What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer
Publication date: Available online 7 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Kasper Bendix Johnsen, Johann Mar Gudbergsson, Thomas Lars Andresen, Jens Bæk SimonsenAbstractCirculating biomarkers have a great potential in diagnosing cancer diseases at early stages, where curative treatment is a realistic possibility. In the recent years, using extracellular vesicles (EVs) derived from blood as biomarkers has gained widespread popularity, mainly because they are thought to be easy to isolate and carry a vast variety of biological cargos that can be analyzed for biomarker pu...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 7, 2018 Category: Cancer & Oncology Source Type: research

Advancing the understanding of NAFLD to hepatocellular carcinoma development: From experimental models to humans
Publication date: Available online 5 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Kan Chen, Jianbo Ma, Xiaoyuan Jia, Wen Ai, Zhongren Ma, Qiuwei PanAbstractNonalcoholic fatty liver disease (NAFLD) has recently been recognized as an important etiology contributing to the increased incidence of hepatocellular carcinoma (HCC). NAFLD, characterized by fat accumulation in the liver, is affecting at least one-third of the global population. The more aggressive form, nonalcoholic steatohepatitis (NASH), is characterized by hepatocyte necrosis and inflammation. The development of effective...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 6, 2018 Category: Cancer & Oncology Source Type: research

An emerging role for nanomaterials in increasing immunogenicity of cancer cell death
Publication date: Available online 6 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Tatiana Mishchenko, Elena Mitroshina, Irina Balalaeva, Olga Krysko, Maria Vedunova, Dmitri V. KryskoAbstractIn the last decade, it has become clear that anti-cancer therapy is more successful when it can also induce an immunogenic form of cancer cell death (ICD). ICD is an umbrella term covering several cell death modalities, including apoptosis and necroptosis. In general, ICD is characterized by the emission of damage-associated molecular patterns (DAMPs) and/or cytokines/chemokines, leading to the ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 6, 2018 Category: Cancer & Oncology Source Type: research

Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Nyamao M. Rose, Jing Wu, Li Yu, Xiao Xiao, Feng-Min ZhangAbstractThe DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed in many tumors, and is linked to the regulation of many cancer-related pathways. It co-activates many transcription factors, with profound implications for cancer development, and the de-regulation of its functions is...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Unraveling the Journey of Cancer Stem Cells from Origin to Metastasis
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Rama Krishna Nimmakayala, Surinder K. Batra, Moorthy P. PonnusamyAbstractCancer biology research over recent decades has given ample evidence for the existence of self-renewing and drug-resistant populations within heterogeneous tumors, widely recognized as cancer stem cells (CSCs). However, a lack of clear understanding about the origin, existence, maintenance, and metastatic roles of CSCs limit efforts towards the development of CSC-targeted therapy. In this review, we describe novel avenues of curr...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Role of Tumor-Derived Exosomes in Cancer Metastasis
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ian Wee, Nicholas Syn, Gautam Sethi, Boon Cher Goh, Lingzhi WangAbstractThe highlights of cancer research include the discovery of exosomes, which are small (30-100 nm) sized vesicular nanoparticles released virtually by all cells. Tumor-derived exosomes (TDEs) are notoriously known for orchestrating the invasion-metastasis cascade via systemic pathways that we have previously proposed (1), resulting in a paradigm shift of our understanding about the pathobiology of metastases. In principle, exosome...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

NF-kappaB-inducing kinase in cancer
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Gunter Maubach, Michael H. Feige, Michelle C.C. Lim, Michael NaumannAbstractDysregulation of the alternative NF-κB signaling has severe developmental consequences that can ultimately lead to oncogenesis. Pivotal for the activation of the alternative NF-κB pathway is the stabilization of the NF-κB-inducing kinase (NIK). The aim of this review is to focus on the emerging role of NIK in cancer. The documented subversion of NIK in cancers highlights NIK as a possible therapeutic target. ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Dancing from bottoms up – Roles of the POZ-ZF transcription factor Kaiso in Cancer
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Christina C. Pierre, Shawn M. Hercules, Clayton Yates, Juliet M. DanielAbstractThe POZ-ZF transcription factor Kaiso was discovered two decades ago as a binding partner for p120ctn. Since its discovery, roles for Kaiso in diverse biological processes (epithelial-to-mesenchymal transition, apoptosis, inflammation) and several signalling pathways (Wnt/β-catenin, TGFβ, EGFR, Notch) have emerged. While Kaiso's biological role in normal tissues has yet to be fully elucidated, Kaiso has been incre...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Functions and clinical implications of exosomes in pancreatic cancer
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ling Qian, Shulin Yu, Zhen Chen, Zhiqiang Meng, Shenglin Huang, Peng WangAbstractPancreatic cancer is one of the most aggressive human malignancies and is associated with a dismal prognosis, which can be contributed to its atypical symptoms, metastatic propensity, and significant chemoresistance. Emerging evidence shows that pancreatic cancer cell-derived exosomes (PEXs) play critical roles in tumorigenesis and tumor development, as they are involved in drug resistance, immune evasion and metabolic re...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

