Editorial Board
Publication date: April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1871, Issue 2Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: research

Achalasia and associated esophageal cancer risk: What lessons can we learn from the molecular analysis of Barrett's–associated adenocarcinoma?
Publication date: Available online 4 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): K. Nesteruk, M.C.W. Spaander, I. Leeuwenburgh, M.P. Peppelenbosch, G.M. FuhlerAbstractIdiopathic achalasia and Barrett's esophagus (BE) are preneoplastic conditions of the esophagus. BE increases the risk of esophageal adenocarcinoma (EAC), while achalasia is associated with both EAC and esophageal squamous cell carcinoma (ESCC). However, while the molecular mechanisms underlying the transformation of esophageal epithelial cells in BE are relatively well characterized, less is known regarding these process...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 5, 2019 Category: Cancer & Oncology Source Type: research

The role of inflammatory programmed cell death in gastrointestinal cancer and immune responses to intestinal microbial infection
Publication date: Available online 3 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Cheng-Bei Zhou, Jing-Yuan FangAbstractInflammatory programmed cell death, also called pyroptosis, is mediated by multiple inflammasomes which can recognize danger signals and activate the secretion of pro-inflammatory cytokines like IL-181 and IL-1β.2 It can induce cancer cell death within the gastrointestinal tract. NLRs,3 AIM2,4 GSDM5 family play important roles in pyroptosis signaling pathways in intestinal cancer such as gastric cancer, colitis-associated colorectal cancer and esophageal cancer, e...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 3, 2019 Category: Cancer & Oncology Source Type: research

Exosomes in cancer development, metastasis, and immunity
Publication date: Available online 30 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Lin Zhang, Dihua YuAbstractExosomes play essential roles in intercellular communications. The exosome was discovered in 1983, when it was found that reticulocytes release 50-nm small vesicles carrying transferrin receptors into the extracellular space. Since then, our understanding of the mechanism and function of the exosome has expanded exponentially that has transformed our perspective of inter-cellular exchanges and the molecular mechanisms that underlie disease progression. Cancer cells generally p...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 30, 2019 Category: Cancer & Oncology Source Type: research

The small members of the JMJD protein family: Enzymatic jewels or jinxes?
Publication date: Available online 26 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Sangphil Oh, Sook Shin, Ralf JanknechtAbstractJumonji C domain-containing (JMJD) proteins are mostly epigenetic regulators that demethylate histones. However, a hitherto neglected subfamily of JMJD proteins, evolutionarily distant and characterized by their relatively small molecular weight, exerts different functions by hydroxylating proteins and RNA. Recently, unsuspected proteolytic and tyrosine kinase activities were also ascribed to some of these small JMJD proteins, further increasing their enzyma...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 27, 2019 Category: Cancer & Oncology Source Type: research

Nanoparticle-mediated targeted drug delivery for breast cancer treatment
In this study, we summarize with a critical analysis of the most recent therapeutic studies involving various NPs-mediated DDS as alternatives for the traditional treatment approaches for BC. It will shed light on the significance of NPs-mediated DDS and serve as a guide to seeking for the ideal methodology for future targeted drug delivery for an efficient BC treatment.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 27, 2019 Category: Cancer & Oncology Source Type: research

The AP-1 transcriptional complex: Local switch or remote command?
Publication date: Available online 26 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Bejjani Fabienne, Evanno Emilie, Zibara Kazem, Piechaczyk Marc, Jariel-Encontre IsabelleSummaryThe ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all cellular and physiological functions. It is paramount for cells to reprogram gene expression in response to cues of many sorts and is involved in many tumorigenic processes. How AP-1 controls gene transcription has largely remained elusive till recently. The advent of the “omics” technologies permitting genom...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 27, 2019 Category: Cancer & Oncology Source Type: research

Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer
Publication date: Available online 26 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Patrycja Nowak-Sliwinska, Leonardo Scapozza, Ariel Ruiz i AltabaAbstractThe strategy of using existing drugs originally developed for one disease to treat other indications has found success across medical fields. Such drug repurposing promises faster access of drugs to patients while reducing costs in the long and difficult process of drug development. However, the number of existing drugs and diseases, together with the heterogeneity of patients and diseases, notably including cancers, can make repurp...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 27, 2019 Category: Cancer & Oncology Source Type: research

