Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Novel signaling aspects of ceramide 1-phosphate
Publication date: Available online 17 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Natalia Presa, Ana Gomez-Larrauri, Asier Dominguez-Herrera, Miguel Trueba, Antonio Gomez-MuñozAbstractThe bioactive sphingolipid ceramide 1-phosphate (C1P) regulates key physiologic cell functions and is implicated in a number of metabolic alterations and pathological processes. Initial studies using different types of fibroblasts and monocytes/macrophages revealed that C1P was mitogenic and that it promoted cell survival through inhibition of apoptosis. Subsequent studies implicat...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 19, 2020 Category: Lipidology Source Type: research

Effects of peptidoglycan on the development of steatohepatitis
Publication date: Available online 14 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Meiling Jin, Yihong Lai, Peili Zhao, Qian Shen, Wen Su, Yue Yin, Weizhen ZhangAbstractElevating evidences suggested roles of peptidoglycan (PGN) for the insulin resistance, metabolic inflammation and liver disorders. But, whether PGN affects the occurrence of steatohepatitis remains unclear. Here, we reported that subcutaneous infusion of purified PGN for 4 weeks significantly increased hepatic levels of triglyceride, inflammation and fibrosis in mice fed normal chow. These altera...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 16, 2020 Category: Lipidology Source Type: research

Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature
Publication date: Available online 15 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Ilaria Del Gaudio, Ivana Sreckovic, Pablo Zardoya-Laguardia, Eva Bernhart, Christina Christoffersen, Saša Frank, Gunther Marsche, Sebastian E. Illanes, Christian WadsackAbstractPerinatal and long-term offspring morbidities are strongly dependent on the preservation of placental vascular homeostasis during pregnancy. In adults, the HDL-apoM-S1P complex protects the endothelium and maintains vascular integrity. However, the metabolism and biology of cord blood-derived HDLs (referred ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 16, 2020 Category: Lipidology Source Type: research

The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells
Publication date: Available online 15 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Mariam Alsanafi, Samuel L. Kelly, Melissa McNaughton, Alfred H. Merrill, Nigel J. Pyne, Susan PyneAbstractSince inhibitors of sphingosine kinases (SK1, SK2) have been shown to induce p53-mediated cell death, we have further investigated their role in regulating p53, stress activated protein kinases and XBP-1s in HEK293T cells. Treatment of these cells with the sphingosine kinase inhibitor, SKi, which fails to induce apoptosis, promoted the conversion of p53 into two proteins with mo...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 16, 2020 Category: Lipidology Source Type: research

Carotenoids and their role in cancer prevention
This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 13, 2020 Category: Lipidology Source Type: research

The macular carotenoids: A biochemical overview
This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 11, 2020 Category: Lipidology Source Type: research

The mitochondrial PKCδ/retinol signal complex exerts real-time control on energy homeostasis
Publication date: Available online 10 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Youn-Kyung Kim, Ulrich HammerlingAbstractThe review focuses on the role of vitamin A (retinol) in the control of energy homeostasis, and on the manner in which certain retinoids subvert this process, leading potentially to disease. In eukaryotic cells, the pyruvate dehydrogenase complex (PDHC) is negatively regulated by four pyruvate dehydrogenase kinases (PDKs) and two antagonistically acting pyruvate dehydrogenase phosphatases (PDPs). The second isoform, PDK2, is regulated by an a...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 10, 2020 Category: Lipidology Source Type: research

Health benefits of fucoxanthin in the prevention of chronic diseases
This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 10, 2020 Category: Lipidology Source Type: research

Altered brain levels of arachidonic acid-derived inflammatory eicosanoids in a rodent model of anorexia nervosa
Publication date: April 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Volume 1865, Issue 4Author(s): Roberto Collu, Julia Maria Post, Maria Scherma, Elisa Giunti, Walter Fratta, Beat Lutz, Paola Fadda, Laura BindilaAbstractIncreasing evidence underline the role of inflammation in the behavioral, emotional and cognitive dysregulations displayed in anorexia nervosa (AN). Among the inflammatory mediators acting at both peripheral and central levels, growing attention receives a class of lipids derived from arachidonic acid (AA), called eicosanoids (eiCs), which exert a complex, multif...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 10, 2020 Category: Lipidology Source Type: research

Sustained maternal smoking-associated changes in the physico-chemical properties of fetal RBC membranes might serve as early markers for vascular comorbidities
Publication date: Available online 8 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Gábor Balogh, Payal Chakraborty, Krisztina N. Dugmonits, Mária Péter, Attila G. Végh, László Vígh, Edit HermeszAbstractMaternal smoking-induced congenital heart and microvascular defects are closely associated with the impaired functioning of the in-utero feto-placental circulation system. Current groundbreaking facts revealed intimate crosstalk between circulating red blood cells (RBCs) and the vascular endothelium. Thus, RBCs have become the protagonists under varied patholo...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 9, 2020 Category: Lipidology Source Type: research

X-box binding protein 1 (XBP1): A key protein for renal osmotic adaptation. Its role in lipogenic program regulation
Publication date: Available online 9 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Cecilia Casali, Ricardo Malvicini, Luciana Erjavec, Leandro Parra, Ayelen Artuch, María C. Fernández TomeAbstractIn renal cells, hyperosmolarity can induce cellular stress or differentiation. Both processes require active endoplasmic reticulum (ER)-associated protein synthesis. Lipid biosynthesis also occurs at ER surface. We showed that hyperosmolarity upregulates glycerophospholipid (GP) and triacylglycerol (GL-TG) de novo synthesis. Considering that massive synthesis of proteins...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 9, 2020 Category: Lipidology Source Type: research

Editorial Board
Publication date: March 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Volume 1865, Issue 3Author(s): (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 9, 2020 Category: Lipidology Source Type: research

Endothelial lipase increases eNOS activating capacity of high-density lipoprotein
In conclusion, EL increases eNOS activating capacity of HDL, a phenomenon accompanied by an enrichment of the plasma membrane eNOS pool, a decreased cell membrane FC and increased cellular CE content. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 8, 2020 Category: Lipidology Source Type: research

Eosinophils synthesize trihydroxyoctadecenoic acids (TriHOMEs) via a 15-lipoxygenase dependent process
Publication date: Available online 7 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): David Fuchs, Xiao Tang, Anna-Karin Johnsson, Sven-Erik Dahlén, Mats Hamberg, Craig E. WheelockAbstractTrihydroxyoctadecenoic acids (TriHOMEs) are linoleic acid-derived lipid mediators reported to be dysregulated in obstructive lung disease. In contrast to many other oxylipins, TriHOME biosynthesis in humans is still poorly understood. The association of TriHOMEs with inflammation prompted the current investigation into the ability of human granulocytes to synthesize the 16 different...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 7, 2020 Category: Lipidology Source Type: research

Changes in redox and endoplasmic reticulum homeostasis are related to congenital generalized lipodystrophy type 2
Publication date: Available online 7 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Aquiles Sales Craveiro Sarmento, Josivan Gomes Lima, Ana Rafaela de Souza Timoteo, Marcela Abbott Galvão Ururahy, Aurigena Antunes de Araújo, Roseane Carvalho Vasconcelos, Verônica Kristina Cândido Dantas, Lucymara Fassarella Agnez-Lima, Julliane Tamara Araújo de Melo CamposAbstractCGL type 2 is a rare autosomal recessive syndrome characterized by an almost complete lack of body fat. CGL is caused by loss-of-function mutations in both alleles of the BSCL2 gene that codifies to s...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 7, 2020 Category: Lipidology Source Type: research