The cornerstone of integrating circulating tumor DNA into cancer management
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ziyang Li, Lang Yi, Peng Gao, Rui Zhang, Jinming LiAbstractRecent circulating tumor DNA (ctDNA) research has demonstrated its potential as a non-invasive biomarker for cancer. However, the deployment of ctDNA assays in routine clinical practice remains challenging owing to variability in analytical approaches and the assessment of clinical significance. A well-developed, analytically valid ctDNA assay is a prerequisite for integrating ctDNA into cancer management, and an appropriate analytical technol...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Neural regulation of drug resistance in cancer treatment
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Dan Liu, Xiaoxi Li, Xintian Chen, Yu Sun, Anqun Tang, Zhongwei Li, Junnian Zheng, Ming ShiAbstractThe treatment of cancer has made great progress. However, drug resistance remains problematic. Multiple physiologic processes of tumor development can be dominated by central and sympathetic nervous systems. The interactions between the nervous system, immune system, and tumor occur consistently and dynamically. Recent evidence suggests that nerves and neural signals are intimately involved in the develop...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

EMT: A mechanism for escape from EGFR-targeted therapy in lung cancer
Publication date: Available online 10 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Eugene Tulchinsky, Oleg Demidov, Marina Kriajevska, Nickolai A. Barlev, Evgeny ImyanitovAbstractEpithelial mesenchymal transition (EMT) is a reversible developmental genetic programme of transdifferentiation of polarised epithelial cells to mesenchymal cells. In cancer, EMT is an important factor of tumour cell plasticity and has received increasing attention for its role in the resistance to conventional and targeted therapies. In this paper we provide an overview of EMT in human malignancies, and d...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 11, 2018 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1870, Issue 2Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 3, 2018 Category: Cancer & Oncology Source Type: research

Dynamic Matrisome: ECM Remodeling Factors Licensing Cancer Progression and Metastasis
Publication date: Available online 12 October 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Arseniy E. Yuzhalin, Su Yin Lim, Anton G. Kutikhin, Alex N. Gordon-WeeksAbstractThe main cause of cancer-related mortality, metastasis, is a complex, multi-step process. The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic progression; however, the ECM exists as a complex macromolecular substrate and it is unclear how its molecular composition promotes cancer progression. ECM homeostasis is regulated by various secreted proteins including cross-linkers (e.g., lysy...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - October 12, 2018 Category: Cancer & Oncology Source Type: research

PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Publication date: Available online 6 October 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Soonbum Park, Young Sik Kim, Davis Yeon Kim, Insuk So, Ju-Hong JeonAbstractThe phosphoinositide 3-kinase (PI3K) pathway integrates multifarious environmental cues to regulate cell survival, growth, and metabolism. Hyperactivation of the PI3K pathway increases biological fitness by offering a high degree of adaptability to and resilience against diverse perturbations, thus conferring survival benefits on premalignant and transformed cells. In prostate cancer, the PI3K pathway is aberrantly activated by ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - October 7, 2018 Category: Cancer & Oncology Source Type: research

Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment
Publication date: Available online 21 August 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Shu Chun Chang, Jeak Ling DingAbstractCells and soluble mediators of the innate and adaptive immune systems are fundamental components of the tumor microenvironment. Nuclear factors, e.g. transcription factors (TFs) and oncoproteins/cancer suppressors, play important roles in controlling cytokine functions leading to the development, maintenance and metastasis of cancers. Studies focusing on the regulators of the pro-tumorigenic microenvironment are particularly pertinent to early diagnosis and potenti...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 21, 2018 Category: Cancer & Oncology Source Type: research

