Source Type: research

The fibrotic tumor stroma
Publication date: Available online 5 March 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Bram Piersma, Mary-Kate Hayward, Valerie M. Weaver (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 6, 2020 Category: Cancer & Oncology Source Type: research

HOX genes function in Breast Cancer development
Publication date: Available online 5 March 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Simone Aparecida de Bessa Garcia, Mafalda Araújo, Tiago Pereira, João Mouta, Renata Freitas (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 6, 2020 Category: Cancer & Oncology Source Type: research

HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential
Publication date: Available online 2 March 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Siyi He, Mohamed Taha Moutaoufik, Saadul Islam, Amit Persad, Adam Wu, Khaled A. Aly, Humphrey Fonge, Mohan Babu, Francisco S. Cayabyab (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 2, 2020 Category: Cancer & Oncology Source Type: research

Role of fibrillin-2 in the control of TGF-β activation in tumor angiogenesis and connective tissue disorders
Publication date: Available online 28 February 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Karlijn van Loon, Julia Yemelyanenko-Lyalenko, Coert Margadant, Arjan W. Griffioen, Elisabeth J.M. Huijbers (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 28, 2020 Category: Cancer & Oncology Source Type: research

Super-enhancers: A new frontier for glioma treatment
Publication date: Available online 26 February 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Meng Cheng, Zheng Wei Zhang, Xing Hu Ji, Yadi Xu, Erbao Bian, Bing Zhao (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 27, 2020 Category: Cancer & Oncology Source Type: research

Control of tumor angiogenesis and metastasis through modulation of cell redox state
Publication date: Available online 5 February 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): José J. Serrano, Belén Delgado, Miguel Ángel MedinaAbstractRedox reactions pervade all biology. The control of cellular redox state is essential for bioenergetics and for the proper functioning of many biological functions. This review traces a timeline of findings regarding the connections between redox and cancer. There is ample evidence of the involvement of cellular redox state on the different hallmarks of cancer. Evidence of the control of tumor angiogenesis and metastasis t...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 6, 2020 Category: Cancer & Oncology Source Type: research

Cholesterol and beyond - The role of the mevalonate pathway in cancer biology
Publication date: Available online 30 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Andy Göbel, Martina Rauner, Lorenz C. Hofbauer, Tilman D. RachnerAbstractCancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming and loss of cell growth control. Recently, the mevalonate pathway has emerged as a crucial regulator of tumor biology and a potential therapeutic target. This pathway controls cholesterol production and posttranslational modifications of Rho-...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 31, 2020 Category: Cancer & Oncology Source Type: research

Application of organoids in translational research of human diseases with a particular focus on gastrointestinal cancers
Publication date: Available online 30 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Romario Nguyen, Sarah Da Won Bae, Gang Zhou, Scott Read, Golo Ahlenstiel, Jacob George, Liang QiaoAbstractGastrointestinal (GI) cancers constitute the largest portion of all human cancers and represent a significant health burden on modern society. Conventional therapeutic approaches such as chemotherapy and surgical resections often fail due to poor treatment response or tumour relapse. Unfortunately, drug discovery for GI cancers has stalled as current cancer models fail to recapitulate critical fea...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 31, 2020 Category: Cancer & Oncology Source Type: research

Epigenetic memory in development and disease: Unraveling the mechanism
Publication date: Available online 23 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Sam ThiagalingamAbstractEpigenetic memory is an essential process of life that governs the inheritance of predestined functional characteristics of normal cells and the newly acquired properties of cells affected by cancer and other diseases from parental to progeny cells. Unraveling the molecular basis of epigenetic memory dictated by protein and RNA factors in conjunction with epigenetic marks that are erased and re-established during embryogenesis/development during the formation of somatic, stem a...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 24, 2020 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1873, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 18, 2020 Category: Cancer & Oncology Source Type: research

Multiple roles and context-specific mechanisms underlying YAP and TAZ-mediated resistance to anti-cancer therapy
Publication date: Available online 10 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Francesca Reggiani, Giulia Gobbi, Alessia Ciarrocchi, Davide Carlo Ambrosetti, Valentina SancisiAbstractUnderstanding the molecular mechanisms driving resistance to anti-cancer drugs is both a crucial step to define markers of response to therapy and a clinical need in many cancer settings. YAP and TAZ transcriptional cofactors behave as oncogenes in different cancer types. Deregulation of YAP/TAZ expression or alterations in components of the multiple signaling pathways converging on these factors ar...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 12, 2020 Category: Cancer & Oncology Source Type: research

Communication in tiny packages: Exosomes as means of tumor-stroma communication
Publication date: Available online 8 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Juliane Daßler-Plenker, Victoria Küttner, Mikala EgebladAbstractTumor-derived exosomes are nano-sized vesicles acting as multi-signal devices influencing tumor growth at local and distant sites. Exosomes are derived from the endolysosomal compartment and can shuttle diverse biomolecules like nucleic acids (microRNAs, DNA fragments), lipids, proteins and even pharmacological compounds from a donor cell to recipient cells. The transfer of cargo to recipient cells enables tumor-derived exosomes...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 9, 2020 Category: Cancer & Oncology Source Type: research

BRCA1/P53: Two strengths in cancer chemoprevention
Publication date: Available online 7 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Liliana Raimundo, Helena Ramos, Joana B. Loureiro, Juliana Calheiros, Lucília SaraivaAbstractIncreasing emphasis has been given to prevention as a feasible approach to reduce the cancer burden. However, for its clinical success, further advances are required to identify effective chemopreventive agents. This review affords a critical and up-to-date discussion of issues related to cancer prevention, including an in-depth knowledge on BRCA1 and p53 tumor suppressor proteins as key molecular player...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 7, 2020 Category: Cancer & Oncology Source Type: research