The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer
In conclusion, breast harbors a community of microbes that can communicate with the host cells inducing downstream signaling pathways and modulating various aspects of breast cancer growth and metastatic progression and an improved understanding of microbial dysbiosis can potentially reduce breast cancer risk and improve outcomes of breast cancer patients.The human microbiome, now referred to as, the “forgotten organ” contains a metagenome that is 100-fold more diverse compared to the human genome, thereby, is critically associated with human health [1,2]. With the revelations of the human microbiome project an...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 12, 2019 Category: Cancer & Oncology Source Type: research

Targeting the mTOR regulatory network in hepatocellular carcinoma: Are we making headway?
Publication date: Available online 2 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Xiang-Nan Yu, Hong Chen, Tao-Tao Liu, Jian Wu, Ji-Min Zhu, Xi-Zhong ShenAbstractThe mechanistic target of rapamycin (mTOR) pathway coordinates organismal growth and homeostasis in response to growth factors, nutrients, and cellular energy stage. The pathway regulates several major cellular processes and is implicated in various pathological conditions, including hepatocellular carcinoma (HCC). This review summarizes recent advances of the mTOR pathway, highlights the potential of the mTOR pathway as a th...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 3, 2019 Category: Cancer & Oncology Source Type: research

Atomic force microscopy-based cancer diagnosis by detecting cancer-specific biomolecules and cells
Publication date: Available online 2 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Taeyun Kwon, Sundaram Gunasekaran, Kilho EomAbstractAtomic force microscopy (AFM) has recently attracted much attention due to its ability to analyze biomolecular interactions and to detect certain biomolecules, which play a crucial role in disease expression. Despite recent studies reporting AFM imaging for the analyses of biomolecules, the application of AFM-based cancer-specific biomolecule/cell detection has remained largely underexplored, especially for the early diagnosis of cancer. In this paper, ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 3, 2019 Category: Cancer & Oncology Source Type: research

Targeting PI3K signaling in cancer: Challenges and advances
Publication date: Available online 1 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Maria Chiara De Santis, Federico Gulluni, Carlo Cosimo Campa, Miriam Martini, Emilio HirschAbstractThe key role of phosphoinositide 3-kinase (PI3K) pathway in different cellular processes and several disorders, together with the presence of targetable proteins, opened the way to promising studies for the development of small molecule inhibitors. Despite the high expectation, the shift of PI3K inhibitors to the clinic met several limitations due to the emergence of dose-limiting, on-target adverse effects...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 3, 2019 Category: Cancer & Oncology Source Type: research

Pyruvate kinase M2: A multifarious enzyme in non-canonical localization to promote cancer progression
Publication date: April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1871, Issue 2Author(s): Sajid Amin, Peng Yang, Zhuoyu LiAbstractRewiring glucose metabolism, termed as Warburg effect or aerobic glycolysis, is a common signature of cancer cells to meet their high energetic and biosynthetic demands of rapid growth and proliferation. Pyruvate kinase M2 isoform (PKM2) is a key player in such metabolic reshuffle, which functions as a rate-limiting glycolytic enzyme in the cytosol of highly-proliferative cancer cells. During the recent decades, PKM2 has been extensively studied in non-canonical...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 16, 2019 Category: Cancer & Oncology Source Type: research

Non-canonical localization of PKM2 in cancer progression: Mechanism of nuclear translocation
Publication date: Available online 28 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Sajid Amin, Peng Yang, Zhuoyu LiAbstractCancer cells upregulate pyruvate kinase M2 isoform (PKM2) for their imperiously high energetic and biosynthetic demands to achieve enhanced proliferation, a common fingerprint of all type of cancers. PKM2 was primitively discovered as a cytosolic glycolytic enzyme, now has been extensively reported in non-canonical localizations such as extracellular secretion, mitochondrial localization, nuclear translocation, and exclusively pertained to novel biological func...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 1, 2019 Category: Cancer & Oncology Source Type: research