The next generation of PI3K-Akt-mTOR pathway inhibitors in breast cancer cohorts
Publication date: Available online 21 August 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Michael Mc Kenna, Sarah McGarrigle, Graham P. PidgeonAbstractThe PI3K/Akt/mTOR pathway plays a role in various oncogenic processes in breast cancer and key pathway aberrations have been identified which drive the different molecular subtypes. Early drugs developed targeting this pathway produced some clinical success but were hampered by pharmacokinetics, tolerability and efficacy problems. This created a need for new PI3K pathway-inhibiting drugs, which would produce more robust results allowing incor...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 21, 2018 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: August 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1870, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 13, 2018 Category: Cancer & Oncology Source Type: research

Cancer Metabolism: the Known, Unknowns
Publication date: August 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1870, Issue 1Author(s): Chi Van Dang (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 13, 2018 Category: Cancer & Oncology Source Type: research

Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism
Publication date: Available online 6 August 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Michael S. Dahabieh, Erminia Di Pietro, Maïka Jangal, Christophe Goncalves, Michael Witcher, Nancy E. Braverman, Sonia V. del RincónAbstractCancer is irrevocably linked to aberrant metabolic processes. While once considered a vestigial organelle, we now know that peroxisomes play a central role in the metabolism of reactive oxygen species, bile acids, ether phospholipids (e.g. plasmalogens), very-long chain, and branched-chain fatty acids. Immune system evasion is a hallmark of cancer, and p...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 7, 2018 Category: Cancer & Oncology Source Type: research

Mitochondrial dynamics in cancer-induced cachexia
Publication date: Available online 29 July 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Miranda van der Ende, Sander Grefte, Rogier Plas, Jocelijn Meijerink, Renger Witkamp, Jaap Keijer, Klaske van NorrenAbstractCancer-induced cachexia has a negative impact on quality of life and adversely affects therapeutic outcomes and survival rates. It is characterized by, often severe, loss of muscle, with or without loss of fat mass. Insight in the pathophysiology of this complex metabolic syndrome and direct treatment options are still limited, which creates a research demand. Results from recent st...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 29, 2018 Category: Cancer & Oncology Source Type: research

Glutaminase isoenzymes in the metabolic therapy of cancer
Publication date: Available online 24 July 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): José M. Matés, José A. Campos-Sandoval, Javier MárquezAbstractAltered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine metabolism and their expression correlate with malignancy of tumours. The two types of glutaminase isoenzymes, GLS and GLS2, differ in their expression patterns and functional roles: GLS has oncogenic properties and GLS2 has been described as ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 24, 2018 Category: Cancer & Oncology Source Type: research

ARID1A mutant ovarian clear cell carcinoma: A clear target for synthetic lethal strategies
Publication date: Available online 17 July 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Joseph J. Caumanns, G. Bea A. Wisman, Katrien Berns, Ate G.J. van der Zee, Steven de JongAbstractSWI/SNF chromatin remodeling complexes play an important role in the epigenetic regulation of chromatin structure and gene transcription. Mutual exclusive subunits in the SWI/SNF complex include the DNA targeting members ARID1A and ARID1B as well as the ATPases SMARCA2 and SMARCA4. SWI/SNF complexes are predominantly mutated across cancers. The highest mutation incidence is found in ARID1A, primarily consisti...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 18, 2018 Category: Cancer & Oncology Source Type: research

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
Publication date: Available online 11 July 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Debangshu Samanta, Gregg L. SemenzaAbstractCancer cells are characterized by high metabolic demand. The substrates in demand include oxygen, glucose, glutamine and lipids. Oxygen serves as a key substrate in cellular metabolism and bioenergetics. Hypoxia or low oxygen abundance is a common feature of the tumor microenvironment that occurs due to an imbalance in supply and demand. The metabolic response to hypoxia in both cancer cells and stromal cells is orchestrated by hypoxia-inducible factors (HIFs). ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 11, 2018 Category: Cancer & Oncology Source Type: research

