Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The complex CBX7-PRMT1 has a critical role in regulating E-cadherin gene expression and cell migration
Publication date: Available online 28 February 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Antonella Federico, Romina Sepe, Flora Cozzolino, Claudia Piccolo, Carla Iannone, Ilaria Iacobucci, Piero Pucci, Maria Monti, Alfredo FuscoAbstractThe Chromobox protein homolog 7 (CBX7) belongs to the Polycomb Group (PcG) family, and, as part of the Polycomb repressive complex (PRC1), contributes to maintain transcriptional gene repression. Loss of CBX7 expression has been reported in several human malignant neoplasias, where it often correlates with an advanced cancer state and poor surviva...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - March 1, 2019 Category: Genetics & Stem Cells Source Type: research

The nuclear receptors PXR and LXR are regulators of the scaffold protein PDZK1
Publication date: Available online 1 March 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Celio Ferreira, Ramona Meyer, Henriette E. Meyer zu SchwabedissenAbstractPDZK1 (NHERF3) interacts with membrane proteins whereby modulating their spatial arrangement, membrane stability, and function. One of the membrane proteins shown to be stabilized by interaction with PDZK1 is the HDL-receptor SR-BI (SCARB1). Testing the influence of TO 901317, a known activator of liver X receptor alpha (LXRα, NR1H3) which is a central regulator of the lipid homeostasis, Grefhorst et al. reported in 2012 t...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - March 1, 2019 Category: Genetics & Stem Cells Source Type: research

The bZIP mutant CEBPB (V285A) has sequence specific DNA binding propensities similar to CREB1
Publication date: Available online 27 February 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Sreejana Ray, Aniekanabasi Ufot, Nima Assad, Jocelyn Singh, Stewart R. Durell, Aleksey Porollo, Desiree Tillo, Charles VinsonAbstractThe bZIP homodimers CEBPB and CREB1 bind DNA containing methylated cytosines differently. CREB1 binds stronger to the C/EBP half-site GCAA when this cytosine, is methylated. For CEBPB, methylation of the same cytosine does not affect DNA binding. The X-ray structure of CREB1 binding the half site GTCA identifies an alanine in the DNA binding region interacting ...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - February 28, 2019 Category: Genetics & Stem Cells Source Type: research

Cytosine methylation of mitochondrial DNA at CpG sequences impacts transcription factor A DNA binding and transcription
Publication date: Available online 23 February 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Vishantie Dostal, Mair E.A. ChurchillAbstractIn eukaryotes, cytosine methylation of nuclear DNA at CpG sequences (5mCpG) regulates epigenetic inheritance through alterations in chromatin structure. However, mitochondria lack nucleosomal chromatin, therefore the molecular mechanisms by which 5mCpG influences mitochondria must be different and are as yet unknown. Mitochondrial Transcription Factor A (TFAM) is both the primary DNA-compacting protein in the mitochondrial DNA (mtDNA) nucleoid and...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - February 25, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: February 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1862, Issue 2Author(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - February 14, 2019 Category: Genetics & Stem Cells Source Type: research

Regulatory effect of host miR-101b-3p on parasitism of nematode Angiostrongylus cantonensis via superoxide dismutase 3
Publication date: Available online 11 February 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Dongjuan Yuan, Shiqi Luo, Lian Xu, Xingda Zeng, Zhongdao WuAbstractMicroRNA plays a vital role in the regulation of host-parasite interaction. In recent years, genomic and transcriptomic resources have become increasingly available for many helminths, but only a limited number of reports in this area are on the regulatory effects of host microRNAs on parasitic nematodes. In this work, we screened increased expression of host microRNAs after nematode infection from miRNA-seq data and predicte...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - February 12, 2019 Category: Genetics & Stem Cells Source Type: research

MiR-15/16 mediate crosstalk between the MAPK and Wnt/β-catenin pathways during hepatocyte differentiation from amniotic epithelial cells
In this study, we showed up-regulation of miR-15/16 during HGF- and FGF4-induced hepatocyte differentiation from amniotic epithelial cells (AECs). To elucidate the role of miR-15/16 and their targets in hepatocyte differentiation, we investigated the roles of miR-15/16 in both the MAPK and Wnt/β-catenin pathways, which were predicted to be involved in miR-15/16 signaling. Our results demonstrated that the transcription of miR-15/16 was enhanced by c-Fos, c-Jun, and CREB, important elements of the MAPK pathway, and miR-15/16 in turn directly targeted adenomatous polyposis coli (APC) protein, a major member of the β-cateni...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - February 11, 2019 Category: Genetics & Stem Cells Source Type: research