Rethinking pulmonary toxicity in advanced non-small cell lung Cancer in the era of combining anti-PD-1/PD-L1 therapy with thoracic radiotherapy
Publication date: Available online 28 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Mengqian Li, Limei Yin, Andrew Song, Jianxin Xue, You LuAbstractThe combination of programmed cell death 1/programmed cell death ligand 1 blockade and thoracic radiotherapy has become the new standard of care in the treatment of locally advanced non-small-cell lung cancer. The information regarding the pulmonary safety of such therapy remains limited to mostly retrospective studies and case reports with a small portion of data from prospective clinical trials. By analyzing the underlying mechanisms o...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 1, 2019 Category: Cancer & Oncology Source Type: research

Many ways to resistance: How melanoma cells evade targeted therapies
Publication date: Available online 15 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ines Kozar, Christiane Margue, Sonja Rothengatter, Claude Haan, Stephanie KreisAbstractMelanoma is an aggressive malignancy originating from pigment-producing melanocytes. The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies (immune checkpoint inhibitors) led to a substantial improvement in overall survival of patients. However, the long-term efficacy of such treatments is limited by side effects, lack of clinical effects and the rapidly emerging resistance to treatment...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 16, 2019 Category: Cancer & Oncology Source Type: research

RLIP: An existential requirement for breast carcinogenesis
Publication date: Available online 13 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Sharad S. Singhal, Ravi Salgia, Sulabh Singhal, David Horne, Sanjay AwasthiAbstractBreast cancer (BC) is the most common cancer among women worldwide. Due to its complexity in nature, effective BC treatment can encounter many challenges. The human RALBP1 gene encodes a 76-kDa splice variant protein, RLIP (ral-binding protein1, RalBP1), a stress-protective mercapturic acid pathway (MAP) transporter protein, that also plays a key role in regulating clathrin-dependent endocytosis (CDE) as a Ral effector...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 14, 2019 Category: Cancer & Oncology Source Type: research

Reflections on depletion of tumor stroma in pancreatic cancer
Publication date: Available online 6 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Wen-Quan Wang, Liang Liu, Jin-Zhi Xu, Xian-Jun YuAbstractPancreatic cancer characteristically has an extremely dense stroma, which facilitates chemoresistance by creating physical and biological barriers to therapeutic agents. Thus, stroma-depleting agents may enhance the delivery and efficacy of chemotherapy drugs. However, stroma-targeting therapy for pancreatic cancer is a double-edged sword, as the stroma can also inhibit tumor metastasis and malignancy. In-depth understanding of the critical role...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 7, 2019 Category: Cancer & Oncology Source Type: research

Recent advances in extracellular vesicle research for urological cancers: from technology to application
Publication date: Available online 7 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Liang Dong, Richard C. Zieren, Yanqing Wang, Theo M. de Reijke, Wei Xue, Kenneth J. PientaAbstractUrological malignancies, including prostate cancer, bladder cancer and kidney cancer are major causes of morbidity and mortality worldwide. Because of the high incidence, diversity in biology, and especially direct interaction with urine, urological cancers are an important resource for both scientists and clinicians for novel diagnostic and therapeutic discovery. Extracellular vesicles (EVs) are lipid bi...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 7, 2019 Category: Cancer & Oncology Source Type: research

The role of necroptosis in cancer: A double-edged sword?
Publication date: Available online 1 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Xia Qin, Dan Ma, Ye-xiong Tan, Hong-yang Wang, Zhenyu CaiAbstractNecroptosis is a programmed, caspase-independent cell death that is morphologically similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by releasing damage-associated molecular patterns. Recent studies suggest that tumor undergoes necroptosis in vivo and necroptosis has pro- or anti-tumoral effects in cancer development and progression. Furthermore, triggering necroptosis in tumor cells has been explored as a...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 3, 2019 Category: Cancer & Oncology Source Type: research

A critical review of the role of M2PYK in the Warburg effect
Publication date: Available online 29 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Robert A. Harris, Aron W. FentonAbstractIt is becoming generally accepted in recent literature that the Warburg effect in cancer depends on inhibition of M2PYK, the pyruvate kinase isozyme most commonly expressed in tumors. We remain skeptical. There continues to be a general lack of solid experimental evidence for the underlying idea that a bottle neck in aerobic glycolysis at the level of M2PYK results in an expanded pool of glycolytic intermediates (which are thought to serve as building blocks nec...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 30, 2019 Category: Cancer & Oncology Source Type: research