Triple negative breast cancer: Key role of Tumor-Associated Macrophages in regulating the activity of anti-PD-1/PD-L1 agents
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Matteo Santoni, Emanuela Romagnoli, Tiziana Saladino, Laura Foghini, Stefania Guarino, Marco Capponi, Massimo Giannini, Paolo Decembrini Cognigni, Gerardo Ferrara, Nicola BattelliAbstractTriple-negative breast cancer (TNBC) is associated with a poor prognosis, due to its aggressive behaviour and lack of effective targeted therapies. Immunocheckpoint inhibitors, such as anti-programmed cell death 1 (PD-1) and anti-PD-ligand(L)1 agents, are in course of investigation in TNBC, used alone or in combinat...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

The key role of extracellular vesicles in the metastatic process
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Hongyun Zhao, Abhinav Achreja, Elisabetta Iessi, Mariantonia Logozzi, Davide Mizzoni, Rossella Di Raimo, Deepak Nagrath, Stefano FaisAbstractExtracellular vesicles (EVs), including exosomes, have a key role in the paracrine communication between organs and compartments. EVs shuttle virtually all types of biomolecules such as proteins, lipids, nucleic acids, metabolites and even pharmacological compounds. Their ability to transfer their biomolecular cargo into target cells enables EVs to play a key r...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Long pentraxin 3: A novel multifaceted player in cancer
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Arianna Giacomini, Gaia Cristina Ghedini, Marco Presta, Roberto RoncaAbstractSince its discovery in 1992, long pentraxin 3 (PTX3) has been characterized as soluble patter recognition receptor, a key player of the innate immunity arm with non-redundant functions in pathogen recognition and inflammatory responses. As a component of the extra-cellular matrix milieu, PTX3 has been implicated also in wound healing/tissue remodeling, cardiovascular diseases, fertility, and infectious diseases. Consequentl...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Genetic host factors in Helicobacter pylori-induced carcinogenesis: Emerging new paradigms
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Michiel C. Mommersteeg, Jun Yu, Maikel P. Peppelenbosch, Gwenny M. FuhlerAbstractHelicobacter Pylori is a gram negative rod shaped microaerophilic bacterium that colonizes the stomach of approximately half the world's population. Infection with c may cause chronic gastritis which via a quite well described process known as Correas cascade can progress through sequential development of atrophic gastritis, intestinal metaplasia and dysplasia to gastric cancer. H. pylori is currently the only bacterium...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Ryszard Olinski, Daniel Gackowski, Marcus S. CookeAbstractThe DNA of all living cells undergoes continuous structural and chemical alteration, which may be derived from exogenous sources, or endogenous, metabolic pathways, such as cellular respiration, replication and DNA demethylation. It has been estimated that approximately 70,000 DNA lesions may be generated per day in a single cell, and this has been linked to a wide variety of diseases, including cancer. However, it is puzzling why potentially...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Functional analysis of Cullin 3 E3 ligases in tumorigenesis
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Ji Cheng, Jianping Guo, Zhiwei Wang, Brian J. North, Kaixiong Tao, Xiangpeng Dai, Wenyi WeiAbstractCullin 3-RING ligases (CRL3) play pivotal roles in the regulation of various physiological and pathological processes, including neoplastic events. The substrate adaptors of CRL3 typically contain a BTB domain that mediates the interaction between Cullin 3 and target substrates to promote their ubiquitination and subsequent degradation. The biological implications of CRL3 adaptor proteins have been wel...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Deubiquitylating enzymes as cancer stem cell therapeutics
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): Saba Haq, Bharathi Suresh, Suresh RamakrishnaAbstractThe focus of basic and applied research on core stem cell transcription factors has paved the way to initial delineation of their characteristics, their regulatory mechanisms, and the applicability of their regulatory proteins for protein-induced pluripotent stem cells (protein-IPSC) generation and in further clinical settings. Striking parallels have been observed between cancer stem cells (CSCs) and stem cells. For the maintenance of stem cells ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: January 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Fusion genes: A promising tool combating against cancer
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Xiaofeng Dai, Rutaganda Theobard, Hongye Cheng, Mengtao Xing, Jianying ZhangAbstractThe driving roles of fusion genes during tumorigenesis have been recognized for decades, with efficacies demonstrated in clinical diagnosis and targeted therapy. With advances in sequencing technologies and computational biology, a surge in the identification of fusion genes has been witnessed during the past decade. The discovery and presence of splicing based fusions in normal tissues have challenged our canonical co...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Bartosz Wawrzynow, Alicja Zylicz, Maciej ZyliczAbstractOrganized networks of heat shock proteins, which possess molecular chaperone activity, protect cells from abrupt environmental changes. Additionally, molecular chaperones are essential during stress-free periods, where they moderate housekeeping functions. During tumorigenesis, these chaperone networks are extensively remodeled in such a way that they are advantageous to the transforming cell. Molecular chaperones by buffering critical elements of...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Catherine J. Libby, Anh Nhat Tran, Sarah E. Scott, Corinne Griguer, Anita B. HjelmelandAbstractDe-regulated cellular energetics is an emerging hallmark of cancer with alterations to glycolysis, oxidative phosphorylation, the pentose phosphate pathway, lipid oxidation and synthesis and amino acid metabolism. Understanding and targeting of metabolic reprogramming in cancers may yield new treatment options, but metabolic heterogeneity and plasticity complicate this strategy. One highly heterogeneous canc...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): I. Marques-Aleixo, E. Santos-Alves, P.J. Oliveira, P.I. Moreira, J. Magalhães, A. AscensãoAbstractDoxorubicin (DOX) is a widely used antineoplastic agent for a wide range of cancers, including hematological malignancies, soft tissue sarcomas and solid tumors. However, DOX exhibits a dose-related toxicity that results in life-threatening cardiomyopathy. In addition to the heart, there is evidence that DOX toxicity extends to other organs. This general toxicity seems to be related to mitoc...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Reformation in chimeric antigen receptor based cancer immunotherapy: Redirecting natural killer cell
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Chu Lin, Jun ZhangAbstractNatural killer (NK) cells are an important subset of lymphocytes which play a critical role in host immunity against cancers. With MHC-independent recognition, short lifespan and potent cytotoxicity, NK cells make a promising candidate for chimeric antigen receptor (CAR)-engineered cancer immunotherapy. Due to innate biological properties of NK cells, CAR-NK may outperform CAR-T therapy in terms of less side effects and more universal access, which may become a great reformat...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

