Shotgun lipidomics-based characterization of the landscape of lipid metabolism in colorectal cancer
Publication date: Available online 30 November 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Yuting Wang, Sebastian Hinz, Ortrud Uckermann, Pia Hönscheid, Witigo von Schönfels, Greta Burmeister, Alexander Hendricks, Jacobo Miranda Ackerman, Gustavo B. Baretton, Jochen Hampe, Mario Brosch, Clemens Schafmayer, Andrej Shevchenko, Sebastian ZeissigAbstractSolid tumors are characterized by global metabolic alterations which contribute to their growth and progression. Altered gene expression profiles and plasma lipid composition suggested a role for metabolic reprogramming in ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 1, 2019 Category: Lipidology Source Type: research

Carotenoid metabolism at the intestinal barrier
This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - November 30, 2019 Category: Lipidology Source Type: research

Conserved mechanism of phospholipid substrate recognition by the P4-ATPase Neo1 from Saccharomyces cerevisiae
Publication date: Available online 28 November 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Yannan Huang, Mehmet Takar, Jordan T. Best, Todd R. GrahamAbstractThe type IV P-type ATPases (P4-ATPases) thus far characterized are lipid flippases that transport specific substrates, such as phosphatidylserine (PS) and phosphatidylethanolamine (PE), from the exofacial leaflet to the cytofacial leaflet of membranes. This transport activity generates compositional asymmetry between the two leaflets important for signal transduction, cytokinesis, vesicular transport, and host-pathog...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - November 30, 2019 Category: Lipidology Source Type: research

Altered arachidonic acid-derived inflammatory eicosanoids brain levels in a rodent model of anorexia nervosa
Publication date: Available online 26 November 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): R. Collu, J.M. Post, M. Scherma, E. Giunti, W. Fratta, B. Lutz, P. Fadda, L. BindilaAbstractIncreasing evidence underline the role of inflammation in the behavioral, emotional and cognitive dysregulations displayed in anorexia nervosa (AN). Among the inflammatory mediators acting at both, peripheral and central levels, growing attention receives a class of lipids derived from arachidonic acid (AA), called eicosanoids (eiCs), which exert a complex, multifaceted role in a wide range ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - November 27, 2019 Category: Lipidology Source Type: research

Lipid accumulation and mitochondrial abnormalities are associated with fiber atrophy in the skeletal muscle of rats with collagen-induced arthritis
In conclusion, the reduced adipose tissue adipogenic capacity and skeletal muscle mitochondrial capacity are probably involved in the activation of protein catabolism, inhibition of myogenesis, accumulation of lipids and fiber atrophy in the skeletal muscle during RA. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - November 25, 2019 Category: Lipidology Source Type: research