Prostate Cancer-specific Hallmarks of Amino Acids Metabolism: Towards a Paradigm of Precision Medicine
Publication date: Available online 29 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Vladislav Strmiska, Petr Michalek, Tomas Eckschlager, Marie Stiborova, Vojtech Adam, Sona Krizkova, Zbynek HegerAbstractSo far multiple differences in prostate cancer-specific amino acids metabolism have been discovered. Moreover, some attempts to utilize these alterations for prostate cancer diagnosis and treatment have been made. The prostate cancer metabolism and biosynthesis of amino acids are particularly focused on anaplerosis more than on energy production. Other crucial requirements on amino a...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 30, 2019 Category: Cancer & Oncology Source Type: research

Targeting acidity in cancer and diabetes
Publication date: Available online 30 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Robert J. Gillies, Christian Pilot, Yoshinori Marunaka, Stefano FaisAbstractWhile cancer is commonly described as “a disease of the genes”, it is also a disease of metabolism. Indeed, carcinogenesis and malignancy are highly associated with metabolic re-programming, and there is clinical evidence that interrupting a cancer's metabolic program can improve patients' outcomes. Notably, many of the metabolic adaptations observed in cancer are similar to the same perturbations observed in diabe...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 30, 2019 Category: Cancer & Oncology Source Type: research

Combination therapies with HSP90 inhibitors against colorectal cancer
Publication date: Available online 30 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Kushtrim Kryeziu, Jarle Bruun, Tormod K. Guren, Anita Sveen, Ragnhild A. LotheAbstractOncogene stability and homeostasis mediated by the HSP90 chaperone is a crucial protection trait of cancer cells. Therefore, HSP90 represents an attractive therapeutic target for many cancers, including colorectal cancer. Although monotherapy has limited clinical efficacy, preclinical and early-phase clinical studies indicate improved antitumor activity when HSP90 inhibitors are combined with chemotherapies or target...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 30, 2019 Category: Cancer & Oncology Source Type: research

Potential Roles and Targeted Therapy of the CXCLs/CXCR2 Axis in Cancer and Inflammatory Diseases
Publication date: Available online 29 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Yuan Cheng, Xue-lei Ma, Yu-quan Wei, Xia-Wei WeiAbstractThe chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple signalling pathways, including the PI3K, p38/ERK, and JAK pathways, and regulates cell survival and migration. The CXCLs/CXCR2 axis plays a vital role in the tumour microenvironment and in recruiting neutrophils to inflammatory sites. Extensive infiltration of neutrophil...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 29, 2019 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1871, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 23, 2019 Category: Cancer & Oncology Source Type: research

The expression of FOXP3 and its role in human cancers
Publication date: Available online 7 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Hao Jia, Haolong Qi, Zhongqin Gong, Shucai Yang, Jianwei Ren, Yi Liu, Mingyue Li, George Gong ChenAbstractFOXP3 is a transcription factor, which belongs to the family of FOX protein. FOXP3 was initially discovered in regulatory T cells and supposed to play a significant role in the process of regulatory T cell differentiation. Increasing evidence has shown that FOXP3 is also expressed in tumor cells. However, the results of tumor FOXP3 is inconsistent and even the opposite. In some types of human cance...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 8, 2019 Category: Cancer & Oncology Source Type: research

Targeting mitosis exit: A brake for cancer cell proliferation
Publication date: Available online 3 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Xinran Liu, Yuchen Chen, Yangkai Li, Robert B. Petersen, Kun HuangAbstractThe transition from mitosis to interphase, referred to as mitotic exit, is a critical mitotic process which involves activation and inactivation of multiple mitotic kinases and counteracting protein phosphatases. Loss of mitotic exit checkpoints is a common feature of cancer cells, leading to mitotic dysregulation and confers cancer cells with oncogenic characteristics, such as aberrant proliferation and microtubule-targeting age...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 4, 2019 Category: Cancer & Oncology Source Type: research