High Mobility Group A (HMGA) proteins: Molecular instigators of breast cancer onset and progression
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Riccardo Sgarra, Silvia Pegoraro, Gloria Ros, Carlotta Penzo, Eusebio Chiefari, Daniela Foti, Antonio Brunetti, Guidalberto ManfiolettiAbstractCancer heterogeneity is one of the factors that constitute an obstacle towards an efficient targeting of this multifaceted disease. Molecular information can help in classifying cancer subtypes and in providing clinicians with novel targeted therapeutic opportunities. In this regard, classification of breast cancer into intrinsic subtypes based on molecular pro...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

HOX cluster-embedded micro-RNAs and cancer
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Sebastian Fantini, Valentina Salsi, Vincenzo Zappavigna (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Molecular classification as prognostic factor and guide for treatment decision of pancreatic cancer
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): David J. Birnbaum, François Bertucci, Pascal Finetti, Daniel Birnbaum, Emilie MamessierAbstractClinico-pathological factors fail to consistently predict the outcome after pancreatic resection for pancreatic ductal adenocarcinoma (PDAC). PDACs show a high level of inter- and intra- tumor genetic heterogeneity. A molecular classification should help sort patients into less heterogeneous and more appropriate groups regarding the metastatic risk and the therapeutic response, with the consequences o...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Protein restriction and cancer
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Jie Yin, Wenkai Ren, Xingguo Huang, Tiejun Li, Yulong YinAbstractProtein restriction without malnutrition is currently an effective nutritional intervention known to prevent diseases and promote health span from yeast to human. Recently, low protein diets are reported to be associated with lowered cancer incidence and mortality risk of cancers in human. In murine models, protein restriction inhibits tumor growth via mTOR signaling pathway. IGF-1, amino acid metabolic programing, FGF21, and autophagy m...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Oligonucleotide aptamers against tyrosine kinase receptors: Prospect for anticancer applications
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Simona Camorani, Elvira Crescenzi, Monica Fedele, Laura CerchiaAbstractTransmembrane receptor tyrosine kinases (RTKs) play crucial roles in cancer cell proliferation, survival, migration and differentiation. Area of intense research is searching for effective anticancer therapies targeting these receptors and, to date, several monoclonal antibodies and small-molecule tyrosine kinase inhibitors have entered the clinic. However, some of these drugs show limited efficacy and give rise to acquired resista...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