Rice Trithorax factor ULTRAPETALA 1 (OsULT1) specifically binds to “GAGAG” sequence motif present in Polycomb response elements
In this study, we have characterised DNA binding property of rice trithorax group factor ULTRAPETALA1 (OsULT1) which has a SAND domain and B–box motif. Chromatin immunoprecipitation assay indicates cold induced enrichment of OsULT1 occupancy and a decrease in H3K27me3 mark in the promoter region of OsDREB1b gene, during transcription activation. OsULT1 binds to the cis motif “GAGAG”, and the sequence specificity is contributed mainly by the SAND domain. GAGAG is one of the cis motifs present in PREs that are recognized by Drosophila GAGA factor and Pipsqueak. Thus, binding of OsULT1 to GAGAG motif, along with a decre...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - February 11, 2019 Category: Genetics & Stem Cells Source Type: research

Delineation of critical amino acids in activation function 1 of progesterone receptor for recruitment of transcription coregulators
This study focuses on the progesterone receptor (PR) and reports the identification of K464, K481 and R492 (KKR) as the key functional residues of PR AF1. The KKR are monomethylated and function cooperatively. The combined mutations of KKR to QQQ render PR isoform B (PRB) hyperactive, whereas KKR to FFF mutations abolishes as much as 80% of PR activity. Furthermore, the hyperactive QQQ mutation rescues the loss of PR activity due to E911A mutation in AF2. The study also finds that the magnitudes of the mutational effect differ in different cell types as a result of differential effects on the functional interaction with co...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - February 2, 2019 Category: Genetics & Stem Cells Source Type: research

Class II transactivator (CIITA) mediates IFN-γ induced eNOS repression by enlisting SUV39H1
In conclusion, our data reveal a novel role for CIITA in endothelial cells and present SUV39H1 as a druggable target in the intervention of endothelial dysfunction. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - February 2, 2019 Category: Genetics & Stem Cells Source Type: research

Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-κB/EZH2/YY1 axis in early-stage colon cancers
Publication date: Available online 1 February 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Hsiang-Chi Huang, Chia-Chun Chao, Po-Han Wu, Hsiao-Yu Chung, Hsueh-Yi Lee, Ching-Shu Suen, Ming-Jing Hwang, Bi-He Cai, Reiji KannagiAbstractNormal colonic epithelial cells express sialyl 6-sulfo Lewisx and disialyl Lewisa on their cell surface, which are ligands for the immunosuppressive molecule Siglec-7. Expression of these normal glycans is frequently lost upon malignant transformation by silencing DTDST and ST6GalNAc6 at the early stage of colorectal carcinogenesis, and leads to productio...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - February 1, 2019 Category: Genetics & Stem Cells Source Type: research

Hallmarks of HPV carcinogenesis: The role of E6, E7 and E5 oncoproteins in cellular malignancy
Publication date: Available online 29 January 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Diogo Estêvão, Natália Rios Costa, Rui M. Gil da Costa, Rui MedeirosAbstractHuman papillomavirus (HPV) is the most common sexually transmitted infectious agent worldwide, being also responsible for 5% of all human cancers. The integration and hypermethylation mechanisms of the HPV viral genome promote the unbalanced expression of the E6, E7 and E5 oncoproteins, which are crucial factors for the carcinogenic cascade in HPV-induced cancers. This review highlights the action of E6, E7 and E5 ...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 30, 2019 Category: Genetics & Stem Cells Source Type: research

Characterization of Toxoplasma gondii Spt5 like transcription elongation factor
Publication date: Available online 29 January 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Pallabi Mitra, Abhijit S. Deshmukh, Rajkumar Gurupwar, Poonam KashyapAbstractElongation has emerged as a highly regulated step in the multistage process of transcription. Control of gene expression mediated through transcription elongation remains an unexplored area of study in Toxoplasma gondii where the demands of complex lifecycle necessitate a regulated transcription program. Here, we elucidate the central role of Spt5 homolog in T. gondii mRNA transcription. We demonstrate that TgSpt5 fu...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 29, 2019 Category: Genetics & Stem Cells Source Type: research

Readers of the m6A epitranscriptomic code
This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - January 18, 2019 Category: Genetics & Stem Cells Source Type: research

The adaptive potential of RNA editing-mediated miRNA-retargeting in cancer
This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - December 31, 2018 Category: Genetics & Stem Cells Source Type: research