Immune checkpoint blockade and its combination therapy with small-molecule inhibitors for cancer treatment
Publication date: Available online 31 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Wang Manni, Yu Liu, Yuan Cheng, Wei Xiawei, Wei YuquanAbstractInitially understood for its physiological maintenance of self-tolerance, the immune checkpoint molecule has recently been recognized as a promising anti-cancer target. There has been considerable interest in the biology and the action mechanism of the immune checkpoint therapy, and their incorporation with other therapeutic regimens. Recently the small-molecule inhibitor (SMI) has been identified as an attractive combination partner for i...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 1, 2019 Category: Cancer & Oncology Source Type: research

Modulation of radiation sensitivity and antitumor immunity by viral pathogenic factors: Implications for radio-immunotherapy
Publication date: Available online 31 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Franz Rödel, Daniel Martin, Panagiotis Balermpas, Ulrike Wieland, Ria Winkelmann, Thorsten Riekmann, Stephan Falk, Claus Rödel, Emmanouil FokasAbstractSeveral DNA viruses including Human Papillomavirus (HPV), Epstein-Barr virus (EBV), and Human Cytomegalovirus (HCMV) are mechanistically associated with the development of human cancers (HPV, EBV) and/or modulation of the immune system (HCMV). Moreover, a number of distinct mechanisms have been described regarding the modulation of tumor cell...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 1, 2019 Category: Cancer & Oncology Source Type: research

The emerging role for Cullin 4 family of E3 ligases in tumorigenesis
Publication date: Available online 30 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ji Cheng, Jianping Guo, Brian J. North, Kaixiong Tao, Pengbo Zhou, Wenyi WeiAbstractAs a member of the Cullin-RING ligase family, Cullin-RING ligase 4 (CRL4) has drawn much attention due to its broad regulatory roles under physiological and pathological conditions, especially in neoplastic events. Based on evidence from knockout and transgenic mouse models, human clinical data, and biochemical interactions, we summarize the distinct roles of the CRL4 E3 ligase complexes in tumorigenesis, which appear...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 31, 2018 Category: Cancer & Oncology Source Type: research

Genetic aberrations and alterations in signaling cascades implicated in the pathogenesis of anaplastic thyroid cancer
Publication date: Available online 31 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Shikha Saini, Ajay V. Maker, Kenneth D. Burman, Bellur S. PrabhakarAbstractAnaplastic Thyroid Cancer (ATC) accounts for>40% thyroid cancer-related deaths and has a dismal prognosis. In the past decade, significant efforts have been made towards understanding the pathogenesis of this disease and developing novel therapeutics. Unfortunately, effective treatment is still lacking and a more thorough understanding of ATC pathogenesis may provide new opportunities to improve ATC therapeutics. This revie...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 31, 2018 Category: Cancer & Oncology Source Type: research

Role of mesenchymal stromal cell-derived extracellular vesicles in tumour microenvironment
Publication date: Available online 30 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): A. Adamo, G. Dal Collo, R. Bazzoni, M. KramperaAbstractStromal cells, deriving from mesenchymal stromal cells (MSCs), are crucial component of tumour microenvironment and represent key regulators of tumour processes. MSCs can be recruited to the tumour environment and interact with many cellular elements, thus influencing tumour biology. Cell-to-cell communication is in part mediated by the release of extracellular vesicle (EVs). EVs can induce significant molecular changes in recipient cells, delive...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 30, 2018 Category: Cancer & Oncology Source Type: research

Piwi-interacting RNAs (piRNAs) and cancer: Emerging biological concepts and potential clinical implications
Publication date: Available online 30 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Wenhao Weng, Hanhua Li, Ajay GoelAbstractPiwi-interacting RNAs (piRNAs) are a very recently discovered class of small non-coding RNAs (ncRNAs), with approximately 20,000 piRNA genes already identified within the human genome. These short RNAs were originally described as key functional regulators for the germline maintenance and transposon silencing. However, due to our limited knowledge regarding their function, piRNAs were for a long time assumed to be the “dark matter” of ncRNAs in our...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 30, 2018 Category: Cancer & Oncology Source Type: research