ILT4 functions as a potential checkpoint molecule for tumor immunotherapy
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Aiqin Gao, Yuping Sun, Guangyong PengAbstractImmune checkpoint blockade therapy targeting CTLA4 and PD-1/PD-L1 is a promising strategy in the treatment of different types of cancers. However, the clinical success rates of these therapies are still moderate and varied among cancer types. Therefore, identification of alternative and novel checkpoint molecules or interrupting tolerogenic pathways is urgently needed for successful tumor immunotherapy. Immunoglobulin-like transcript 4 (ILT4) is as an immun...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Nervous system and primary liver cancer
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Seogsong Jeong, Bo Zheng, Hongyang Wang, Qiang Xia, Lei ChenAbstractRecent advances have found irregular activities of the nervous system-associated factors in the development and progression of primary liver cancer. These factors contributed in the regulation of migration, proliferation, and apoptosis of cancer cells, and took a role in modulating invasion, metastasis, and recurrence after curative treatment. In clinical researches, neural-related factors were found to be significant prognostic facto...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

The role of compartmentalized signaling pathways in the control of mitochondrial activities in cancer cells
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Laura Rinaldi, Rossella Delle Donne, Domenica Borzacchiello, Luigi Insabato, Antonio FelicielloAbstractMitochondria are the powerhouse organelles present in all eukaryotic cells. They play a fundamental role in cell respiration, survival and metabolism. Stimulation of G-protein coupled receptors (GPCRs) by dedicated ligands and consequent activation of the cAMP·PKA pathway finely couple energy production and metabolism to cell growth and survival. Compartmentalization of PKA signaling at mitoch...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Phosphate toxicity and tumorigenesis
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Ronald B. Brown, Mohammed S. RazzaqueAbstractIn this article, we briefly summarized evidence that cellular phosphate burden from phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells express more phosphate cotransporters and store more inorganic phosphate than normal cells, and dysregulated phosphate homeostasis is associated with the genesis of various human tumors. High dietary phosphate consumption causes the growth of lung and skin tumors in experimental animal ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

Microcalcifications in breast cancer: From pathophysiology to diagnosis and prognosis
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): S. O'Grady, M.P. MorganAbstractThe implementation of mammographic screening programmes in many countries has been linked to a marked increase in early detection and improved prognosis for breast cancer patients. Breast tumours can be detected by assessing several features in mammographic images but one of the most common are the presence of small deposits of calcium known as microcalcifications, which in many cases may be the only detectable sign of a breast tumour. In addition to their efficacy in th...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

RGD cadherins and α2β1 integrin in cancer metastasis: A dangerous liaison
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): J. Ignacio Casal, Rubén A. BartoloméAbstractWe propose a new cadherin family classification comprising epithelial cadherins (cadherin 17 [CDH17], cadherin 16, VE-cadherin, cadherin 6 and cadherin 20) containing RGD motifs within their sequences. Expression of some RGD cadherins is associated with aggressive forms of cancer during the late stages of metastasis, and CDH17 and VE-cadherin have emerged as critical actors in cancer metastasis. After binding to α2β1 integrin, these ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastoma
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Diana A. Aderetti, Vashendriya V.V. Hira, Remco J. Molenaar, Cornelis J.F. van NoordenAbstractGlioblastoma is the most lethal primary brain tumor and poor survival of glioblastoma patients is attributed to the presence of glioma stem cells (GSCs). These therapy-resistant, quiescent and pluripotent cells reside in GSC niches, which are specific microenvironments that protect GSCs against radiotherapy and chemotherapy. We previously showed the existence of hypoxic peri-arteriolar GSC niches in glioblast...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research

An epi(c)genetic war: Pathogens, cancer and human genome
Publication date: April 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1869, Issue 2Author(s): Deepa Rajagopalan, Sudhakar JhaAbstractCancer is characterized by inter- and intra-tumor heterogeneity and this is also observed in the context of cancers caused by pathogens. Nearly 20% of all cancers are attributable to pathogenic organisms. Pathogenic infections result in deregulation of gene expression both by genetic and epigenetic mechanisms, thereby causing malignant transformation. Another characteristic of pathogen-induced cancers is the occurrence of chronic inflammation due to activation of...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 10, 2018 Category: Cancer & Oncology Source Type: research