The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds
Publication date: Available online 3 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Fabrizio Fontana, Michela Raimondi, Monica Marzagalli, Alessandro Di Domizio, Patrizia LimontaAbstractStandard anti-cancer therapies promote tumor growth suppression via induction of apoptosis. However, in most cases cancer cells acquire the ability to escape apoptotic cell death, thus becoming resistant to current treatments. In this setting, the interest in alternative cell death modes has recently increased. Paraptosis is a new form of programmed cell death displaying endoplasmic reticulum (ER) and/...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 4, 2020 Category: Cancer & Oncology Source Type: research

RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis
Publication date: Available online 2 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Sharad S. Singhal, Ravi Salgia, Nisan Verma, David Horne, Sanjay AwasthiAbstractRLIP (Ral-interacting protein) is a multifunctional protein that couples ATP hydrolysis with the movement of substances. Its primary function appears to be in the plasma membrane, where it catalyzes the ATP-dependent efflux of glutathione-conjugates (GS-Es), as well as un-metabolized drugs and toxins. In the plasma membrane, its interaction with the clathrin adaptor protein AP2 localizes it to endocytic vesicle, where its G...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 4, 2020 Category: Cancer & Oncology Source Type: research

The conflicting role of E2F1 in prostate cancer: A matter of cell context or interpretational flexibility?
Publication date: Available online 21 December 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Jung Nyeo Chun, Minsoo Cho, Soonbum Park, Insuk So, Ju-Hong JeonAbstractThe transcription factor E2F1 plays a crucial role in mediating multiple cancer hallmark capabilities that regulate cell cycle, survival, apoptosis, metabolism, and metastasis. Aberrant activation of E2F1 is closely associated with a poor clinical outcome in various human cancers. However, E2F1 has conflictingly been reported to exert tumor suppressive activity, raising a question as to the nature of its substantive role in the c...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 22, 2019 Category: Cancer & Oncology Source Type: research

The role of AhR in transcriptional regulation of immune cell development and function
Publication date: Available online 6 December 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Prashant Trikha, Dean A. LeeAbstractThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor (TF) that is a member of the Per-Arnt-Sim family of proteins. AhR regulates diverse processes, including malignant transformation, hematopoietic cell development, and fate determination of immune cell lineages. Moreover, AhR forms a crucial link between innate and adaptive arms of the immune system. Malignant cells frequently evolve multiple mechanisms for suppressing tumor-specific res...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 7, 2019 Category: Cancer & Oncology Source Type: research

Mechanism of colorectal carcinogenesis triggered by heme iron from red meat
Publication date: Available online 26 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Nina Seiwert, Daniel Heylmann, Solveig Hasselwander, Jörg FahrerAbstractColorectal cancer (CRC) is one of the major tumor entities worldwide, with an increasing incidence in younger people CRC formation is causally linked to various genetic, life-style and dietary risk factors. Among the ladder, the consumption of red meat has emerged as important risk factor contributing to CRC. A large body of evidence shows that heme iron is the critical component of red meat, which promotes colorectal carcin...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 26, 2019 Category: Cancer & Oncology Source Type: research

Principles and methods of integrative chromatin analysis in primary tissues and tumors
Publication date: Available online 22 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Paloma Cejas, Henry W. LongAbstractRecent methodological advances have enabled the genome-wide interrogation of chromatin from primary tumor tissues. Integrative analysis of histone post-translational modifications, transcription factor (TF) binding and open chromatin sites in tumors across cancer stages can elucidate the aberrant epigenetic states accompanying tumor progression. Cancer-associated chromatin alterations can activate or inactivate enhancers at genes involved in cancer while still respe...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 23, 2019 Category: Cancer & Oncology Source Type: research

Targeting citrate as a novel therapeutic strategy in cancer treatment
Publication date: Available online 18 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Lan Huang, Cindy Wang, Huaxi Xu, Guangyong PengAbstractAn important feature shared by many cancer cells is drastically altered metabolism that is critical for rapid growth and proliferation. The distinctly reprogrammed metabolism in cancer cells makes it possible to manipulate the levels of metabolites for cancer treatment. Citrate is a key metabolite that bridges many important metabolic pathways. Recent studies indicate that manipulating the level of citrate can impact the behaviors of both cancer ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 20, 2019 Category: Cancer & Oncology Source Type: research

The intricate relationship between diabetes, obesity and pancreatic cancer
Publication date: Available online 9 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Silvano Paternoster, Marco FalascaAbstractPancreatic cancer is one of the leading determinants of global cancer mortality, and its incidence is predicted to increase, to become in 2030 the second most common cause of cancer-related death. Obesity and diabetes are recognized risk factors for the development of pancreatic cancer. In the last few decades an epidemic of diabetes and obesity has been spreading worldwide, forewarning an increase in incidence of pancreatic cancer. This review considers the m...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 9, 2019 Category: Cancer & Oncology Source Type: research

Venous thromboembolism GWAS reported genetic makeup and the hallmarks of cancer: Linkage to ovarian tumour behaviour
Publication date: Available online 2 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Valéria Tavares, Ricardo Pinto, Joana Assis, Deolinda Pereira, Rui MedeirosAbstractVenous thromboembolism (VTE) is a common cardiovascular disease thought to be the outcome of an intricate interplay between acquired and inherited factors that act together to modify disease risk. Over the years, several single-nucleotide polymorphisms (SNPs) in candidate genes have been associated with disease risk, including F5 rs6025, F2 rs1799963, FGG rs2066865, ABO genetic variants, among others less common....
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 3, 2019 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: December 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1872, Issue 2Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 2, 2019 Category: Cancer & Oncology Source Type: research