What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer
Publication date: Available online 7 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Kasper Bendix Johnsen, Johann Mar Gudbergsson, Thomas Lars Andresen, Jens Bæk SimonsenAbstractCirculating biomarkers have a great potential in diagnosing cancer diseases at early stages, where curative treatment is a realistic possibility. In the recent years, using extracellular vesicles (EVs) derived from blood as biomarkers has gained widespread popularity, mainly because they are thought to be easy to isolate and carry a vast variety of biological cargos that can be analyzed for biomarker pu...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 7, 2018 Category: Cancer & Oncology Source Type: research

Advancing the understanding of NAFLD to hepatocellular carcinoma development: From experimental models to humans
Publication date: Available online 5 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Kan Chen, Jianbo Ma, Xiaoyuan Jia, Wen Ai, Zhongren Ma, Qiuwei PanAbstractNonalcoholic fatty liver disease (NAFLD) has recently been recognized as an important etiology contributing to the increased incidence of hepatocellular carcinoma (HCC). NAFLD, characterized by fat accumulation in the liver, is affecting at least one-third of the global population. The more aggressive form, nonalcoholic steatohepatitis (NASH), is characterized by hepatocyte necrosis and inflammation. The development of effective...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 6, 2018 Category: Cancer & Oncology Source Type: research

An emerging role for nanomaterials in increasing immunogenicity of cancer cell death
Publication date: Available online 6 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Tatiana Mishchenko, Elena Mitroshina, Irina Balalaeva, Olga Krysko, Maria Vedunova, Dmitri V. KryskoAbstractIn the last decade, it has become clear that anti-cancer therapy is more successful when it can also induce an immunogenic form of cancer cell death (ICD). ICD is an umbrella term covering several cell death modalities, including apoptosis and necroptosis. In general, ICD is characterized by the emission of damage-associated molecular patterns (DAMPs) and/or cytokines/chemokines, leading to the ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 6, 2018 Category: Cancer & Oncology Source Type: research

Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Nyamao M. Rose, Jing Wu, Li Yu, Xiao Xiao, Feng-Min ZhangAbstractThe DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed in many tumors, and is linked to the regulation of many cancer-related pathways. It co-activates many transcription factors, with profound implications for cancer development, and the de-regulation of its functions is...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Unraveling the Journey of Cancer Stem Cells from Origin to Metastasis
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Rama Krishna Nimmakayala, Surinder K. Batra, Moorthy P. PonnusamyAbstractCancer biology research over recent decades has given ample evidence for the existence of self-renewing and drug-resistant populations within heterogeneous tumors, widely recognized as cancer stem cells (CSCs). However, a lack of clear understanding about the origin, existence, maintenance, and metastatic roles of CSCs limit efforts towards the development of CSC-targeted therapy. In this review, we describe novel avenues of curr...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Role of Tumor-Derived Exosomes in Cancer Metastasis
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ian Wee, Nicholas Syn, Gautam Sethi, Boon Cher Goh, Lingzhi WangAbstractThe highlights of cancer research include the discovery of exosomes, which are small (30-100 nm) sized vesicular nanoparticles released virtually by all cells. Tumor-derived exosomes (TDEs) are notoriously known for orchestrating the invasion-metastasis cascade via systemic pathways that we have previously proposed (1), resulting in a paradigm shift of our understanding about the pathobiology of metastases. In principle, exosome...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

NF-kappaB-inducing kinase in cancer
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Gunter Maubach, Michael H. Feige, Michelle C.C. Lim, Michael NaumannAbstractDysregulation of the alternative NF-κB signaling has severe developmental consequences that can ultimately lead to oncogenesis. Pivotal for the activation of the alternative NF-κB pathway is the stabilization of the NF-κB-inducing kinase (NIK). The aim of this review is to focus on the emerging role of NIK in cancer. The documented subversion of NIK in cancers highlights NIK as a possible therapeutic target. ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Dancing from bottoms up – Roles of the POZ-ZF transcription factor Kaiso in Cancer
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Christina C. Pierre, Shawn M. Hercules, Clayton Yates, Juliet M. DanielAbstractThe POZ-ZF transcription factor Kaiso was discovered two decades ago as a binding partner for p120ctn. Since its discovery, roles for Kaiso in diverse biological processes (epithelial-to-mesenchymal transition, apoptosis, inflammation) and several signalling pathways (Wnt/β-catenin, TGFβ, EGFR, Notch) have emerged. While Kaiso's biological role in normal tissues has yet to be fully elucidated, Kaiso has been incre...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Functions and clinical implications of exosomes in pancreatic cancer
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ling Qian, Shulin Yu, Zhen Chen, Zhiqiang Meng, Shenglin Huang, Peng WangAbstractPancreatic cancer is one of the most aggressive human malignancies and is associated with a dismal prognosis, which can be contributed to its atypical symptoms, metastatic propensity, and significant chemoresistance. Emerging evidence shows that pancreatic cancer cell-derived exosomes (PEXs) play critical roles in tumorigenesis and tumor development, as they are involved in drug resistance, immune evasion and metabolic re...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

The cornerstone of integrating circulating tumor DNA into cancer management
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ziyang Li, Lang Yi, Peng Gao, Rui Zhang, Jinming LiAbstractRecent circulating tumor DNA (ctDNA) research has demonstrated its potential as a non-invasive biomarker for cancer. However, the deployment of ctDNA assays in routine clinical practice remains challenging owing to variability in analytical approaches and the assessment of clinical significance. A well-developed, analytically valid ctDNA assay is a prerequisite for integrating ctDNA into cancer management, and an appropriate analytical technol...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Neural regulation of drug resistance in cancer treatment
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Dan Liu, Xiaoxi Li, Xintian Chen, Yu Sun, Anqun Tang, Zhongwei Li, Junnian Zheng, Ming ShiAbstractThe treatment of cancer has made great progress. However, drug resistance remains problematic. Multiple physiologic processes of tumor development can be dominated by central and sympathetic nervous systems. The interactions between the nervous system, immune system, and tumor occur consistently and dynamically. Recent evidence suggests that nerves and neural signals are intimately involved in the develop...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

EMT: A mechanism for escape from EGFR-targeted therapy in lung cancer
Publication date: Available online 10 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Eugene Tulchinsky, Oleg Demidov, Marina Kriajevska, Nickolai A. Barlev, Evgeny ImyanitovAbstractEpithelial mesenchymal transition (EMT) is a reversible developmental genetic programme of transdifferentiation of polarised epithelial cells to mesenchymal cells. In cancer, EMT is an important factor of tumour cell plasticity and has received increasing attention for its role in the resistance to conventional and targeted therapies. In this paper we provide an overview of EMT in human malignancies, and d...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1870, Issue 2Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 3, 2018 Category: Cancer & Oncology Source Type: research

Dynamic Matrisome: ECM Remodeling Factors Licensing Cancer Progression and Metastasis
Publication date: Available online 12 October 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Arseniy E. Yuzhalin, Su Yin Lim, Anton G. Kutikhin, Alex N. Gordon-WeeksAbstractThe main cause of cancer-related mortality, metastasis, is a complex, multi-step process. The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic progression; however, the ECM exists as a complex macromolecular substrate and it is unclear how its molecular composition promotes cancer progression. ECM homeostasis is regulated by various secreted proteins including cross-linkers (e.g., lysy...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - October 13, 2018 Category: Cancer & Oncology Source Type: research

PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Publication date: Available online 6 October 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Soonbum Park, Young Sik Kim, Davis Yeon Kim, Insuk So, Ju-Hong JeonAbstractThe phosphoinositide 3-kinase (PI3K) pathway integrates multifarious environmental cues to regulate cell survival, growth, and metabolism. Hyperactivation of the PI3K pathway increases biological fitness by offering a high degree of adaptability to and resilience against diverse perturbations, thus conferring survival benefits on premalignant and transformed cells. In prostate cancer, the PI3K pathway is aberrantly activated by ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - October 7, 2018 Category: Cancer & Oncology Source Type: research

Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment
Publication date: Available online 21 August 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Shu Chun Chang, Jeak Ling DingAbstractCells and soluble mediators of the innate and adaptive immune systems are fundamental components of the tumor microenvironment. Nuclear factors, e.g. transcription factors (TFs) and oncoproteins/cancer suppressors, play important roles in controlling cytokine functions leading to the development, maintenance and metastasis of cancers. Studies focusing on the regulators of the pro-tumorigenic microenvironment are particularly pertinent to early diagnosis and potenti...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 21, 2018 Category: Cancer & Oncology Source Type: research